{"id":"https://openalex.org/W4389943268","doi":"https://doi.org/10.21203/rs.3.rs-3763231/v1","title":"Causal association between metabolites and cardiovascular MACE events: a two-sample Mendelian randomization study","display_name":"Causal association between metabolites and cardiovascular MACE events: a two-sample Mendelian randomization study","publication_year":2023,"publication_date":"2023-12-19","ids":{"openalex":"https://openalex.org/W4389943268","doi":"https://doi.org/10.21203/rs.3.rs-3763231/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-3763231/v1","doi":"https://doi.org/10.21203/rs.3.rs-3763231/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3763231/v1","pdf_url":"https://www.researchsquare.com/article/rs-3763231/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-3763231/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102649643","display_name":"Xuanchun Huang","orcid":"https://orcid.org/0009-0009-8486-6496","observed_orcids":["https://orcid.org/0009-0009-8486-6496"]},"institutions":[{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210127599","display_name":"Xiyuan Hospital","ror":"https://ror.org/02y0vze35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127599"]},{"id":"https://openalex.org/I4210146387","display_name":"Guang\u2019anmen Hospital","ror":"https://ror.org/04gjmb875","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146387"]}],"countries":["CN","FR"],"is_corresponding":false,"raw_author_name":"Xuanchun Huang","raw_affiliation_strings":["Guang\u2019anmen Hospital","Guang'anmen Hospital Research","PSL University","Xiyuan Hospital","anmen Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guang\u2019anmen Hospital","institution_ids":["https://openalex.org/I4210146387"]},{"raw_affiliation_string":"Guang'anmen Hospital Research","institution_ids":["https://openalex.org/I4210146387"]},{"raw_affiliation_string":"PSL University","institution_ids":["https://openalex.org/I2746051580"]},{"raw_affiliation_string":"Xiyuan Hospital","institution_ids":["https://openalex.org/I4210127599"]},{"raw_affiliation_string":"anmen Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102594276","display_name":"Lanshuo Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210127599","display_name":"Xiyuan Hospital","ror":"https://ror.org/02y0vze35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127599"]},{"id":"https://openalex.org/I4210146387","display_name":"Guang\u2019anmen Hospital","ror":"https://ror.org/04gjmb875","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146387"]}],"countries":["CN","FR"],"is_corresponding":false,"raw_author_name":"Lanshuo Hu","raw_affiliation_strings":["Xiyuan Hospital","Guang'anmen Hospital Research","PSL University","anmen Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xiyuan Hospital","institution_ids":["https://openalex.org/I4210127599"]},{"raw_affiliation_string":"Guang'anmen Hospital Research","institution_ids":["https://openalex.org/I4210146387"]},{"raw_affiliation_string":"PSL University","institution_ids":["https://openalex.org/I2746051580"]},{"raw_affiliation_string":"anmen Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362092","display_name":"Jun Li","orcid":"https://orcid.org/0000-0003-3519-8638","observed_orcids":["https://orcid.org/0000-0003-3519-8638"]},"institutions":[{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210127599","display_name":"Xiyuan Hospital","ror":"https://ror.org/02y0vze35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127599"]},{"id":"https://openalex.org/I4210146387","display_name":"Guang\u2019anmen Hospital","ror":"https://ror.org/04gjmb875","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146387"]}],"countries":["CN","FR"],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":["Guang\u2019anmen Hospital","Guang'anmen Hospital Research","PSL University","Xiyuan Hospital","anmen Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guang\u2019anmen Hospital","institution_ids":["https://openalex.org/I4210146387"]},{"raw_affiliation_string":"Guang'anmen Hospital Research","institution_ids":["https://openalex.org/I4210146387"]},{"raw_affiliation_string":"PSL University","institution_ids":["https://openalex.org/I2746051580"]},{"raw_affiliation_string":"Xiyuan