{"id":"https://openalex.org/W4389945179","doi":"https://doi.org/10.1161/circ.148.suppl_1.13727","title":"Abstract 13727: Cost-Effectiveness of Sotagliflozin in Heart Failure Patients With Preserved and Reduced Ejection Fractions\u2014Results From the SOLOIST-WHF","display_name":"Abstract 13727: Cost-Effectiveness of Sotagliflozin in Heart Failure Patients With Preserved and Reduced Ejection Fractions\u2014Results From the SOLOIST-WHF","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4389945179","doi":"https://doi.org/10.1161/circ.148.suppl_1.13727"},"language":"en","primary_location":{"id":"doi:10.1161/circ.148.suppl_1.13727","doi":"https://doi.org/10.1161/circ.148.suppl_1.13727","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.13727","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052993534","display_name":"William S. Weintraub","orcid":"https://orcid.org/0000-0002-5384-5571","observed_orcids":["https://orcid.org/0000-0002-5384-5571"]},"institutions":[{"id":"https://openalex.org/I1285739803","display_name":"MedStar Washington Hospital Center","ror":"https://ror.org/05ry42w04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285739803","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William S Weintraub","raw_affiliation_strings":["Medstar Washington Hosp Cntr, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medstar Washington Hosp Cntr, Washington, DC","institution_ids":["https://openalex.org/I1285739803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077294928","display_name":"Sarahfaye F. Dolman","orcid":"https://orcid.org/0000-0003-3651-9069","observed_orcids":["https://orcid.org/0000-0003-3651-9069"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarahfaye Dolman","raw_affiliation_strings":["Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington, DC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032478554","display_name":"Paul Kolm","orcid":"https://orcid.org/0000-0003-2653-5452","observed_orcids":["https://orcid.org/0000-0003-2653-5452"]},"institutions":[{"id":"https://openalex.org/I1285739803","display_name":"MedStar Washington Hospital Center","ror":"https://ror.org/05ry42w04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285739803","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Kolm","raw_affiliation_strings":["MedStar Washington Hosp, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Washington Hosp, Washington, DC","institution_ids":["https://openalex.org/I1285739803"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068516468","display_name":"Zugui Zhang","orcid":"https://orcid.org/0000-0001-5173-5371","observed_orcids":["https://orcid.org/0000-0001-5173-5371"]},"institutions":[{"id":"https://openalex.org/I1281704429","display_name":"Christiana Care Health System","ror":"https://ror.org/02h905004","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281704429"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zugui Zhang","raw_affiliation_strings":["Christiana Care Health System, Wilmiton, DE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christiana Care Health System, Wilmiton, DE","institution_ids":["https://openalex.org/I1281704429"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"148","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.6693999767303467,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.6693999767303467,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.2621999979019165,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0551999993622303,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sotagliflozin","display_name":"sotagliflozin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.875},{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":0.8970000147819519},{"id":"https://openalex.org/keywords/heart-failure-with-reduced-ejection-fraction","display_name":"heart failure with reduced ejection fraction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9169999957084656},{"id":"https://openalex.org/keywords/worsening-heart-failure","display_name":"worsening heart failure","score":0.8109999895095825},{"id":"https://openalex.org/keywords/quality-adjusted-life-years","display_name":"quality-adjusted life years","score":0.8450000286102295},{"id":"https://openalex.org/keywords/incremental-cost-effectiveness-ratio","display_name":"incremental cost-effectiveness ratio","score":0.9190000295639038},{"id":"https://openalex.org/keywords/health-care-costs","display_name":"health care costs","score":0.6629999876022339},{"id":"https://openalex.org/keywords/microsimulation-model","display_name":"microsimulation model","score":0.6909999847412109},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.7580000162124634},{"id":"https://openalex.org/keywords/payer-perspective","display_name":"payer