{"id":"https://openalex.org/W4389957356","doi":"https://doi.org/10.1161/circ.148.suppl_1.15900","title":"Abstract 15900: Probing Mitochondrial Dysfunction in Mouse Hearts With Doxorubicin-Induced Cardiotoxicity Using Ungated 4D Oxy-Wavelet MRI","display_name":"Abstract 15900: Probing Mitochondrial Dysfunction in Mouse Hearts With Doxorubicin-Induced Cardiotoxicity Using Ungated 4D Oxy-Wavelet MRI","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4389957356","doi":"https://doi.org/10.1161/circ.148.suppl_1.15900"},"language":"en","primary_location":{"id":"doi:10.1161/circ.148.suppl_1.15900","doi":"https://doi.org/10.1161/circ.148.suppl_1.15900","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.15900","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037249079","display_name":"Devin Raine Everaldo Cortes","orcid":"https://orcid.org/0009-0004-8130-8513","observed_orcids":["https://orcid.org/0009-0004-8130-8513"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Devin Raine Everaldo Cortes","raw_affiliation_strings":["Dept of Developmental Biology, Dept of Bioengineering, Univ of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Developmental Biology, Dept of Bioengineering, Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104152105","display_name":"Margaret Caroline Stapleton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret Stapleton","raw_affiliation_strings":["Univ of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104103022","display_name":"Kristina Elsa Schwab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristina Schwab","raw_affiliation_strings":["Rangos Rsch Cntr Animal Imaging CORE, Children's Hosp Of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rangos Rsch Cntr Animal Imaging CORE, Children's Hosp Of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210130600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093533531","display_name":"Noah William Coulson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noah Coulson","raw_affiliation_strings":["Dept of Developmental Biology, Univ of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Developmental Biology, Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108887243","display_name":"Elizabeth Mazzella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Mazzella","raw_affiliation_strings":["Dept of Chemistry, Univ of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Chemistry, Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109763627","display_name":"Dalton West","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dalton West","raw_affiliation_strings":["Dept of Biological Sciences, Univ of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Biological Sciences, Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093533532","display_name":"Thomas Becker-Szurszewski","orcid":"https://orcid.org/0009-0008-0540-4289","observed_orcids":["https://orcid.org/0009-0008-0540-4289"]},"institutions":[{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Becker-Szurszewski","raw_affiliation_strings":["Rangos Rsch Cntr Animal Imaging CORE, Children's Hosp of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rangos Rsch Cntr Animal Imaging CORE, Children's Hosp of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210130600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051375191","display_name":"Sean Hartwick","orcid":"https://orcid.org/0009-0006-2474-5623","observed_orcids":["https://orcid.org/0009-0006-2474-5623"]},"institutions":[{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Hartwick","raw_affiliation_strings":["Rangos Rsch Cntr Animal Imaging CORE, Children's Hosp of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rangos Rsch Cntr Animal Imaging CORE, Children's Hosp of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I4210130600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104962456","display_name":"Anthony Christodoulou","orcid":"https://orcid.org/0000-0002-9334-8684","observed_orcids":["https://orcid.org/0000-0002-9334-8684"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony G Christodoulou","raw_affiliation_strings":["Cedars-Sinai Med Cntr, West Hollywood, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Med Cntr, West Hollywood, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022501599","display_name":"Yijen Lin Wu","orcid":"https://orcid.org/0000-0001-9509-5417","observed_orcids":["https://orcid.org/0000-0001-9509-5417"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yijen L Wu","raw_affiliation_strings":["Univ of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"148","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin-induced-cardiotoxicity","display_name":"doxorubicin cardiotoxicity","score":0.9179999828338623},{"id":"https://openalex.org/keywords/anthracycline-induced-cardiomyopathy","display_name":"anthracycline-induced cardiomyopathy","score":0.9319999814033508},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bold-signal","display_name":"BOLD signal","score":0.8119999766349792},{"id":"https://openalex.org/keywords/early-detection-of-cardiotoxicity","display_name":"early detection of