{"id":"https://openalex.org/W4389945232","doi":"https://doi.org/10.1161/circ.148.suppl_1.19102","title":"Abstract 19102: E-Cigarettes Induce Persistent Cardiac Autonomic Dysfunction and Molecular Signatures of Dilated and Arrhythmogenic Cardiomyopathy","display_name":"Abstract 19102: E-Cigarettes Induce Persistent Cardiac Autonomic Dysfunction and Molecular Signatures of Dilated and Arrhythmogenic Cardiomyopathy","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4389945232","doi":"https://doi.org/10.1161/circ.148.suppl_1.19102"},"language":"en","primary_location":{"id":"doi:10.1161/circ.148.suppl_1.19102","doi":"https://doi.org/10.1161/circ.148.suppl_1.19102","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.19102","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078157032","display_name":"Anand R. Ramalingam","orcid":"https://orcid.org/0000-0003-1800-1020","observed_orcids":["https://orcid.org/0000-0003-1800-1020"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anand Ramalingam","raw_affiliation_strings":["Univ of Louisville, Louisville, KY","Anand Ramalingam Univ of Louisville, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Anand Ramalingam Univ of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093252427","display_name":"Cory Kucera","orcid":"https://orcid.org/0000-0002-7346-1321","observed_orcids":["https://orcid.org/0000-0002-7346-1321"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cory Kucera","raw_affiliation_strings":["Univ of Louisville, Louisville, KY","Cory Kucera Univ of Louisville, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Cory Kucera Univ of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085061817","display_name":"Michael L. Merchant","orcid":"https://orcid.org/0000-0003-4128-4057","observed_orcids":["https://orcid.org/0000-0003-4128-4057"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Merchant","raw_affiliation_strings":["CIEHS, Univ of Louisville, Louisville, KY","Michael Merchant CIEHS, Univ of Louisville, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIEHS, Univ of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Michael Merchant CIEHS, Univ of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012248310","display_name":"Aruni Bhatnagar","orcid":"https://orcid.org/0000-0001-6818-0384","observed_orcids":["https://orcid.org/0000-0001-6818-0384"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aruni Bhatnagar","raw_affiliation_strings":["Univ of Louisville, Louisville, KY","Aruni Bhatnagar Univ of Louisville, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Aruni Bhatnagar Univ of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040450827","display_name":"Alex P. Carll","orcid":"https://orcid.org/0000-0003-1832-3070","observed_orcids":["https://orcid.org/0000-0003-1832-3070"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex P Carll","raw_affiliation_strings":["Univ of Louisville, Louisville, KY","Alex P Carll Univ of Louisville, Louisville, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Alex P Carll Univ of Louisville, Louisville, KY","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"148","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.6518999934196472,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.6518999934196472,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.23720000684261322,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.0729999989271164,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/e-cigarettes","display_name":"electronic cigarettes","score":0.9139999747276306},{"id":"https://openalex.org/keywords/menthol","display_name":"menthol","score":0.7570000290870667},{"id":"https://openalex.org/keywords/cardiovascular-autonomic-dysfunction","display_name":"cardiac autonomic dysfunction","score":0.9419999718666077},{"id":"https://openalex.org/keywords/dilated-cardiomyopathy","display_name":"dilated cardiomyopathy","score":0.8859999775886536},{"id":"https://openalex.org/keywords/arrhythmogenic-cardiomyopathy","display_name":"arrhythmogenic cardiomyopathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ventricular-arrhythmias","display_name":"ventricular arrhythmias","score":0.9700000286102295},{"id":"https://openalex.org/keywords/protein-kinase-a-signaling","display_name":"protein kinase A signaling","score":0.9269999861717224},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9380000233650208},{"id":"https://openalex.org/keywords/phosphoproteomics","display_name":"phosphoproteomics","score":0.8109999895095825},{"id":"https://openalex.org/keywords/qtc-prolongation","display_name":"QTc prolongation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/stress-reactivity","display_name":"stress reactivity","score":0.5989999771118164},{"id":"https://openalex.org/keywords/atenolol","display_name":"atenolol","score":0.6850000023841858},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.414000004529953},{"id":"https://openalex.org/keywords/juul","display_name":"JUUL","score":0.6050000190734863},{"id":"https://openalex.org/keywords/tobacco-flavor","display_name":"tobacco