Hospital","institution_ids":["https://openalex.org/I4210127599"]},{"raw_affiliation_string":"anmen Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078427812","display_name":"Shiyi Tao","orcid":"https://orcid.org/0000-0003-1339-6449","observed_orcids":["https://orcid.org/0000-0003-1339-6449"]},"institutions":[{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210127599","display_name":"Xiyuan Hospital","ror":"https://ror.org/02y0vze35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127599"]},{"id":"https://openalex.org/I4210146387","display_name":"Guang\u2019anmen Hospital","ror":"https://ror.org/04gjmb875","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146387"]}],"countries":["CN","FR"],"is_corresponding":false,"raw_author_name":"Shiyi Tao","raw_affiliation_strings":["Guang\u2019anmen Hospital","Guang'anmen Hospital Research","PSL University","Xiyuan Hospital","anmen Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guang\u2019anmen Hospital","institution_ids":["https://openalex.org/I4210146387"]},{"raw_affiliation_string":"Guang'anmen Hospital Research","institution_ids":["https://openalex.org/I4210146387"]},{"raw_affiliation_string":"PSL University","institution_ids":["https://openalex.org/I2746051580"]},{"raw_affiliation_string":"Xiyuan Hospital","institution_ids":["https://openalex.org/I4210127599"]},{"raw_affiliation_string":"anmen Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tiantian Xue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210127599","display_name":"Xiyuan Hospital","ror":"https://ror.org/02y0vze35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127599"]},{"id":"https://openalex.org/I4210146387","display_name":"Guang\u2019anmen Hospital","ror":"https://ror.org/04gjmb875","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146387"]}],"countries":["CN","FR"],"is_corresponding":false,"raw_author_name":"Tiantian Xue","raw_affiliation_strings":["Guang\u2019anmen Hospital","Guang'anmen Hospital Research","PSL University","Xiyuan Hospital","anmen Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guang\u2019anmen Hospital","institution_ids":["https://openalex.org/I4210146387"]},{"raw_affiliation_string":"Guang'anmen Hospital Research","institution_ids":["https://openalex.org/I4210146387"]},{"raw_affiliation_string":"PSL University","institution_ids":["https://openalex.org/I2746051580"]},{"raw_affiliation_string":"Xiyuan Hospital","institution_ids":["https://openalex.org/I4210127599"]},{"raw_affiliation_string":"anmen Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111339440","display_name":"Zihao Jia","orcid":"https://orcid.org/0000-0001-8416-2207","observed_orcids":["https://orcid.org/0000-0001-8416-2207"]},"institutions":[{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210127599","display_name":"Xiyuan Hospital","ror":"https://ror.org/02y0vze35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127599"]},{"id":"https://openalex.org/I4210146387","display_name":"Guang\u2019anmen Hospital","ror":"https://ror.org/04gjmb875","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146387"]}],"countries":["CN","FR"],"is_corresponding":false,"raw_author_name":"Zihao Jia","raw_affiliation_strings":["PSL University","Guang'anmen Hospital Research","Xiyuan Hospital","anmen Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PSL University","institution_ids":["https://openalex.org/I2746051580"]},{"raw_affiliation_string":"Guang'anmen Hospital Research","institution_ids":["https://openalex.org/I4210146387"]},{"raw_affiliation_string":"Xiyuan Hospital","institution_ids":["https://openalex.org/I4210127599"]},{"raw_affiliation_string":"anmen Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114626525","display_name":"Yuqing Tan","orcid":"https://orcid.org/0000-0001-9016-2043","observed_orcids":["https://orcid.org/0000-0001-9016-2043"]},"institutions":[{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210127599","display_name":"Xiyuan Hospital","ror":"https://ror.org/02y0vze35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127599"]},{"id":"https://openalex.org/I4210146387","display_name":"Guang\u2019anmen Hospital","ror":"https://ror.org/04gjmb875","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146387"]}],"countries":["CN","FR"],"is_corresponding":false,"raw_author_name":"Yuqing