{"id":"https://openalex.org/W4389958500","doi":"https://doi.org/10.1161/circ.148.suppl_1.15316","title":"Abstract 15316: Neonatal Mesenchymal Stem Cells Ameliorate Cardiac Fibrosis and Diastolic Dysfunction in HFpEF via Expanding CD4 + CD25 + Foxp3 + T regs","display_name":"Abstract 15316: Neonatal Mesenchymal Stem Cells Ameliorate Cardiac Fibrosis and Diastolic Dysfunction in HFpEF via Expanding CD4 + CD25 + Foxp3 + T regs","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4389958500","doi":"https://doi.org/10.1161/circ.148.suppl_1.15316"},"language":"en","primary_location":{"id":"doi:10.1161/circ.148.suppl_1.15316","doi":"https://doi.org/10.1161/circ.148.suppl_1.15316","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.15316","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035915140","display_name":"Zhi\u2010Dong Ge","orcid":"https://orcid.org/0000-0002-7045-0846","observed_orcids":["https://orcid.org/0000-0002-7045-0846"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhi-Dong Ge","raw_affiliation_strings":["Pediatrics, Surgery, Pathology, Northwestern Univ, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, Surgery, Pathology, Northwestern Univ, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101651529","display_name":"Rachana Mishra","orcid":"https://orcid.org/0000-0002-8826-3440","observed_orcids":["https://orcid.org/0000-0002-8826-3440"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachana Mishra","raw_affiliation_strings":["Robert H. Lurie Med Rsch Ct, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert H. Lurie Med Rsch Ct, Chicago, IL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052651149","display_name":"Xuebin Fu","orcid":"https://orcid.org/0000-0002-1281-2466","observed_orcids":["https://orcid.org/0000-0002-1281-2466"]},"institutions":[{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuebin Fu","raw_affiliation_strings":["Stanley Manne Children's Rsch Institute, Lurie Children's Hosp, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanley Manne Children's Rsch Institute, Lurie Children's Hosp, Chicago, IL","institution_ids":["https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112666817","display_name":"Sudhish Sharma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudhish Sharma","raw_affiliation_strings":["Stanley Manne Children's Rsch Institute, Northwestern Univ, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanley Manne Children's Rsch Institute, Northwestern Univ, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066031091","display_name":"Mallory E. Filipp","orcid":"https://orcid.org/0000-0003-2957-3753","observed_orcids":["https://orcid.org/0000-0003-2957-3753"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mallory Filipp","raw_affiliation_strings":["Pathology, Northwestern Univ, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Northwestern Univ, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100411104","display_name":"Ling Chen","orcid":"https://orcid.org/0000-0002-1723-5282","observed_orcids":["https://orcid.org/0000-0002-1723-5282"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ling Chen","raw_affiliation_strings":["Stanley Manne Children's Rsch Institute, Northwestern Univ, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanley Manne Children's Rsch Institute, Northwestern Univ, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004685955","display_name":"Progyaparamita Saha","orcid":"https://orcid.org/0000-0002-0248-3531","observed_orcids":["https://orcid.org/0000-0002-0248-3531"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Progyaparamita Saha","raw_affiliation_strings":["Stanley Manne Children's Rsch Institute, Northwestern Univ, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanley Manne Children's Rsch Institute, Northwestern Univ, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000562062","display_name":"Ching Man Wai","orcid":"https://orcid.org/0000-0002-2913-5721","observed_orcids":["https://orcid.org/0000-0002-2913-5721"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ching Man Wai","raw_affiliation_strings":["Northwestern Univ, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern Univ, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014846775","display_name":"Ning\u2010Yi Shao","orcid":"https://orcid.org/0000-0003-4231-828X","observed_orcids":["https://orcid.org/0000-0003-4231-828X"]},"institutions":[{"id":"https://openalex.org/I204512498","display_name":"University of Macau","ror":"https://ror.org/01r4q9n85","country_code":"MO","type":"education","lineage":["https://openalex.org/I204512498"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Ning-Yi Shao","raw_affiliation_strings":["Faculty of Health Sciences, Univ of Macau, Macau, Macao"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, Univ of Macau, Macau, Macao","institution_ids":["https://openalex.org/I204512498"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anshuman Sinha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anshuman Sinha","raw_affiliation_strings":["Stanley Manne Children's Rsch Institute, Northwestern Univ, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanley Manne Children's Rsch