{"id":"https://openalex.org/W4389943995","doi":"https://doi.org/10.1152/ajplung.00096.2023","title":"Direct thrombin inhibitors fail to reverse the negative effects of heparin on lung growth and function after murine left pneumonectomy","display_name":"Direct thrombin inhibitors fail to reverse the negative effects of heparin on lung growth and function after murine left pneumonectomy","publication_year":2023,"publication_date":"2023-12-19","ids":{"openalex":"https://openalex.org/W4389943995","doi":"https://doi.org/10.1152/ajplung.00096.2023","pmid":"https://pubmed.ncbi.nlm.nih.gov/38113296","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11280676"},"language":"en","primary_location":{"id":"doi:10.1152/ajplung.00096.2023","doi":"https://doi.org/10.1152/ajplung.00096.2023","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00096.2023","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11280676","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009395727","display_name":"Savas T. Tsikis","orcid":"https://orcid.org/0000-0001-7588-8372","observed_orcids":["https://orcid.org/0000-0001-7588-8372"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Savas T. Tsikis","raw_affiliation_strings":["Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","Vascular Biology Program, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Vascular Biology Program, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006895638","display_name":"Thomas I. Hirsch","orcid":"https://orcid.org/0000-0002-1373-2388","observed_orcids":["https://orcid.org/0000-0002-1373-2388"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas I. Hirsch","raw_affiliation_strings":["Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","Vascular Biology Program, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Vascular Biology Program, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061112239","display_name":"Timothy M. Klouda","orcid":"https://orcid.org/0000-0002-8485-9773","observed_orcids":["https://orcid.org/0000-0002-8485-9773"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Klouda","raw_affiliation_strings":["Division of Pulmonary Medicine, Boston Children\u2019s Hospital, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Medicine, Boston Children\u2019s Hospital, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004978310","display_name":"Scott C. Fligor","orcid":"https://orcid.org/0000-0003-4591-9371","observed_orcids":["https://orcid.org/0000-0003-4591-9371"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott C. Fligor","raw_affiliation_strings":["Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","Vascular Biology Program, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Vascular Biology Program, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102840958","display_name":"Amy Pan","orcid":"https://orcid.org/0000-0002-7615-9590","observed_orcids":["https://orcid.org/0000-0002-7615-9590"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Pan","raw_affiliation_strings":["Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","Vascular Biology Program, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Vascular Biology Program, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089547675","display_name":"Malachi M. Joiner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malachi M. Joiner","raw_affiliation_strings":["Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","Vascular Biology Program, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Vascular Biology Program, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016705813","display_name":"Sarah Ziqi Wang","orcid":"https://orcid.org/0000-0003-3080-6665","observed_orcids":["https://orcid.org/0000-0003-3080-6665"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Z. Wang","raw_affiliation_strings":["Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","Vascular Biology Program, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States"],"raw_orcid":"https://orcid.org/0000-0003-3080-6665","affiliations":[{"raw_affiliation_string":"Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Vascular Biology Program, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073961807","display_name":"Mikayla Quigley","orcid":"https://orcid.org/0000-0002-5143-9879","observed_orcids":["https://orcid.org/0000-0002-5143-9879"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mikayla Quigley","raw_affiliation_strings":["Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","Vascular Biology Program, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States"],"raw_orcid":"https://orcid.org/0000-0002-5143-9879","affiliations":[{"raw_affiliation_string":"Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Vascular Biology Program, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013514065","display_name":"Angela Devietro","orcid":"https://orcid.org/0009-0000-3785-5203","observed_orcids":["https://orcid.org/0009-0000-3785-5203"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Devietro","raw_affiliation_strings":["Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","Vascular Biology Program, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Vascular Biology Program, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036335734","display_name":"Paul