{"id":"https://openalex.org/W4389953314","doi":"https://doi.org/10.1161/circ.148.suppl_1.12241","title":"Abstract 12241: Low-Efficiency Gene Editing is Capable of Suppressing Arrhythmogenesis in Long QT Syndrome Type II: Computer Simulation Study","display_name":"Abstract 12241: Low-Efficiency Gene Editing is Capable of Suppressing Arrhythmogenesis in Long QT Syndrome Type II: Computer Simulation Study","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4389953314","doi":"https://doi.org/10.1161/circ.148.suppl_1.12241"},"language":"en","primary_location":{"id":"doi:10.1161/circ.148.suppl_1.12241","doi":"https://doi.org/10.1161/circ.148.suppl_1.12241","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.148.suppl_1.12241","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072214137","display_name":"Allison Navarrete-Welton","orcid":"https://orcid.org/0000-0002-3124-5743","observed_orcids":["https://orcid.org/0000-0002-3124-5743"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison Navarrete-Welton","raw_affiliation_strings":["Warren Alpert Med Sch at Brown Univ, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Med Sch at Brown Univ, Providence, RI","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100785930","display_name":"Tae Yun Kim","orcid":"https://orcid.org/0000-0003-0605-9575","observed_orcids":["https://orcid.org/0000-0003-0605-9575"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tae Yun Kim","raw_affiliation_strings":["Dept of Physics, Korea Univ, Seoul, Korea, Republic of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Physics, Korea Univ, Seoul, Korea, Republic of","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036295223","display_name":"Peter Bronk","orcid":"https://orcid.org/0000-0002-9067-2016","observed_orcids":["https://orcid.org/0000-0002-9067-2016"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Bronk","raw_affiliation_strings":["Cardiovascular Rsch Cntr of Rhode Island Hosp and Brown Univ, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Rsch Cntr of Rhode Island Hosp and Brown Univ, Providence, RI","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051699207","display_name":"Zhilin Qu","orcid":"https://orcid.org/0000-0001-5217-6022","observed_orcids":["https://orcid.org/0000-0001-5217-6022"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhilin Qu","raw_affiliation_strings":["UCLA, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gideon Koren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gideon Koren","raw_affiliation_strings":["Cardiovascular Rsch Cntr of Rhode Island Hosp and Brown Univ, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Rsch Cntr of Rhode Island Hosp and Brown Univ, Providence, RI","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010699823","display_name":"Bum\u2010Rak Choi","orcid":"https://orcid.org/0000-0001-7319-3219","observed_orcids":["https://orcid.org/0000-0001-7319-3219"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bum-rak Choi","raw_affiliation_strings":["Cardiovascular Rsch Cntr of Rhode Island Hosp and Brown Univ, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Rsch Cntr of Rhode Island Hosp and Brown Univ, Providence, RI","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"148","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herg-channel","display_name":"hERG","score":0.8679999709129333},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.6970000267028809},{"id":"https://openalex.org/keywords/early-afterdepolarizations","display_name":"early afterdepolarizations","score":0.9639999866485596},{"id":"https://openalex.org/keywords/arrhythmogenesis","display_name":"arrhythmogenesis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/electrical-coupling","display_name":"electrical coupling","score":0.9190000295639038},{"id":"https://openalex.org/keywords/hopf-bifurcation","display_name":"Hopf bifurcation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cardiac-electrophysiology-modeling","display_name":"cardiac electrophysiology modeling","score":0.6190000176429749},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"sudden cardiac death","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C155730078","wikidata":"https://www.wikidata.org/wiki/Q2898697","display_name":"Afterdepolarization","level":4,"score":0.7889660596847534},{"id":"https://openalex.org/C2779362680","wikidata":"https://www.wikidata.org/wiki/Q905000","display_name":"hERG","level":3,"score":0.7771041393280029},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.6158112287521362},{"id":"https://openalex.org/C2779703243","wikidata":"https://www.wikidata.org/wiki/Q653924","display_name":"Long QT