{"id":"https://openalex.org/W4389956738","doi":"https://doi.org/10.1161/circ.148.suppl_1.18445","title":"Abstract 18445: Rigorous Mechanics in Engineered Heart Tissues","display_name":"Abstract 18445: Rigorous Mechanics in Engineered Heart Tissues","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4389956738","doi":"https://doi.org/10.1161/circ.148.suppl_1.18445"},"language":"en","primary_location":{"id":"doi:10.1161/circ.148.suppl_1.18445","doi":"https://doi.org/10.1161/circ.148.suppl_1.18445","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.18445","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007068933","display_name":"Benjamin W. Lee","orcid":"https://orcid.org/0000-0003-1319-0563","observed_orcids":["https://orcid.org/0000-0003-1319-0563","https://orcid.org/0000-0003-2307-075X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin W Lee","raw_affiliation_strings":["Univ of Pennsylvania, Philadelphia, PA","Benjamin W Lee Univ of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Benjamin W Lee Univ of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093533429","display_name":"Jamie Moni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie Moni","raw_affiliation_strings":["Univ of Pennsylvania, Philadelphia, PA","Jamie Moni Univ of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Jamie Moni Univ of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041570656","display_name":"Nesrine Bouhrira","orcid":"https://orcid.org/0000-0002-6406-2302","observed_orcids":["https://orcid.org/0000-0002-6406-2302"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"NESRINE BOUHRIRA","raw_affiliation_strings":["Univ of Pennsylvania, Philadelphia, PA","NESRINE BOUHRIRA Univ of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"NESRINE BOUHRIRA Univ of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073087480","display_name":"Alisa Nicole DeGrave","orcid":"https://orcid.org/0000-0002-8890-1238","observed_orcids":["https://orcid.org/0000-0002-8890-1238"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alisa N DeGrave","raw_affiliation_strings":["Univ of Pennsylvania, Philadelphia, PA","Alisa N DeGrave Univ of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Alisa N DeGrave Univ of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093533430","display_name":"Noah R Boone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noah R Boone","raw_affiliation_strings":["Univ of Pennsylvania, Philadelphia, PA","Noah R Boone Univ of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Noah R Boone Univ of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066493672","display_name":"Elise A. Corbin","orcid":"https://orcid.org/0000-0003-2373-0420","observed_orcids":["https://orcid.org/0000-0003-2373-0420"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elise A Corbin","raw_affiliation_strings":["Univ of Delaware, Newark, DE","Elise A Corbin Univ of Delaware, Newark, DE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Delaware, Newark, DE","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Elise A Corbin Univ of Delaware, Newark, DE","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003776673","display_name":"Kenneth B. Margulies","orcid":"https://orcid.org/0000-0002-8093-4465","observed_orcids":["https://orcid.org/0000-0002-8093-4465","https://orcid.org/0000-0003-3588-9324"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth B Margulies","raw_affiliation_strings":["Univ Pennsylvania Sch of Medicine, Philadelphia, PA","Kenneth B Margulies Univ Pennsylvania Sch of Medicine, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ Pennsylvania Sch of Medicine, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Kenneth B Margulies Univ Pennsylvania Sch of Medicine, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"148","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0414000004529953,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.04100000113248825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/engineered-heart-tissue","display_name":"engineered heart tissue","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cardiac-tissue-mechanics","display_name":"cardiac tissue mechanics","score":0.765999972820282},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell-derived-cardiomyocytes","display_name":"iPSC-derived cardiomyocytes","score":0.8949999809265137},{"id":"https://openalex.org/keywords/ventricular-fibroblasts","display_name":"ventricular fibroblasts","score":0.9039999842643738},{"id":"https://openalex.org/keywords/length-tension-relationship","display_name":"length-tension relationship","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.47999998927116394},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.6349999904632568},{"id":"https://openalex.org/keywords/preload-and-afterload","display_name":"preload and afterload","score":0.7200000286102295},{"id":"https://openalex.org/keywords/tissue-compaction","display_name":"tissue compaction","score":0.593999981880188},{"id":"https://openalex.org/keywords/sarcomere-alignment","display_name":"sarcomere