{"id":"https://openalex.org/W4389952854","doi":"https://doi.org/10.1161/circ.148.suppl_1.18306","title":"Abstract 18306: Race, Natriuretic Peptides, and Physiological Perturbations","display_name":"Abstract 18306: Race, Natriuretic Peptides, and Physiological Perturbations","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4389952854","doi":"https://doi.org/10.1161/circ.148.suppl_1.18306"},"language":"en","primary_location":{"id":"doi:10.1161/circ.148.suppl_1.18306","doi":"https://doi.org/10.1161/circ.148.suppl_1.18306","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.18306","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004245426","display_name":"Naman S. Shetty","orcid":"https://orcid.org/0000-0003-3600-126X","observed_orcids":["https://orcid.org/0000-0003-3600-126X"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naman S Shetty","raw_affiliation_strings":["Div of Cardiovascular Disease, Univ of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Div of Cardiovascular Disease, Univ of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101783361","display_name":"Nirav Patel","orcid":"https://orcid.org/0000-0003-1798-1880","observed_orcids":["https://orcid.org/0000-0003-1798-1880"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nirav Patel","raw_affiliation_strings":["Univ of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113405944","display_name":"Mokshad P. Gaonkar","orcid":"https://orcid.org/0000-0003-0309-6813","observed_orcids":["https://orcid.org/0000-0003-0309-6813"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mokshad Gaonkar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092741667","display_name":"Nehal Vekariya","orcid":"https://orcid.org/0009-0002-3372-8375","observed_orcids":["https://orcid.org/0009-0002-3372-8375"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nehal Vekariya","raw_affiliation_strings":["AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037069754","display_name":"Yuxin Chu","orcid":"https://orcid.org/0000-0003-0739-8544","observed_orcids":["https://orcid.org/0000-0003-0739-8544"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuxin Chu","raw_affiliation_strings":["Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birmingham, AL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106499010","display_name":"Min Xie","orcid":"https://orcid.org/0000-0001-9079-1712","observed_orcids":["https://orcid.org/0000-0001-9079-1712"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Xie","raw_affiliation_strings":["Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birmingham, AL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040984920","display_name":"Niklaus H. Evitt","orcid":"https://orcid.org/0000-0003-2117-9073","observed_orcids":["https://orcid.org/0000-0003-2117-9073"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Niklaus Evitt","raw_affiliation_strings":["PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040568538","display_name":"Kiran Musunuru","orcid":"https://orcid.org/0000-0003-3298-0368","observed_orcids":["https://orcid.org/0000-0003-3298-0368"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kiran Musunuru","raw_affiliation_strings":["Univ of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113902097","display_name":"Garima Arora","orcid":"https://orcid.org/0000-0001-6402-6910","observed_orcids":["https://orcid.org/0000-0001-6402-6910"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garima Arora","raw_affiliation_strings":["Univ of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073142943","display_name":"Pankaj Kumar Arora","orcid":"https://orcid.org/0000-0003-2420-3550","observed_orcids":["https://orcid.org/0000-0003-2420-3550"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pankaj Arora","raw_affiliation_strings":["Univ of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"148","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.8213000297546387,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.8213000297546387,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.05779999867081642,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.027899999171495438,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/racial-differences","display_name":"racial differences","score":0.9129999876022339},{"id":"https://openalex.org/keywords/natriuretic-peptides","display_name":"natriuretic peptides","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nt-probnp","display_name":"NT-proBNP","score":0.8690000176429749},{"id":"https://openalex.org/keywords/mr-proanp","display_name":"MR-proANP","score":0.9729999899864197},{"id":"https://openalex.org/keywords/atrial-natriuretic-peptide","display_name":"atrial natriuretic peptide","score":0.6710000038146973},{"id":"https://openalex.org/keywords/metoprolol","display_name":"metoprolol","score":0.8640000224113464},{"id":"https://openalex.org/keywords/exercise-response","display_name":"exercise response","score":0.8610000014305115},{"id":"https://openalex.org/keywords/young-adults","display_name":"young