Institute, Northwestern Univ, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004982660","display_name":"Agata Bilewska","orcid":"https://orcid.org/0009-0008-2090-8450","observed_orcids":["https://orcid.org/0009-0008-2090-8450"]},"institutions":[{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Agata Bilewska","raw_affiliation_strings":["Stanley Manne Children's Rsch Institute, Lurie Childrens Hosp of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanley Manne Children's Rsch Institute, Lurie Childrens Hosp of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082052681","display_name":"Sameer Ahmad Guru","orcid":"https://orcid.org/0000-0003-0447-0176","observed_orcids":["https://orcid.org/0000-0003-0447-0176"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sameer A Guru","raw_affiliation_strings":["Stanley Manne Children's Rsch Institute, Northwestern Univ, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanley Manne Children's Rsch Institute, Northwestern Univ, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030262052","display_name":"Artur Stefanowicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Artur Stefanowicz","raw_affiliation_strings":["Stanley Manne Children's Rsch Institute, Northwestern Univ, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanley Manne Children's Rsch Institute, Northwestern Univ, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092180668","display_name":"Emily Ciolak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Ciolak","raw_affiliation_strings":["Stanley Manne Children's Rsch Institute, Lurie Children's Hosp of Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanley Manne Children's Rsch Institute, Lurie Children's Hosp of Chicago, IL","institution_ids":["https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104177530","display_name":"Lydia Simms","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lydia Simms","raw_affiliation_strings":["Stanley Manne Children's Rsch Institute, Lurie Children's Hosp of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanley Manne Children's Rsch Institute, Lurie Children's Hosp of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044518020","display_name":"Vivek Mehta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivek M Mehta","raw_affiliation_strings":["Stanley Manne Children's Rsch Institute, Lurie Children's Hosp of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanley Manne Children's Rsch Institute, Lurie Children's Hosp of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113812314","display_name":"Muthukumar Gunasekaran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muthukumar Gunasekaran","raw_affiliation_strings":["Stanley Manne Children's Rsch Institute, Northwestern Univ, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanley Manne Children's Rsch Institute, Northwestern Univ, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005215114","display_name":"Sanjiv Jayendra Shah","orcid":"https://orcid.org/0000-0002-5655-8201","observed_orcids":["https://orcid.org/0000-0002-5655-8201"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjiv J Shah","raw_affiliation_strings":["Northwestern Univ, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern Univ, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027947816","display_name":"Edward Benjamin Thorp","orcid":"https://orcid.org/0000-0003-1387-7058","observed_orcids":["https://orcid.org/0000-0003-1387-7058"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward B Thorp","raw_affiliation_strings":["Northwestern Univ, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern Univ, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058847058","display_name":"Sunjay Kaushal","orcid":"https://orcid.org/0000-0001-7733-7320","observed_orcids":["https://orcid.org/0000-0001-7733-7320"]},"institutions":[{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunjay Kaushal","raw_affiliation_strings":["Lurie Children's Hosp of Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lurie Children's Hosp of Chicago, IL","institution_ids":["https://openalex.org/I1294278766"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"148","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.6934000253677368,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.6934000253677368,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.3003000020980835,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.7919999957084656},{"id":"https://openalex.org/keywords/diastolic-dysfunction","display_name":"diastolic dysfunction","score":0.921999990940094},{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.9129999876022339},{"id":"https://openalex.org/keywords/stem-cell-secretome","display_name":"stem cell secretome","score":0.8450000286102295},{"id":"https://openalex.org/keywords/fingolimod","display_name":"fingolimod","score":0.9319999814033508},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8190000057220459},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.9599999785423279},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.7680000066757202},{"id":"https://openalex.org/keywords/exercise-intolerance","display_name":"exercise