{"id":"https://openalex.org/W4389957981","doi":"https://doi.org/10.1161/circ.148.suppl_1.17666","title":"Abstract 17666: Impact of Myocardial Fibrosis and Female Sex on Life-Threatening Arrhythmias and Sudden Cardiac Death in MVP Patients: A Prospective CMR Study With Over 2300 Patient-Years of Follow Up","display_name":"Abstract 17666: Impact of Myocardial Fibrosis and Female Sex on Life-Threatening Arrhythmias and Sudden Cardiac Death in MVP Patients: A Prospective CMR Study With Over 2300 Patient-Years of Follow Up","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4389957981","doi":"https://doi.org/10.1161/circ.148.suppl_1.17666"},"language":"en","primary_location":{"id":"doi:10.1161/circ.148.suppl_1.17666","doi":"https://doi.org/10.1161/circ.148.suppl_1.17666","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.17666","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089885800","display_name":"Amr Darwish","orcid":"https://orcid.org/0000-0002-8540-1916","observed_orcids":["https://orcid.org/0000-0002-8540-1916"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amr Darwish","raw_affiliation_strings":["Houston Methodist DeBakey Heart &amp; Vascular Cntr, Houston, TX","Amr Darwish Houston Methodist DeBakey Heart & Vascular Cntr, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist DeBakey Heart &amp; Vascular Cntr, Houston, TX","institution_ids":["https://openalex.org/I1295876152"]},{"raw_affiliation_string":"Amr Darwish Houston Methodist DeBakey Heart & Vascular Cntr, Houston, TX","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081825134","display_name":"Duc T. Nguyen","orcid":"https://orcid.org/0000-0002-5059-4404","observed_orcids":["https://orcid.org/0000-0002-5059-4404"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Duc Nguyen","raw_affiliation_strings":["Houston, TX","Duc Nguyen Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston, TX","institution_ids":[]},{"raw_affiliation_string":"Duc Nguyen Houston, TX","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005364163","display_name":"Danai Kitkungvan","orcid":"https://orcid.org/0000-0003-0719-6993","observed_orcids":["https://orcid.org/0000-0003-0719-6993"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Danai Kitkungvan","raw_affiliation_strings":["Houston, TX","Danai Kitkungvan Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston, TX","institution_ids":[]},{"raw_affiliation_string":"Danai Kitkungvan Houston, TX","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109485632","display_name":"Kinan Carlos El-Tallawi","orcid":"https://orcid.org/0000-0001-5897-8923","observed_orcids":["https://orcid.org/0000-0001-5897-8923"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kinan Carlos El Tallawi","raw_affiliation_strings":["Houston Methodist Hosp, Houston, TX","Kinan Carlos El Tallawi Houston Methodist Hosp, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist Hosp, Houston, TX","institution_ids":["https://openalex.org/I1295876152"]},{"raw_affiliation_string":"Kinan Carlos El Tallawi Houston Methodist Hosp, Houston, TX","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078543435","display_name":"Akila Bersali","orcid":"https://orcid.org/0000-0003-2217-1567","observed_orcids":["https://orcid.org/0000-0003-2217-1567"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akila Bersali","raw_affiliation_strings":["Houston, TX","Akila Bersali Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston, TX","institution_ids":[]},{"raw_affiliation_string":"Akila Bersali Houston, TX","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012784033","display_name":"Mujtaba Saeed","orcid":"https://orcid.org/0000-0003-1876-0238","observed_orcids":["https://orcid.org/0000-0003-1876-0238"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mujtaba Saeed","raw_affiliation_strings":["Houston, TX","Mujtaba Saeed Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston, TX","institution_ids":[]},{"raw_affiliation_string":"Mujtaba Saeed Houston, TX","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084491938","display_name":"Fatima Qamar","orcid":"https://orcid.org/0000-0002-6035-5706","observed_orcids":["https://orcid.org/0000-0002-6035-5706"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fatima Qamar","raw_affiliation_strings":["Houston Methodist, Houston, TX","Fatima Qamar Houston Methodist, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist, Houston, TX","institution_ids":["https://openalex.org/I1295876152"]},{"raw_affiliation_string":"Fatima Qamar Houston Methodist, Houston, TX","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088347449","display_name":"Miguel