{"id":"https://openalex.org/W4389953039","doi":"https://doi.org/10.1161/circ.148.suppl_1.17607","title":"Abstract 17607: Clonal Hematopoiesis of Indeterminate Potential (CHIP) is an Independent Risk Factor for Cardiomyopathy in Patients With Solid Malignancy","display_name":"Abstract 17607: Clonal Hematopoiesis of Indeterminate Potential (CHIP) is an Independent Risk Factor for Cardiomyopathy in Patients With Solid Malignancy","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4389953039","doi":"https://doi.org/10.1161/circ.148.suppl_1.17607"},"language":"en","primary_location":{"id":"doi:10.1161/circ.148.suppl_1.17607","doi":"https://doi.org/10.1161/circ.148.suppl_1.17607","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.17607","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038531690","display_name":"Carlos Felipe Matute Martinez","orcid":"https://orcid.org/0000-0002-5174-1349","observed_orcids":["https://orcid.org/0000-0002-5174-1349"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos F Matute Martinez","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005997847","display_name":"Ritujith Jayakrishnan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ritujith Jayakrishnan","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113075470","display_name":"Ana Ferrigno Guajardo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana Ferrigno Guajardo","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018763923","display_name":"Etienne L\u00e9veill\u00e9","orcid":"https://orcid.org/0000-0001-5269-9544","observed_orcids":["https://orcid.org/0000-0001-5269-9544"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Etienne Leveille","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104636466","display_name":"Derrick T. Lin","orcid":"https://orcid.org/0009-0000-5022-3438","observed_orcids":["https://orcid.org/0009-0000-5022-3438"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derrick Lin","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020009178","display_name":"Yunju Im","orcid":"https://orcid.org/0000-0001-7596-3803","observed_orcids":["https://orcid.org/0000-0001-7596-3803"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunju Im","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091402777","display_name":"Anthos Christofides","orcid":"https://orcid.org/0000-0003-1769-6182","observed_orcids":["https://orcid.org/0000-0003-1769-6182"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthos Christofides","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019753464","display_name":"Nathan Chen","orcid":"https://orcid.org/0000-0001-8524-2858","observed_orcids":["https://orcid.org/0000-0001-8524-2858"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Chen","raw_affiliation_strings":["Yale Univ, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Univ, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013299754","display_name":"Lauren Anne Baldassarre","orcid":"https://orcid.org/0000-0003-4173-3449","observed_orcids":["https://orcid.org/0000-0003-4173-3449"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren A Baldassarre","raw_affiliation_strings":["Yale Univ, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Univ, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058778175","display_name":"Jennifer VanOudenhove","orcid":"https://orcid.org/0000-0001-8206-5542","observed_orcids":["https://orcid.org/0000-0001-8206-5542"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer VanOudenhove","raw_affiliation_strings":["Yale Univ, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Univ, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054557581","display_name":"Stephanie Halene","orcid":"https://orcid.org/0000-0002-2737-9810","observed_orcids":["https://orcid.org/0000-0002-2737-9810"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Halene","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077834308","display_name":"John Hwa","orcid":"https://orcid.org/0000-0001-7366-2628","observed_orcids":["https://orcid.org/0000-0001-7366-2628"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Hwa","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045297813","display_name":"Jennifer M. Kwan","orcid":"https://orcid.org/0000-0002-4715-1848","observed_orcids":["https://orcid.org/0000-0002-4715-1848"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer M Kwan","raw_affiliation_strings":["Yale Sch of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Sch of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"148","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.026100000366568565,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clonal-hematopoiesis-of-indeterminate-potential","display_name":"clonal hematopoiesis of indeterminate potential","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.9710000157356262},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.9520000219345093},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.8019999861717224},{"id":"https://openalex.org/keywords/diastolic-dysfunction","display_name":"diastolic