syndrome","level":3,"score":0.5127252340316772},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5026898384094238},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.44615912437438965},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.43318092823028564},{"id":"https://openalex.org/C79743260","wikidata":"https://www.wikidata.org/wiki/Q2882301","display_name":"Cardiac action potential","level":4,"score":0.42329925298690796},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.41977107524871826},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39295727014541626},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3022764325141907},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29605546593666077},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.29318350553512573},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20948737859725952},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.17307841777801514},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.15403777360916138},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.13662195205688477}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.148.suppl_1.12241","doi":"https://doi.org/10.1161/circ.148.suppl_1.12241","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.148.suppl_1.12241","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7213303405","https://openalex.org/W6908706342","https://openalex.org/W2100870841","https://openalex.org/W3203306641","https://openalex.org/W6939119776","https://openalex.org/W2738118069","https://openalex.org/W1518382928","https://openalex.org/W4313308040","https://openalex.org/W4244933903","https://openalex.org/W3129278535"],"abstract_inverted_index":{"Background:":[0],"Long":[1],"QT":[2],"Syndrome":[3],"Type":[4],"II":[5],"(LQT2)":[6],"is":[7,59,84,296],"a":[8,42,131,139,297],"congenital":[9],"cause":[10],"of":[11,82,108,154,173,234,270],"arrhythmia":[12],"and":[13,97,110,122,138,206],"sudden":[14],"cardiac":[15,55,112],"death":[16],"due":[17],"to":[18,53,65,73,86,225,287],"mutations":[19],"in":[20,36,41,57,116,163,189,303],"ion":[21],"channel":[22],"hERG":[23,83],"responsible":[24],"for":[25,45,135,300],"the":[26,48,67,152,170,190,218,232,256,271,282],"rapid":[27],"inward":[28],"rectifying":[29],"potassium":[30],"current":[31,251,261],"(I":[32],"Kr":[33,95,100,137,156,175,182,201,209,240,264,277],").":[34],"Progress":[35],"gene":[37,49,69,164,294],"therapy":[38],"may":[39],"result":[40],"viable":[43,298],"treatment":[44],"LQT2.":[46],"However,":[47],"transduction":[50,70,80,146,220,245],"efficacy":[51,71,81,147,221,246],"required":[52,243],"prevent":[54,275],"arrhythmias":[56],"LQT2":[58,304],"unknown.":[60],"We":[61],"used":[62],"computer":[63],"simulation":[64],"examine":[66],"minimum":[68,219],"necessary":[72],"suppress":[74,87],"early":[75],"afterdepolarizations":[76],"(EADs).":[77],"Hypothesis:":[78],"Low":[79],"sufficient":[85],"EADs":[88,195],"through":[89],"electrotonic":[90],"coupling":[91],"between":[92],"transduced":[93],"I":[94,99,136,155,174,181,200,208,239,263,276],"(+)":[96,157,176,183,202,210,241,265],"non-transduced":[98],"(-)":[101,278],"cardiomyocytes":[102,158],"(Fig":[103,214,247],"1A).":[104],"Methods:":[105],"Computational":[106,290],"models":[107,291],"rabbit":[109],"human":[111],"tissue":[113],"were":[114,186,196],"implemented":[115],"2D":[117],"(100":[118],"x":[119,125,127],"100":[120],"cells)":[121,129],"3D":[123],"(13":[124],"13":[126,128],"with":[130,198],"multi-state":[132],"Markov":[133],"model":[134],"dynamic":[140],"gap":[141,259],"junction":[142,260],"resistance":[143],"model.":[144],"Gene":[145],"was":[148,166,222],"modeled":[149,167],"by":[150,168],"varying":[151,169],"percentage":[153],"from":[159,178,262,280],"0-100%.":[160],"Spatial":[161],"heterogeneity":[162],"delivery":[165],"cluster":[171],"size":[172],"cells":[177,203,211,242,266,279],"1-400":[179],"cells.":[180],"cell":[184],"clusters":[185],"distributed":[187],"randomly":[188],"tissue.":[191],"Results:":[192],"In":[193,216],"2D,":[194],"suppressed":[197],"14%":[199],"(rabbit":[204,227],"model)":[205,213,228],"12%":[207],"(human":[212],"1B).":[215],"3D,":[217],"further":[223],"reduced":[224],"10%":[226],"which":[229],"likely":[230],"reflects":[231],"impact":[233],"increased":[235],"cell-cell":[236],"coupling.":[237],"Clustering":[238],"greater":[244],"1C).":[248],"Detailed":[249],"ionic":[250],"trajectory":[252],"analysis":[253],"suggests":[254],"that":[255,285],"sufficiently":[257],"large":[258],"during":[267],"phase":[268],"2":[269],"action":[272],"potential":[273],"can":[274],"undergoing":[281],"Andronov-Hopf":[283],"bifurcation":[284],"leads":[286],"EADs.":[288],"Conclusions:":[289],"suggest":[292],"low-efficiency":[293],"editing":[295],"approach":[299],"suppressing":[301],"arrhythmogenesis":[302],"patients.":[305]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2023-12-20T00:00:00"}