Tan","raw_affiliation_strings":["Guang\u2019anmen Hospital","Guang'anmen Hospital Research","PSL University","Xiyuan Hospital","anmen Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guang\u2019anmen Hospital","institution_ids":["https://openalex.org/I4210146387"]},{"raw_affiliation_string":"Guang'anmen Hospital Research","institution_ids":["https://openalex.org/I4210146387"]},{"raw_affiliation_string":"PSL University","institution_ids":["https://openalex.org/I2746051580"]},{"raw_affiliation_string":"Xiyuan Hospital","institution_ids":["https://openalex.org/I4210127599"]},{"raw_affiliation_string":"anmen Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100385514","display_name":"Wenjie Zhang","orcid":"https://orcid.org/0000-0002-7753-695X","observed_orcids":["https://orcid.org/0000-0002-7753-695X","https://orcid.org/0009-0006-7757-6536","https://orcid.org/0009-0007-2231-4253"]},"institutions":[{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210127599","display_name":"Xiyuan Hospital","ror":"https://ror.org/02y0vze35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127599"]},{"id":"https://openalex.org/I4210146387","display_name":"Guang\u2019anmen Hospital","ror":"https://ror.org/04gjmb875","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146387"]}],"countries":["CN","FR"],"is_corresponding":false,"raw_author_name":"Wenjie Zhang","raw_affiliation_strings":["Guang\u2019anmen Hospital","Guang'anmen Hospital Research","PSL University","Xiyuan Hospital","anmen Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guang\u2019anmen Hospital","institution_ids":["https://openalex.org/I4210146387"]},{"raw_affiliation_string":"Guang'anmen Hospital Research","institution_ids":["https://openalex.org/I4210146387"]},{"raw_affiliation_string":"PSL University","institution_ids":["https://openalex.org/I2746051580"]},{"raw_affiliation_string":"Xiyuan Hospital","institution_ids":["https://openalex.org/I4210127599"]},{"raw_affiliation_string":"anmen Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014432483","display_name":"Chengzhi Hou","orcid":"https://orcid.org/0009-0007-3842-1934","observed_orcids":["https://orcid.org/0009-0007-3842-1934","https://orcid.org/0009-0002-7468-6140"]},"institutions":[{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210127599","display_name":"Xiyuan Hospital","ror":"https://ror.org/02y0vze35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127599"]},{"id":"https://openalex.org/I4210146387","display_name":"Guang\u2019anmen Hospital","ror":"https://ror.org/04gjmb875","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146387"]}],"countries":["CN","FR"],"is_corresponding":false,"raw_author_name":"Chengzhi Hou","raw_affiliation_strings":["Guang\u2019anmen Hospital","Guang'anmen Hospital Research","PSL University","Xiyuan Hospital","anmen Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guang\u2019anmen Hospital","institution_ids":["https://openalex.org/I4210146387"]},{"raw_affiliation_string":"Guang'anmen Hospital Research","institution_ids":["https://openalex.org/I4210146387"]},{"raw_affiliation_string":"PSL University","institution_ids":["https://openalex.org/I2746051580"]},{"raw_affiliation_string":"Xiyuan Hospital","institution_ids":["https://openalex.org/I4210127599"]},{"raw_affiliation_string":"anmen Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100994385","display_name":"Lijun Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210127599","display_name":"Xiyuan Hospital","ror":"https://ror.org/02y0vze35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127599"]},{"id":"https://openalex.org/I4210146387","display_name":"Guang\u2019anmen Hospital","ror":"https://ror.org/04gjmb875","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146387"]}],"countries":["CN","FR"],"is_corresponding":false,"raw_author_name":"Lijun Zhou","raw_affiliation_strings":["Guang\u2019anmen Hospital","Guang'anmen Hospital Research","PSL University","Xiyuan Hospital","anmen Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guang\u2019anmen Hospital","institution_ids":["https://openalex.org/I4210146387"]},{"raw_affiliation_string":"Guang'anmen Hospital Research","institution_ids":["https://openalex.org/I4210146387"]},{"raw_affiliation_string":"PSL