{"id":"https://openalex.org/W4389953262","doi":"https://doi.org/10.1161/circ.148.suppl_1.12425","title":"Abstract 12425: Stim1 Deletion in Treg Cell Protects From HFpEF Pathogenesis","display_name":"Abstract 12425: Stim1 Deletion in Treg Cell Protects From HFpEF Pathogenesis","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4389953262","doi":"https://doi.org/10.1161/circ.148.suppl_1.12425"},"language":"en","primary_location":{"id":"doi:10.1161/circ.148.suppl_1.12425","doi":"https://doi.org/10.1161/circ.148.suppl_1.12425","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.12425","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058513484","display_name":"Balaji Srinivas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"BALAJI SRINIVAS","raw_affiliation_strings":["Eastern Virginia Med Sch, Norfolk,, VA","BALAJI SRINIVAS Eastern Virginia Med Sch, Norfolk,, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eastern Virginia Med Sch, Norfolk,, VA","institution_ids":["https://openalex.org/I156802259"]},{"raw_affiliation_string":"BALAJI SRINIVAS Eastern Virginia Med Sch, Norfolk,, VA","institution_ids":["https://openalex.org/I156802259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101270620","display_name":"Jiang Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiang Xu","raw_affiliation_strings":["Henry Ford Hosp, Detroit, MI","Jiang Xu Henry Ford Hosp, Detroit, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Jiang Xu Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090118006","display_name":"Hongmei Peng","orcid":"https://orcid.org/0000-0001-7214-5995","observed_orcids":["https://orcid.org/0000-0001-7214-5995"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongmei Peng","raw_affiliation_strings":["Henry Ford Hosp, Detroit, MI","Hongmei Peng Henry Ford Hosp, Detroit, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Hongmei Peng Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091291156","display_name":"Hani N. Sabbah","orcid":"https://orcid.org/0000-0002-2850-6105","observed_orcids":["https://orcid.org/0000-0002-2850-6105"]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hani N Sabbah","raw_affiliation_strings":["Henry Ford Health, Detroit, MI","Hani N Sabbah Henry Ford Health, Detroit, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Health, Detroit, MI","institution_ids":["https://openalex.org/I154057602"]},{"raw_affiliation_string":"Hani N Sabbah Henry Ford Health, Detroit, MI","institution_ids":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051900468","display_name":"Souad Belmadani","orcid":"https://orcid.org/0000-0002-7355-9142","observed_orcids":["https://orcid.org/0000-0002-7355-9142"]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Souad Belmadani","raw_affiliation_strings":["Eastern Virginia Med Sch","Souad Belmadani Eastern Virginia Med Sch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eastern Virginia Med Sch","institution_ids":["https://openalex.org/I156802259"]},{"raw_affiliation_string":"Souad Belmadani Eastern Virginia Med Sch","institution_ids":["https://openalex.org/I156802259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113075477","display_name":"Nour Eddine Rhaleb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nour E Rhaleb","raw_affiliation_strings":["Henry Ford Hosp, Detroit, MI","Nour E Rhaleb Henry Ford Hosp, Detroit, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Nour E Rhaleb Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019498408","display_name":"Khalid Matrougui","orcid":"https://orcid.org/0000-0001-9269-2937","observed_orcids":["https://orcid.org/0000-0001-9269-2937","https://orcid.org/0000-0002-7355-9142"]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khalid Matrougui","raw_affiliation_strings":["Eastern Virginia Med Sch, Norfolk, VA","Khalid Matrougui Eastern Virginia Med Sch, Norfolk, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eastern Virginia Med Sch, Norfolk, VA","institution_ids":["https://openalex.org/I156802259"]},{"raw_affiliation_string":"Khalid Matrougui Eastern Virginia Med Sch, Norfolk, VA","institution_ids":["https://openalex.org/I156802259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"148","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.586899995803833,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.586899995803833,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.25589999556541443,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":0.9739999771118164},{"id":"https://openalex.org/keywords/stromal-interaction-molecule-1","display_name":"STIM1","score":0.949999988079071},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8899999856948853},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.6159999966621399},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.953000009059906},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.8180000185966492},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.949999988079071},{"id":"https://openalex.org/keywords/kidney-injury","display_name":"kidney injury","score":0.8629999756813049},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.7720000147819519},{"id":"https://openalex.org/keywords/metabolic-dysfunction","display_name":"metabolic