{"id":"https://openalex.org/W4389944636","doi":"https://doi.org/10.1161/circ.148.suppl_1.17599","title":"Abstract 17599: Sotatercept for the Treatment of Pulmonary Arterial Hypertension: A Systematic Review and Single-Arm Meta-Analysis","display_name":"Abstract 17599: Sotatercept for the Treatment of Pulmonary Arterial Hypertension: A Systematic Review and Single-Arm Meta-Analysis","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4389944636","doi":"https://doi.org/10.1161/circ.148.suppl_1.17599"},"language":"en","primary_location":{"id":"doi:10.1161/circ.148.suppl_1.17599","doi":"https://doi.org/10.1161/circ.148.suppl_1.17599","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.17599","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055870392","display_name":"Nicole Santos Felix","orcid":"https://orcid.org/0000-0001-8174-3866","observed_orcids":["https://orcid.org/0000-0001-8174-3866"]},"institutions":[{"id":"https://openalex.org/I41455075","display_name":"Universidade Federal de Campina Grande","ror":"https://ror.org/00eftnx64","country_code":"BR","type":"education","lineage":["https://openalex.org/I41455075"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Nicole Felix","raw_affiliation_strings":["Federal Univ of Campina Grande, Campina Grande, Brazil","Nicole Felix Federal Univ of Campina Grande, Campina Grande, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Univ of Campina Grande, Campina Grande, Brazil","institution_ids":["https://openalex.org/I41455075"]},{"raw_affiliation_string":"Nicole Felix Federal Univ of Campina Grande, Campina Grande, Brazil","institution_ids":["https://openalex.org/I41455075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011465472","display_name":"Larissa Teixeira","orcid":"https://orcid.org/0009-0000-7714-7148","observed_orcids":["https://orcid.org/0009-0000-7714-7148"]},"institutions":[{"id":"https://openalex.org/I41455075","display_name":"Universidade Federal de Campina Grande","ror":"https://ror.org/00eftnx64","country_code":"BR","type":"education","lineage":["https://openalex.org/I41455075"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Larissa Teixeira","raw_affiliation_strings":["Federal Univ of Campina Grande, Campina Grande, Brazil","Larissa Teixeira Federal Univ of Campina Grande, Campina Grande, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Univ of Campina Grande, Campina Grande, Brazil","institution_ids":["https://openalex.org/I41455075"]},{"raw_affiliation_string":"Larissa Teixeira Federal Univ of Campina Grande, Campina Grande, Brazil","institution_ids":["https://openalex.org/I41455075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061465866","display_name":"Luiz Campedelli","orcid":"https://orcid.org/0009-0007-4311-7654","observed_orcids":["https://orcid.org/0009-0007-4311-7654"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luiz Campedelli","raw_affiliation_strings":["Univ of Pittsburgh, Pittsburgh, PA","Luiz Campedelli Univ of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Luiz Campedelli Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009316322","display_name":"All\u00eah Nogueira","orcid":"https://orcid.org/0000-0001-5995-6179","observed_orcids":["https://orcid.org/0000-0001-5995-6179"]},"institutions":[{"id":"https://openalex.org/I132950312","display_name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica","ror":"https://ror.org/0300yd604","country_code":"BR","type":"education","lineage":["https://openalex.org/I132950312"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Alleh Nogueira","raw_affiliation_strings":["Bahiana Sch of Medicine and Public Health, Salvador, Brazil","Alleh Nogueira Bahiana Sch of Medicine and Public Health, Salvador, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bahiana Sch of Medicine and Public Health, Salvador, Brazil","institution_ids":["https://openalex.org/I132950312"]},{"raw_affiliation_string":"Alleh Nogueira Bahiana Sch of Medicine and Public Health, Salvador, Brazil","institution_ids":["https://openalex.org/I132950312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057570261","display_name":"Amanda Godoi","orcid":"https://orcid.org/0000-0001-8666-7786","observed_orcids":["https://orcid.org/0000-0001-8666-7786"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Amanda Godoi","raw_affiliation_strings":["Cardiff Univ Sch of Medicine, Cardiff, United Kingdom","Amanda Godoi Cardiff Univ Sch of Medicine, Cardiff, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiff Univ Sch of Medicine, Cardiff, United Kingdom","institution_ids":["https://openalex.org/I79510175"]},{"raw_affiliation_string":"Amanda Godoi Cardiff Univ Sch of Medicine, Cardiff, United Kingdom","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064881715","display_name":"Alice Deberaldini Marinho","orcid":"https://orcid.org/0000-0002-3838-5765","observed_orcids":["https://orcid.org/0000-0002-3838-5765"]},"institutions":[{"id":"https://openalex.org/I83648350","display_name":"Universidade Federal do Estado do Rio de Janeiro","ror":"https://ror.org/04tec8z30","country_code":"BR","type":"education","lineage":["https://openalex.org/I83648350"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Alice Deberaldini Marinho","raw_affiliation_strings":["Federal Univ of the State of Rio de Janeiro, Rio de Janeiro, Brazil","Alice Deberaldini Marinho Federal Univ of the State of Rio de Janeiro, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Univ of the State of Rio de Janeiro, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I83648350"]},{"raw_affiliation_string":"Alice Deberaldini Marinho Federal Univ of the State of Rio de Janeiro, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I83648350"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Beatriz Deberaldini Marinho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beatriz Deberaldini Marinho","raw_affiliation_strings":["Universidade Estacio de Sa, Rio De Janeiro, Brazil","Beatriz Deberaldini Marinho Universidade Estacio de Sa, Rio De Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Estacio de Sa, Rio De Janeiro, Brazil","institution_ids":[]},{"raw_affiliation_string":"Beatriz Deberaldini Marinho Universidade Estacio de Sa, Rio De Janeiro, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093530274","display_name":"Victor Perim C N","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83648350","display_name":"Universidade Federal do Estado do Rio de Janeiro","ror":"https://ror.org/04tec8z30","country_code":"BR","type":"education","lineage":["https://openalex.org/I83648350"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Victor Perim C N","raw_affiliation_strings":["Federal Univ of the State of Rio de Janeiro, Rio de Janeiro, Brazil","Victor Perim C N Federal Univ of the State of Rio de Janeiro, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Univ of the State of Rio de Janeiro, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I83648350"]},{"raw_affiliation_string":"Victor Perim C N Federal Univ of the State of Rio de Janeiro, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I83648350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033877515","display_name":"Thomaz Alexandre Costa","orcid":"https://orcid.org/0000-0003-1789-6694","observed_orcids":["https://orcid.org/0000-0003-1789-6694"]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Thomaz A Costa","raw_affiliation_strings":["Federal Univ of Cear\u00e1, Fortaleza, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Univ of Cear\u00e1, Fortaleza, Brazil","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068216869","display_name":"Michael G. Risbano","orcid":"https://orcid.org/0000-0003-3334-7046","observed_orcids":["https://orcid.org/0000-0003-3334-7046"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael G Risbano","raw_affiliation_strings":["Univ of Pittsburgh, Pittsburgh, PA","Michael G Risbano Univ of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Michael G Risbano Univ of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"148","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sotatercept","display_name":"sotatercept","score":1.0},{"id":"https://openalex.org/keywords/pulmonary-arterial-hypertension","display_name":"pulmonary arterial hypertension","score":1.0},{"id":"https://openalex.org/keywords/fusion-protein","display_name":"fusion protein","score":0.4860000014305115},{"id":"https://openalex.org/keywords/clinical-deterioration","display_name":"clinical deterioration","score":0.722000002861023},{"id":"https://openalex.org/keywords/pulmonary-vascular-resistance","display_name":"pulmonary vascular resistance","score":0.9940000176429749},{"id":"https://openalex.org/keywords/6-minute-walk-distance","display_name":"6-minute