{"id":"https://openalex.org/W4389944062","doi":"https://doi.org/10.1186/s12864-023-09875-4","title":"Evaluation of noninvasive biospecimens for transcriptome studies","display_name":"Evaluation of noninvasive biospecimens for transcriptome studies","publication_year":2023,"publication_date":"2023-12-19","ids":{"openalex":"https://openalex.org/W4389944062","doi":"https://doi.org/10.1186/s12864-023-09875-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/38114913","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10729488"},"language":"en","primary_location":{"id":"doi:10.1186/s12864-023-09875-4","doi":"https://doi.org/10.1186/s12864-023-09875-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-023-09875-4","pdf_url":null,"source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12864-023-09875-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043938185","display_name":"Molly Martorella","orcid":"https://orcid.org/0000-0002-3306-6650","observed_orcids":["https://orcid.org/0000-0002-3306-6650"]},"institutions":[{"id":"https://openalex.org/I4210151462","display_name":"New York Genome Center","ror":"https://ror.org/05wf2ga96","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210151462"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Molly Martorella","raw_affiliation_strings":["Department of Systems Biology, Columbia University, New York, NY, USA","New York Genome Center, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-3306-6650","affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"New York Genome Center, New York, NY, USA","institution_ids":["https://openalex.org/I4210151462"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072639794","display_name":"Silva Kasela","orcid":"https://orcid.org/0000-0003-4362-0034","observed_orcids":["https://orcid.org/0000-0003-4362-0034"]},"institutions":[{"id":"https://openalex.org/I4210151462","display_name":"New York Genome Center","ror":"https://ror.org/05wf2ga96","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210151462"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Silva Kasela","raw_affiliation_strings":["Department of Systems Biology, Columbia University, New York, NY, USA","New York Genome Center, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0003-4362-0034","affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"New York Genome Center, New York, NY, USA","institution_ids":["https://openalex.org/I4210151462"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073565311","display_name":"Renee Garcia-Flores","orcid":"https://orcid.org/0000-0001-8812-120X","observed_orcids":["https://orcid.org/0000-0001-8812-120X"]},"institutions":[{"id":"https://openalex.org/I4210151462","display_name":"New York Genome Center","ror":"https://ror.org/05wf2ga96","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210151462"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renee Garcia-Flores","raw_affiliation_strings":["Department of Computer Science, Columbia University, New York, NY, USA","New York Genome Center, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0001-8812-120X","affiliations":[{"raw_affiliation_string":"Department of Computer Science, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"New York Genome Center, New York, NY, USA","institution_ids":["https://openalex.org/I4210151462"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056774700","display_name":"Alper Gokden","orcid":"https://orcid.org/0000-0002-9659-7352","observed_orcids":["https://orcid.org/0000-0002-9659-7352"]},"institutions":[{"id":"https://openalex.org/I4210151462","display_name":"New York Genome Center","ror":"https://ror.org/05wf2ga96","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210151462"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alper Gokden","raw_affiliation_strings":["New York Genome Center, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-9659-7352","affiliations":[{"raw_affiliation_string":"New York Genome Center, New York, NY, USA","institution_ids":["https://openalex.org/I4210151462"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046180340","display_name":"Stephane E. Castel","orcid":"https://orcid.org/0000-0002-0707-2133","observed_orcids":["https://orcid.org/0000-0002-0707-2133"]},"institutions":[{"id":"https://openalex.org/I4210151462","display_name":"New York Genome Center","ror":"https://ror.org/05wf2ga96","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210151462"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephane E. Castel","raw_affiliation_strings":["Department of Systems Biology, Columbia University, New York, NY, USA","New York Genome Center, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-0707-2133","affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"New York Genome Center, New York, NY, USA","institution_ids":["https://openalex.org/I4210151462"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064165945","display_name":"Tuuli Lappalainen","orcid":"https://orcid.org/0000-0002-7746-8109","observed_orcids":["https://orcid.org/0000-0002-7746-8109"]},"institutions":[{"id":"https://openalex.org/I4210151462","display_name":"New York Genome Center","ror":"https://ror.org/05wf2ga96","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210151462"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE","US"],"is_corresponding":true,"raw_author_name":"Tuuli Lappalainen","raw_affiliation_strings":["Department of Gene Technology, KTH Royal Institute of Technology, Stockholm, Sweden","Department of Systems Biology, Columbia University, New York, NY, USA","New York Genome Center, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-7746-8109","affiliations":[{"raw_affiliation_string":"Department of Gene Technology, KTH Royal Institute of