{"id":"https://openalex.org/W4389953025","doi":"https://doi.org/10.1161/circ.148.suppl_1.17603","title":"Abstract 17603: Novel Cardiac Dynamics Modeling of Clinical Cardiac MRIs Can Identify Who Has Clonal Hematopoiesis of Indeterminate Potential With High Accuracy","display_name":"Abstract 17603: Novel Cardiac Dynamics Modeling of Clinical Cardiac MRIs Can Identify Who Has Clonal Hematopoiesis of Indeterminate Potential With High Accuracy","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4389953025","doi":"https://doi.org/10.1161/circ.148.suppl_1.17603"},"language":"en","primary_location":{"id":"doi:10.1161/circ.148.suppl_1.17603","doi":"https://doi.org/10.1161/circ.148.suppl_1.17603","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.17603","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006040096","display_name":"Emanuele Zappala","orcid":"https://orcid.org/0000-0002-9684-9441","observed_orcids":["https://orcid.org/0000-0002-9684-9441"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emanuele Zappala","raw_affiliation_strings":["Yale, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James Cross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Cross","raw_affiliation_strings":["Yale, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091402777","display_name":"Anthos Christofides","orcid":"https://orcid.org/0000-0003-1769-6182","observed_orcids":["https://orcid.org/0000-0003-1769-6182"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthos Christofides","raw_affiliation_strings":["Yale, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038531690","display_name":"Carlos Felipe Matute Martinez","orcid":"https://orcid.org/0000-0002-5174-1349","observed_orcids":["https://orcid.org/0000-0002-5174-1349"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos Matute Martinez","raw_affiliation_strings":["Yale, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005997847","display_name":"Ritujith Jayakrishnan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ritujith Jayakrishnan","raw_affiliation_strings":["Yale, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020009178","display_name":"Yunju Im","orcid":"https://orcid.org/0000-0001-7596-3803","observed_orcids":["https://orcid.org/0000-0001-7596-3803"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunju Im","raw_affiliation_strings":["Yale, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113075470","display_name":"Ana Ferrigno Guajardo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana Ferrigno Guajardo","raw_affiliation_strings":["Yale, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040167774","display_name":"Shawn S. Ahn","orcid":"https://orcid.org/0000-0002-5961-3376","observed_orcids":["https://orcid.org/0000-0002-5961-3376"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shawn Ahn","raw_affiliation_strings":["New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Haven, CT","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011470209","display_name":"Alokkumar Jha","orcid":"https://orcid.org/0000-0002-8024-5854","observed_orcids":["https://orcid.org/0000-0002-8024-5854"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alokkumar Jha","raw_affiliation_strings":["Weill Cornell Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054557581","display_name":"Stephanie Halene","orcid":"https://orcid.org/0000-0002-2737-9810","observed_orcids":["https://orcid.org/0000-0002-2737-9810"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Halene","raw_affiliation_strings":["Yale, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058778175","display_name":"Jennifer VanOudenhove","orcid":"https://orcid.org/0000-0001-8206-5542","observed_orcids":["https://orcid.org/0000-0001-8206-5542"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer VanOudenhove","raw_affiliation_strings":["Yale, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019679682","display_name":"David van Dijk","orcid":"https://orcid.org/0000-0003-3911-9925","observed_orcids":["https://orcid.org/0000-0003-3911-9925"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Van Dijk","raw_affiliation_strings":["Yale Univ, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Univ, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045297813","display_name":"Jennifer M. Kwan","orcid":"https://orcid.org/0000-0002-4715-1848","observed_orcids":["https://orcid.org/0000-0002-4715-1848"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer M Kwan","raw_affiliation_strings":["Yale, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"148","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.4961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.4961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.15690000355243683,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.11509999632835388,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clonal-hematopoiesis-of-indeterminate-potential","display_name":"clonal