{"id":"https://openalex.org/W4389958097","doi":"https://doi.org/10.1161/circ.148.suppl_1.16118","title":"Abstract 16118: Vitamin D3 Significantly Decreases Vascular Stiffness, Improving Cognitive Impairment and Sarcopenia in a Frail, Elderly Population From Buenos Aires, Argentina","display_name":"Abstract 16118: Vitamin D3 Significantly Decreases Vascular Stiffness, Improving Cognitive Impairment and Sarcopenia in a Frail, Elderly Population From Buenos Aires, Argentina","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4389958097","doi":"https://doi.org/10.1161/circ.148.suppl_1.16118"},"language":"en","primary_location":{"id":"doi:10.1161/circ.148.suppl_1.16118","doi":"https://doi.org/10.1161/circ.148.suppl_1.16118","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.16118","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113543237","display_name":"Mariano Duarte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Mariano Duarte","raw_affiliation_strings":["Hosp de Clinicas - II Catedra de Fisiolog\u00eda Facultad de Medicina UBA, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hosp de Clinicas - II Catedra de Fisiolog\u00eda Facultad de Medicina UBA, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077034737","display_name":"Ignacio G. D\u00e1volos","orcid":"https://orcid.org/0000-0002-3443-9025","observed_orcids":["https://orcid.org/0000-0002-3443-9025"]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Ignacio Davolos","raw_affiliation_strings":["Hosp de Clinicas - Facultad de Medicina UBA, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hosp de Clinicas - Facultad de Medicina UBA, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029764518","display_name":"Anal\u00eda Aquieri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Analia Aquieri","raw_affiliation_strings":["Cardiology, Hosp de Clinicas - Facultad de Medicina UBA, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology, Hosp de Clinicas - Facultad de Medicina UBA, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049609789","display_name":"Javier Coyle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Javier Coyle","raw_affiliation_strings":["Cardiology, Hosp de Clinicas - Facultad de Medicina UBA, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology, Hosp de Clinicas - Facultad de Medicina UBA, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093533646","display_name":"Adela Allevato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Adela Allevato","raw_affiliation_strings":["Hosp de Clinicas - Facultad de Medicina UBA, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hosp de Clinicas - Facultad de Medicina UBA, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093533647","display_name":"Maria A. Litta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Maria A. Litta","raw_affiliation_strings":["Nutrition, Hosp de Clinicas - Facultad de Medicina UBA, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition, Hosp de Clinicas - Facultad de Medicina UBA, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113815054","display_name":"M. Delucchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Maria Clara Delucchi","raw_affiliation_strings":["Nutrition, Hosp de Clinicas - Facultad de Medicina UBA, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition, Hosp de Clinicas - Facultad de Medicina UBA, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030522623","display_name":"Marcela Lecouna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124752","display_name":"Instituto Nacional de Formaci\u00f3n T\u00e9cnica Profesional","ror":"https://ror.org/02z3q8x80","country_code":"CO","type":"education","lineage":["https://openalex.org/I4210124752"]},{"id":"https://openalex.org/I4387152659","display_name":"Ministerio de Medio Ambiente y Recursos Naturales","ror":"https://ror.org/042ywsw21","country_code":"SV","type":"government","lineage":["https://openalex.org/I4387152659"]}],"countries":["CO","SV"],"is_corresponding":false,"raw_author_name":"Marcela Lecouna","raw_affiliation_strings":["Municipalidad San Andr\u00e9s de Giles, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Municipalidad San Andr\u00e9s de