{"id":"https://openalex.org/W4389958629","doi":"https://doi.org/10.1161/hypertensionaha.123.22180","title":"Sex Differences in the Association of Age at Hypertension Diagnosis With Brain Structure","display_name":"Sex Differences in the Association of Age at Hypertension Diagnosis With Brain Structure","publication_year":2024,"publication_date":"2024-01-17","ids":{"openalex":"https://openalex.org/W4389958629","doi":"https://doi.org/10.1161/hypertensionaha.123.22180","pmid":"https://pubmed.ncbi.nlm.nih.gov/38112100"},"language":"en","primary_location":{"id":"doi:10.1161/hypertensionaha.123.22180","doi":"https://doi.org/10.1161/hypertensionaha.123.22180","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.123.22180","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101997662","display_name":"Amanpreet Kaur","orcid":"https://orcid.org/0000-0001-5004-7614","observed_orcids":["https://orcid.org/0000-0001-5004-7614"]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405263283","display_name":"Research Institute of the McGill University Health Centre","ror":"https://ror.org/04pemf943","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405263283","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Amanpreet Kaur","raw_affiliation_strings":["Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Canada (A.K., A.A.F., H.B., L.P.)","Department of Medicine, Faculty of Medicine and Health Sciences, McGill University Health Centre, Montreal, Canada (A.K., L.P.)","Amanpreet Kaur https://orcid.org/0000-0001-5004-7614 Department of Medicine, Faculty of Medicine and Health Sciences, McGill University Health Centre, Montreal, Canada (A.K., L.P.). Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Canada (A.K., A.A.F., H.B., L.P.)"],"raw_orcid":"https://orcid.org/0000-0001-5004-7614","affiliations":[{"raw_affiliation_string":"Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Canada (A.K., A.A.F., H.B., L.P.)","institution_ids":["https://openalex.org/I4405263283"]},{"raw_affiliation_string":"Department of Medicine, Faculty of Medicine and Health Sciences, McGill University Health Centre, Montreal, Canada (A.K., L.P.)","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Amanpreet Kaur https://orcid.org/0000-0001-5004-7614 Department of Medicine, Faculty of Medicine and Health Sciences, McGill University Health Centre, Montreal, Canada (A.K., L.P.). Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Canada (A.K., A.A.F., H.B., L.P.)","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I4405263283","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076672052","display_name":"Adriana Angarita Fonseca","orcid":"https://orcid.org/0000-0003-3806-8468","observed_orcids":["https://orcid.org/0000-0003-3806-8468"]},"institutions":[{"id":"https://openalex.org/I4405263283","display_name":"Research Institute of the McGill University Health Centre","ror":"https://ror.org/04pemf943","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405263283","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Adriana Angarita Fonseca","raw_affiliation_strings":["Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Canada (A.K., A.A.F., H.B., L.P.)","Adriana Angarita Fonseca Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Canada (A.K., A.A.F., H.B., L.P.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Canada (A.K., A.A.F., H.B., L.P.)","institution_ids":["https://openalex.org/I4405263283"]},{"raw_affiliation_string":"Adriana Angarita Fonseca Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Canada (A.K., A.A.F., H.B., L.P.)","institution_ids":["https://openalex.org/I4405263283"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002100222","display_name":"Rikki Lissaman","orcid":"https://orcid.org/0000-0002-4927-6740","observed_orcids":["https://orcid.org/0000-0002-4927-6740"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Rikki Lissaman","raw_affiliation_strings":["Department of Psychiatry, Faculty of Medicine and Health Sciences (R.L., M.N.R.), McGill University, Montreal, Canada","Douglas Institute Research Centre (R.L.), McGill University, Montreal, Canada","Rikki Lissaman https://orcid.org/0000-0002-4927-6740 Douglas Institute Research Centre (R.L.), McGill University, Montreal, Canada. Department of Psychiatry, Faculty of Medicine and Health Sciences (R.L., M.N.R.), McGill University, Montreal, Canada"],"raw_orcid":"https://orcid.org/0000-0002-4927-6740","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Faculty of Medicine and Health Sciences (R.L., M.N.R.