Technology, Stockholm, Sweden","institution_ids":["https://openalex.org/I86987016"]},{"raw_affiliation_string":"Department of Systems Biology, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"New York Genome Center, New York, NY, USA","institution_ids":["https://openalex.org/I4210151462"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5043938185","https://openalex.org/A5046180340","https://openalex.org/A5064165945"],"corresponding_institution_ids":["https://openalex.org/I4210151462","https://openalex.org/I78577930","https://openalex.org/I86987016"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.9511,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.71831465,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"24","issue":"1","first_page":"790","last_page":"790"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.7836999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.7836999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0869000032544136,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.07810000330209732,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.7450000047683716},{"id":"https://openalex.org/keywords/hair-follicle","display_name":"hair follicle","score":0.7960000038146973},{"id":"https://openalex.org/keywords/buccal-swabs","display_name":"buccal swabs","score":0.9850000143051147},{"id":"https://openalex.org/keywords/saliva","display_name":"saliva","score":0.9879999756813049},{"id":"https://openalex.org/keywords/library-preparation","display_name":"library preparation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/specimen-quality","display_name":"sample quality","score":0.7120000123977661},{"id":"https://openalex.org/keywords/longitudinal-sampling","display_name":"longitudinal sampling","score":0.5299999713897705},{"id":"https://openalex.org/keywords/gene-expression-profiles","display_name":"gene expression profiles","score":0.6309999823570251},{"id":"https://openalex.org/keywords/cell-types","display_name":"cell types","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6418644189834595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6322431564331055},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5901265144348145},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5043221712112427},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3549194037914276},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34733083844184875},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3059540390968323},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20496731996536255},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12778571248054504},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11726680397987366}],"mesh":[{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12864-023-09875-4","doi":"https://doi.org/10.1186/s12864-023-09875-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-023-09875-4","pdf_url":null,"source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},{"id":"doi:10.1101/2022.09.06.506813","doi":"https://doi.org/10.1101/2022.09.06.506813","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.09.06.506813","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/09/06/2022.09.06.506813.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10729488","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10729488","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10729488/pdf/12864_2023_Article_9875.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"Text"},{"id":"pmid:38114913","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38114913","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC genomics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a13417159d034e4eaf9a66dc788edabb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a13417159d034e4eaf9a66dc788edabb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Genomics, Vol 24, Iss 1, Pp 1-18 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12864-023-09875-4","doi":"https://doi.org/10.1186/s12864-023-09875-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-023-09875-4","pdf_url":null,"source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2654893885","display_name":"Characterizing genetic, longitudinal, and developmental effects on the transcriptome using a novel non-invasive RNA-sequencing method","funder_award_id":"1k99hg009916-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G367329587","display_name":"Integration of omics data to improve interpretation of genetic risk variants in lung disease","funder_award_id":"R01HL142028","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6236086411","display_name":"Experimental and Computational Methods for Scaling-up Transcriptome Analyses and Improving Disease Risk Predictions","funder_award_id":"F30HG011194","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G6474947825","display_name":"UNDERSTANDING CELLULAR AND TRANSCRIPTIONAL REGULATORY CHANGES IN HUMAN AGING","funder_award_id":"R01AG057422","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7871733508","display_name":null,"funder_award_id":"1K99HG009916","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G8083334890","display_name":null,"funder_award_id":"K99 HG009916","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320316384","display_name":"New York Genome Center","ror":"https://ror.org/05wf2ga96"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389944062.pdf","grobid_xml":"https://content.openalex.org/works/W4389944062.