{"id":"https://openalex.org/W4389945172","doi":"https://doi.org/10.1161/circ.148.suppl_1.13577","title":"Abstract 13577: Burden of Cardiometabolic Risk Factors and Vascular Health","display_name":"Abstract 13577: Burden of Cardiometabolic Risk Factors and Vascular Health","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4389945172","doi":"https://doi.org/10.1161/circ.148.suppl_1.13577"},"language":"en","primary_location":{"id":"doi:10.1161/circ.148.suppl_1.13577","doi":"https://doi.org/10.1161/circ.148.suppl_1.13577","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.13577","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012106161","display_name":"CARINE E. HAMO","orcid":"https://orcid.org/0000-0002-7063-1727","observed_orcids":["https://orcid.org/0000-0002-7063-1727"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carine Hamo","raw_affiliation_strings":["Medicine, New York Univ, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, New York Univ, New York, NY","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077847735","display_name":"Florencia Schlamp","orcid":"https://orcid.org/0000-0003-3319-6778","observed_orcids":["https://orcid.org/0000-0003-3319-6778"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Florencia Schlamp","raw_affiliation_strings":["NYU Langone Health, New York City, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Langone Health, New York City, NY","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035635951","display_name":"Kamelia Drenkova","orcid":"https://orcid.org/0000-0001-5278-4028","observed_orcids":["https://orcid.org/0000-0001-5278-4028"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kamelia Drenkova","raw_affiliation_strings":["New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, NY","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027163865","display_name":"Manila Jindal","orcid":"https://orcid.org/0000-0002-1222-2415","observed_orcids":["https://orcid.org/0000-0002-1222-2415"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manila Jindal","raw_affiliation_strings":["NYU Langone Med Cntr, Franklin Square, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Langone Med Cntr, Franklin Square, NY","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076948489","display_name":"Maja Fadzan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maja Fadzan","raw_affiliation_strings":["New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, NY","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066020568","display_name":"Adedoyin A Akinlonu","orcid":"https://orcid.org/0000-0002-4704-7784","observed_orcids":["https://orcid.org/0000-0002-4704-7784"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adedoyin Akinlonu","raw_affiliation_strings":["New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York, NY","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066507748","display_name":"Ira J. Goldberg","orcid":"https://orcid.org/0000-0002-8701-2201","observed_orcids":["https://orcid.org/0000-0002-8701-2201"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ira J Goldberg","raw_affiliation_strings":["New York Univ, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Univ, New York, NY","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070144685","display_name":"Michael Seth Garshick","orcid":"https://orcid.org/0000-0002-6649-3755","observed_orcids":["https://orcid.org/0000-0002-6649-3755"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Garshick","raw_affiliation_strings":["Medicine, New York Univ, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, New York Univ, New York, NY","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088731576","display_name":"Jeffrey S. Berger","orcid":"https://orcid.org/0000-0001-8216-4647","observed_orcids":["https://orcid.org/0000-0001-8216-4647"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Berger","raw_affiliation_strings":["Medicine, New York Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, New York Univ","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"148","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.8779000043869019,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.8779000043869019,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.042899999767541885,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiometabolic-risk-factors","display_name":"cardiometabolic risk factors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.6869999766349792},{"id":"https://openalex.org/keywords/risk-factor-burden","display_name":"risk factor burden","score":0.7260000109672546},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7160000205039978},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/leukocyte-differentiation","display_name":"leukocyte