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Douglas Institute Research Centre (R.L.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Rikki Lissaman https://orcid.org/0000-0002-4927-6740 Douglas Institute Research Centre (R.L.), McGill University, Montreal, Canada. Department of Psychiatry, Faculty of Medicine and Health Sciences (R.L., M.N.R.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037490018","display_name":"Hassan Behlouli","orcid":"https://orcid.org/0000-0002-8636-0423","observed_orcids":["https://orcid.org/0000-0002-8636-0423"]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405263283","display_name":"Research Institute of the McGill University Health Centre","ror":"https://ror.org/04pemf943","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405263283","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hassan Behlouli","raw_affiliation_strings":["Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Canada (A.K., A.A.F., H.B., L.P.)","Hassan Behlouli Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Canada (A.K., A.A.F., H.B., L.P.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Canada (A.K., A.A.F., H.B., L.P.)","institution_ids":["https://openalex.org/I4405263283"]},{"raw_affiliation_string":"Hassan Behlouli Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Canada (A.K., A.A.F., H.B., L.P.)","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I4405263283"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053523610","display_name":"Maria Natasha Rajah","orcid":"https://orcid.org/0000-0001-6177-7049","observed_orcids":["https://orcid.org/0000-0001-6177-7049"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]},{"id":"https://openalex.org/I530967","display_name":"Toronto Metropolitan University","ror":"https://ror.org/05g13zd79","country_code":"CA","type":"education","lineage":["https://openalex.org/I530967"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M. Natasha Rajah","raw_affiliation_strings":["Department of Psychiatry, Faculty of Medicine and Health Sciences (R.L., M.N.R.), McGill University, Montreal, Canada","Department of Psychology, Faculty of Arts, Toronto Metropolitan University, Canada (M.N.R.)","M. Natasha Rajah https://orcid.org/0000-0001-6177-7049 Department of Psychiatry, Faculty of Medicine and Health Sciences (R.L., M.N.R.), McGill University, Montreal, Canada. Department of Psychology, Faculty of Arts, Toronto Metropolitan University, Canada (M.N.R.)"],"raw_orcid":"https://orcid.org/0000-0001-6177-7049","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Faculty of Medicine and Health Sciences (R.L., M.N.R.), McGill University, Montreal, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Department of Psychology, Faculty of Arts, Toronto Metropolitan University, Canada (M.N.R.)","institution_ids":["https://openalex.org/I530967"]},{"raw_affiliation_string":"M. Natasha Rajah https://orcid.org/0000-0001-6177-7049 Department of Psychiatry, Faculty of Medicine and Health Sciences (R.L., M.N.R.), McGill University, Montreal, Canada. Department of Psychology, Faculty of Arts, Toronto Metropolitan University, Canada (M.N.R.)","institution_ids":["https://openalex.org/I5023651","https://openalex.org/I530967"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017235084","display_name":"Louise Pilote","orcid":"https://orcid.org/0000-0002-6159-0628","observed_orcids":["https://orcid.org/0000-0002-6159-0628"]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405263283","display_name":"Research Institute of the McGill University Health Centre","ror":"https://ror.org/04pemf943","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405263283","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Louise Pilote","raw_affiliation_strings":["Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Canada (A.K., A.A.F., H.B., L.P.)","Department of Medicine, Faculty of Medicine