University","institution_ids":["https://openalex.org/I2746051580"]},{"raw_affiliation_string":"Xiyuan Hospital","institution_ids":["https://openalex.org/I4210127599"]},{"raw_affiliation_string":"anmen Hospital","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.711899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.711899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.2078000009059906,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13522","display_name":"Cardiovascular Health and Risk Factors","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-metabolites","display_name":"circulating metabolites","score":0.9700000286102295},{"id":"https://openalex.org/keywords/metabolite-ratios","display_name":"metabolite ratios","score":0.871999979019165},{"id":"https://openalex.org/keywords/adverse-cardiovascular-events","display_name":"cardiovascular adverse events","score":0.8949999809265137},{"id":"https://openalex.org/keywords/major-adverse-cardiovascular-events","display_name":"major adverse cardiovascular events","score":0.949999988079071},{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.9869999885559082},{"id":"https://openalex.org/keywords/unstable-angina","display_name":"unstable angina","score":0.996999979019165},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"sudden cardiac death","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cardiac-arrest","display_name":"cardiac arrest","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ventricular-tachycardia","display_name":"ventricular tachycardia","score":0.9779999852180481},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cerebral-infarction","display_name":"cerebral infarction","score":0.9909999966621399},{"id":"https://openalex.org/keywords/metabolic-pathways","display_name":"metabolic pathways","score":0.5920000076293945},{"id":"https://openalex.org/keywords/causal-inference","display_name":"causal inference","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.7291671633720398},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6965950131416321},{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.6913630366325378},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.630276083946228},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5531021952629089},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5186923742294312},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5151687860488892},{"id":"https://openalex.org/C2780739214","wikidata":"https://www.wikidata.org/wiki/Q6723023","display_name":"Mace","level":4,"score":0.4170154929161072},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.19106149673461914},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10912144184112549},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C45393284","wikidata":"https://www.wikidata.org/wiki/Q191012","display_name":"Conventional PCI","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-3763231/v1","doi":"https://doi.org/10.21203/rs.3.rs-3763231/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3763231/v1","pdf_url":"https://www.researchsquare.com/article/rs-3763231/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-3763231/v1","doi":"https://doi.org/10.21203/rs.3.rs-3763231/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3763231/v1","pdf_url":"https://www.researchsquare.com/article/rs-3763231/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2732488210","display_name":null,"funder_award_id":"2022YFC3500102","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8136752133","display_name":null,"funder_award_id":"81973836","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389943268.pdf","grobid_xml":"https://content.openalex.org/works/W4389943268.