D. Mitchell","orcid":"https://orcid.org/0000-0001-7034-1669","observed_orcids":["https://orcid.org/0000-0001-7034-1669"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul D. Mitchell","raw_affiliation_strings":["Institutional Centers for Clinical and Translational Research, Boston Children\u2019s Hospital, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institutional Centers for Clinical and Translational Research, Boston Children\u2019s Hospital, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005190420","display_name":"Hiroko Kishikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroko Kishikawa","raw_affiliation_strings":["Vascular Biology Program, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Biology Program, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055481715","display_name":"Ke Yuan","orcid":"https://orcid.org/0000-0001-8085-5452","observed_orcids":["https://orcid.org/0000-0001-8085-5452"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ke Yuan","raw_affiliation_strings":["Division of Pulmonary Medicine, Boston Children\u2019s Hospital, Boston, Massachusetts, United States"],"raw_orcid":"https://orcid.org/0000-0001-8085-5452","affiliations":[{"raw_affiliation_string":"Division of Pulmonary Medicine, Boston Children\u2019s Hospital, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062540776","display_name":"Mark Puder","orcid":"https://orcid.org/0000-0002-7941-2926","observed_orcids":["https://orcid.org/0000-0002-7941-2926"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark Puder","raw_affiliation_strings":["Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","Vascular Biology Program, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States"],"raw_orcid":"https://orcid.org/0000-0002-7941-2926","affiliations":[{"raw_affiliation_string":"Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Vascular Biology Program, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062540776"],"corresponding_institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":0.5189,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.66820589,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"326","issue":"3","first_page":"L213","last_page":"L225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11586","display_name":"Congenital Diaphragmatic Hernia Studies","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/direct-thrombin-inhibitors","display_name":"direct thrombin inhibitors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/compensatory-lung-growth","display_name":"compensatory lung growth","score":0.9739999771118164},{"id":"https://openalex.org/keywords/left-pneumonectomy","display_name":"left pneumonectomy","score":0.7879999876022339},{"id":"https://openalex.org/keywords/pulmonary-hypoplasia","display_name":"pulmonary hypoplasia","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lung-growth","display_name":"lung growth","score":0.5889999866485596},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.9850000143051147},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cardiopulmonary-bypass","display_name":"cardiopulmonary bypass","score":0.9679999947547913},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C2779612170","wikidata":"https://www.wikidata.org/wiki/Q474880","display_name":"Argatroban","level":4,"score":0.9036273956298828},{"id":"https://openalex.org/C2777565915","wikidata":"https://www.wikidata.org/wiki/Q4919218","display_name":"Bivalirudin","level":4,"score":0.873926043510437},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.7733253240585327},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7495182156562805},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46117934584617615},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.44765225052833557},{"id":"https://openalex.org/C2776710957","wikidata":"https://www.wikidata.org/wiki/Q5280395","display_name":"Direct thrombin inhibitor","level":5,"score":0.4360389709472656},{"id":"https://openalex.org/C2778205648","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant","level":2,"score":0.4161386787891388},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3408561944961548},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.32903730869293213},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3123067319393158},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.2168940305709839},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.07078021764755249},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.05821794271469116},{"id":"https://openalex.org/C2778810321","wikidata":"https://www.wikidata.org/wiki/Q419345","display_name":"Dabigatran","level":4,"score":0.0},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.0},{"id":"https://openalex.org/C2780400711","wikidata":"https://www.wikidata.org/wiki/Q2008344","display_name":"Percutaneous coronary