{"id":"https://openalex.org/W4389938463","doi":"https://doi.org/10.7554/elife.89465.2","title":"Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling","display_name":"Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling","publication_year":2023,"publication_date":"2023-12-19","ids":{"openalex":"https://openalex.org/W4389938463","doi":"https://doi.org/10.7554/elife.89465.2"},"language":"en","primary_location":{"id":"doi:10.7554/elife.89465.2","doi":"https://doi.org/10.7554/elife.89465.2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.89465.2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.89465.2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"E. Nicholas Petersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Nicholas Petersen","raw_affiliation_strings":["Departments of Molecular Medicine, The Scripps Research Institute","Scripps Research Skaggs Graduate School of Chemical and Biological Science, The Scripps Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Medicine, The Scripps Research Institute","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Scripps Research Skaggs Graduate School of Chemical and Biological Science, The Scripps Research Institute","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025659709","display_name":"Mahmud Arif Pavel","orcid":"https://orcid.org/0009-0005-2813-315X","observed_orcids":["https://orcid.org/0009-0005-2813-315X","https://orcid.org/0000-0002-2709-8744"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahmud Arif Pavel","raw_affiliation_strings":["Departments of Molecular Medicine, The Scripps Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Medicine, The Scripps Research Institute","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104249369","display_name":"Samuel S. Hansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel S. Hansen","raw_affiliation_strings":["Departments of Molecular Medicine, The Scripps Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Medicine, The Scripps Research Institute","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079553489","display_name":"Manasa V. Gudheti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manasa Gudheti","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100446197","display_name":"Hao Wang","orcid":"https://orcid.org/0000-0003-1966-7940","observed_orcids":["https://orcid.org/0000-0003-1966-7940"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Wang","raw_affiliation_strings":["Departments of Molecular Medicine, The Scripps Research Institute","Scripps Research Skaggs Graduate School of Chemical and Biological Science, The Scripps Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Medicine, The Scripps Research Institute","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Scripps Research Skaggs Graduate School of Chemical and Biological Science, The Scripps Research Institute","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004297048","display_name":"Zixuan Yuan","orcid":"https://orcid.org/0000-0003-0665-5086","observed_orcids":["https://orcid.org/0000-0003-0665-5086"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zixuan Yuan","raw_affiliation_strings":["Departments of Molecular Medicine, The Scripps Research Institute","Scripps Research Skaggs Graduate School of Chemical and Biological Science, The Scripps Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Medicine, The Scripps Research Institute","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Scripps Research Skaggs Graduate School of Chemical and Biological Science, The Scripps Research Institute","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103875971","display_name":"Keith R. Murphy","orcid":"https://orcid.org/0000-0001-6085-7477","observed_orcids":["https://orcid.org/0000-0001-6085-7477"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith R. Murphy","raw_affiliation_strings":["Center on Aging, The Scripps Research Institute","Department of Neuroscience, The Scripps Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center on Aging, The Scripps Research Institute","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Department of Neuroscience, The Scripps Research Institute","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014717275","display_name":"William W. Ja","orcid":"https://orcid.org/0000-0002-4003-7356","observed_orcids":["https://orcid.org/0000-0002-4003-7356"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William W. Ja","raw_affiliation_strings":["Center on Aging, The Scripps Research Institute","Department of Neuroscience, The Scripps Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center on Aging, The Scripps Research Institute","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Department of Neuroscience, The Scripps Research Institute","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075413007","display_name":"Heather Anne Ferris","orcid":"https://orcid.org/0000-0002-6321-3447","observed_orcids":["https://orcid.org/0000-0002-6321-3447"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather A Ferris","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia"],"raw_orcid":"https://orcid.org/0000-0002-6321-3447","affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026863162","display_name":"Erik M. J\u00f8rgensen","orcid":"https://orcid.org/0000-0002-2978-8028","observed_orcids":["https://orcid.org/0000-0002-2978-8028"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erik M. Jorgensen","raw_affiliation_strings":["Department of Biology, Howard Hughes Medical Institute, University of Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Howard Hughes Medical Institute, University of Utah","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019457716","display_name":"Scott B. Hansen","orcid":"https://orcid.org/0000-0003-0086-9753","observed_orcids":["https://orcid.org/0000-0003-0086-9753"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott B. Hansen","raw_affiliation_strings":["Departments of Molecular Medicine, The Scripps Research Institute"],"raw_orcid":"https://orcid.org/0000-0003-0086-9753","affiliations":[{"raw_affiliation_string":"Departments of Molecular Medicine, The Scripps Research Institute","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7583000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7583000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.05559999868273735,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.051100000739097595,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.7950000166893005},{"id":"https://openalex.org/keywords/trek-1","display_name":"TREK-1","score":0.7879999876022339},{"id":"https://openalex.org/keywords/pld2","display_name":"phospholipase