and Health Sciences, McGill University Health Centre, Montreal, Canada (A.K., L.P.)"],"raw_orcid":"https://orcid.org/0000-0002-6159-0628","affiliations":[{"raw_affiliation_string":"Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Canada (A.K., A.A.F., H.B., L.P.)","institution_ids":["https://openalex.org/I4405263283"]},{"raw_affiliation_string":"Department of Medicine, Faculty of Medicine and Health Sciences, McGill University Health Centre, Montreal, Canada (A.K., L.P.)","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5997,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.89715746,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"81","issue":"2","first_page":"291","last_page":"301"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cerebral-small-vessel-disease","display_name":"cerebral small vessel disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/brain-structure","display_name":"brain structure","score":0.7379999756813049},{"id":"https://openalex.org/keywords/white-matter-hyperintensities","display_name":"white matter hyperintensities","score":0.9589999914169312},{"id":"https://openalex.org/keywords/white-matter-microstructure","display_name":"white matter microstructure","score":0.9710000157356262},{"id":"https://openalex.org/keywords/grey-matter-volume","display_name":"gray matter volume","score":0.8799999952316284},{"id":"https://openalex.org/keywords/white-matter-volume","display_name":"white matter volume","score":0.8149999976158142},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.722000002861023},{"id":"https://openalex.org/keywords/vascular-risk-factors","display_name":"vascular risk factors","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.674411416053772},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.6618900299072266},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6128689050674438},{"id":"https://openalex.org/C146638467","wikidata":"https://www.wikidata.org/wiki/Q10529587","display_name":"Hyperintensity","level":3,"score":0.6070705056190491},{"id":"https://openalex.org/C2776191500","wikidata":"https://www.wikidata.org/wiki/Q2123166","display_name":"Leukoaraiosis","level":4,"score":0.6013286113739014},{"id":"https://openalex.org/C65835030","wikidata":"https://www.wikidata.org/wiki/Q1030681","display_name":"Brain size","level":3,"score":0.5561491250991821},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5014872550964355},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4965575337409973},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.475728303194046},{"id":"https://openalex.org/C2777097880","wikidata":"https://www.wikidata.org/wiki/Q988405","display_name":"Essential hypertension","level":3,"score":0.42114678025245667},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3265857696533203},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.1585579514503479}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059345","descriptor_name":"Cerebral Small Vessel Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D059345","descriptor_name":"Cerebral Small Vessel Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1161/hypertensionaha.123.22180","doi":"https://doi.org/10.1161/hypertensionaha.123.22180","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.123.22180","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},{"id":"pmid:38112100","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38112100","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension (Dallas, Tex. : 1979)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1934592423","https://openalex.org/W1969474603","https://openalex.org/W1977168501","https://openalex.org/W1988082450","https://openalex.org/W1998011018","https://openalex.org/W2032756463","https://openalex.org/W2032931995","https://openalex.org/W2054122029","https://openalex.org/W2080432250","https://openalex.org/W2082704080","https://openalex.org/W2088396659","https://openalex.org/W2111958870","https://openalex.org/W2117987496","https://openalex.org/W2126416892","https://openalex.org/W2131078911","https://openalex.org/W2156717321","https://openalex.org/W2158742097","https://openalex.org/W2412184846","https://openalex.org/W2504981678","https