walk distance","score":0.972000002861023},{"id":"https://openalex.org/keywords/exercise-capacity","display_name":"exercise capacity","score":0.9559999704360962},{"id":"https://openalex.org/keywords/who-functional-class","display_name":"WHO functional class","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9372211694717407},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5805120468139648},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5623886585235596},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.561151385307312},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5503482222557068},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.44322526454925537},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.41898825764656067},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3833761513233185},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.148.suppl_1.17599","doi":"https://doi.org/10.1161/circ.148.suppl_1.17599","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.17599","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4390673603","https://openalex.org/W7223254207","https://openalex.org/W7171669959","https://openalex.org/W4412015340","https://openalex.org/W4412473177","https://openalex.org/W4414340714","https://openalex.org/W4413791885","https://openalex.org/W7140207921","https://openalex.org/W4407850043","https://openalex.org/W7165172072"],"abstract_inverted_index":{"Introduction:":[0],"Pulmonary":[1],"arterial":[2],"hypertension":[3],"(PAH)":[4],"is":[5,22],"associated":[6,179],"with":[7,17,27,52,92,147,180,241],"progressive":[8],"clinical":[9,34,48,83,142,167,232],"worsening":[10,168,233],"and":[11,77,108,119,134,234],"a":[12,23,95,100,181],"50%":[13],"5-year":[14],"survival":[15],"rate":[16],"current":[18],"PAH":[19,41,66],"therapies.":[20],"Sotatercept":[21,45,176],"first-in-class":[24],"fusion":[25],"protein":[26],"promising":[28],"results":[29],"in":[30,39,62,68,79,90,183,239],"preclinical":[31],"trials,":[32],"but":[33],"evidence":[35],"on":[36,162],"its":[37],"role":[38],"treating":[40],"remains":[42],"limited.":[43],"Hypothesis:":[44],"may":[46,226],"provide":[47],"benefits":[49],"for":[50,82,105,123],"patients":[51,91,146,161,240],"symptomatic":[53],"PAH.":[54,93,154,245],"Aims:":[55],"To":[56],"assess":[57],"the":[58],"efficacy":[59,86],"of":[60,88,103,160,166],"sotatercept":[61,89,163,225],"addition":[63],"to":[64,115,172,198,216,243],"background":[65],"therapy":[67],"this":[69],"population.":[70],"Methods:":[71],"We":[72,139],"searched":[73],"PubMed,":[74],"Embase,":[75],"Cochrane":[76],"Clinicaltrials.gov":[78],"April":[80],"2023":[81],"trials":[84,143],"assessing":[85],"outcomes":[87,107],"Using":[94],"random-effects":[96],"model,":[97],"we":[98],"performed":[99,129],"single-arm":[101],"meta-analysis":[102],"proportions":[104],"binary":[106],"applied":[109],"generic":[110],"inverse":[111],"variance":[112],"weighting":[113],"formulas":[114],"pool":[116],"arithmetic":[117],"means":[118,122],"least":[120],"squares":[121],"continuous":[124],"outcomes.":[125],"Statistical":[126],"analyses":[127],"were":[128],"using":[130],"Review":[131],"Manager":[132],"5.4.1":[133],"R":[135],"software":[136],"4.2.2.":[137],"Results:":[138],"included":[140],"three":[141],"comprising":[144],"254":[145],"WHO":[148],"functional":[149],"class":[150],"II":[151],"or":[152],"III":[153],"At":[155],"24":[156],"weeks,":[157],"only":[158],"2%":[159],"experienced":[164],"symptoms":[165],"(95%":[169],"CI":[170,196,214],"1":[171],"5;":[173],"Fig.":[174,200,218],"1A).":[175],"was":[177],"also":[178],"reduction":[182],"pulmonary":[184,236],"vascular":[185,237],"resistance":[186,238],"(mean":[187,207],"change":[188,208],"from":[189,209],"baseline":[190,210],"-199.92":[191],"dyn\u00b7sec\u00b7cm":[192],"-5":[193],";":[194],"95%":[195,213],"-256.83":[197],"-143.0;":[199],"1B),":[201],"while":[202,230],"improving":[203],"6-minute":[204],"walk":[205],"distance":[206],"45.86":[211],"m;":[212],"28.54":[215],"63.18;":[217],"1C).":[219],"Conclusions:":[220],"These":[221],"findings":[222],"suggest":[223],"that":[224],"improve":[227],"exercise":[228],"capacity":[229],"decelerating":[231],"attenuating":[235],"mild":[242],"moderate":[244]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2023-12-20T00:00:00"}