{"id":"https://openalex.org/W4389945010","doi":"https://doi.org/10.1161/circ.148.suppl_1.13321","title":"Abstract 13321: Novel Regional Analysis of Left Atrial Strain From Computed Tomography Separates Patients With Persistent versus Paroxysmal Atrial Fibrillation","display_name":"Abstract 13321: Novel Regional Analysis of Left Atrial Strain From Computed Tomography Separates Patients With Persistent versus Paroxysmal Atrial Fibrillation","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4389945010","doi":"https://doi.org/10.1161/circ.148.suppl_1.13321"},"language":"en","primary_location":{"id":"doi:10.1161/circ.148.suppl_1.13321","doi":"https://doi.org/10.1161/circ.148.suppl_1.13321","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.13321","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060173650","display_name":"Charles Sillett","orcid":"https://orcid.org/0000-0003-2930-7818","observed_orcids":["https://orcid.org/0000-0003-2930-7818"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles Sillett","raw_affiliation_strings":["London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019828522","display_name":"Orod Razeghi","orcid":"https://orcid.org/0000-0003-4989-5565","observed_orcids":["https://orcid.org/0000-0003-4989-5565"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Orod Razeghi","raw_affiliation_strings":["King's College London, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King's College London, London","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100652513","display_name":"Angela Lee","orcid":"https://orcid.org/0000-0002-7591-825X","observed_orcids":["https://orcid.org/0000-0002-7591-825X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Angela Lee","raw_affiliation_strings":["Imperial College London, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, London","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032466066","display_name":"Jos\u00e9 Alonso Sol\u00eds-Lemus","orcid":"https://orcid.org/0000-0002-2596-7811","observed_orcids":["https://orcid.org/0000-0002-2596-7811"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jose Alonso Solis Lemus","raw_affiliation_strings":["Imperial College London, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, London","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064867651","display_name":"Caroline H. Roney","orcid":"https://orcid.org/0000-0001-6809-0928","observed_orcids":["https://orcid.org/0000-0001-6809-0928"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caroline Roney","raw_affiliation_strings":["London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"London","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101839862","display_name":"Prasanth Ganesan","orcid":"https://orcid.org/0000-0002-1885-0690","observed_orcids":["https://orcid.org/0000-0002-1885-0690"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prasanth Ganesan","raw_affiliation_strings":["Stanford Univ, Palo Alto, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ, Palo Alto, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101087155","display_name":"Ruibin Feng","orcid":"https://orcid.org/0000-0002-0777-8195","observed_orcids":["https://orcid.org/0000-0002-0777-8195"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruibin Feng","raw_affiliation_strings":["San Jose, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Jose, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013029524","display_name":"Henry Chubb","orcid":"https://orcid.org/0000-0002-2859-3536","observed_orcids":["https://orcid.org/0000-0002-2859-3536"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henry Chubb","raw_affiliation_strings":["Portola Valley, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Portola Valley, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053535508","display_name":"Koen Nieman","orcid":"https://orcid.org/0000-0002-8312-0598","observed_orcids":["https://orcid.org/0000-0002-8312-0598"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Koen NIEMAN","raw_affiliation_strings":["Stanford Univ, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005580719","display_name":"Albert Joseph Rogers","orcid":"https://orcid.org/0000-0001-6585-534X","observed_orcids":["https://orcid.org/0000-0001-6585-534X"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert J Rogers","raw_affiliation_strings":["Stanford Univ, Redwood City, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ, Redwood City, CA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082544361","display_name":"Ronak Rajani","orcid":"https://orcid.org/0000-0002-8816-6296","observed_orcids":["https://orcid.org/0000-0002-8816-6296"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronak Rajani","raw_affiliation_strings":["Guy's and St Thomas' Hosps, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guy's and St Thomas' Hosps, London","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026533006","display_name":"Sanjiv M. Narayan","orcid":"https://orcid.org/0000-0001-7552-5053","observed_orcids":["https://orcid.org/0000-0001-7552-5053"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjiv M Narayan","raw_affiliation_strings":["Stanford Medicine, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Medicine, Stanford, CA","institution_ids":["https://openalex.org/I4210137306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000435552","display_name":"Steven Niederer","orcid":"https://orcid.org/0000-0002-4612-6982","observed_orcids":["https://orcid.org/0000-0002-4612-6982"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steven A Niederer","raw_affiliation_strings":["King's College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King's College London, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"148","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.05009999871253967,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/persistent-atrial-fibrillation","display_name":"persistent atrial fibrillation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/paroxysmal-atrial-fibrillation","display_name":"paroxysmal atrial fibrillation","score":1.0},{"id":"https://openalex.org/keywords/left-atrial-strain","display_name":"left atrial strain","score":0.9430000185966492},{"id":"https://openalex.org/keywords/atrial-fibrosis","display_name":"atrial fibrosis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/atrial-stiffness","display_name":"atrial stiffness","score":0.902999997138977},{"id":"https://openalex.org/keywords/atrial-reservoir-strain","display_name":"atrial reservoir strain","score":0.49300000071525574},{"id":"https://openalex.org/keywords/atrial-remodeling","display_name":"atrial remodeling","score":0.5059999823570251},{"id":"https://openalex.org/keywords/atrial-fibrillation-classification","display_name":"atrial fibrillation classification","score":0.6190000176429749},{"id":"https://openalex.org/keywords/gated-ct","display_name":"gated CT","score":0.39100000262260437},{"id":"https://openalex.org/keywords/feature-tracking","display_name":"feature tracking","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cha2ds2-vasc-score","display_name":"CHA2DS2-VASc score","score":0.8700000047683716},{"id":"https://openalex.org/keywords/atrial-volume","display_name":"atrial volume","score":0.6909999847412109},{"id":"https://openalex.org/keywords/atrial-fibrillation-ablation","display_name":"atrial fibrillation ablation","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.937151312828064},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.7477983832359314},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6200293302536011},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6123669147491455},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5121443271636963},{"id":"https://openalex.org/C2776131983","wikidata":"https://www.wikidata.org/wiki/Q436572","display_name":"Catheter ablation","level":3,"score":0.49531856179237366},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4893426299095154},{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.4378723204135895},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.30626195669174194}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.148.suppl_1.13321","doi":"https://doi.org/10.1161/circ.148.suppl_1.13321","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.13321","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4286308545","https://openalex.org/W2104499450","https://openalex.org/W4399799435","https://openalex.org/W7099732109","https://openalex.org/W4377197308","https://openalex.org/W6939819564","https://openalex.org/W7206175247","https://openalex.org/W7165937998","https://openalex.org/W4410620903","https://openalex.org/W4415041564"],"abstract_inverted_index":{"Introduction:":[0],"It":[1,38],"is":[2,13,27],"difficult":[3,28],"to":[4,23,29,112,311],"quantify":[5],"progression":[6],"of":[7,16,61,79,281,308],"atrial":[8,47,72,287],"fibrillation":[9],"(AF).":[10],"Atrial":[11,144],"fibrosis":[12,42,53],"a":[14,106],"hallmark":[15],"the":[17,75,125,306],"AF":[18,93,113,160,186,309],"substrate,":[19],"increasing":[20],"from":[21],"paroxysmal":[22,82,88,159,294],"persistent":[24,80,91,157,185,292],"AF,":[25],"but":[26],"assess":[30],"by":[31,46,59],"voltage":[32],"mapping":[33],"or":[34,305],"magnetic":[35],"resonance":[36],"imaging.":[37],"remains":[39],"unclear":[40],"if":[41],"could":[43,298],"be":[44,57],"revealed":[45],"stiffness,":[48],"which":[49,104],"increases":[50],"with":[51,87,156,291],"regional":[52,70],"burden":[54],"and":[55,77,90,122,177,255],"can":[56],"measured":[58,120],"analysis":[60,245],"retrospective":[62,107,282],"gated":[63,108,283],"computed":[64],"tomography":[65],"(CT).":[66],"Hypothesis:":[67],"Differences":[68],"in":[69,154,184,289],"CT-derived":[71],"strain":[73,118,150,249,257,288],"enable":[74],"identification":[76,307],"characterization":[78],"versus":[81,158,293],"AF.":[83,295],"Methods:":[84],"Fifty":[85],"patients":[86,155,187,290],"(60%)":[89],"(40%)":[92],"(age":[94],"59.8":[95],"\u00b1":[96,162,167,190,195,203,208,216,221,229,234],"12.8,":[97],"34%":[98],"female)":[99],"underwent":[100],"CT":[101,109,284],"coronary":[102],"angiography":[103],"included":[105],"protocol":[110],"prior":[111],"ablation.":[114,313],"LA":[115,126,135,253,266],"reservoir":[116],"area":[117],"was":[119,137,151],"globally":[121],"regionally":[123],"on":[124],"endocardium":[127],"using":[128,142],"an":[129],"optimised":[130],"feature":[131,279],"tracking":[132,280],"algorithm.":[133],"The":[134,173],"body":[136],"classified":[138],"into":[139,302],"five":[140],"regions":[141],"Universal":[143],"Coordinates":[145],"(Fig":[146],"A).":[147],"Results:":[148],"Global":[149],"significantly":[152,182],"lower":[153,183],"(13.6":[161],"8.2":[163],"%":[164,192,205,218,231],"vs":[165,193,206,219,232],"24.5":[166],"12.0":[168],"%,":[169,197,210,223,236],"p":[170,198,211,224,237],"=":[171,199,212,225,238],"0.0008).":[172],"posterior,":[174],"septal,":[175],"anterior":[176],"inferior":[178],"wall":[179,248],"strains":[180],"were":[181],"(posterior:":[188],"16.6":[189,228],"9.5":[191,230],"30.3":[194,233],"15.9":[196,235],"0.007;":[200],"septum:":[201],"20.8":[202],"11.8":[204],"39.6":[207],"15.8":[209],"0.00004;":[213],"anterior:":[214],"17.5":[215],"10.6":[217],"28.7":[220],"15.7":[222],"0.008,":[226],"inferior:":[227],"0.001,":[239],"Fig":[240,275],"B).":[241],"Receiver":[242],"operator":[243],"curve":[244],"showed":[246],"septal":[247,272],"outperformed":[250],"CHA2DS2-VASc":[251],"score,":[252],"volume":[254],"global":[256,269],"for":[258],"binary":[259],"classification":[260],"between":[261],"groups":[262],"(AUC:":[263],"CHA2DS2-VASc:":[264],"0.67;":[265],"volume:":[267],"0.79;":[268],"strain:":[270,273],"0.78;":[271],"0.84,":[274],"C).":[276],"Conclusions:":[277],"Novel":[278],"reveals":[285],"abnormal":[286],"Future":[296],"work":[297],"incorporate":[299],"this":[300],"tool":[301],"patient":[303],"phenotyping":[304],"substrates":[310],"target":[312]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2023-12-20T00:00:00"}