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1980969588","https://openalex.org/W1988440417","https://openalex.org/W2110658722","https://openalex.org/W2122684027","https://openalex.org/W2143568518","https://openalex.org/W2145303015","https://openalex.org/W2151872224","https://openalex.org/W2156997639","https://openalex.org/W2605386896","https://openalex.org/W2733189736","https://openalex.org/W2803072880","https://openalex.org/W2805983714","https://openalex.org/W2818417770","https://openalex.org/W2888234192","https://openalex.org/W2896968341","https://openalex.org/W2921416645","https://openalex.org/W2968365563","https://openalex.org/W2970508404","https://openalex.org/W3030688161","https://openalex.org/W3085836815","https://openalex.org/W3091206828","https://openalex.org/W3108705101","https://openalex.org/W3164708567","https://openalex.org/W3176700441","https://openalex.org/W3209061495","https://openalex.org/W3209105871","https://openalex.org/W3211659156","https://openalex.org/W3211761308","https://openalex.org/W3211941066","https://openalex.org/W3213406154","https://openalex.org/W3214398689","https://openalex.org/W4211103501","https://openalex.org/W4221112734","https://openalex.org/W4294678292","https://openalex.org/W4294751956","https://openalex.org/W4311902572","https://openalex.org/W4313575607","https://openalex.org/W4315779240","https://openalex.org/W4321788006","https://openalex.org/W4380301670","https://openalex.org/W4385060542"],"related_works":["https://openalex.org/W4408918347","https://openalex.org/W4401631760","https://openalex.org/W7126160609","https://openalex.org/W3206251030","https://openalex.org/W7163739130","https://openalex.org/W4402943491","https://openalex.org/W3131762117","https://openalex.org/W4388080415","https://openalex.org/W4398170755","https://openalex.org/W7164908854"],"abstract_inverted_index":{"Abstract":[0],"Objective:":[1],"Adverse":[2],"cardiovascular":[3,10,48,80,176,233,259],"events":[4,50,82],"are":[5],"key":[6],"clinical":[7],"endpoints":[8],"in":[9,25,63],"diseases.":[11],"Recent":[12],"metabolomics":[13],"studies":[14],"have":[15],"highlighted":[16],"the":[17,26,38,109,112,145,150,236,239,243,268],"significant":[18,125,224],"role":[19],"of":[20,30,47,124,149,184,238,245,271],"metabolites":[21,43,70,123,160,170,186,225,256],"and":[22,28,44,74,98,111,126,138,147,171,215,220,226,265],"their":[23,76],"ratios":[24,173],"occurrence":[27],"progression":[29],"these":[31,188,272],"events.":[32,178,273],"This":[33],"study":[34,167,270],"aims":[35],"to":[36,116,121,143,232],"explore":[37],"causal":[39,163,182],"relationship":[40],"between":[41],"circulating":[42,69],"seven":[45,79],"types":[46],"adverse":[49,81,177,234,260],"using":[51],"Mendelian":[52,58,250],"randomization":[53,59,251],"analysis.":[54],"Methods:":[55],"A":[56],"two-sample":[57],"analysis":[60,155,241],"was":[61,105,156],"employed":[62],"this":[64],"study.":[65],"We":[66,179],"selected":[67],"1,400":[68],"as":[71],"exposure":[72],"factors":[73],"examined":[75],"association":[77],"with":[78,161,175,187,191,195,199,204,208,212,217,258],"(including":[83],"Acute":[84,200],"Myocardial":[85,201],"Infarction,":[86,193,202],"Unstable":[87,196],"Angina,":[88,197],"sudden":[89],"Cardiac":[90,92,209],"Death,":[91,214],"Arrest,":[93,210],"Ventricular":[94],"Tachycardia,":[95],"Heart":[96,218],"Failure,":[97],"Cerebral":[99,192],"Infarction).":[100],"The":[101],"inverse-variance":[102],"weighted":[103],"method":[104],"primarily":[106],"used":[107],"for":[108,158,267],"analysis,":[110,252],"results":[113,237],"were":[114,141],"subjected":[115],"FDR":[117],"multiple":[118,130,255],"testing":[119],"correction":[120],"identify":[122],"potential":[127,181],"relevance.":[128],"Additionally,":[129],"sensitivity":[131,240],"analyses,":[132],"including":[133],"MR":[134],"Egger":[135],"intercept,":[136],"MR-PRESSO,":[137],"Cochran":[139],"Q,":[140],"conducted":[142],"enhance":[144],"reliability":[146],"accuracy":[148],"findings.":[151,247],"Finally,":[152],"metabolic":[153,228],"pathway":[154],"performed":[157],"all":[159],"established":[162],"relationships.":[164],"Results:":[165],"Our":[166],"identified":[168,254],"254":[169],"metabolite":[172],"associated":[174,257],"confirmed":[180],"relationships":[183],"339":[185],"diseases":[189],"(53":[190],"29":[194],"22":[198],"53":[203],"Malignant":[205],"Arrhythmias,":[206],"57":[207],"62":[211],"Cardiogenic":[213],"63":[216],"Failure),":[219],"eventually":[221],"pinpointed":[222],"7":[223],"12":[227],"pathways":[229],"closely":[230],"related":[231],"events.Meanwhile,":[235],"showed":[242],"stability":[244],"our":[246],"Conclusion:":[248],"Through":[249],"we":[253],"events,":[261],"providing":[262],"vital":[263],"evidence":[264],"support":[266],"metabolomic":[269]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-12-20T00:00:00"}