{"id":"https://openalex.org/W4389940253","doi":"https://doi.org/10.1161/circ.148.suppl_1.12968","title":"Abstract 12968: Atorvastatin for the Treatment of Endocardial Fibroelastosis Formation in a Preclinical Animal Model","display_name":"Abstract 12968: Atorvastatin for the Treatment of Endocardial Fibroelastosis Formation in a Preclinical Animal Model","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4389940253","doi":"https://doi.org/10.1161/circ.148.suppl_1.12968"},"language":"en","primary_location":{"id":"doi:10.1161/circ.148.suppl_1.12968","doi":"https://doi.org/10.1161/circ.148.suppl_1.12968","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.12968","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031025266","display_name":"Gregor Gierlinger","orcid":"https://orcid.org/0000-0002-6358-5048","observed_orcids":["https://orcid.org/0000-0002-6358-5048"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregor Gierlinger","raw_affiliation_strings":["Cardiac Surgery, Boston Children's Hosp, Harvard Med Sch, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiac Surgery, Boston Children's Hosp, Harvard Med Sch, Boston, MA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040937065","display_name":"Lavinia Rech","orcid":"https://orcid.org/0000-0002-0787-446X","observed_orcids":["https://orcid.org/0000-0002-0787-446X"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lavinia Rech","raw_affiliation_strings":["Cardiac Surgery, Boston Children's Hosp, Harvard Med Sch, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiac Surgery, Boston Children's Hosp, Harvard Med Sch, Boston, MA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031855645","display_name":"Sophia Koutsogiannaki","orcid":"https://orcid.org/0000-0003-3555-1681","observed_orcids":["https://orcid.org/0000-0003-3555-1681"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sophia Koutsogiannaki","raw_affiliation_strings":["Dept of Anesthesiology, Critical Care and Pain Medicine, Cardiac Anesthesia Div, Boston Children's Hosp, Harvard Med Sch, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Anesthesiology, Critical Care and Pain Medicine, Cardiac Anesthesia Div, Boston Children's Hosp, Harvard Med Sch, Boston, MA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072175237","display_name":"Sitaram M. Emani","orcid":"https://orcid.org/0000-0002-6048-2078","observed_orcids":["https://orcid.org/0000-0002-6048-2078"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sitaram M Emani","raw_affiliation_strings":["Cardiac Surgery, Boston Children's Hosp, Harvard Med Sch, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiac Surgery, Boston Children's Hosp, Harvard Med Sch, Boston, MA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001927963","display_name":"Pedro J. del Nido","orcid":"https://orcid.org/0000-0003-4252-8789","observed_orcids":["https://orcid.org/0000-0003-4252-8789"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pedro J Del Nido","raw_affiliation_strings":["Cardiac Surgery, Boston Children's Hosp, Harvard Med Sch, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiac Surgery, Boston Children's Hosp, Harvard Med Sch, Boston, MA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022775023","display_name":"Ingeborg Friehs","orcid":"https://orcid.org/0000-0002-2631-2972","observed_orcids":["https://orcid.org/0000-0002-2631-2972"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ingeborg Friehs","raw_affiliation_strings":["Cardiac Surgery, Boston Children's Hosp, Harvard Med Sch, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiac Surgery, Boston Children's Hosp, Harvard Med Sch, Boston, MA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"148","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.46950000524520874,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.46950000524520874,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.37450000643730164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endocardial-fibroelastosis","display_name":"endocardial fibroelastosis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":0.996999979019165},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.7369999885559082},{"id":"https://openalex.org/keywords/klf2","display_name":"KLF2","score":0.8019999861717224},{"id":"https://openalex.org/keywords/endothelial-mesenchymal-transition","display_name":"endothelial-to-mesenchymal transition","score":0.8550000190734863},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8199999928474426},{"id":"https://openalex.org/keywords/smad2-3","display_name":"Smad2/3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.824999988079071},{"id":"https://openalex.org/keywords/heterotopic-heart-transplantation","display_name":"heterotopic heart transplantation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/hypoplastic-left-heart-syndrome","display_name":"hypoplastic left heart syndrome","score":0.7839999794960022},{"id":"https://openalex.org/keywords/aortic-stenosis","display_name":"aortic stenosis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/neonatal-rat-heart","display_name":"neonatal rat