Valderr\u00e1bano","orcid":"https://orcid.org/0000-0002-8401-1684","observed_orcids":["https://orcid.org/0000-0002-8401-1684"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miguel Valderrabano","raw_affiliation_strings":["Houston, TX","Miguel Valderrabano Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston, TX","institution_ids":[]},{"raw_affiliation_string":"Miguel Valderrabano Houston, TX","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064423706","display_name":"Edward A. Graviss","orcid":"https://orcid.org/0000-0003-1024-5813","observed_orcids":["https://orcid.org/0000-0003-1024-5813"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Graviss","raw_affiliation_strings":["Houston Methodist Hosp, Houston, TX","Edward Graviss Houston Methodist Hosp, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist Hosp, Houston, TX","institution_ids":["https://openalex.org/I1295876152"]},{"raw_affiliation_string":"Edward Graviss Houston Methodist Hosp, Houston, TX","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043965596","display_name":"Dipan J. Shah","orcid":"https://orcid.org/0000-0002-6179-2393","observed_orcids":["https://orcid.org/0000-0002-6179-2393"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dipan J Shah","raw_affiliation_strings":["Houston Methodist Hosp, Houston, TX","Dipan J Shah Houston Methodist Hosp, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist Hosp, Houston, TX","institution_ids":["https://openalex.org/I1295876152"]},{"raw_affiliation_string":"Dipan J Shah Houston Methodist Hosp, Houston, TX","institution_ids":["https://openalex.org/I1295876152"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"148","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.4765999913215637,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.4765999913215637,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.3449999988079071,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.06210000067949295,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitral-valve-prolapse","display_name":"mitral valve prolapse","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"sudden cardiac death","score":0.8690000176429749},{"id":"https://openalex.org/keywords/life-threatening-arrhythmias","display_name":"malignant arrhythmias","score":0.8679999709129333},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/late-gadolinium-enhancement","display_name":"late gadolinium enhancement","score":0.925000011920929},{"id":"https://openalex.org/keywords/female-sex","display_name":"female sex","score":0.8450000286102295},{"id":"https://openalex.org/keywords/ventricular-tachycardia","display_name":"ventricular tachycardia","score":0.9520000219345093},{"id":"https://openalex.org/keywords/risk-prediction","display_name":"risk prediction","score":0.6119999885559082},{"id":"https://openalex.org/keywords/mitral-annular-disjunction","display_name":"mitral annular disjunction","score":0.8230000138282776},{"id":"https://openalex.org/keywords/mitral-regurgitation","display_name":"mitral regurgitation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/implantable-cardioverter-defibrillator","display_name":"implantable cardioverter-defibrillator","score":0.8069999814033508},{"id":"https://openalex.org/keywords/cardiac-magnetic-resonance","display_name":"cardiac magnetic resonance","score":0.7599999904632568},{"id":"https://openalex.org/keywords/long-term-follow-up","display_name":"long-term follow-up","score":0.7609999775886536},{"id":"https://openalex.org/keywords/women-in-cardiology","display_name":"women in cardiology","score":0.45399999618530273},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.31299999356269836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9560809135437012},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7791221737861633},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.741222620010376},{"id":"https://openalex.org/C2775935837","wikidata":"https://www.wikidata.org/wiki/Q202837","display_name":"Sudden cardiac death","level":2,"score":0.6499473452568054},{"id":"https://openalex.org/C2776331378","wikidata":"https://www.wikidata.org/wiki/Q56002","display_name":"Ventricular tachycardia","level":2,"score":0.6012314558029175},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5849045515060425},{"id":"https://openalex.org/C2781030672","wikidata":"https://www.wikidata.org/wiki/Q735652","display_name":"Mitral valve prolapse","level":3,"score":0.5344687104225159},{"id":"https://openalex.org/C2993373945","wikidata":"https://www.wikidata.org/wiki/Q268292","display_name":"Mitral