Giles, Argentina","institution_ids":["https://openalex.org/I4210124752","https://openalex.org/I4387152659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093533648","display_name":"Ciantia Giacobone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ciantia Giacobone","raw_affiliation_strings":["Psycology, Municipalidad de San Andres de Giles, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psycology, Municipalidad de San Andres de Giles, Argentina","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083952002","display_name":"Eleonora Savio Galimberti","orcid":"https://orcid.org/0000-0001-9974-6213","observed_orcids":["https://orcid.org/0000-0001-9974-6213"]},"institutions":[{"id":"https://openalex.org/I106460735","display_name":"Philadelphia College of Osteopathic Medicine","ror":"https://ror.org/00m9c2804","country_code":"US","type":"education","lineage":["https://openalex.org/I106460735"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eleonora Savio Galimberti","raw_affiliation_strings":["Biomedical Sciences, Philadelthia College of Osteopathic, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences, Philadelthia College of Osteopathic, PA","institution_ids":["https://openalex.org/I106460735"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"148","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.05310000106692314,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d3-supplementation","display_name":"vitamin D3 supplementation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/arterial-stiffness","display_name":"arterial stiffness","score":0.7630000114440918},{"id":"https://openalex.org/keywords/vascular-stiffness","display_name":"vascular stiffness","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.9070000052452087},{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/frail-elderly","display_name":"frail elderly","score":0.8360000252723694},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9269999861717224},{"id":"https://openalex.org/keywords/muscle-strength","display_name":"muscle strength","score":0.7070000171661377},{"id":"https://openalex.org/keywords/augmentation-index","display_name":"augmentation index","score":0.6819999814033508},{"id":"https://openalex.org/keywords/central-pulse-pressure","display_name":"central pulse pressure","score":0.7870000004768372},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.5559999942779541},{"id":"https://openalex.org/keywords/nutritional-status","display_name":"nutritional status","score":0.6520000100135803},{"id":"https://openalex.org/keywords/buenos-aires-argentina","display_name":"Buenos Aires, Argentina","score":0.7929999828338623},{"id":"https://openalex.org/keywords/argentina","display_name":"Argentina","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8905802965164185},{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.8624056577682495},{"id":"https://openalex.org/C2775850156","wikidata":"https://www.wikidata.org/wiki/Q4797538","display_name":"Arterial stiffness","level":3,"score":0.742176353931427},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5735710859298706},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5627740025520325},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5357574224472046},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4990348815917969},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.4737185835838318},{"id":"https://openalex.org/C17140001","wikidata":"https://www.wikidata.org/wiki/Q1759415","display_name":"Pulse pressure","level":3,"score":0.47263213992118835},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.44247063994407654},{"id":"https://openalex.org/C2778319312","wikidata":"https://www.wikidata.org/wiki/Q2118022","display_name":"Pulse wave