heart","score":0.7910000085830688},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.3179999887943268}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8633910417556763},{"id":"https://openalex.org/C2777482532","wikidata":"https://www.wikidata.org/wiki/Q668093","display_name":"Atorvastatin","level":2,"score":0.8536306023597717},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7518608570098877},{"id":"https://openalex.org/C2777350992","wikidata":"https://www.wikidata.org/wiki/Q18035329","display_name":"KLF2","level":4,"score":0.6611641645431519},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.5719237327575684},{"id":"https://openalex.org/C2781278803","wikidata":"https://www.wikidata.org/wiki/Q5376225","display_name":"Endocardial fibroelastosis","level":2,"score":0.5542270541191101},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4896283745765686},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43897706270217896},{"id":"https://openalex.org/C2778849806","wikidata":"https://www.wikidata.org/wiki/Q643396","display_name":"Heart transplantation","level":3,"score":0.42440056800842285},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39231547713279724},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.35220810770988464},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3433641195297241},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.148.suppl_1.12968","doi":"https://doi.org/10.1161/circ.148.suppl_1.12968","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.12968","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7400000095367432}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391017860","https://openalex.org/W4391990057","https://openalex.org/W4328026537","https://openalex.org/W4380794814","https://openalex.org/W4232936722","https://openalex.org/W3103177437","https://openalex.org/W2759095427","https://openalex.org/W2131977410","https://openalex.org/W4389074559","https://openalex.org/W138647887"],"abstract_inverted_index":{"Background:":[0],"Endocardial":[1],"fibroelastosis":[2],"(EFE)":[3],"frequently":[4],"associated":[5],"with":[6,89],"development":[7],"of":[8,15,22,37,87,147,262],"HLHS":[9],"or":[10],"critical":[11],"AS,":[12],"restricting":[13],"growth":[14,220],"the":[16,26,45,55,85,175,183,207,236,252,260],"left":[17],"ventricle":[18],"(LV).":[19],"The":[20,79],"mechanism":[21],"EFE":[23,92,112,137,169,223,249],"formation":[24,224,250],"is":[25,42],"transition":[27],"from":[28,227],"endocardial":[29],"endothelial":[30],"cells":[31,34],"to":[32,82,128,180],"mesenchymal":[33],"(EndMT).":[35],"Regulation":[36],"EndMT":[38],"in":[39,174,182,193,206,255],"cardiac":[40],"fibrosis":[41],"mainly":[43],"through":[44,222,259],"TGF-\u03b2":[46],"pathway,":[47],"and":[48,72,126,153,158,164,201,211],"upregulated":[49,192],"Kr\u00fcppel-like":[50],"factor":[51],"2":[52],"(KLF2)":[53],"inhibits":[54,91],"TGF-\u00df":[56],"pathway":[57],"by":[58,151,156],"blocking":[59],"SMAD2/3.":[60],"Besides":[61],"their":[62],"plasma":[63],"lipid-lowering":[64],"effect,":[65],"statins":[66],"(e.g.":[67],"Atorvastatin)":[68],"directly":[69],"upregulate":[70],"KLF2":[71,88,148,189],"are":[73],"thereby":[74],"atheroprotective":[75],"(i.e.,":[76],"inhibit":[77],"EndMT).":[78],"aim":[80],"was":[81,99,116,139,149,171,190],"evaluate":[83],"whether":[84],"upregulation":[86,261],"Atorvastatin":[90,114,176,194,247,264],"formation.":[93],"Methods:":[94],"Heterotopic":[95],"rat":[96,257],"heart":[97],"transplantation":[98],"performed":[100],"using":[101],"2-4":[102],"day-old":[103],"donor":[104],"hearts":[105,196,258],"into":[106],"adolescent":[107],"recipients,":[108],"which":[109],"induces":[110],"LV":[111,136,168,219,253],"growth.":[113],"(n=7)":[115],"administered":[117],"daily":[118],"at":[119],"3":[120],"mg/kg":[121],"intraperitoneally":[122],"for":[123,162],"two":[124],"weeks":[125],"compared":[127,179],"untreated/vehicle":[129],"(n=5)":[130],"controls.":[131],"At":[132],"postoperative":[133],"day":[134],"14,":[135],"thickness":[138,170],"determined":[140],"on":[141],"Masson\u2019s":[142],"trichrome-stained":[143],"slides.":[144],"Gene":[145],"expression":[146,155],"analyzed":[150],"qRT-PCR":[152],"protein":[154],"Westernblot":[157],"quantified":[159],"via":[160],"densitometry":[161],"SMAD2/3":[163,200],"collagen.":[165],"Results:":[166],"Mean":[167],"significantly":[172,191,204],"decreased":[173],"group":[177,185],"(22.3\u00b12.5\u03bcm)":[178],"176.8\u00b122.6\u03bcm":[181],"untreated/vehicle-treated":[184],"(p<0.0001,":[186],"A":[187],").":[188,199,217],"treated":[195],"(p=0.0173,":[197],"B":[198],"collagen":[202],"were":[203],"elevated":[205],"control":[208],"group,":[209],"p=0.0014":[210],"p=0.048,":[212],"respectively":[213],"(":[214],"C,":[215],"D":[216],"Conclusion:":[218],"restriction":[221],"precludes":[225],"patients":[226],"biventricular":[228],"repair.":[229],"Until":[230],"now,":[231],"surgical":[232],"resection":[233],"has":[234],"been":[235],"only":[237],"available":[238],"therapeutic":[239,269],"option.":[240],"With":[241],"this":[242],"study,":[243],"we":[244],"show":[245],"that":[246],"impedes":[248],"within":[251],"cavity":[254],"neonatal":[256],"KLF2.":[263],"is,":[265],"therefore":[266],"a":[267],"promising":[268],"agent.":[270]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2023-12-20T00:00:00"}