{"id":"https://openalex.org/W4389957482","doi":"https://doi.org/10.1161/circ.148.suppl_1.14173","title":"Abstract 14173: Generation and Characterization of Clinically Relevant Disease Models for Port Wine Birthmark Using Induced Pluripotent Stem Cells","display_name":"Abstract 14173: Generation and Characterization of Clinically Relevant Disease Models for Port Wine Birthmark Using Induced Pluripotent Stem Cells","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4389957482","doi":"https://doi.org/10.1161/circ.148.suppl_1.14173"},"language":"en","primary_location":{"id":"doi:10.1161/circ.148.suppl_1.14173","doi":"https://doi.org/10.1161/circ.148.suppl_1.14173","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.14173","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060654566","display_name":"Vi Nguyen","orcid":"https://orcid.org/0000-0002-0688-0286","observed_orcids":["https://orcid.org/0000-0002-0688-0286"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vi Nguyen","raw_affiliation_strings":["Cell Biology and Anatomy, Univ of South Carolina Sch of Medicine, Columbia, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Anatomy, Univ of South Carolina Sch of Medicine, Columbia, SC","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071166680","display_name":"Chao Gao","orcid":"https://orcid.org/0000-0003-3489-3989","observed_orcids":["https://orcid.org/0000-0003-3489-3989"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chao Gao","raw_affiliation_strings":["Cell Biology and Anatomy, Univ of South Carolina Sch of Medicine, Columbia, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Anatomy, Univ of South Carolina Sch of Medicine, Columbia, SC","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967221","display_name":"Marcelo L. Hochman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcelo L Hochman","raw_affiliation_strings":["Otolaryngology - Head and Neck Surgery, Med Univ of South Carolina, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otolaryngology - Head and Neck Surgery, Med Univ of South Carolina, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105358120","display_name":"Harold Ira Friedman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harold I Friedman","raw_affiliation_strings":["Surgery, Univ of South Carolina Sch of Medicine, Columbia, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Univ of South Carolina Sch of Medicine, Columbia, SC","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038655152","display_name":"Elliot Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elliot H Chen","raw_affiliation_strings":["Surgery, Univ of South Carolina Sch of Medicine, Columbia, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Univ of South Carolina Sch of Medicine, Columbia, SC","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076559813","display_name":"Yunguan Wang","orcid":"https://orcid.org/0000-0003-0767-6188","observed_orcids":["https://orcid.org/0000-0003-0767-6188"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunguan Wang","raw_affiliation_strings":["Pediatrics, Cincinnati Children's Hosp Med Cntr, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, Cincinnati Children's Hosp Med Cntr, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061689835","display_name":"Anil Goud Jegga","orcid":"https://orcid.org/0000-0002-4881-7752","observed_orcids":["https://orcid.org/0000-0002-4881-7752"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil Jegga","raw_affiliation_strings":["Pediatrics, Cincinnati Children's Hosp Med Cntr, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, Cincinnati Children's Hosp Med Cntr, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064832796","display_name":"J. Stuart Nelson","orcid":"https://orcid.org/0000-0002-2697-9152","observed_orcids":["https://orcid.org/0000-0002-2697-9152"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210133819","display_name":"Beckman Laser Institute and Medical Clinic","ror":"https://ror.org/03bfp2076","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133819"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John S Nelson","raw_affiliation_strings":["Beckman Laser Institute and Med Clinic, Univ of California Irvine Sch of Medicine, Irivine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beckman Laser Institute and Med Clinic, Univ of California Irvine Sch of Medicine, Irivine, CA","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I4210133819"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021246092","display_name":"Wenbin Tan","orcid":"https://orcid.org/0000-0002-2334-8988","observed_orcids":["https://orcid.org/0000-0002-2334-8988"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenbin Tan","raw_affiliation_strings":["Cell Biology and Anatomy, Univ of South Carolina Sch of Medicine, Columbia, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Anatomy, Univ of South Carolina Sch of Medicine, Columbia, SC","institution_ids":["https://openalex.org/I155781252"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"148","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.03880000114440918,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/port-wine-stain","display_name":"port-wine stain","score":0.9350000023841858},{"id":"https://openalex.org/keywords/congenital-vascular-malformation","display_name":"congenital vascular malformation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/ipsc-derived-endothelial-cells","display_name":"iPSC-derived endothelial cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/disease-modeling","display_name":"disease modeling","score":0.7699999809265137},{"id":"https://openalex.org/keywords/endothelial-tube-formation","display_name":"endothelial tube formation","score":0.6740000247955322},{"id":"https://openalex.org/keywords/pericyte-like-cells","display_name":"pericyte-like