{"id":"https://openalex.org/W4389957323","doi":"https://doi.org/10.1161/circ.148.suppl_1.14407","title":"Abstract 14407: Right Ventricular Myocardial Stiffening is Associated With Pulmonary Arterial Stiffening in Pulmonary Hypertension","display_name":"Abstract 14407: Right Ventricular Myocardial Stiffening is Associated With Pulmonary Arterial Stiffening in Pulmonary Hypertension","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4389957323","doi":"https://doi.org/10.1161/circ.148.suppl_1.14407"},"language":"en","primary_location":{"id":"doi:10.1161/circ.148.suppl_1.14407","doi":"https://doi.org/10.1161/circ.148.suppl_1.14407","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.148.suppl_1.14407","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073424685","display_name":"Sunder Neelakantan","orcid":"https://orcid.org/0000-0002-5445-4070","observed_orcids":["https://orcid.org/0000-0002-5445-4070"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunder Neelakantan","raw_affiliation_strings":["TAMU, College Station, TX","Sunder Neelakantan TAMU, College Station, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TAMU, College Station, TX","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Sunder Neelakantan TAMU, College Station, TX","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089823979","display_name":"Edward P. Manning","orcid":"https://orcid.org/0000-0002-4430-8168","observed_orcids":["https://orcid.org/0000-0002-4430-8168"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"EDWARD P MANNING","raw_affiliation_strings":["Woodbridge, CT","EDWARD P MANNING Woodbridge, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Woodbridge, CT","institution_ids":[]},{"raw_affiliation_string":"EDWARD P MANNING Woodbridge, CT","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062158571","display_name":"Peng Zhang","orcid":"https://orcid.org/0000-0002-0190-5384","observed_orcids":["https://orcid.org/0000-0002-0190-5384"]},"institutions":[{"id":"https://openalex.org/I2802759389","display_name":"Providence VA Medical Center","ror":"https://ror.org/041m0cc93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802759389","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng Zhang","raw_affiliation_strings":["OSRI at Providence VAMC, Providence, RI","Peng Zhang OSRI at Providence VAMC, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OSRI at Providence VAMC, Providence, RI","institution_ids":["https://openalex.org/I2802759389"]},{"raw_affiliation_string":"Peng Zhang OSRI at Providence VAMC, Providence, RI","institution_ids":["https://openalex.org/I2802759389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006335310","display_name":"Gaurav Choudhary","orcid":"https://orcid.org/0000-0001-9343-5481","observed_orcids":["https://orcid.org/0000-0001-9343-5481"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2802759389","display_name":"Providence VA Medical Center","ror":"https://ror.org/041m0cc93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802759389","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gaurav Choudhary","raw_affiliation_strings":["Providence VAMC, Brown Univ, Providence, RI","Gaurav Choudhary Providence VAMC, Brown Univ, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Providence VAMC, Brown Univ, Providence, RI","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2802759389"]},{"raw_affiliation_string":"Gaurav Choudhary Providence VAMC, Brown Univ, Providence, RI","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2802759389"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006348854","display_name":"Reza Avazmohammadi","orcid":"https://orcid.org/0000-0001-9787-1117","observed_orcids":["https://orcid.org/0000-0001-9787-1117"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reza Avazmohammadi","raw_affiliation_strings":["Texas AM Univ, College Station, TX","Reza Avazmohammadi Texas AM Univ, College Station, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas AM Univ, College Station, TX","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Reza Avazmohammadi Texas AM Univ, College Station, TX","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"148","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pulmonary-arterial-stiffness","display_name":"pulmonary arterial stiffness","score":0.843999981880188},{"id":"https://openalex.org/keywords/right-ventricular-free-wall","display_name":"right ventricular free wall","score":0.8399999737739563},{"id":"https://openalex.org/keywords/tissue-stiffness","display_name":"tissue stiffness","score":0.6790000200271606},{"id":"https://openalex.org/keywords/hypoxia-induced-pulmonary-hypertension","display_name":"hypoxia-induced pulmonary hypertension","score":0.7720000147819519},{"id":"https://openalex.org/keywords/su5416","display_name":"SU5416","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8060086965560913},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7352116703987122},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.7139914035797119},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6558986306190491},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.6276628375053406},{"id":"https://openalex.org/C2775850156","wikidata":"https://www.wikidata.org/wiki/Q4797538","display_name":"Arterial