dysfunction","score":0.8330000042915344},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.902999997138977},{"id":"https://openalex.org/keywords/dnmt3a","display_name":"DNMT3A","score":0.9549999833106995},{"id":"https://openalex.org/keywords/tet2","display_name":"TET2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/idh2","display_name":"IDH2","score":0.996999979019165},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8600000143051147},{"id":"https://openalex.org/keywords/metastatic-disease","display_name":"metastatic disease","score":0.875},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8248862028121948},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6291998624801636},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.6228366494178772},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5316465497016907},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5276124477386475},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.4864761531352997},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.44821256399154663},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4295494854450226},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.252032607793808},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.1813373863697052},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.139126718044281},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10797297954559326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08794912695884705},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.148.suppl_1.17607","doi":"https://doi.org/10.1161/circ.148.suppl_1.17607","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.17607","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4413054238","https://openalex.org/W4405049812","https://openalex.org/W3172417861","https://openalex.org/W4290546266","https://openalex.org/W2947975822","https://openalex.org/W2984695514","https://openalex.org/W7156027720","https://openalex.org/W4399328009","https://openalex.org/W4379282016","https://openalex.org/W4310947824"],"abstract_inverted_index":{"Background:":[0],"Somatic":[1],"mutations":[2,147],"linked":[3],"to":[4,182,200,205,258,263],"clonal":[5],"hematopoiesis":[6],"of":[7,16,64,86,92,112,122,152,190],"indeterminate":[8],"potential":[9],"(CHIP)":[10],"are":[11],"associated":[12],"with":[13,34,68,95,109,119,172,194,250,255,265],"increased":[14],"risk":[15,49,225,237,270,286],"cardiomyopathy":[17],"(CM)":[18],"and":[19,37,61,124,131,142,159,202,217,229,260,292,296],"all-cause":[20],"mortality":[21],"in":[22,32,66,150,156],"the":[23,57,62,120],"general":[24],"population.":[25],"However,":[26],"this":[27],"relationship":[28],"is":[29,39],"less":[30],"clear":[31],"patients":[33,47,67,166,171,249,280],"solid":[35,69,96,247],"malignancy,":[36,70],"it":[38],"unclear":[40],"if":[41],"knowing":[42],"CHIP":[43,60,78,107,117,146,173,195,230,251,266,274],"status":[44,80],"can":[45,276],"identify":[46,279],"at":[48,284],"for":[50,105,227,239,272,287],"adverse":[51,288],"cardiac":[52],"outcomes.":[53],"Objectives:":[54],"To":[55],"determine":[56],"association":[58,118],"between":[59,115],"development":[63],"CM":[65,125,240],"as":[71,73],"well":[72],"overall":[74],"survival":[75,130],"(OS).":[76],"Methods:":[77],"mutation":[79],"was":[81,126,139,234],"determined":[82],"by":[83],"next-generation":[84],"sequencing":[85],"DNA":[87],"from":[88],"peripheral":[89],"blood":[90],"samples":[91],"173":[93],"participants":[94],"malignancy.":[97],"A":[98],"somatic":[99,106],"variant":[100,111],"pipeline":[101],"using":[102,128],"MUTECT2":[103],"selected":[104],"variants":[108],"a":[110,187],"allele":[113],"frequency":[114],"2-40%.":[116],"outcomes":[121,254],"OS":[123],"assessed":[127],"Kaplan-Meier":[129],"Cox":[132,207],"regression":[133,208],"analyses.":[134],"Results:":[135],"Participants\u2019":[136],"median":[137,188],"age":[138],"63":[140],"years,":[141],"76%":[143],"were":[144,148,163,223],"female.":[145],"detected":[149],"39%":[151],"participants,":[153],"most":[154],"commonly":[155],"DNMT3A,":[157],"TET2,":[158],"IDH2":[160],"genes.":[161],"Majority":[162],"breast":[164],"cancer":[165,294],"54%":[167],"(n=":[168],"94).":[169],"More":[170],"had":[174,196,252],"diastolic":[175],"dysfunction":[176],"(21%":[177],"vs":[178],"9%,":[179],"p=0.037)":[180],"compared":[181],"those":[183,193],"without":[184],"CHIP.":[185],"After":[186],"follow-up":[189],"36":[191],"months,":[192],"an":[197,235,268],"earlier":[198,203],"time":[199,204,257,262],"death":[201,259],"CM.":[206,273],"analysis":[209],"showed":[210,245],"that":[211,246],"metastatic":[212],"disease":[213],"(HR":[214,220,231],"2.92,":[215],"P=0.003)":[216],"male":[218],"gender":[219],"2.35,":[221],"P=0.03)":[222],"independent":[224,236,269],"factors":[226],"death,":[228],"2.120,":[232],"P=0.02)":[233],"factor":[238,271],"(Figure).":[241],"Conclusions:":[242],"Our":[243],"study":[244],"malignancy":[248],"worse":[253],"shorter":[256,261],"CM,":[264],"being":[267],"assessment":[275],"help":[277],"us":[278],"who":[281,297],"may":[282,298],"be":[283],"greater":[285],"cardiovascular":[289],"events":[290],"during":[291],"after":[293],"therapy":[295],"warrant":[299],"closer":[300],"monitoring.":[301]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2023-12-20T00:00:00"}