differentiation","score":0.824999988079071},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.45899999141693115},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8090000152587891},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.921999990940094},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":1.0}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8707454204559326},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6623830795288086},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5930567979812622},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5247752070426941},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5108551383018494},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5102849006652832},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.45915523171424866},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.42029517889022827},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.4128308892250061},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40114128589630127},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33518487215042114},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.27085524797439575},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2562664747238159},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24428430199623108},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11175298690795898},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1038438081741333}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.148.suppl_1.13577","doi":"https://doi.org/10.1161/circ.148.suppl_1.13577","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.13577","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4390599398","https://openalex.org/W4406964355","https://openalex.org/W2034830540","https://openalex.org/W7120589925","https://openalex.org/W2554702414","https://openalex.org/W4210532559","https://openalex.org/W3212410664","https://openalex.org/W4415207183","https://openalex.org/W4301013191","https://openalex.org/W1966294883"],"abstract_inverted_index":{"Introduction:":[0],"Cardiometabolic":[1],"risk":[2,50,76,90,131,224,244,254],"factors":[3,77,255],"(diabetes,":[4],"obesity,":[5],"and":[6,11,93,105,118,124,128,149,163,178,184,210,236],"hypertension)":[7],"are":[8],"highly":[9],"prevalent":[10,130],"contribute":[12],"to":[13],"cardiovascular":[14],"disease":[15],"(CVD).":[16],"Endothelial":[17],"dysfunction":[18],"often":[19],"precedes":[20],"CVD":[21,62],"development.":[22],"Direct":[23],"brachial":[24],"vein":[25],"endothelial":[26,188],"cell":[27,189],"(EC)":[28],"harvesting":[29,65],"enables":[30],"the":[31,87,257],"examination":[32],"of":[33,38,75,166,187,223,259],"vascular":[34],"health":[35],"via":[36],"assessment":[37],"EC":[39,56,64,134,238],"gene":[40],"expression.":[41],"Hypothesis:":[42],"We":[43,70,231],"hypothesized":[44],"that":[45],"individuals":[46,72,110],"with":[47,144,212,220,241,256],"greater":[48],"cardiometabolic":[49,243,253],"would":[51],"demonstrate":[52,232],"a":[53,213,233],"more":[54],"pro-inflammatory":[55],"transcriptome.":[57],"Methods:":[58],"Adult":[59],"participants":[60],"without":[61],"underwent":[63],"followed":[66],"by":[67,73],"RNA":[68,135],"sequencing.":[69],"categorized":[71],"number":[74,222],"(hypertension,":[78],"diabetes,":[79],"obesity)":[80],"as":[81],"0":[82],"through":[83],"3.":[84],"To":[85],"evaluate":[86],"association":[88],"between":[89],"factor":[91,245],"burden":[92,246],"outcome":[94],"transcripts,":[95],"we":[96],"performed":[97],"multivariable":[98],"linear":[99],"regression,":[100],"adjusting":[101],"for":[102],"age,":[103],"sex,":[104],"race/ethnicity.":[106],"Results:":[107],"Among":[108],"18":[109],"(mean":[111],"age":[112],"47":[113],"\u00b1":[114],"14,":[115],"44%":[116],"female,":[117],"61%":[119],"white),":[120],"17%,":[121],"44%,":[122],"28%,":[123],"11%":[125],"had":[126],"0,1,2,":[127],"3":[129,147],"factors,":[132],"respectively.":[133],"sequencing":[136],"revealed":[137],"588":[138],"differentially":[139],"expressed":[140],"transcripts":[141],"(p-adj":[142],"<0.05)":[143],"585":[145],"upregulated,":[146],"downregulated,":[148],"excellent":[150],"clustering":[151],"(":[152,194,226],"Fig.":[153,195,227],"a,":[154],"b":[155],").":[156],"Gene":[157],"ontology":[158],"enrichment":[159],"analysis":[160],"demonstrated":[161],"enriched":[162],"upregulated":[164,199],"pathways":[165,186],"T-cell":[167],"activation":[168],"(NES":[169],"=":[170],"2.22,":[171],"p<0.001),":[172,177],"leukocyte":[173],"differentiation":[174],"(NES=":[175,181,191],"2.16,":[176],"platelet":[179],"aggregation":[180],"1.66,":[182],"p=0.03)":[183],"downregulated":[185],"proliferation":[190],"-1.68,":[192],"p=0.03).":[193],"c":[196],")":[197,229],"Select":[198],"genes":[200],"(log":[201],"2FC":[202],">3,":[203],"p-adj<0.05)":[204],"included":[205],"VCAM1,":[206],"CEACAM1,":[207],"ADAM":[208],"17,":[209],"CD99L2,":[211],"graded":[214],"increase":[215],"in":[216],"mean":[217],"normalized":[218],"counts":[219],"increasing":[221],"factors.":[225],"d":[228],"Conclusions:":[230],"proinflammatory,":[234],"pro-adhesive,":[235],"pro-coagulant":[237],"transcriptome":[239],"associated":[240],"increased":[242],"offering":[247],"insight":[248],"into":[249],"potential":[250],"mechanisms":[251],"linking":[252],"development":[258],"CVD.":[260]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-20T00:00:00"}