stiffness","level":3,"score":0.6046337485313416},{"id":"https://openalex.org/C123576724","wikidata":"https://www.wikidata.org/wiki/Q1299082","display_name":"Afterload","level":3,"score":0.5703474283218384},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5216805934906006},{"id":"https://openalex.org/C2779537366","wikidata":"https://www.wikidata.org/wiki/Q7920323","display_name":"Ventricular remodeling","level":3,"score":0.4397934079170227},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.3908815383911133},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.19819477200508118},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.15794646739959717},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.07006564736366272},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.148.suppl_1.14407","doi":"https://doi.org/10.1161/circ.148.suppl_1.14407","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.148.suppl_1.14407","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6399999856948853,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3167656805","https://openalex.org/W1994536035","https://openalex.org/W4387339386","https://openalex.org/W4362677580","https://openalex.org/W4409733590","https://openalex.org/W4411698688","https://openalex.org/W2078069441","https://openalex.org/W7221014914","https://openalex.org/W4399127094","https://openalex.org/W2023314610"],"abstract_inverted_index":{"Introduction:":[0],"Pulmonary":[1],"hypertension":[2],"(PH)":[3],"increases":[4,299],"vascular":[5],"resistance":[6],"in":[7,36,83,133,193,201,216,256,300,318],"the":[8,14,23,42,47,50,120,163,166,182,202,217,245,262,266,271,289,310,319],"lung":[9],"leading":[10],"to":[11,22,270,277,308],"remodeling":[12,27,35,52],"of":[13,33,49,74,96,101,109,165,171,265,282,298,312,321],"proximal":[15,59,290],"pulmonary":[16],"artery":[17],"(PA).":[18],"PH":[19,37,75,102],"also":[20],"leads":[21],"right":[24],"ventricular":[25],"(RV)":[26],"following":[28],"increased":[29,213],"RV":[30,43,65,267,283,295,316,322],"afterload.":[31],"Studies":[32],"tissue":[34,60],"have":[38],"focused":[39],"on":[40],"either":[41],"or":[44],"PA,":[45],"leaving":[46],"understanding":[48],"RV-PA":[51],"relationship":[53],"elusive.":[54],"We":[55],"hypothesize":[56],"that":[57,288],"PA":[58,149,185,211,230,254,259,291,301],"stiffening":[61,255,260,292,296],"is":[62,275],"associated":[63],"with":[64],"free":[66],"wall":[67],"(RVFW)":[68],"stiffening.":[69],"Methods:":[70],"The":[71,98],"mild":[72],"model":[73,100,204,219],"was":[76,103,140,160,232],"developed":[77,104],"by":[78,93,105,119],"placing":[79],"SD":[80,128],"rats":[81,116,124],"(n=6)":[82,117],"a":[84,177,248,279],"hypoxia":[85,121],"chamber":[86],"(10%":[87],"O2)":[88],"for":[89,127,181,244],"3":[90],"weeks,":[91],"followed":[92,118],"one":[94,107],"week":[95],"normoxia.":[97],"severe":[99,203,218],"injecting":[106],"dose":[108],"SU5416":[110],"(20":[111],"mg/kg":[112],"sc)":[113],"into":[114],"CDF":[115],"protocol.":[122],"Control":[123],"(n=6":[125],"each":[126],"and":[129,143,147,153,173,184,190,210,229,253],"CDF)":[130],"were":[131,151,198],"kept":[132],"normoxia":[134],"at":[135,176],"all":[136],"times.":[137],"Each":[138],"group":[139],"half":[141,144],"male":[142],"female.":[145],"RVFW":[146,183,209,228,252,272],"main":[148],"tissues":[150],"harvested":[152],"characterized":[154],"through":[155],"mechanical":[156],"tests.":[157],"Tissue":[158],"stiffness":[159,231],"calculated":[161],"as":[162],"slope":[164],"ensemble":[167],"stress-strain":[168],"curve":[169],"(sum":[170],"circumferential":[172],"longitudinal":[174],"stress)":[175],"large":[178],"strain":[179],"(>30%)":[180],"specimens.":[186],"Results:":[187],"RVSP":[188],"increased,":[189],"PAT":[191],"decreased":[192],"both":[194],"models.":[195],"These":[196],"changes":[197,261],"significant":[199,224,249],"only":[200,215],"(Figs.":[205,220],"1A,":[206],"B).":[207],"Similarly,":[208],"stiffnesses":[212],"significantly":[214],"1C,":[221],"D).":[222],"A":[223],"positive":[225],"correlation":[226,250],"between":[227,251],"observed":[233],"(R2":[234],"=":[235],"0.59,":[236],"p=0.0001,":[237],"Fig.":[238],"1E).":[239],"Conclusions.":[240],"Our":[241,285],"results":[242,286],"demonstrate,":[243],"first":[246],"time,":[247],"PH.":[257],"Proximal":[258],"pulsatile":[263,315],"component":[264],"afterload,":[268],"contributing":[269],"stiffening,":[273],"which":[274],"known":[276],"be":[278],"key":[280],"precursor":[281],"failure.":[284],"suggest":[287],"may":[293],"worsen":[294],"independent":[297],"distal":[302],"resistance.":[303],"Further":[304],"studies":[305],"are":[306],"needed":[307],"determine":[309],"role":[311],"resistive":[313],"vs.":[314],"afterload":[317],"outcome":[320],"remodeling.":[323]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2023-12-20T00:00:00"}