regurgitation","level":2,"score":0.4827520251274109},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.47698575258255005},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4576013386249542},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4211004972457886},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.419705331325531},{"id":"https://openalex.org/C2993353509","wikidata":"https://www.wikidata.org/wiki/Q411867","display_name":"Sudden death","level":2,"score":0.41299986839294434},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.21808159351348877},{"id":"https://openalex.org/C2777543888","wikidata":"https://www.wikidata.org/wiki/Q369939","display_name":"Mitral valve","level":2,"score":0.18644168972969055},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.148.suppl_1.17666","doi":"https://doi.org/10.1161/circ.148.suppl_1.17666","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.17666","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7172410460","https://openalex.org/W2922913585","https://openalex.org/W2888411027","https://openalex.org/W7127985080","https://openalex.org/W7213512218","https://openalex.org/W7126197657","https://openalex.org/W2160641761","https://openalex.org/W4403904369","https://openalex.org/W4295358301","https://openalex.org/W7126242630"],"abstract_inverted_index":{"Background:":[0],"Mitral":[1],"valve":[2],"prolapse":[3],"(MVP)":[4],"is":[5],"a":[6,11,15,80,103,140,209],"common":[7],"condition":[8],"that":[9,264],"exhibits":[10],"benign":[12],"course.":[13],"Conversely,":[14],"small":[16],"subset":[17],"of":[18,46,57,83,143,157,170,214,253,271],"patients":[19,60,147,205,260],"experiences":[20],"life-threatening":[21,254],"arrhythmias":[22],"and":[23,67,121,182,232,247,257],"sudden":[24],"cardiac":[25,72,95],"death":[26],"(SCD).":[27],"Multiple":[28],"risk":[29,237,272],"factors":[30],"have":[31,40],"been":[32,41],"proposed":[33],"for":[34,79,110],"arrhythmia":[35],"in":[36,168,196,259,275],"MVP;":[37],"however,":[38],"few":[39],"validated":[42],"as":[43],"independent":[44,236,251],"predictors":[45,238,252],"hard":[47],"arrhythmic":[48,215,255],"events":[49,217,256],"on":[50],"longitudinal":[51],"follow-up.":[52],"Methods:":[53],"A":[54],"prospective":[55],"cohort":[56,128],"550":[58],"consecutive":[59],"with":[61,193,206,261],"MVP":[62,114,278],"underwent":[63],"comprehensive":[64],"clinical":[65],"assessment":[66],"late":[68],"gadolinium":[69],"enhancement":[70],"(LGE)":[71,165],"magnetic":[73],"resonance.":[74],"Patients":[75],"were":[76,161,191],"longitudinally":[77],"followed":[78],"composite":[81,155,216],"outcome":[82,172],"SCD,":[84,86],"aborted":[85],"sustained":[87],"or":[88,99],"symptomatic":[89],"ventricular":[90,100],"tachycardia":[91],"(VT)":[92],"requiring":[93],"implantable":[94],"defibrillator":[96],"(ICD)":[97],"placement,":[98],"ablation.":[101],"In":[102],"multivariable":[104,228],"cox":[105],"regression":[106],"analysis,":[107,229],"we":[108],"adjusted":[109],"female":[111,183,230,277],"sex,":[112],"LGE,":[113],"leaflet":[115],"involvement,":[116],"mitral":[117,122],"annular":[118],"disjunction":[119],"(MAD),":[120],"regurgitation":[123],"(MR)":[124],"severity.":[125],"Results:":[126],"The":[127],"median":[129],"age":[130,149],"was":[131,166],"62":[132],"(IQR":[133],"51-71)":[134],"years,":[135,145],"comprising":[136],"50%":[137],"women.":[138,162],"Over":[139],"mean":[141],"follow-up":[142],"4.3":[144],"44":[146],"(mean":[148],"62.5":[150],"years":[151],"\u00b110)":[152],"met":[153],"the":[154,171,276],"outcome,":[156],"which":[158],"n=33":[159],"(75%)":[160],"Myocardial":[163],"fibrosis":[164,234,249],"present":[167],"61%":[169],"group":[173],"(n=27).":[174],"LGE":[175,207,221,265],"(HR":[176,185],"3.52":[177],"[95%CI,":[178,187],"1.87-6.63],":[179],"P":[180,189,225],"<0.001)":[181,190],"sex":[184,231,246],"3.90":[186],"1.92-7.95],":[188],"associated":[192],"worse":[194],"outcomes":[195],"univariate":[197],"analysis.":[198],"Kaplan":[199],"Meier":[200],"statistics":[201],"(Figure,":[202,242],"A)":[203],"indicated":[204],"had":[208],"higher":[210],"5-year":[211],"cumulative":[212],"incidence":[213],"than":[218],"those":[219],"without":[220],"(14.8%":[222],"vs":[223],"4.4%,":[224],"<0.001).":[226],"On":[227],"myocardial":[233,248],"remained":[235],"across":[239],"all":[240],"models.":[241],"B).":[243],"Conclusion:":[244],"Female":[245],"are":[250],"SCD":[258],"MVP,":[262],"suggesting":[263],"should":[266],"be":[267],"an":[268],"important":[269],"component":[270],"stratification,":[273],"especially":[274],"population.":[279]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2023-12-20T00:00:00"}