cells","score":0.46799999475479126},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.4620000123977661},{"id":"https://openalex.org/keywords/atac-seq","display_name":"ATAC-seq","score":0.7799999713897705},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.4830000102519989},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/organogenesis","display_name":"organogenesis","score":0.8489999771118164},{"id":"https://openalex.org/keywords/treatment-development","display_name":"treatment development","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.899459958076477},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7429460287094116},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.5193384885787964},{"id":"https://openalex.org/C2993005525","wikidata":"https://www.wikidata.org/wiki/Q191034","display_name":"Port wine","level":2,"score":0.5009458065032959},{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.49211519956588745},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4385935664176941},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4084933400154114},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37709951400756836},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30040377378463745},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.2733958959579468},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.18960431218147278},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15323150157928467},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1253962516784668},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09454312920570374},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.148.suppl_1.14173","doi":"https://doi.org/10.1161/circ.148.suppl_1.14173","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.14173","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4382931189","https://openalex.org/W4386501533","https://openalex.org/W7111813813","https://openalex.org/W6989029801","https://openalex.org/W4400952456","https://openalex.org/W7220901879","https://openalex.org/W4397046386","https://openalex.org/W7113189615","https://openalex.org/W2774774727","https://openalex.org/W207510663"],"abstract_inverted_index":{"Introduction:":[0],"Port":[1],"Wine":[2],"Birthmark":[3],"(PWB)":[4],"is":[5,34,41,61,71],"a":[6,11,42,72],"congenital":[7],"vascular":[8,98],"malformation":[9],"with":[10,162,205,218,300],"progressive":[12],"development.":[13],"The":[14,148,177],"current":[15],"treatments":[16],"for":[17,55,104,138],"PWB":[18,105,112,130,151,197,241,268,294,329],"are":[19],"Pulse":[20],"Dye":[21],"Laser":[22,25],"and":[23,36,57,79,87,96,132,152,167,174,190,211,233,249,290,296,315,320],"Photodynamic":[24],"Treatment.":[26],"However,":[27],"the":[28,32,37,62,89,119,224],"efficacy":[29],"of":[30,140,150,180,263,277],"blanching":[31],"birthmark":[33],"inadequate,":[35],"reoccurrence":[38],"after":[39],"treatment":[40],"major":[43],"clinical":[44],"barrier.":[45],"Developing":[46],"clinically":[47,125],"relevant":[48,126],"disease":[49,77,90,120,127,308],"models":[50,78,103],"that":[51,111],"can":[52,85,324],"be":[53,101,325],"used":[54],"mechanistic":[56],"therapeutic":[58],"development":[59],"studies":[60],"critical":[63,307],"unmet":[64],"need.":[65],"Induced":[66],"pluripotent":[67],"stem":[68],"cell":[69,115,286],"(iPSC)":[70],"powerful":[73],"tool":[74],"in":[75,186,191,203,293,318,321],"different":[76],"drug":[80],"discovery.":[81],"Besides,":[82],"iPSC-derived":[83,113,175,181],"cells":[84,99],"retain":[86,118],"exhibit":[88],"phenotypes":[91,179,310],"from":[92],"donors.":[93],"Therefore,":[94],"iPSCs":[95,295],"their-derived":[97],"could":[100,117],"potential":[102],"study.":[106],"Hypothesis:":[107],"It":[108],"was":[109,157],"hypothesized":[110],"endothelial":[114],"(EC)":[116],"phenotypes,":[121],"thus":[122],"serving":[123],"as":[124,298,327],"models.":[128,330],"Methods:":[129],"lesions":[131],"normal":[133,153,219,259,301],"skin":[134],"biopsies":[135],"were":[136,169,183,228],"cultured":[137],"outgrowths":[139],"fibroblasts,":[141],"followed":[142],"by":[143,230,240,258,267],"reprogramming":[144],"using":[145,159,185,231],"CytoTune-iPS":[146],"Kit.":[147],"induction":[149],"iPSC":[154,173],"into":[155],"EC":[156,198,242,269,305],"performed":[158,170],"reported":[160],"protocols":[161],"tailored":[163],"modifications.":[164],"Bulk":[165],"RNA":[166],"ATAC-seq":[168],"on":[171],"both":[172],"EC.":[176,220,260],"functional":[178],"ECs":[182,297],"characterized":[184,229],"vitro":[187,204,319],"capillary":[188],"formation":[189,202],"vivo":[192],"Matrigel":[193],"plug-in":[194,222],"assays.":[195],"Results:":[196],"showed":[199,243,270,280],"impaired":[200],"tube":[201],"larger":[206,244],"perimeters":[207,245,271],"(p=6.22x10":[208],"-24":[209],")":[210,216,248,254],"thicker":[212],"branches":[213,317],"(p=1.07x10":[214],"-77":[215],"comparing":[217],"In":[221],"assay,":[223],"perfused":[225,264],"human":[226],"vasculatures":[227],"UEA1":[232],"anti-human":[234],"CD31":[235],"antibodies.":[236],"Perfused":[237],"vasculature":[238],"formed":[239,257,266],"(p=8.45x10":[246],"-6":[247],"greater":[250],"densities":[251],"(p=7.34x10":[252],"-8":[253],"than":[255],"those":[256],"Additionally,":[261],"16.6%":[262],"vessels":[265,314],"over":[272],"300":[273],"\u03bcm.":[274],"KEGG":[275],"analysis":[276],"RNA-seq":[278],"DEGs":[279],"significantly":[281],"dysregulated":[282],"pathways":[283],"related":[284,309],"to":[285],"differentiation,":[287],"organ":[288],"development,":[289],"lipid":[291],"metabolism":[292],"compared":[299],"ones.":[302],"Conclusions:":[303],"PWB-derived":[304],"retained":[306],"including":[311],"forming":[312],"enlarged":[313],"thick":[316],"vivo,":[322],"which":[323],"utilized":[326],"valuable":[328]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-12-20T00:00:00"}