cardiotoxicity","score":0.8050000071525574},{"id":"https://openalex.org/keywords/time-frequency-analysis","display_name":"time-frequency analysis","score":0.7509999871253967},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.9024221897125244},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8177467584609985},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.728272557258606},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.6580840945243835},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5579240918159485},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5382779240608215},{"id":"https://openalex.org/C2776802502","wikidata":"https://www.wikidata.org/wiki/Q417589","display_name":"Anthracycline","level":4,"score":0.5243425965309143},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.4954475164413452},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.49008357524871826},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4516134560108185},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42496258020401},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41193628311157227},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.26138949394226074},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2351212501525879},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.148.suppl_1.15900","doi":"https://doi.org/10.1161/circ.148.suppl_1.15900","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.15900","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8600000143051147,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4401576193","https://openalex.org/W3098978443","https://openalex.org/W4288038993","https://openalex.org/W2913576840","https://openalex.org/W4388600828","https://openalex.org/W4401570968","https://openalex.org/W4283324594","https://openalex.org/W3036027575","https://openalex.org/W4248288365","https://openalex.org/W4285204156"],"abstract_inverted_index":{"Introduction:":[0],"Despite":[1],"advances":[2],"in":[3,96,125,168],"cancer":[4,14,43],"therapy":[5],"greatly":[6],"improving":[7],"patient":[8],"survival,":[9],"more":[10],"than":[11],"two-thirds":[12],"of":[13,52,70,172,181,190,202],"survivors":[15],"will":[16],"still":[17],"face":[18],"serious":[19],"life-threatening":[20],"cardiomyopathy":[21,61],"caused":[22],"by":[23],"anti-cancer":[24],"anthracyclines.":[25],"Doxorubicin":[26],"(Dox),":[27],"a":[28,34,160,169,177,241],"well-known,":[29],"well":[30],"studied":[31],"anthracycline,":[32],"is":[33,49,66],"major":[35],"cause":[36],"for":[37,144],"long-term":[38],"morbidity":[39],"and":[40,99,216,255],"mortality":[41],"among":[42],"survivors.":[44],"Pertinent":[45],"to":[46,83,148,164,186,218,222,244,251],"this":[47,84,90,263],"issue":[48],"the":[50,126,142,166,182,188,200,220,245],"lack":[51],"non-invasive":[53],"imaging":[54],"tools":[55],"that":[56,78,89,231,259],"can":[57,121],"detect":[58,224],"DOX":[59,226],"induced":[60,227],"before":[62],"irreversible":[63],"tissue":[64],"damage":[65],"done.":[67],"Current":[68],"research":[69],"cellular":[71],"mechanisms":[72],"underlying":[73,256],"DOX-induced":[74,173],"cardiotoxicity":[75],"has":[76],"shown":[77],"mitochondrial":[79,91,106,146,191],"dysfunction":[80,92,192],"are":[81],"central":[82],"cardiomyopathy.":[85],"Hypothesis:":[86],"We":[87,154,175,229],"hypothesize":[88],"precedes":[93],"clinical":[94],"changes":[95,124],"cardiac":[97],"strain":[98],"left-ventricle":[100],"ejection":[101],"fraction.":[102],"Methods:":[103],"To":[104],"probe":[105],"function":[107,147],"non-invasively,":[108],"we":[109],"use":[110,176],"motion-and-time":[111],"resolved":[112],"4D":[113,117,205],"functional":[114],"MRI,":[115],"coined":[116],"Oxy-Wavelet.":[118],"Our":[119,137],"methodology":[120,158],"capture":[122],"dynamic":[123],"blood":[127],"oxygenation":[128,151],"level":[129],"dependent":[130],"(BOLD)":[131],"signal":[132],"with":[133,159],"high":[134],"spatiotemporal":[135],"resolution.":[136],"cyclic":[138,161],"hypoxia":[139,162,246],"challenge":[140,163],"leverages":[141],"need":[143],"in-tact":[145],"maintain":[149,252],"homeostatic":[150,253],"during":[152],"hypoxia.":[153],"combine":[155],"our":[156],"4D-fMRI":[157],"stress-test":[165],"mitochondria":[167,257],"mouse":[170],"model":[171],"cardiotoxicity.":[174,228],"novel":[178],"time-frequency":[179],"analysis":[180],"event-driven":[183],"BOLD":[184],"response":[185,243],"automate":[187],"detection":[189],"in-vivo.":[193],"Results:":[194],"C57BL6/J":[195],"were":[196],"given":[197],"Dox":[198],"over":[199],"course":[201],"one":[203,236],"week.":[204],"oxy-wavelet":[206],"MRI":[207],"was":[208,260],"performed":[209],"at":[210],"baseline,":[211],"day":[212,235],"1,":[213],"3,":[214],"4,":[215],"7":[217],"evaluate":[219],"ability":[221],"rapidly":[223],"acute":[225,264],"found":[230],"as":[232,234],"early":[233],"post":[237],"exposure,":[238],"mice":[239],"exhibited":[240],"passive":[242],"challenge,":[247],"representing":[248],"an":[249],"inability":[250],"oxygen":[254],"dysfunction,":[258],"maintained":[261],"through":[262],"period.":[265]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2023-12-20T00:00:00"}