{"id":"https://openalex.org/W4389945361","doi":"https://doi.org/10.1161/circ.148.suppl_1.18612","title":"Abstract 18612: Stem Cell-Derived Extracellular Matrix as a Treatment for Cardiac Remodeling in Post-MI Hearts: A Pilot Study","display_name":"Abstract 18612: Stem Cell-Derived Extracellular Matrix as a Treatment for Cardiac Remodeling in Post-MI Hearts: A Pilot Study","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4389945361","doi":"https://doi.org/10.1161/circ.148.suppl_1.18612"},"language":"en","primary_location":{"id":"doi:10.1161/circ.148.suppl_1.18612","doi":"https://doi.org/10.1161/circ.148.suppl_1.18612","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.18612","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015286684","display_name":"Mark Broadwin","orcid":"https://orcid.org/0000-0002-0393-9983","observed_orcids":["https://orcid.org/0000-0002-0393-9983"]},"institutions":[{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Broadwin","raw_affiliation_strings":["Cardiovascular Rsch Cntr, Rhode Island Hosp, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Rsch Cntr, Rhode Island Hosp, Providence, RI","institution_ids":["https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001760558","display_name":"Cynthia Xu","orcid":"https://orcid.org/0000-0002-2191-3066","observed_orcids":["https://orcid.org/0000-0002-2191-3066"]},"institutions":[{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia Xu","raw_affiliation_strings":["Cardiovascular Rsch Cntr, Rhode Island Hosp, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Rsch Cntr, Rhode Island Hosp, Providence, RI","institution_ids":["https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026287360","display_name":"Dwight Douglas Harris","orcid":"https://orcid.org/0000-0001-8289-2740","observed_orcids":["https://orcid.org/0000-0001-8289-2740"]},"institutions":[{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dwight Harris","raw_affiliation_strings":["Cardiovascular Rsch Cntr, Rhode Island Hosp, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Rsch Cntr, Rhode Island Hosp, Providence, RI","institution_ids":["https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093530379","display_name":"Katerina St. Angelo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katerina St Angelo","raw_affiliation_strings":["Dept of Pathology and Laboratory Medicine, Brown Univ, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Pathology and Laboratory Medicine, Brown Univ, Providence, RI","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012657061","display_name":"Frank William Sellke","orcid":"https://orcid.org/0000-0002-8886-801X","observed_orcids":["https://orcid.org/0000-0002-8886-801X"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank W Sellke","raw_affiliation_strings":["Brown Med Sch, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brown Med Sch, Providence, RI","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042802176","display_name":"Jeffrey A. Morgan","orcid":"https://orcid.org/0009-0006-6476-161X","observed_orcids":["https://orcid.org/0009-0006-6476-161X"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Morgan","raw_affiliation_strings":["Dept of Pathology and Laboratory Medicine, Brown Univ, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Pathology and Laboratory Medicine, Brown Univ, Providence, RI","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110596538","display_name":"Ruhul Abid","orcid":"https://orcid.org/0000-0003-2981-2638","observed_orcids":["https://orcid.org/0000-0003-2981-2638"]},"institutions":[{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruhul Abid","raw_affiliation_strings":["Rhode Island Hosp, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rhode Island Hosp, Providence, RI","institution_ids":["https://openalex.org/I2800446032"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"148","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.09229999780654907,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.6970000267028809},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.996999979019165},{"id":"https://openalex.org/keywords/bone-marrow-mesenchymal-stem-cells","display_name":"bone marrow mesenchymal stem cells","score":0.8999999761581421},{"id":"https://openalex.org/keywords/intramyocardial-injection","display_name":"intramyocardial injection","score":0.8880000114440918},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.5569999814033508},{"id":"https://openalex.org/keywords/ejection-fraction","display_name":"ejection fraction","score":0.7889999747276306},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7978905439376831},{"id":"https://openalex.org/C137776501","wikidata":"https://www.wikidata.org/wiki/Q7208270","display_name":"Point of delivery","level":2,"score":0.7384806871414185},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.68814617395401},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.61073237657547},{"id":"https://openalex.org/C2779537366","wikidata":"https://www.wikidata.org/wiki/Q7920323","display_name":"Ventricular