aroma","score":0.3199999928474426},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8596596717834473},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6278016567230225},{"id":"https://openalex.org/C2780194911","wikidata":"https://www.wikidata.org/wiki/Q407418","display_name":"Menthol","level":2,"score":0.6145591735839844},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5366615056991577},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.48920226097106934},{"id":"https://openalex.org/C2777495988","wikidata":"https://www.wikidata.org/wiki/Q217111","display_name":"Bradycardia","level":4,"score":0.47620996832847595},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.41279250383377075},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3869023323059082},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.148.suppl_1.19102","doi":"https://doi.org/10.1161/circ.148.suppl_1.19102","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.19102","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4409797847","https://openalex.org/W3109491207","https://openalex.org/W4388627462","https://openalex.org/W4307210689","https://openalex.org/W7164836597","https://openalex.org/W7117574511","https://openalex.org/W4389068628","https://openalex.org/W4395036925","https://openalex.org/W7135584233","https://openalex.org/W4404381535"],"abstract_inverted_index":{"Introduction:":[0],"Evidence":[1],"is":[2],"mounting":[3],"that":[4,255],"use":[5,287],"of":[6,21,170,221,267,285,288],"e-cigarettes":[7],"(e-cigs)":[8],"promotes":[9],"cardiopulmonary":[10],"injury":[11],"and":[12,33,69,94,124,183,192,207,226,244,274],"dysfunction,":[13],"but":[14,134],"the":[15,139,281],"long-term":[16,282],"consequences":[17],"remain":[18],"unclear.":[19],"Consumption":[20],"menthol":[22,31,41,80,256],"e-cigs":[23,55,257],"has":[24],"surged":[25],"amid":[26],"imminent":[27],"bans":[28],"on":[29,130],"combustible":[30],"cigarettes":[32],"cigars.":[34],"Recently,":[35],"we":[36],"found":[37],"e-cig":[38,81,117],"aerosols":[39,82],"with":[40,66,96,158,234,264],"(but":[42],"not":[43],"tobacco)":[44],"flavor":[45],"acutely":[46],"induced":[47],"spontaneous":[48],"ventricular":[49,126,212],"arrhythmias":[50],"in":[51,150,229,249],"mice.":[52,231,251],"Hypothesis:":[53],"Menthol":[54,116,176],"induces":[56],"persistent":[57,259],"cardiac":[58,260,275],"autonomic":[59,261],"imbalance.":[60],"Methods:":[61],"Adult":[62],"C57BL/6J":[63],"male":[64],"mice":[65,178],"electrocardiogram":[67],"(ECG)":[68],"blood":[70],"pressure":[71],"(BP)":[72],"telemeters":[73],"were":[74,107,208,246],"exposed":[75],"for":[76,113],"4":[77],"weeks":[78,204],"to":[79,99,103,195,202,280],"(JUUL,":[83],"180":[84],"puffs/day,":[85],"5":[86],"days/week;":[87],"n=8)":[88],"or":[89],"filtered":[90],"air":[91],"(Air;":[92],"n=7)":[93],"challenged":[95],"restraint":[97],"stress":[98,185],"determine":[100],"cardiovascular":[101],"reactivity":[102],"stress.":[104],"Hearts":[105],"(n=5/group)":[106],"collected":[108],"immediately":[109],"after":[110],"final":[111],"exposure":[112,131,141],"phosphoproteomics.":[114],"Results:":[115],"exposures":[118,149],"increased":[119,136],"HR,":[120],"decreased":[121],"HR":[122,191],"variability,":[123],"evoked":[125],"premature":[127],"beats":[128],"only":[129],"day":[132],"1,":[133],"consistently":[135],"BP":[137,145],"throughout":[138],"20-day":[140],"(+16":[142],"mmHg":[143],"systolic":[144],"vs.":[146],"Air).":[147],"Additional":[148],"females":[151],"(n=4)":[152],"recapitulated":[153],"these":[154],"acute":[155],"effects.":[156],"Pre-treatment":[157],"atenolol":[159],"(n=4":[160],"males)":[161],"abolished":[162],"e-cig-induced":[163,171],"arrhythmias,":[164],"suggesting":[165],"\u03b2":[166],"1":[167],"-adrenergic":[168],"mediation":[169],"arrhythmias.":[172],"After":[173],"4-week":[174],"JUUL":[175],"exposure,":[177],"had":[179],"basal":[180],"sinus":[181],"bradycardia":[182],"impaired":[184],"reactivity,":[186],"characterized":[187],"by":[188,210],"reduced":[189],"maximal":[190],"rapid":[193],"recovery":[194],"baseline.":[196],"All":[197],"three":[198],"effects":[199,284],"persisted":[200],"up":[201],"3":[203],"following":[205],"cessation":[206],"accompanied":[209],"prolonged":[211],"repolarization":[213],"(QT":[214],"c":[215],").":[216],"Phosphoproteomic":[217],"analysis":[218],"revealed":[219],"upregulation":[220],"protein":[222],"kinase":[223],"A":[224],"signaling,":[225],"mitochondrial":[227],"dysfunction":[228,277],"e-cig-exposed":[230,250],"Phosphoproteins":[232],"associated":[233,263],"dilated":[235,268],"&":[236,269],"arrhythmogenic":[237,270],"cardiomyopathy":[238],"(ATP2A2,":[239],"FN1,":[240],"CACNB2,":[241],"PFKM,":[242],"ADCY6,":[243],"PRKAR1A)":[245],"differentially":[247],"regulated":[248],"Conclusions:":[252],"We":[253],"demonstrate":[254],"induce":[258],"imbalance":[262,273],"molecular":[265],"signatures":[266],"cardiomyopathy.":[271],"Autonomic":[272],"electrical":[276],"may":[278],"contribute":[279],"health":[283],"repeated":[286],"e-cigarettes.":[289]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-20T00:00:00"}