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W1557369697","https://openalex.org/W1816176398","https://openalex.org/W1948961602","https://openalex.org/W1964895626","https://openalex.org/W1969007368","https://openalex.org/W1973012451","https://openalex.org/W1980991473","https://openalex.org/W1986911601","https://openalex.org/W1993616000","https://openalex.org/W2012034410","https://openalex.org/W2066231767","https://openalex.org/W2067890885","https://openalex.org/W2099918260","https://openalex.org/W2104549677","https://openalex.org/W2108234281","https://openalex.org/W2110905563","https://openalex.org/W2114104545","https://openalex.org/W2127571714","https://openalex.org/W2130410032","https://openalex.org/W2131271579","https://openalex.org/W2137526110","https://openalex.org/W2142933606","https://openalex.org/W2157752701","https://openalex.org/W2160443244","https://openalex.org/W2161633633","https://openalex.org/W2162151166","https://openalex.org/W2169456326","https://openalex.org/W2179438025","https://openalex.org/W2273953524","https://openalex.org/W2406250479","https://openalex.org/W2417483443","https://openalex.org/W2432815617","https://openalex.org/W2511515754","https://openalex.org/W2529241974","https://openalex.org/W2626606138","https://openalex.org/W2725988230","https://openalex.org/W2750586496","https://openalex.org/W2768277839","https://openalex.org/W2784164089","https://openalex.org/W2788823524","https://openalex.org/W2805415233","https://openalex.org/W2811205482","https://openalex.org/W2869857059","https://openalex.org/W2886250128","https://openalex.org/W2949444664","https://openalex.org/W2950545834","https://openalex.org/W2952001873","https://openalex.org/W2952216579","https://openalex.org/W2952240264","https://openalex.org/W2975979350","https://openalex.org/W2980062155","https://openalex.org/W2981104463","https://openalex.org/W2999081734","https://openalex.org/W3008983522","https://openalex.org/W3013484278","https://openalex.org/W3025047014","https://openalex.org/W3025060722","https://openalex.org/W3041678484","https://openalex.org/W3083216853","https://openalex.org/W3084033366","https://openalex.org/W3084331777","https://openalex.org/W3099862724","https://openalex.org/W3103898717","https://openalex.org/W3106143834","https://openalex.org/W3116855495","https://openalex.org/W3126904753","https://openalex.org/W3128200801","https://openalex.org/W3129869677","https://openalex.org/W3131256500","https://openalex.org/W3133859624","https://openalex.org/W3145093875","https://openalex.org/W3158922343","https://openalex.org/W3171726680","https://openalex.org/W3185213122","https://openalex.org/W3192493086","https://openalex.org/W3195232032","https://openalex.org/W3199622685","https://openalex.org/W3213769184","https://openalex.org/W3216511043","https://openalex.org/W4297977428","https://openalex.org/W6931332985","https://openalex.org/W7096869818"],"related_works":["https://openalex.org/W6921016367","https://openalex.org/W4323042664","https://openalex.org/W4297783785","https://openalex.org/W1539137394","https://openalex.org/W7213375186","https://openalex.org/W6885097222","https://openalex.org/W6892221150","https://openalex.org/W1929484410","https://openalex.org/W4313857634","https://openalex.org/W7167813357"],"abstract_inverted_index":{"Transcriptome":[0],"studies":[1],"disentangle":[2],"functional":[3],"mechanisms":[4],"of":[5,15,21,104,111,136,155,180,209,220,229,237],"gene":[6],"expression":[7,187],"regulation":[8],"and":[9,57,63,73,93,100,121,168,186,191,206,212,222,235],"may":[10,43],"elucidate":[11],"the":[12,19,102,159,178,183,199],"underlying":[13],"biology":[14],"disease":[16],"processes.":[17],"However,":[18],"types":[20,37,185],"tissues":[22,42,107,161],"currently":[23],"collected":[24,115],"typically":[25],"assay":[26],"a":[27,109,134,152,217],"single":[28],"post-mortem":[29],"timepoint":[30],"or":[31],"are":[32],"limited":[33],"to":[34,69,130,172,177,202],"investigating":[35],"cell":[36,61,123,170,184],"found":[38,165],"in":[39,108,194,216],"blood.":[40],"Noninvasive":[41],"improve":[44],"disease-relevant":[45,195],"discovery":[46,234],"by":[47,54,64],"enabling":[48],"more":[49,59],"complex":[50],"longitudinal":[51],"study":[52,201],"designs,":[53],"capturing":[55],"different":[56],"potentially":[58],"applicable":[60],"types,":[62],"increasing":[65],"sample":[66,181],"sizes":[67],"due":[68,176],"reduced":[70],"collection":[71],"costs":[72],"possible":[74],"higher":[75],"enrollment":[76],"from":[77,125],"vulnerable":[78],"populations.":[79],"Here,":[80],"we":[81,142,162,164,189],"develop":[82],"methods":[83],"for":[84,133,151],"sampling":[85],"noninvasive":[86,106,210],"biospecimens,":[87],"investigate":[88],"their":[89,98,192,214],"performance":[90,193],"across":[91,147],"commercial":[92],"in-house":[94],"library":[95,149],"preparations,":[96,150],"characterize":[97],"biology,":[99],"assess":[101],"feasibility":[103],"using":[105],"multitude":[110],"transcriptomic":[112,221],"applications.":[113,196,239],"We":[114,225],"buccal":[116],"swabs,":[117],"hair":[118,166],"follicles,":[119],"saliva,":[120],"urine":[122,169],"pellets":[124,171],"19":[126],"individuals":[127],"over":[128],"three":[129,148],"four":[131,160],"timepoints,":[132],"total":[135],"300":[137],"unique":[138],"biological":[139,205],"samples,":[140],"which":[141],"then":[143],"prepared":[144],"with":[145],"replicates":[146],"final":[153],"tally":[154],"472":[156],"transcriptomes.":[157],"Of":[158],"studied,":[163],"follicles":[167],"be":[173],"most":[174],"promising":[175],"consistency":[179],"quality,":[182],"profiles":[188],"observed,":[190],"This":[197],"is":[198],"first":[200],"thoroughly":[203],"delineate":[204],"technical":[207],"features":[208],"samples":[211],"demonstrate":[213],"use":[215,228],"wide":[218],"array":[219],"clinical":[223,238],"analyses.":[224],"anticipate":[226],"future":[227],"these":[230],"biospecimens":[231],"will":[232],"facilitate":[233],"development":[236]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-20T00:00:00"}