{"id":"https://openalex.org/W4389939858","doi":"https://doi.org/10.1161/circ.148.suppl_1.15427","title":"Abstract 15427: Lipoprotein(a) Proteomic Signatures and Links to Metabolic Pathways","display_name":"Abstract 15427: Lipoprotein(a) Proteomic Signatures and Links to Metabolic Pathways","publication_year":2023,"publication_date":"2023-11-07","ids":{"openalex":"https://openalex.org/W4389939858","doi":"https://doi.org/10.1161/circ.148.suppl_1.15427"},"language":"en","primary_location":{"id":"doi:10.1161/circ.148.suppl_1.15427","doi":"https://doi.org/10.1161/circ.148.suppl_1.15427","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.15427","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066455990","display_name":"Nelsa Matienzo","orcid":"https://orcid.org/0000-0002-8826-0311","observed_orcids":["https://orcid.org/0000-0002-8826-0311"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nelsa Matienzo","raw_affiliation_strings":["Preventive Medicine, Columbia Univ, New York, NY","Nelsa Matienzo Preventive Medicine, Columbia Univ, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preventive Medicine, Columbia Univ, New York, NY","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Nelsa Matienzo Preventive Medicine, Columbia Univ, New York, NY","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008128204","display_name":"Anastasiya Matveyenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anastasiya Matveyenko","raw_affiliation_strings":["Columbia Univ Med Cntr, New York, NY","Anastasiya Matveyenko Columbia Univ Med Cntr, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia Univ Med Cntr, New York, NY","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Anastasiya Matveyenko Columbia Univ Med Cntr, New York, NY","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079956746","display_name":"Rajesh Kumar Soni","orcid":"https://orcid.org/0000-0002-4556-4358","observed_orcids":["https://orcid.org/0000-0002-4556-4358"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajesh Soni","raw_affiliation_strings":["Columbia Univ, New York, NY","Rajesh Soni Columbia Univ, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia Univ, New York, NY","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Rajesh Soni Columbia Univ, New York, NY","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012063139","display_name":"Gissette Reyes\u2010Soffer","orcid":"https://orcid.org/0000-0002-6746-4569","observed_orcids":["https://orcid.org/0000-0002-6746-4569"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gissette Reyes-Soffer","raw_affiliation_strings":["Columbia Univ Med Cntr, New York, NY","Gissette Reyes-Soffer Columbia Univ Med Cntr, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia Univ Med Cntr, New York, NY","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Gissette Reyes-Soffer Columbia Univ Med Cntr, New York, NY","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064861833","display_name":"Masanori Aikawa","orcid":"https://orcid.org/0000-0002-9275-2079","observed_orcids":["https://orcid.org/0000-0002-9275-2079"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masanori Aikawa","raw_affiliation_strings":["Brigham and Women`s Hosp, Boston, MA","Masanori Aikawa Brigham and Women`s Hosp, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women`s Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Masanori Aikawa Brigham and Women`s Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015707475","display_name":"Sasha A. Singh","orcid":"https://orcid.org/0000-0003-0929-3164","observed_orcids":["https://orcid.org/0000-0003-0929-3164"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sasha A Singh","raw_affiliation_strings":["Harvard BWH, Boston, MA","Sasha A Singh Harvard BWH, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard BWH, Boston, MA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Sasha A Singh Harvard BWH, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"148","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.7271000146865845,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.7271000146865845,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.1615000069141388,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.031700000166893005,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipoprotein-a","display_name":"lipoprotein(a)","score":0.996999979019165},{"id":"https://openalex.org/keywords/apolipoprotein-a","display_name":"apolipoprotein(a)","score":0.9660000205039978},{"id":"https://openalex.org/keywords/apolipoprotein-b-100","display_name":"apolipoprotein B-100","score":0.9909999966621399},{"id":"https://openalex.org/keywords/atherosclerotic-cardiovascular-disease","display_name":"atherosclerotic cardiovascular disease","score":0.9440000057220459},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7879999876022339},{"id":"https://openalex.org/keywords/metabolic-pathways","display_name":"metabolic