dysfunction","score":0.8259999752044678},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8720199465751648},{"id":"https://openalex.org/C2777099384","wikidata":"https://www.wikidata.org/wiki/Q3799239","display_name":"Heart failure with preserved ejection fraction","level":4,"score":0.7421582937240601},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7022176384925842},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6973937749862671},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5373538732528687},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5351287722587585},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.5229700207710266},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.4901157319545746},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.4330797791481018},{"id":"https://openalex.org/C2777420927","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Cardiac fibrosis","level":3,"score":0.41665199398994446},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4114895761013031},{"id":"https://openalex.org/C162740809","wikidata":"https://www.wikidata.org/wiki/Q15334560","display_name":"STIM1","level":3,"score":0.41075190901756287},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40106019377708435},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3957253694534302},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.06612342596054077}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.148.suppl_1.12425","doi":"https://doi.org/10.1161/circ.148.suppl_1.12425","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.12425","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.46000000834465027,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7167704038","https://openalex.org/W7172130078","https://openalex.org/W7135011444","https://openalex.org/W4380793651","https://openalex.org/W4403246585","https://openalex.org/W3215794772","https://openalex.org/W4280506772","https://openalex.org/W3166463258","https://openalex.org/W7159969683","https://openalex.org/W4400914212"],"abstract_inverted_index":{"Introduction:":[0],"Heart":[1],"failure":[2],"with":[3,200,204],"preserved":[4],"ejection":[5,224],"fraction":[6],"(HFpEF)":[7],"is":[8,20],"a":[9,21,122,134],"cardiovascular":[10,60],"disease":[11,47],"that":[12,40,53,83],"remains":[13],"untreatable":[14],"in":[15,58,88,145,250],"its":[16,99,238],"pathogenesis.":[17],"Therefore,":[18],"there":[19],"critical":[22],"need":[23],"to":[24,186,253],"uncover":[25],"the":[26,66,77,84,94,146,245,256],"cellular":[27],"and":[28,34,45,62,98,110,125,130,138,154,163,168,172,188,209,216,222,234,237,258],"molecular":[29],"mechanisms":[30],"underlying":[31],"HFpEF":[32,97,131,236],"pathogenesis":[33,259],"identify":[35],"potential":[36],"targets":[37],"for":[38,127,149],"treatment":[39],"can":[41,91],"enhance":[42],"cardiac":[43,198,220],"function":[44,67],"restrict":[46],"progression.":[48],"Previous":[49],"studies":[50],"have":[51],"shown":[52],"Treg":[54,89,111,227,251],"cells":[55,90,252],"are":[56],"crucial":[57],"hypertension-induced":[59],"complications":[61],"metabolic":[63,196],"dysregulation.":[64],"Moreover,":[65],"of":[68,86,96,161,166,174,192,247,260],"Stromal":[69],"interaction":[70],"molecule":[71],"1":[72],"(STIM1)":[73],"varies":[74],"depending":[75],"on":[76],"cell":[78],"type.":[79],"Hypothesis:":[80],"We":[81],"hypothesize":[82],"deletion":[85],"STIM1":[87,249],"protect":[92,254],"against":[93,232],"development":[95,257],"associated":[100,239],"conditions.":[101],"Methods:":[102],"Male":[103],"mice":[104,184,229],"aged":[105],"eight":[106],"weeks":[107],"(Stim1":[108],"flx/flx":[109,183],"Stim1-/-":[112,228],")":[113],"were":[114,156,230],"divided":[115],"into":[116],"four":[117],"groups:":[118],"control":[119],"groups":[120,132],"receiving":[121],"standard":[123],"diet":[124,136],"water":[126,148],"five":[128,150,180],"weeks,":[129,181],"fed":[133],"high-fat":[135],"(HFD)":[137],"N[w]-nitro-l-arginine":[139],"methyl":[140],"ester":[141],"(L-NAME":[142],"-":[143],"0.5g/L)":[144],"drinking":[147],"weeks.":[151],"Various":[152],"measurements":[153],"assessments":[155],"conducted,":[157],"including":[158,194],"echocardiography,":[159],"evaluations":[160],"metabolism":[162],"hypertension,":[164,195],"analysis":[165],"heart":[167],"kidney":[169,202],"injury":[170,203],"markers,":[171],"assessment":[173],"vascular":[175,210],"endothelial":[176,211],"function.":[177],"Results:":[178],"After":[179],"Stim1":[182],"subjected":[185],"HFD":[187,233],"L-NAME":[189],"displayed":[190],"evidence":[191],"HFpEF,":[193],"disorders,":[197],"hypertrophy":[199],"fibrosis,":[201,205],"impaired":[206],"exercise":[207],"tolerance":[208],"function,":[212],"increased":[213],"body":[214],"weight":[215],"E/E'":[217],"ratio,":[218],"reduced":[219],"index,":[221],"unchanged":[223],"fraction.":[225],"Interestingly,":[226],"protected":[231],"L-NAME-induced":[235],"pathologies.":[240],"Conclusions:":[241],"These":[242],"findings":[243],"underscore":[244],"significance":[246],"targeting":[248],"from":[255],"HFpEF.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-12-20T00:00:00"}