adults","score":0.6470000147819519},{"id":"https://openalex.org/keywords/black-white-disparities","display_name":"black-white disparities","score":0.6359999775886536},{"id":"https://openalex.org/keywords/mir-425","display_name":"miR-425","score":0.8889999985694885},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell-derived-cardiomyocytes","display_name":"iPSC-derived cardiomyocytes","score":0.9399999976158142},{"id":"https://openalex.org/keywords/cardiovascular-biomarkers","display_name":"cardiovascular biomarkers","score":0.5109999775886536},{"id":"https://openalex.org/keywords/nhanes","display_name":"NHANES","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9511672258377075},{"id":"https://openalex.org/C2781280847","wikidata":"https://www.wikidata.org/wiki/Q409468","display_name":"Metoprolol","level":2,"score":0.71091628074646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6238164901733398},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.523786187171936},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4696713387966156},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.4384463429450989},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4189060628414154},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.40824198722839355},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39805036783218384},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.148.suppl_1.18306","doi":"https://doi.org/10.1161/circ.148.suppl_1.18306","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.18306","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4407448025","https://openalex.org/W2977532504","https://openalex.org/W594443207","https://openalex.org/W2924652987","https://openalex.org/W2917339989","https://openalex.org/W2731815195","https://openalex.org/W2768157658","https://openalex.org/W3163669566","https://openalex.org/W4395040114","https://openalex.org/W2135769284"],"abstract_inverted_index":{"Introduction:":[0],"Racial":[1],"differences":[2,14,82],"in":[3,15,31,72,74,83,132,137,160,165,191,211,271],"natriuretic":[4],"peptide":[5],"(NP)":[6],"levels":[7,64,134,155,199,252,266],"among":[8],"young":[9,33,122,247],"adults":[10,123],"are":[11,23],"uncharacterized.":[12],"Race-based":[13],"NP":[16,84,251,257],"response":[17,85,258],"to":[18,78,86,187,259,282],"physiological":[19],"and":[20,26,45,89,98,107,112,162,180,253],"pharmacological":[21],"perturbations":[22],"unknown.":[24],"Methods":[25],"Results:":[27],"A":[28],"population-level":[29],"study":[30,54,118,243],"healthy":[32,246],"individuals":[34],"(18-40":[35],"years)":[36],"with":[37,66,142,185,218,262,276,289],"NT-proBNP":[38,63],"measurements":[39],"from":[40],"the":[41,80,130,172,189,203,222,231],"1999-2004":[42],"National":[43],"Health":[44],"Nutrition":[46],"Examination":[47],"Survey":[48],"cycles":[49],"was":[50,104,135],"conducted.":[51],"In":[52],"this":[53,242],"of":[55,92,174,197,209,225,233,240],"3055":[56],"individuals,":[57],"Blacks":[58,143,166,248],"[34.3%":[59],"(29.3-38.9%)]":[60],"had":[61],"lower":[62,250],"compared":[65,141,261],"Whites.":[67,263],"Healthy":[68],"participants":[69],"were":[70,183,200,274],"recruited":[71],"2018-23":[73],"a":[75,255],"mechanistic":[76],"trial":[77],"assess":[79,171,188],"racial":[81],"standardized":[87],"exercise":[88,147,260],"6":[90,234],"weeks":[91,116],"metoprolol":[93,111,186],"(started":[94],"at":[95,202,230],"50":[96],"mg/day":[97],"doubled":[99],"every":[100,114],"2":[101,115],"weeks).":[102],"MR-proANP":[103,133,154],"measured":[105,201],"pre-":[106],"post-exercise,":[108],"before":[109],"starting":[110],"then":[113],"till":[117],"completion.":[119],"Among":[120],"72":[121],"[39":[124],"(54.2%)":[125],"White,":[126],"37":[127],"(51.4%)":[128],"females],":[129],"increase":[131],"higher":[136],"Whites":[138,161],"[49.0%":[139],"(38.2-60.6%)":[140],"[35.9%":[144],"(25.2-47.6%)]":[145],"after":[146],"(p":[148,167],"int":[149,168],":":[150],"0.004).":[151],"With":[152,220],"metoprolol,":[153,221],"increased":[156],"by":[157,228],"36.3%":[158],"(23.3-50.8%)":[159],"28.3%":[163],"(15.0-43.0%)":[164],":0.42).":[169],"To":[170],"mechanism":[173],"ANP":[175,264,272],"increase,":[176],"iPSC-CM":[177,212],"(3":[178],"controls":[179],"3":[181],"experiments)":[182],"treated":[184],"change":[190,215],"NPPA":[192,210],"expression.":[193],"miR-425":[194,226,286],"(negative":[195],"regulator":[196],"ANP)":[198],"abovementioned":[204],"time":[205],"points.":[206],"The":[207],"expression":[208,224,273,287],"did":[213],"not":[214],"on":[216],"treatment":[217],"metoprolol.":[219,277,290],"relative":[223],"reduced":[227],"~10%":[229],"end":[232],"weeks.":[235],"Conclusion:":[236],"Using":[237],"multiple":[238],"lines":[239],"evidence,":[241],"established":[244],"that":[245],"have":[249,254],"blunted":[256],"protein":[265],"differed":[267],"but":[268],"no":[269],"changes":[270],"noted":[275],"Further":[278],"work":[279],"is":[280],"needed":[281],"elucidate":[283],"pathways":[284],"underlying":[285],"responsiveness":[288]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2023-12-20T00:00:00"}