remodeling","level":3,"score":0.5756828188896179},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.5674142241477966},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5617046356201172},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.55830979347229},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.47610506415367126},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47288861870765686},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.4449305236339569},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.4341447651386261},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.43102163076400757},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3771369159221649},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3615192770957947},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2439459264278412},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22499492764472961},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10758611559867859},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.08693841099739075}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.148.suppl_1.18612","doi":"https://doi.org/10.1161/circ.148.suppl_1.18612","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.18612","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3176584728","https://openalex.org/W3177481585","https://openalex.org/W4408973531","https://openalex.org/W7155533443","https://openalex.org/W4409015909","https://openalex.org/W1992918189","https://openalex.org/W2003846699","https://openalex.org/W3022348034","https://openalex.org/W2091923474","https://openalex.org/W4303986712"],"abstract_inverted_index":{"Introduction:":[0],"Post-myocardial":[1],"infarction":[2],"(post-MI)":[3],"cardiac":[4,9,66,79,171],"remodeling":[5],"and":[6,33,81,97,107,163,227,230,253,269],"decline":[7,248],"in":[8,23,77,85,170,178,183,191,208,249,258],"function":[10,80],"remains":[11],"a":[12,39,62,114,176,272,300],"vexing":[13],"problem.":[14],"Tissue":[15],"engineered":[16],"extracellular":[17],"matrix":[18],"(ECM)":[19],"has":[20],"been":[21],"used":[22],"the":[24,30,55,150,286,296],"past":[25],"but":[26],"was":[27,175,199,212],"restricted":[28],"by":[29,44,136,288],"manufactured":[31],"structure":[32,57],"mechanical":[34],"limitations.":[35],"Here,":[36],"we":[37],"use":[38],"novel":[40],"ECM":[41,59,73,98,109,146,184,244,290],"substrate":[42],"generated":[43],"self-assembled":[45],"cells":[46,94],"seeded":[47,102],"into":[48,103],"spherical":[49],"molds,":[50,105],"that":[51],"are":[52,263],"devoid":[53],"of":[54,58,72,116,139,141,243,274],"hierarchical":[56],"fabrication,":[60],"as":[61],"treatment":[63],"for":[64,303],"post-MI":[65,86,192,259],"remodeling.":[67],"Hypothesis:":[68],"Intramyocardial":[69],"(IM)":[70],"injection":[71,138,185,190,242],"particles":[74,99,110,118],"will":[75,233],"result":[76],"improved":[78],"reduced":[82],"infarct":[83],"size":[84],"hearts.":[87,260],"Methods:":[88],"Human":[89],"bone":[90],"marrow":[91],"mesenchymal":[92],"stem":[93],"were":[95,100,111],"cultured":[96],"isolated,":[101],"micro":[104],"purified,":[106],"characterized.":[108],"suspended":[112],"at":[113,193,201,214,222,251],"concentration":[115],"63,400":[117],"per":[119,283],"mL":[120],"to":[121,149,167,188,236,295],"create":[122],"an":[123],"injectable":[124],"solution.":[125],"WT":[126],"mice":[127],"underwent":[128,157],"left":[129],"anterior":[130],"descending":[131],"(LAD)":[132],"artery":[133],"ligation":[134],"followed":[135],"IM":[137,241],"10uL":[140],"saline":[142],"control":[143,189],"(n=3)":[144],"or":[145,217],"solution":[147],"(n=7)":[148],"infarcted":[151],"area":[152],"(Figure":[153,204,219],"1A).":[154],"Mice":[155],"then":[156],"post-operative":[158],"day":[159],"3":[160,195,216],"(POD":[161],"3)":[162],"POD":[164,194,202,215,223,225,228],"7":[165,203],"echocardiogram":[166],"determine":[168],"changes":[169],"function.":[172],"Results:":[173],"There":[174],"trend":[177],"improving":[179],"ejection":[180],"fraction":[181],"(EF)":[182],"group":[186],"compared":[187],"while":[196],"no":[197],"difference":[198,207],"seen":[200],"1B).":[205],"No":[206],"fractional":[209],"shortening":[210],"(FS)":[211],"observed":[213],"POD7":[218],"1C).":[220],"Echos":[221],"14,":[224],"21,":[226],"28":[229],"additional":[231],"animals":[232],"be":[234,271],"added":[235],"increase":[237],"study":[238],"power.":[239],"Conclusion:":[240],"trends":[245],"towards":[246],"mitigating":[247],"EF":[250],"POD3":[252],"does":[254],"not":[255],"affect":[256],"FS":[257],"These":[261],"results":[262],"likely":[264],"underpowered":[265],"(n=3":[266],"versus":[267],"n=7)":[268],"may":[270,298],"portent":[273],"significant":[275],"myocardial":[276],"protection":[277],"post-MI.":[278],"Our":[279],"ongoing":[280],"studies":[281],"(n=10":[282],"group)":[284],"investigating":[285],"mechanisms":[287],"which":[289],"injections":[291],"assuage":[292],"ischemic":[293],"insult":[294],"myocardium":[297],"represent":[299],"future":[301],"strategy":[302],"clinical":[304],"therapy.":[305]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-12-20T00:00:00"}
