{"id":"https://openalex.org/W4389957146","doi":"https://doi.org/10.1161/circ.148.suppl_1.16842","title":"Abstract 16842: Progression of Myocardial Fibrosis in Hypertrophic Cardiomyopathy","display_name":"Abstract 16842: Progression of Myocardial Fibrosis in Hypertrophic Cardiomyopathy","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4389957146","doi":"https://doi.org/10.1161/circ.148.suppl_1.16842"},"language":"en","primary_location":{"id":"doi:10.1161/circ.148.suppl_1.16842","doi":"https://doi.org/10.1161/circ.148.suppl_1.16842","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.16842","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079054986","display_name":"Shiro Nakamori","orcid":"https://orcid.org/0000-0001-8165-5268","observed_orcids":["https://orcid.org/0000-0001-8165-5268"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801337628","display_name":"Beth Israel Deaconess Hospital","ror":"https://ror.org/02cpjkp59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801337628"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shiro Nakamori","raw_affiliation_strings":["BIDMC / Harvard Med Sch, Boston, MA","Shiro Nakamori BIDMC / Harvard Med Sch, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIDMC / Harvard Med Sch, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I2801337628"]},{"raw_affiliation_string":"Shiro Nakamori BIDMC / Harvard Med Sch, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012431017","display_name":"Ethan J. Rowin","orcid":"https://orcid.org/0000-0002-3953-0143","observed_orcids":["https://orcid.org/0000-0002-3953-0143","https://orcid.org/0009-0003-7454-9311"]},"institutions":[{"id":"https://openalex.org/I1289019353","display_name":"Lahey Hospital and Medical Center","ror":"https://ror.org/03mbq3y29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289019353"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethan J Rowin","raw_affiliation_strings":["Lahey Hosp, Burlington, MA","Ethan J Rowin Lahey Hosp, Burlington, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lahey Hosp, Burlington, MA","institution_ids":["https://openalex.org/I1289019353"]},{"raw_affiliation_string":"Ethan J Rowin Lahey Hosp, Burlington, MA","institution_ids":["https://openalex.org/I1289019353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068196455","display_name":"Narjes Jaafar","orcid":"https://orcid.org/0000-0002-6315-3325","observed_orcids":["https://orcid.org/0000-0002-6315-3325"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I2801337628","display_name":"Beth Israel Deaconess Hospital","ror":"https://ror.org/02cpjkp59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801337628"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Narjes Jaafar","raw_affiliation_strings":["BIDMC, Boston, MA","Narjes Jaafar BIDMC, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIDMC, Boston, MA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I2801337628"]},{"raw_affiliation_string":"Narjes Jaafar BIDMC, Boston, MA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021635721","display_name":"Jennifer Rodriguez","orcid":"https://orcid.org/0000-0002-6291-9173","observed_orcids":["https://orcid.org/0000-0002-6291-9173"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer Rodriguez","raw_affiliation_strings":["Boston, MA","Jennifer Rodriguez Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston, MA","institution_ids":[]},{"raw_affiliation_string":"Jennifer Rodriguez Boston, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087979959","display_name":"Long H. Ngo","orcid":"https://orcid.org/0000-0001-9349-7981","observed_orcids":["https://orcid.org/0000-0001-9349-7981","https://orcid.org/0000-0002-8903-9352","https://orcid.org/0009-0002-7254-4464"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Long H Ngo","raw_affiliation_strings":["Long H Ngo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Long H Ngo","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002927848","display_name":"Warren J. Manning","orcid":"https://orcid.org/0000-0001-7199-2543","observed_orcids":["https://orcid.org/0000-0001-7199-2543"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Warren J Manning","raw_affiliation_strings":["Beth Israel Deaconess Med Ctr, Boston, MA","Warren J Manning Beth Israel Deaconess Med Ctr, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Med Ctr, Boston, MA","institution_ids":["https://openalex.org/I1316535847"]},{"raw_affiliation_string":"Warren J Manning Beth Israel Deaconess Med Ctr, Boston, MA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058059684","display_name":"Martin S. Maron","orcid":"https://orcid.org/0000-0002-9923-3853","observed_orcids":["https://orcid.org/0000-0002-9923-3853"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Maron","raw_affiliation_strings":["Lahey, Swampscott","Martin Maron Lahey, Swampscott"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lahey, Swampscott","institution_ids":[]},{"raw_affiliation_string":"Martin Maron Lahey, Swampscott","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021251913","display_name":"Reza Nezafat","orcid":"https://orcid.org/0000-0002-1963-7138","observed_orcids":["https://orcid.org/0000-0002-1963-7138"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reza Nezafat","raw_affiliation_strings":["Boston, MA","Reza Nezafat Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston, MA","institution_ids":[]},{"raw_affiliation_string":"Reza Nezafat Boston, MA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"148","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertrophic-cardiomyopathy","display_name":"hypertrophic cardiomyopathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/late-gadolinium-enhancement","display_name":"late gadolinium