intolerance","score":0.6100000143051147},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.5860000252723694},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.6269999742507935},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7416263222694397},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7010127305984497},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6974201798439026},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.6905533671379089},{"id":"https://openalex.org/C2777420927","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Cardiac fibrosis","level":3,"score":0.6679567694664001},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.64280104637146},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.6146339178085327},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5932241082191467},{"id":"https://openalex.org/C3018763269","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Myocardial fibrosis","level":3,"score":0.5885559320449829},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5368960499763489},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.4948086142539978},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.09742823243141174}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.148.suppl_1.15316","doi":"https://doi.org/10.1161/circ.148.suppl_1.15316","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.15316","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7126247652","https://openalex.org/W4224301931","https://openalex.org/W4400119536","https://openalex.org/W4387253136","https://openalex.org/W3161836841","https://openalex.org/W4405397357","https://openalex.org/W3160676215","https://openalex.org/W2745125081","https://openalex.org/W4389945033","https://openalex.org/W3168920631"],"abstract_inverted_index":{"Introduction:":[0],"We":[1,86],"have":[2,343],"demonstrated":[3],"that":[4,88,339],"neonatal":[5,13],"mesenchymal":[6],"stem":[7],"cells":[8,46],"(nMSCs)":[9],"extracted":[10],"from":[11,264],"human":[12],"cardiac":[14,22,26,58,68,93,102,172,246,255,291,308,318],"tissues":[15],"and":[16,24,65,70,90,95,114,128,171,202,214,222,249,253,280,290,305,310,315,320,341],"their":[17],"exosomes,":[18],"secretome,":[19,150],"potently":[20],"decrease":[21],"fibrosis":[23,59,69,94,163,248,309,319],"improve":[25],"function":[27,129],"in":[28,60,98,166,218,294,334],"the":[29,55,136,140,235,277,283,295,300],"rat":[30],"model":[31],"of":[32,57,73,149,154,186,228,282,303],"myocardial":[33,61,209],"infarction.":[34,62],"CD4":[35,256,325],"+":[36,38,40,257,259,261,326,328,330],"CD25":[37,258,327],"Foxp3":[39],"(forkhead":[41],"box":[42],"3)":[43],"regulatory":[44],"T":[45,71,103,173,262,292,331],"(T":[47],"regs":[48,72,104,174,263,293],")":[49],"are":[50],"recently":[51],"shown":[52],"to":[53,116,234,266],"regulate":[54],"formation":[56],"How":[63],"nMSCs":[64,89,241,273,304,314],"secretome":[66,91,243,275,306,316,342],"affect":[67],"animals":[74,141],"with":[75,78,225],"heart":[76,168],"failure":[77],"preserved":[79],"ejection":[80,231],"fraction":[81],"(HFpEF)":[82],"is":[83],"unknown.":[84],"Hypothesis:":[85],"hypothesized":[87],"ameliorate":[92,317],"diastolic":[96,215,311,321],"dysfunction":[97,216,322],"HFpEF":[99,118,236,284,296],"by":[100,323],"regulating":[101],".":[105],"Methods:":[106],"C57BL/6":[107,197],"mice":[108,137,198,237],"were":[109,130,142,175],"fed":[110,199],"60%":[111],"high-fat":[112,200],"diet":[113,201],"L-NAME":[115,203],"induce":[117],"or":[119,151,242,274],"normal":[120],"chow":[121],"as":[122,156],"a":[123,157,178,184],"control.":[124],"Left":[125],"ventricular":[126,212,230],"morphology":[127],"evaluated":[131],"using":[132],"an":[133],"echocardiography.":[134],"After":[135],"developed":[138,207],"HFpEF,":[139],"injected":[143,191],"10":[144,147],"6":[145],"nMSCs,":[146],"mg/kg":[148,188],"equivalent":[152],"amounts":[153],"vehicle":[155],"control":[158],"via":[159],"tail":[160],"vein.":[161],"Myocardial":[162],"was":[164,189],"quantified":[165],"trichrome-stained":[167],"sections.":[169],"Circulating":[170],"measured":[176],"on":[177,307],"FACSCanto":[179],"II":[180],"cytometer.":[181],"Fingolimod":[182,286],"at":[183],"dose":[185],"3":[187],"intraperitoneally":[190],"daily":[192],"for":[193,204,347],"18":[194],"days.":[195],"Results:":[196],"5":[205],"weeks":[206,268],"obesity,":[208],"fibrosis,":[210],"left":[211,229],"hypertrophy":[213],"(increases":[217],"mitral":[219,250],"E/e\u2019":[220,251],"ratio),":[221],"exercise":[223,278],"intolerance":[224],">":[226],"50%":[227],"fraction.":[232],"Compared":[233],"receiving":[238],"vehicle,":[239],"either":[240,272],"significantly":[244,287],"decreased":[245,288],"interstitial":[247],"ratio":[252],"increased":[254],"FoxP3":[260,329],"1":[265],"4":[267],"post":[269],"treatment.":[270],"Importantly,":[271],"enhanced":[276],"speed":[279],"distance":[281],"mice.":[285],"circulating":[289],"mice,":[297],"which":[298],"blocked":[299],"beneficial":[301],"effects":[302],"function.":[312],"Conclusions:":[313],"expanding":[324],"reg":[332],"s":[333],"HFpEF.":[335,348],"These":[336],"results":[337],"suggest":[338],"nMSCS":[340],"high":[344],"therapeutic":[345],"potential":[346]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-20T00:00:00"}