velocity","level":3,"score":0.4128507673740387},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.39696046710014343},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08167305588722229},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.148.suppl_1.16118","doi":"https://doi.org/10.1161/circ.148.suppl_1.16118","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.16118","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2890734024","https://openalex.org/W4405886464","https://openalex.org/W2554699372","https://openalex.org/W2795267051","https://openalex.org/W2109317659","https://openalex.org/W2758240697","https://openalex.org/W2728475287","https://openalex.org/W2873433404","https://openalex.org/W4243457846","https://openalex.org/W4318479276"],"abstract_inverted_index":{"Introduction:":[0],"Aging":[1],"is":[2,154],"the":[3,38,125,136,149,167,277],"leading":[4],"risk":[5],"factor":[6],"for":[7,16,107,158,214,283],"multiple":[8],"chronic":[9],"diseases":[10],"especially":[11],"cardio":[12],"and":[13,15,21,30,53,65,73,124,156,169,182,209,271,276,308,335],"cerebrovascular":[14],"a":[17,76,90,129,191,319,322],"decline":[18],"in":[19,45,75,195,223,238,243,260,268,311,340],"physical":[20],"mental":[22,71],"function.":[23],"Progressive":[24],"stiffening":[25],"arterial":[26,303],"wall,":[27],"cognitive":[28,54,306],"impairment":[29],"sarcopenia":[31,74,309],"are":[32],"hallmarks":[33],"of":[34,99,131,325],"aging.":[35],"Due":[36],"to":[37,94,227,250,331,336],"pleiotropic":[39],"actions":[40],"that":[41,58],"have":[42,67],"been":[43],"discovered":[44],"vitamin":[46],"D":[47],"(VD),":[48],"which":[49,153],"include":[50],"vascular":[51,63,299],",muscular":[52],"effects,":[55],"we":[56],"hypothesized":[57],"VD3":[59,100,338],"supplementation":[60,297,339],"might":[61],"decrease":[62,194],"stiffness":[64,111],"could":[66],"beneficial":[68],"effect":[69],"on":[70],"status":[72],"frailty":[77],"elderly":[78,314],"population.":[79,160,342],"Methods:":[80],"We":[81],"randomized":[82],"42":[83],"residents":[84],"(78\u00b16.5":[85],"yo;":[86],"24":[87],"females)":[88],"from":[89,135],"public":[91],"geriatric":[92],"institution,":[93],"receive":[95],"either":[96],"100,000":[97],"IU":[98],"or":[101],"placebo":[102],"(P)":[103],"every":[104],"15":[105],"days":[106],"6":[108],"months.":[109],"Arterial":[110],"(AS)":[112],"was":[113,146,318],"evaluated":[114,147],"through":[115],"central":[116,120],"systolic":[117],"pressure":[118,122,139],"(cSYS),":[119],"pulse":[121],"(cPP),":[123],"augmentation":[126],"index":[127,180],"(AIx)":[128],"measure":[130],"systemic":[132],"AS":[133,196],"derived":[134],"ascending":[137],"aortic":[138],"waveform;":[140],"using":[141,148],"Uscom\u00ae":[142],"device.":[143],"Cognitive":[144],"function":[145],"Clock-Drawing":[150],"Test":[151],"(CDT),":[152],"simple":[155],"effective":[157],"this":[159,312,317,341],"Skeletal":[161],"muscle":[162,173],"strength/sarcopenia,":[163],"were":[164,233,280],"assess":[165],"with":[166,175,265],"up":[168],"go":[170],"test":[171,279],"(UGT),":[172],"strength":[174,242],"hydraulic":[176],"dynamometer,":[177],"body":[178],"mass":[179],"(BMI)":[181],"mini-nutritional":[183],"assessment":[184],"(MNA)":[185],"test.":[186],"Results:":[187],"VD":[188,199,224,244,270,284],"group":[189,225,245,285],"showed":[190],"statistically":[192,235],"significant":[193,236],"vs":[197,257],"P.":[198],"\u0394":[200,204,210],"cSYS":[201],"-12.3":[202],"mmHg,":[203],"cPP":[205],"-6.7":[206],"mmHg":[207,208],"AIx":[211],"-17.8":[212],"%,":[213],"all":[215],"three":[216],"parameters:":[217],"p<0.05.":[218],"The":[219,274],"CDT":[220],"score":[221],"improved":[222,246,264,298,305],"(4.3":[226],"5.9,":[228],"p":[229],"<0.05)":[230],"but":[231],"there":[232],"no":[234,258],"differences":[237],"P":[239,261,272],"group.":[240,262,273],"Muscle":[241],"significantly":[247],"(from":[248],"15.1\u00b19.4":[249],"18.7\u00b13.8":[251],"Kg":[252],"force/cm":[253],"2":[254],",":[255],"p<0.05)":[256],"difference":[259],"UGT":[263],"statistical":[266,291],"significance":[267],"both":[269],"BMI":[275],"MNA":[278],"also":[281],"favorable":[282],"although":[286],"they":[287],"did":[288],"not":[289],"reach":[290],"significance.":[292],"Conclusions:":[293],"Vitamin":[294],"D3":[295],"6-months":[296],"compliance":[300],"by":[301],"decreasing":[302],"stiffness,":[304],"performance":[307],"indicators":[310],"frail":[313],"people.":[315],"Although":[316],"preliminary":[320],"study,":[321],"larger":[323],"number":[324],"patients":[326],"studies":[327],"should":[328],"be":[329],"conducted":[330],"validated":[332],"these":[333],"findings":[334],"consider":[337]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2023-12-20T00:00:00"}