hematopoiesis of indeterminate potential","score":1.0},{"id":"https://openalex.org/keywords/cardiac-mri","display_name":"cardiac MRI","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cine-mri","display_name":"cine MRI","score":0.6269999742507935},{"id":"https://openalex.org/keywords/age-prediction","display_name":"age prediction","score":0.5730000138282776},{"id":"https://openalex.org/keywords/deep-learning","display_name":"deep learning","score":0.6600000262260437},{"id":"https://openalex.org/keywords/cardiovascular-risk-stratification","display_name":"cardiovascular risk stratification","score":0.8579999804496765},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8220705986022949},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5972243547439575},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.476413369178772}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.148.suppl_1.17603","doi":"https://doi.org/10.1161/circ.148.suppl_1.17603","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.17603","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389953052","https://openalex.org/W4400105123","https://openalex.org/W4406958473","https://openalex.org/W7128085063","https://openalex.org/W4389945064","https://openalex.org/W4410620930","https://openalex.org/W7162557517","https://openalex.org/W4292489486","https://openalex.org/W4283446141","https://openalex.org/W4313443766"],"abstract_inverted_index":{"Background:":[0],"Clonal":[1],"hematopoiesis":[2],"of":[3,32,65,88,95,128,132,142,251,259,265,271,304],"indeterminate":[4],"potential":[5],"(CHIP)":[6],"has":[7,43,82],"been":[8],"shown":[9],"to":[10,50,77,111,137,221,246],"be":[11,48,75],"an":[12,229],"independent":[13],"risk":[14,55],"factor":[15],"for":[16,56],"heart":[17,19,215],"disease,":[18],"failure":[20],"and":[21,84,99,140,148,160,163,175,232,294],"is":[22,27,35,282,311],"associated":[23],"with":[24,157,206,224,228,236,254],"aging.":[25],"CHIP":[26,83,139,161,185,188,207,223,293],"diagnosed":[28],"by":[29],"DNA":[30,98],"sequencing":[31,94],"blood.":[33],"It":[34],"unclear":[36],"whether":[37,63],"imaging":[38,126,218],"can":[39,289],"help":[40,51,78],"predict":[41,80,86,222,248],"who":[42,81,114],"CHIP,":[44,210],"which":[45],"would":[46,74],"then":[47],"able":[49,76,220,245],"stratify":[52],"patients":[53,156,189],"at":[54,268],"adverse":[57],"cardiovascular":[58],"events.":[59],"Hypothesis:":[60],"We":[61,152],"investigated":[62],"use":[64],"cardiac":[66,71],"dynamics":[67,280],"modeling":[68,119,281],"on":[69,102,121],"routine":[70],"MRI":[72],"(CMR)":[73],"1)":[79],"2)":[85],"age":[87,141,183,250,262],"the":[89,129,133,143,249,252,260,269,272,302],"patient":[90,253],"Methods:":[91],"Whole":[92],"exome":[93],"peripheral":[96],"blood":[97],"subequent":[100],"analysis":[101],"our":[103],"somatic":[104],"variant":[105],"pipeline":[106],"using":[107,145,274,306,313],"MUTECT2":[108],"was":[109,177,219,244],"used":[110,136],"identify":[112,138],"those":[113,205],"had":[115,168],"CHIP.":[116,169],"Using":[117],"dynamical":[118],"based":[120],"neural":[122],"integral":[123],"equations,":[124],"dynamic":[125],"assessment":[127],"cine":[130],"images":[131],"CMRs":[134],"were":[135,171,198],"myocardium":[144],"both":[146,158,290],"supervised":[147,238,276],"unsupervised":[149,230],"approaches.":[150],"Results:":[151],"identified":[153],"98":[154],"unique":[155],"CMR":[159],"status":[162],"found":[164],"that":[165,288],"40":[166],"(41%)":[167],"Majority":[170],"female":[172],"65":[173],"(66%)":[174],"there":[176],"no":[178,187,199,209],"significant":[179,200],"difference":[180],"in":[181,202,300],"median":[182],"between":[184,204],"vs":[186,193],"(69,":[190],"IQR":[191,195],"62-78":[192],"65,":[194],"54-72).":[196],"There":[197],"differences":[201],"co-morbidities":[203],"or":[208],"including":[211],"CAD,":[212],"diabetes,":[213],"hypertension,":[214],"failure.":[216],"Dynamic":[217],"74%":[225],"accuracy":[226,235,255],"(Figure)":[227],"approach":[231],"above":[233],"90%":[234],"a":[237,275,283,314],"approach.":[239,277],"In":[240],"addition,":[241],"this":[242],"technique":[243,287],"accurately":[247,291],"within":[256],"1":[257],"year":[258],"patient\u2019s":[261],"(standard":[263],"deviation":[264],"0.0012":[266],"years)":[267],"time":[270],"MRI,":[273],"Conclusions:":[278],"Cardiac":[279],"promising":[284],"deep":[285],"learning":[286],"classify":[292],"age.":[295],"Ongoing":[296,309],"work":[297],"shows":[298],"promise":[299],"predicting":[301],"outcome":[303],"cardiomyopathy":[305],"similar":[307],"techniques.":[308],"validation":[310],"underway":[312],"large":[315],"cohort":[316],"from":[317],"UK":[318],"Biobank.":[319]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2023-12-20T00:00:00"}