enhancement","score":0.9480000138282776},{"id":"https://openalex.org/keywords/fibrosis-progression","display_name":"fibrosis progression","score":0.8429999947547913},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"sudden cardiac death","score":0.9959999918937683},{"id":"https://openalex.org/keywords/age-stratified-risk","display_name":"age-stratified risk","score":0.6489999890327454},{"id":"https://openalex.org/keywords/cardiovascular-magnetic-resonance","display_name":"cardiovascular magnetic resonance","score":0.8399999737739563},{"id":"https://openalex.org/keywords/left-ventricular-mass","display_name":"left ventricular mass","score":0.9620000123977661},{"id":"https://openalex.org/keywords/wall-thickness","display_name":"wall thickness","score":0.5799999833106995},{"id":"https://openalex.org/keywords/cardiac-arrest","display_name":"cardiac arrest","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9606258273124695},{"id":"https://openalex.org/C2780185194","wikidata":"https://www.wikidata.org/wiki/Q1364270","display_name":"Hypertrophic cardiomyopathy","level":2,"score":0.8317078351974487},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7372136116027832},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.725068211555481},{"id":"https://openalex.org/C2775935837","wikidata":"https://www.wikidata.org/wiki/Q202837","display_name":"Sudden cardiac death","level":2,"score":0.5886570811271667},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.568764328956604},{"id":"https://openalex.org/C3018763269","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Myocardial fibrosis","level":3,"score":0.4864508807659149},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.4338723123073578},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4326635003089905},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.3858340084552765},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.2382824718952179},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.07690390944480896}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.148.suppl_1.16842","doi":"https://doi.org/10.1161/circ.148.suppl_1.16842","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.16842","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4401263529","https://openalex.org/W2893519084","https://openalex.org/W4415792785","https://openalex.org/W2120520971","https://openalex.org/W7130395309","https://openalex.org/W3109175419","https://openalex.org/W1990481472","https://openalex.org/W2014618785","https://openalex.org/W7095550668","https://openalex.org/W1872516364"],"abstract_inverted_index":{"Background:":[0],"There":[1,194],"is":[2],"limited":[3],"data":[4],"on":[5,11],"the":[6,9,41,102,113,123,134,149,153,199,224,287],"progression":[7,34,154,166,181,204,217,234,284,297],"of":[8,43,51,73,115,179,202,223,274,277,289],"scar":[10],"LGE":[12,33,84,126,147,165,173,180,203,211,216,233,283,296],"in":[13,129,186,206,239,261,298],"patients":[14,54,137,145,162,187,207,266,281],"with":[15,25,164,172,210,237],"hypertrophic":[16],"cardiomyopathy":[17],"(HCM)":[18],"stratified":[19,36],"by":[20,37,93,148],"age":[21,38,59,300],"and":[22,39,119,169,246,267],"its":[23],"relationship":[24,42],"sudden":[26],"cardiac":[27,117],"death":[28],"(SCD).":[29],"Objectives:":[30],"We":[31],"compared":[32],"as":[35],"examined":[40],"this":[44,299],"risk":[45,178,201,273],"to":[46,101,263,279,292],"SCD.":[47,120,275],"Methods:":[48],"A":[49],"total":[50],"102":[52],"HCM":[53,265],"(age":[55],"<60":[56,188,208],"years;":[57,61],"n=75,":[58],"\u226560":[60],"n=27)":[62],"undergoing":[63],"two":[64,79],"consecutive":[65],"cardiovascular":[66],"magnetic":[67],"resonance":[68],"(CMR)":[69],"at":[70,175,213,271],"an":[71],"interval":[72],"4.3":[74],"\u00b1":[75,158],"3.3":[76],"years":[77,189,209],"from":[78,98],"medical":[80],"centers":[81],"were":[82],"evaluated.":[83],"was":[85,106,112,127,156,183,195,219],"quantified":[86],"semi-automatically":[87],"using":[88],"a":[89,139,196,220,269],"6-SD":[90],"threshold":[91],"followed":[92],"manual":[94],"adjustment.":[95],"Median":[96],"follow-up":[97,150],"study":[99],"entry":[100],"most":[103],"recent":[104],"evaluation":[105],"7.3":[107],"years.":[108],"The":[109,177],"primary":[110,225],"endpoint":[111],"composite":[114],"resuscitated":[116],"arrest":[118],"Results:":[121],"At":[122,133],"first":[124],"CMR,":[125],"detected":[128],"61":[130],"(60%)":[131],"patients.":[132],"follow-up,":[135],"25":[136],"developed":[138],"new":[140],"LGE;":[141],"thus,":[142],"86":[143],"(84%)":[144],"had":[146],"CMR.":[151],"Overall,":[152],"rate":[155],"0.7":[157],"1.0%/year,":[159],"including":[160],"21":[161],"(21%)":[163],"\u22651%":[167],"/year":[168],"5":[170],"(5%)":[171],">15%":[174],"follow-up.":[176],"\u22651%/year":[182,205,218],"significantly":[184],"higher":[185],"(25%":[190],"vs.":[191],"7%,":[192],"p=0.02).":[193],"trend":[197],"for":[198,253,294],"highest":[200],">10%":[212],"baseline":[214],"scan.":[215],"strong":[221],"predictor":[222],"outcomes":[226],"(HR":[227],"1.88":[228],"[95%":[229],"CI;":[230],"1.08-3.26],":[231],"p=0.03).":[232],"moderately":[235],"correlated":[236],"changes":[238],"LV":[240,243,248],"mass,":[241],"indexed":[242],"mass":[244],"index,":[245],"maximal":[247],"end-diastolic":[249],"wall":[250],"thickness":[251],"(p<0.001":[252],"all).":[254],"Conclusions:":[255],"Progressive":[256],"fibrosis":[257],"occurs":[258],"more":[259],"frequently":[260],"young":[262,278],"middle-aged":[264,280],"identifies":[268],"cohort":[270],"high":[272],"One-quarter":[276],"exhibit":[282],"\u22651%/year,":[285],"underscoring":[286],"importance":[288],"repeating":[290],"CMR":[291],"re-evaluate":[293],"potential":[295],"group.":[301]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-12-20T00:00:00"}