perspective","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8661787509918213},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6185750365257263},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5841907858848572},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.5577090978622437},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5100663304328918},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.46457844972610474},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4446318745613098},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.41187670826911926},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4039452075958252},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33462047576904297},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1105419397354126},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10954582691192627},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.148.suppl_1.13727","doi":"https://doi.org/10.1161/circ.148.suppl_1.13727","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.13727","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7214934029","https://openalex.org/W4399555430","https://openalex.org/W4398168756","https://openalex.org/W4380151289","https://openalex.org/W4408959460","https://openalex.org/W4308366510","https://openalex.org/W4313558312","https://openalex.org/W4385799193","https://openalex.org/W3176403805","https://openalex.org/W4386723639"],"abstract_inverted_index":{"Background:":[0],"SOLOIST-WHF":[1,122],"(Effect":[2],"of":[3,51,94,173,183,214,221,249,256,265,285],"Sotagliflozin":[4],"on":[5,76],"Cardiovascular":[6],"Events":[7],"in":[8,53,121,267,274,307],"Patients":[9],"with":[10,20,58,309,315],"Type":[11],"2":[12],"Diabetes":[13],"Post":[14],"Worsening":[15],"Heart":[16],"Failure)":[17],"showed":[18],"patients":[19,55,124,308],"diabetes":[21],"and":[22,40,56,62,83,88,109,113,145,163,204,239,283,303,318],"recent":[23,311],"worsening":[24,312],"heart":[25,313],"failure":[26],"(HF),":[27],"sotagliflozin":[28,52,93,118,152,193,231,266,292],"initiated":[29],"before":[30],"or":[31],"shortly":[32],"after":[33],"discharge":[34],"lowered":[35],"incident":[36],"cardiovascular":[37],"deaths,":[38],"hospitalizations,":[39],"HF":[41,108],"urgent":[42],"visits.":[43],"In":[44,190,228],"this":[45],"study,":[46],"we":[47],"evaluated":[48],"the":[49,132,272],"cost-effectiveness":[50,134],"all":[54],"those":[57],"preserved":[59,317],"(HFpEF":[60],"\u226550%)":[61],"reduced":[63,319],"(HFrEF":[64],"<50%)":[65],"ejection":[66,320],"fraction.":[67,321],"Methods:":[68],"We":[69],"ran":[70],"a":[71,126,150,301],"Markov":[72],"microsimulation":[73],"model":[74],"based":[75],"treatment":[77],"effects":[78],"from":[79,85,97,125,271,294],"SOLOIST-WHF,":[80],"healthcare":[81,106],"costs":[82,91,138],"utilities":[84],"national":[86],"sources,":[87],"estimated":[89],"net":[90],"for":[92,117,180,218,253],"$434":[95],"(range":[96],"$407":[98,295],"to":[99,102,154,195,280,296],"$612)":[100],"monthly,":[101],"calculate":[103],"projected":[104],"lifetime":[105],"costs,":[107],"CVD":[110,275],"events,":[111],"survival,":[112],"quality-adjusted":[114],"life-years":[115,165,206,241],"(QALYs)":[116],"vs":[119],"placebo":[120,155,196],"eligible":[123],"payer":[127],"perspective.":[128],"Outcome":[129],"measured":[130],"as":[131],"incremental":[133,137,171,212,247],"ratio":[135],"(ICER),":[136],"/":[139],"QALYs":[140,158,199,234],"gained.":[141],"Sensitivity":[142],"analyses":[143],"assessed":[144],"quantified":[146],"uncertainties.":[147],"Results:":[148],"Over":[149],"lifetime,":[151],"compared":[153,194],"added":[156,197,232],"0.39":[157],"(4.43":[159],"vs.":[160,167,201,208,236,243],"4.04":[161],"QALYs)":[162,203,238],"0.64":[164],"(7.12":[166],"6.48)":[168],"at":[169,210,245],"an":[170,181,211,219,246,254],"cost":[172,213,248,282],"$29,449":[174],"(95%":[175],"uncertainty":[176],"interval":[177],"(UI):":[178],"$26,610-$32,528)":[179],"ICER":[182,220,255],"$75,510":[184],"per":[185,223,258,298],"QALY":[186,224,259,268],"gained":[187,225,260],"(UI:":[188,216,226,251,261],"$55,640-$98,300).":[189],"HFpEF":[191],"patients,":[192,230],"0.43":[198],"(4.53":[200],"4.10":[202],"0.68":[205],"(7.14":[207],"6.46)":[209,244],"$26,615":[215],"$23,376-$29,694)":[217],"$61,488":[222],"$41,618-$84,280).":[227],"HRrEF":[229],"0.37":[233],"(4.33":[235],"3.96":[237],"0.63":[240],"(7.09":[242],"$30,012":[250],"$26,773-$33,251)":[252],"$77,996":[257],"$58,126-$100,780).":[262],"The":[263],"benefit":[264],"mainly":[269],"results":[270],"decrease":[273],"deaths.":[276],"Findings":[277],"were":[278],"sensitive":[279],"drug":[281],"number":[284],"readmissions.":[286],"Conclusions:":[287],"This":[288],"study":[289],"demonstrates":[290],"that":[291],"priced":[293],"$612":[297],"month":[299],"is":[300],"clinically":[302],"economically":[304],"favorable":[305],"medication":[306],"diabetes,":[310],"failure,":[314],"both":[316]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-12-20T00:00:00"}