alignment","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C68731436","wikidata":"https://www.wikidata.org/wiki/Q1337087","display_name":"Sarcomere","level":3,"score":0.6868619322776794},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.6319685578346252},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.592512309551239},{"id":"https://openalex.org/C48277249","wikidata":"https://www.wikidata.org/wiki/Q1406926","display_name":"Preload","level":3,"score":0.5827347636222839},{"id":"https://openalex.org/C103486182","wikidata":"https://www.wikidata.org/wiki/Q1216236","display_name":"Isometric exercise","level":2,"score":0.4849946200847626},{"id":"https://openalex.org/C123576724","wikidata":"https://www.wikidata.org/wiki/Q1299082","display_name":"Afterload","level":3,"score":0.45905837416648865},{"id":"https://openalex.org/C186068551","wikidata":"https://www.wikidata.org/wiki/Q13255585","display_name":"Tension (geology)","level":3,"score":0.41727983951568604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4010867476463318},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3941372036933899},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.36040109395980835},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.2858397364616394},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.2367534637451172},{"id":"https://openalex.org/C112950240","wikidata":"https://www.wikidata.org/wiki/Q76005","display_name":"Ultimate tensile strength","level":2,"score":0.20049256086349487},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.14665251970291138},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.1245039701461792},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11709913611412048},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.148.suppl_1.18445","doi":"https://doi.org/10.1161/circ.148.suppl_1.18445","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.18445","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2898496023","https://openalex.org/W2325411762","https://openalex.org/W4285126879","https://openalex.org/W3136631273","https://openalex.org/W3186563670","https://openalex.org/W4210968705","https://openalex.org/W4210816800","https://openalex.org/W3186062169","https://openalex.org/W4405489712","https://openalex.org/W2406043282"],"abstract_inverted_index":{"Introduction:":[0],"Heart":[1],"failure":[2],"can":[3],"develop":[4,63],"or":[5,136],"be":[6],"exacerbated":[7],"by":[8,174],"mechanical":[9,53,266],"stressors,":[10],"including":[11],"increased":[12,17],"diastolic":[13],"strain":[14],"(preload)":[15],"and":[16,31,39,92,101,111,132,145,156,166,184,212,235,256],"systolic":[18],"impedance":[19],"(afterload).":[20],"Recent":[21],"advances":[22],"in":[23,107,113,164,203,233],"human":[24,259],"induced":[25],"pluripotent":[26],"stem":[27],"cell":[28,182],"(iPSC)":[29],"technology":[30],"tissue":[32,77,81,96,121,151,172],"engineering":[33],"have":[34,250],"enabled":[35],"long":[36],"term":[37],"culture":[38],"maturation":[40],"of":[41,58,76,177,188,241,264],"engineered":[42,260],"heart":[43,261],"tissues":[44,69,180,194,262],"(EHTs).":[45],"Most":[46],"current":[47],"platforms":[48],"do":[49],"not":[50],"allow":[51,71],"for":[52,72,134,142],"assessment":[54],"under":[55],"a":[56,64,139,196],"range":[57],"loading":[59],"conditions.":[60],"Here,":[61],"we":[62,249],"technique":[65],"to":[66,168,254],"engineer":[67],"cardiac":[68,273],"that":[70],"non-destructive":[73],"rigorous":[74,265],"phenotyping":[75],"mechanics.":[78],"Methods:":[79],"Custom":[80],"anchors":[82,122,152],"were":[83,104,117,127,181,239],"3D":[84,149],"printed":[85,150],"using":[86],"Boston":[87],"Micro":[88],"Fabrication":[89],"HTL":[90],"Resin":[91],"placed":[93],"within":[94],"polydimethylsiloxane":[95],"casting":[97],"molds.":[98,115],"iPS":[99],"cardiomyocytes":[100],"ventricular":[102],"fibroblasts":[103],"mixed":[105],"5:1":[106],"2":[108,223,226],"mg/mL":[109],"collagen":[110],"cast":[112],"rectangular":[114],"Tissues":[116,126],"compacted":[118,167],"around":[119],"custom":[120],"over":[123],"14":[124,175],"days.":[125],"dismounted":[128],"from":[129],"the":[130,252],"molds":[131],"fixed":[133],"immunostaining":[135],"hooked":[137],"onto":[138],"force":[140,204,219],"transducer":[141],"length-tension,":[143],"force-frequency,":[144],"work-loop":[146],"analysis.":[147],"Results:":[148],"accommodated":[153],"EHT":[154],"molding":[155],"compaction.":[157],"EHTs":[158,238],"spontaneously":[159],"contracted":[160],"after":[161],"3":[162],"days":[163,176],"culture,":[165],"15.9\u00b10.8%":[169],"their":[170],"initial":[171],"area":[173],"culture.":[178],"Engineered":[179],"dense":[183],"mature,":[185],"with":[186,200,205,231],"bands":[187],"aligned":[189],"sarcomeres.":[190],"During":[191],"isometric":[192],"testing,":[193],"display":[195],"physiologic":[197,243],"length-tension":[198],"relationship,":[199],"linear":[201],"increases":[202,232],"stretch":[206],"between":[207],"L":[208,213],"0":[209],"(slack":[210],"length)":[211],"max":[214],"(length":[215],"at":[216],"maximum":[217],"active":[218],"generation,":[220],"4.3\u00b10.7":[221],"mN/mm":[222],";":[224],"r":[225],"=0.96).":[227],"These":[228],"are":[229],"coupled":[230],"contraction":[234],"relaxation":[236],"velocities.":[237],"capable":[240,263],"mimicking":[242],"work":[244],"loops.":[245],"Conclusions:":[246],"In":[247],"summary,":[248],"shown":[251],"ability":[253],"grow":[255],"mature":[257],"three-dimensional":[258],"assessment,":[267],"enabling":[268],"future":[269],"studies":[270],"on":[271],"load-dependent":[272],"remodeling.":[274]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2023-12-20T00:00:00"}