intervention","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000991","descriptor_name":"Antithrombins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000991","descriptor_name":"Antithrombins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006629","descriptor_name":"Hirudins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010875","descriptor_name":"Pipecolic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011013","descriptor_name":"Pneumonectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajplung.00096.2023","doi":"https://doi.org/10.1152/ajplung.00096.2023","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00096.2023","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11280676","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11280676","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Lung Cell Mol Physiol","raw_type":"Text"},{"id":"pmid:38113296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38113296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Lung cellular and molecular physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11280676","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11280676","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Lung Cell Mol Physiol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9958000183105469,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2156316066","display_name":"Harvard Longwood Research Training in Vascular Surgery","funder_award_id":"5t32hl007734-30","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G388572957","display_name":null,"funder_award_id":"T-32HL007734","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4095947116","display_name":"A novel mouse model of Pulmonary Hypertension due to systemic Endothelial Cell Dysfunction","funder_award_id":"F32HL167554","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5829768055","display_name":"Boston Intellectual and Developmental Disabilities Research Center","funder_award_id":"U54HD090255","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000151253","display_name":null,"funder_award_id":"5T32-HL007734","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000885800","display_name":"Harvard Longwood Short-Term Research Training in Vascular Surgery","funder_award_id":"T35HL110843","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000920798","display_name":"Research Training in Alimentary Tract Surgery","funder_award_id":"T32DK007754","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320308605","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59"},{"id":"https://openalex.org/F4320309356","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1209674312","https://openalex.org/W1985140717","https://openalex.org/W1987099899","https://openalex.org/W2006464386","https://openalex.org/W2019525209","https://openalex.org/W2026283204","https://openalex.org/W2033781842","https://openalex.org/W2037665008","https://openalex.org/W2039337035","https://openalex.org/W2045213325","https://openalex.org/W2047620726","https://openalex.org/W2065282285","https://openalex.org/W2107277218","https://openalex.org/W2114360920","https://openalex.org/W2120964907","https://openalex.org/W2151280162","https://openalex.org/W2155499896","https://openalex.org/W2156018831","https://openalex.org/W2156597171","https://openalex.org/W2160929440","https://openalex.org/W2162965008","https://openalex.org/W2163940367","https://openalex.org/W2164714478","https://openalex.org/W2197255439","https://openalex.org/W2324847023","https://openalex.org/W2404283651","https://openalex.org/W2462946440","https://openalex.org/W2466124353","https://openalex.org/W2522719174","https://openalex.org/W2593243176","https://openalex.org/W2741205354","https://openalex.org/W2797937027","https://openalex.org/W2810728443","https://openalex.org/W2888943055","https://openalex.org/W2921441540","https://openalex.org/W3000723502","https://openalex.org/W3035413757","https://openalex.org/W3042622343","https://openalex.org/W3043929122","https://openalex.org/W3152790783","https://openalex.org/W3164513104","https://openalex.org/W3188682159","https://openalex.org/W4283014351","https://openalex.org/W4301396086","https://openalex.org/W4311582850","https://openalex.org/W4311951437","https://openalex.org/W4378952059","https://openalex.org/W4387540852"],"related_works":["https://openalex.org/W4311582850","https://openalex.org/W2810728443","https://openalex.org/W4301396086","https://openalex.org/W4410007732","https://openalex.org/W2046876029","https://openalex.org/W2325687401","https://openalex.org/W2997218911","https://openalex.org/W4322723744","https://openalex.org/W2048676023","https://openalex.org/W2065824556"],"abstract_inverted_index":{"Infants":[0],"with":[1,66],"pulmonary":[2,29],"hypoplasia":[3],"frequently":[4],"require":[5],"cardiopulmonary":[6],"bypass":[7],"and":[8,20,28,57],"systemic":[9],"anticoagulation.":[10],"We":[11],"investigate":[12],"the":[13,48,62],"effects":[14,50],"of":[15,35,51,64],"simultaneous":[16],"exposure":[17],"to":[18,46],"heparin":[19,53,65],"direct":[21],"thrombin":[22],"inhibitors":[23],"(DTIs)":[24],"on":[25,54,61,68],"lung":[26,37,55],"growth":[27,38,56],"function":[30],"in":[31],"a":[32],"murine":[33],"model":[34],"compensatory":[36],"(CGL).":[39],"Our":[40],"data":[41],"suggest":[42],"that":[43],"DTIs":[44,67],"fail":[45],"reverse":[47],"inhibitory":[49],"subtherapeutic":[52],"function.":[58],"Clinical":[59],"studies":[60],"impact":[63],"clinical":[69],"outcomes":[70],"are":[71],"thus":[72],"warranted.":[73]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-20T00:00:00"}