pathways","score":0.703000009059906},{"id":"https://openalex.org/keywords/immunoprecipitation","display_name":"immunoprecipitation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.41600000858306885},{"id":"https://openalex.org/keywords/gene-ontology-biological-processes","display_name":"Gene Ontology biological process","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.8127001523971558},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.6491091251373291},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.5873106122016907},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5093687772750854},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.4950653612613678},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.4767509400844574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46498459577560425},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.4615815281867981},{"id":"https://openalex.org/C2910703447","wikidata":"https://www.wikidata.org/wiki/Q494918","display_name":"Protein Array Analysis","level":5,"score":0.42776015400886536},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41957688331604004},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4179735779762268},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3780423700809479},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32864871621131897},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3187456429004669},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.28295931220054626},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26874780654907227},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.20090439915657043},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1903107464313507},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.09050467610359192}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.148.suppl_1.15427","doi":"https://doi.org/10.1161/circ.148.suppl_1.15427","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.148.suppl_1.15427","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7141237277","https://openalex.org/W3168909088","https://openalex.org/W2010477467","https://openalex.org/W4417444514","https://openalex.org/W4403809558","https://openalex.org/W7171524977","https://openalex.org/W4415791050","https://openalex.org/W2965500866","https://openalex.org/W2046152785","https://openalex.org/W7212047560"],"abstract_inverted_index":{"Introduction:":[0],"High":[1],"levels":[2,16],"of":[3,11,35,91,216,224,236],"Lp(a)":[4,44,75,177,191,203,217,237],"are":[5,21,193],"positively":[6],"associated":[7,188],"with":[8,102,189],"the":[9,125,145,157,166,190],"development":[10],"ASCVD.":[12],"The":[13,180],"pathways":[14,48,210,230],"regulating":[15],"and":[17,31,45,108,141,163,186,198,228,241],"links":[18,46,218,238],"to":[19,39,47,219,233,239],"disease":[20,52,220],"not":[22],"clear.":[23],"Lipoprotein(a)":[24],"has":[25],"two":[26,95,158,207],"main":[27],"proteins:":[28],"apolipoprotein(a)":[29],"[apo(a)]":[30],"apolipoporoteinB100":[32],"(apoB100).The":[33],"aim":[34],"this":[36],"study":[37],"was":[38,76],"describe":[40],"additional":[41],"proteins":[42,132,143,154],"on":[43,121,195],"that":[49,99,173,211],"may":[50],"drive":[51],"mechanisms.":[53,221],"Methods:":[54],"We":[55,151],"analyzed":[56],"plasma":[57],"from":[58,178],"10":[59],"healthy":[60],"volunteers,":[61],"mean":[62],"age":[63],"47":[64],"\u00b113":[65],"years,":[66],"50%":[67],"female":[68],"(5":[69],"Blacks,":[70],"3":[71,105],"Hispanics,":[72],"2":[73],"Whites).":[74],"isolated":[77],"via":[78,138,148,206],"immunoprecipitation":[79],"(IP).":[80],"Two":[81],"distinct":[82],"proteome":[83,192,204],"analyses":[84],"were":[85,100,114,118,130],"compared:":[86],"in-gel":[87,139],"versus":[88],"in-solution":[89,149],"digestion":[90],"immunoprecipitated":[92,176],"Lp(a),":[93],"in":[94,110,134],"independent":[96],"laboratories.":[97],"Proteins":[98],"identified":[101,133],"at":[103],"least":[104],"unique":[106],"peptides,":[107],"present":[109],"every":[111,135],"IP":[112,136],"sample":[113,137],"considered.":[115],"Biological":[116],"networks":[117,187],"generated":[119],"based":[120],"protein":[122],"abundance":[123],"using":[124],"STRING":[126],"database.":[127],"Results:":[128],"There":[129],"55":[131],"preparation":[140],"92":[142],"met":[144,165],"same":[146],"criteria":[147,168],"preparation.":[150],"found":[152],"26":[153],"overlapping":[155],"between":[156],"methods":[159],"(Table":[160],"1A).":[161],"Apo(a)":[162],"apoB100":[164],"strict":[167],"we":[169,174],"set":[170],"forth,":[171],"showing":[172],"successfully":[175],"plasma.":[179],"top":[181],"gene":[182],"ontology":[183],"biological":[184],"processes":[185],"presented":[194],"Table":[196],"1B":[197],"Figure":[199],"1,":[200],"respectively.":[201],"Conclusions:":[202],"analysis":[205],"platforms":[208],"provides":[209],"can":[212,231],"increase":[213],"our":[214],"understanding":[215,235],"Further":[222],"studies":[223],"these":[225],"protein-protein":[226],"interactions":[227],"their":[229],"lead":[232],"enhanced":[234],"ASCVD":[240],"other":[242],"diseases.":[243]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2023-12-20T00:00:00"}