://openalex.org/W2522628945","https://openalex.org/W2530115453","https://openalex.org/W2546888985","https://openalex.org/W2559884455","https://openalex.org/W2619653998","https://openalex.org/W2757137750","https://openalex.org/W2767355593","https://openalex.org/W2937543516","https://openalex.org/W2940843858","https://openalex.org/W2970465376","https://openalex.org/W2998223455","https://openalex.org/W3024053238","https://openalex.org/W3032784914","https://openalex.org/W3107447173","https://openalex.org/W3111531858","https://openalex.org/W3112943346","https://openalex.org/W3163515123","https://openalex.org/W3166921190","https://openalex.org/W3186947641","https://openalex.org/W3193363280","https://openalex.org/W3199949520","https://openalex.org/W3203323673","https://openalex.org/W4210430784","https://openalex.org/W4212824314","https://openalex.org/W4223437310","https://openalex.org/W4283738412","https://openalex.org/W4296907726","https://openalex.org/W4315796849","https://openalex.org/W4321093046"],"related_works":["https://openalex.org/W4387528965","https://openalex.org/W4387338320","https://openalex.org/W4404302224","https://openalex.org/W4403226084","https://openalex.org/W4206843788","https://openalex.org/W3203323673","https://openalex.org/W7115031851","https://openalex.org/W1934592423","https://openalex.org/W1970331216","https://openalex.org/W2107824989"],"abstract_inverted_index":{"BACKGROUND:":[0],"Sex":[1],"differences":[2,45],"exist":[3],"in":[4,46,148,197,209,224],"the":[5,47,50,68,135,149,240],"likelihood":[6],"of":[7,137,151,191,242],"cognitive":[8],"decline.":[9],"The":[10,189],"age":[11,51,77,93,173,256],"at":[12,52,78,94,109,174,257],"hypertension":[13,53,79,95,106,175,203,243,258],"diagnosis":[14,54,80,176],"is":[15],"a":[16,75,146,171],"unique":[17],"contributor":[18],"to":[19,42,71,145],"brain":[20,60,82,119,179,249],"structural":[21,61,120],"changes":[22],"associated":[23],"with":[24,74,99,159,170,186,202,212,215,226,232],"cerebral":[25,56,245],"small":[26,57,246],"vessel":[27,58,247],"disease.":[28],"However,":[29],"whether":[30],"this":[31],"relationship":[32],"differs":[33,251],"between":[34,49],"sexes":[35],"remains":[36],"unclear.":[37],"Therefore,":[38],"our":[39],"objective":[40],"was":[41,195,222],"evaluate":[43],"sex":[44,91,253],"association":[48],"and":[55,81,87,92,181,200,254],"disease-related":[59,248],"changes.":[62],"METHODS:":[63],"We":[64],"used":[65,126],"data":[66],"from":[67],"UK":[69],"Biobank":[70],"select":[72],"participants":[73,98],"known":[76],"magnetic":[83,100],"resonance":[84,101],"imaging":[85,102],"(n=9430)":[86],"stratified":[88],"them":[89],"by":[90,112,156,252,255],"diagnosis.":[96,259],"Control":[97],"scans":[103],"but":[104,167],"no":[105],"were":[107,125],"chosen":[108],"random":[110],"matched":[111],"using":[113],"propensity":[114],"score":[115],"matching.":[116],"For":[117,134],"morphological":[118],"changes,":[121],"generalized":[122],"linear":[123],"models":[124],"while":[127],"adjusting":[128],"for":[129],"other":[130],"vascular":[131],"risk":[132],"factors.":[133],"assessment":[136],"white":[138,182,192,218],"matter":[139,183,193,219],"microstructure,":[140],"principal":[141,161],"component":[142],"analysis":[143,158],"led":[144],"reduction":[147],"number":[150],"fractional":[152],"anisotropy":[153],"variables,":[154],"followed":[155],"regression":[157],"major":[160],"components":[162],"as":[163],"outcomes.":[164],"RESULTS:":[165],"Males":[166],"not":[168],"females":[169,201,211],"younger":[172],"exhibited":[177],"lower":[178,223],"gray":[180],"volume":[184,190],"compared":[185],"normotensive":[187,205,216],"controls.":[188],"hyperintensities":[194],"greater":[196],"both":[198],"males":[199],"than":[204],"controls,":[206,217],"significantly":[207],"higher":[208],"older":[210],"hypertension.":[213],"Compared":[214],"microstructural":[220],"integrity":[221],"individuals":[225],"hypertension,":[227],"which":[228],"became":[229],"more":[230],"prominent":[231],"increasing":[233],"age.":[234],"CONCLUSIONS:":[235],"Our":[236],"study":[237],"demonstrates":[238],"that":[239],"effect":[241],"on":[244],"structure":[250]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2023-12-20T00:00:00"}