D2","score":0.9900000095367432},{"id":"https://openalex.org/keywords/gm1-ganglioside","display_name":"GM1 ganglioside","score":0.8330000042915344},{"id":"https://openalex.org/keywords/phosphatidic-acid","display_name":"phosphatidic acid","score":0.8019999861717224},{"id":"https://openalex.org/keywords/membrane-cholesterol","display_name":"membrane cholesterol","score":0.7829999923706055},{"id":"https://openalex.org/keywords/second-messenger-signaling","display_name":"second messenger signaling","score":0.7049999833106995},{"id":"https://openalex.org/keywords/stretch-activated-channels","display_name":"stretch-activated channels","score":0.5320000052452087},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C45206210","wikidata":"https://www.wikidata.org/wiki/Q2415817","display_name":"Nanoscopic scale","level":2,"score":0.6409778594970703},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.613332211971283},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.4949471354484558},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.48030489683151245},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.42606645822525024},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.32867610454559326},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3169417381286621},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.30545753240585327},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.29039961099624634},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.20442304015159607},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20157641172409058},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.1373017430305481},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1147233247756958},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11460772156715393},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.89465.2","doi":"https://doi.org/10.7554/elife.89465.2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.89465.2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.7554/elife.89465.2","doi":"https://doi.org/10.7554/elife.89465.2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.89465.2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3013105663","display_name":"The role of lipid raft disruption in the activation of TREK-1 channels by anesthetics","funder_award_id":"R01NS112534","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4569138828","display_name":"Nutritional and Epigenetic Priming of Metabolism and Aging in Drosophila","funder_award_id":"R01AG045036","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G716402209","display_name":"Molecular Mechanism of Mechanosensation","funder_award_id":"1dp2ns087943-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309468","display_name":"Memorial Sloan-Kettering Cancer Center","ror":"https://ror.org/02yrq0923"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W98403486","https://openalex.org/W1882994060","https://openalex.org/W1883044208","https://openalex.org/W1937251821","https://openalex.org/W1969929083","https://openalex.org/W1980802466","https://openalex.org/W1990008286","https://openalex.org/W1998987638","https://openalex.org/W2013853780","https://openalex.org/W2016555254","https://openalex.org/W2020290863","https://openalex.org/W2024012749","https://openalex.org/W2038133979","https://openalex.org/W2055211642","https://openalex.org/W2062409614","https://openalex.org/W2063277345","https://openalex.org/W2070249223","https://openalex.org/W2073576660","https://openalex.org/W2076937557","https://openalex.org/W2079725368","https://openalex.org/W2081481124","https://openalex.org/W2082406934","https://openalex.org/W2084231847","https://openalex.org/W2089702423","https://openalex.org/W2106477171","https://openalex.org/W2109845530","https://openalex.org/W2114956843","https://openalex.org/W2115183962","https://openalex.org/W2130826825","https://openalex.org/W2138936877","https://openalex.org/W2150097452","https://openalex.org/W2157194890","https://openalex.org/W2507162566","https://openalex.org/W2549162961","https://openalex.org/W2551486871","https://openalex.org/W2564652835","https://openalex.org/W2579178448","https://openalex.org/W2590662729","https://openalex.org/W2744096091","https://openalex.org/W2744875884","https://openalex.org/W2764091427","https://openalex.org/W2786890077","https://openalex.org/W2788462601","https://openalex.org/W2792253966","https://openalex.org/W2799813643","https://openalex.org/W2799943205","https://openalex.org/W2802077859","https://openalex.org/W2900754207","https://openalex.org/W2902894675","https://openalex.org/W2943777537","https://openalex.org/W2978278087","https://openalex.org/W2982294226","https://openalex.org/W3013114009","https://openalex.org/W3022559985","https://openalex.org/W3029613935","https://openalex.org/W3103328760","https://openalex.org/W3183975923","https://openalex.org/W4211168555","https://openalex.org/W4211224007","https://openalex.org/W4213264523","https://openalex.org/W4223593055","https://openalex.org/W4295908847","https://openalex.org/W4321372363","https://openalex.org/W4381801298","https://openalex.org/W4382364133","https://openalex.org/W4382680278","https://openalex.org/W4387648722"],"related_works":["https://openalex.org/W3174614074","https://openalex.org/W2982294226","https://openalex.org/W3176490875","https://openalex.org/W2084231847","https://openalex.org/W197227626","https://openalex.org/W98403486","https://openalex.org/W1980802466","https://openalex.org/W6925389291","https://openalex.org/W3217390172","https://openalex.org/W2020290863"],"abstract_inverted_index":{"Abstract":[0],"Rapid":[1],"conversion":[2],"of":[3,35,54,65,100,110,139,153,162,175],"force":[4,21,88],"into":[5],"a":[6,42,49,108,148,198],"biological":[7,149],"signal":[8],"enables":[9],"living":[10],"cells":[11],"to":[12,14,24,114,184,196],"respond":[13],"mechanical":[15,87,185],"forces":[16],"in":[17,147,158,171,179,182],"their":[18],"environment.":[19],"The":[20,119],"is":[22,41,46,70],"believed":[23],"initially":[25],"affect":[26],"the":[27,33,90,98,103,124,128,136,176],"plasma":[28],"membrane":[29,36,95],"and":[30,56,75,81,106,112,160],"then":[31],"alter":[32],"behavior":[34],"proteins.":[37],"Phospholipase":[38],"D2":[39],"(PLD2)":[40],"mechanosensitive":[43],"enzyme":[44],"that":[45,134],"regulated":[47],"by":[48,73],"structured":[50],"membrane-lipid":[51],"site":[52],"comprised":[53],"cholesterol":[55,154,163],"saturated":[57],"ganglioside":[58],"(GM1).":[59],"Here":[60],"we":[61],"show":[62],"stretch":[63,145],"activation":[64],"TWIK-related":[66],"K+":[67],"channel":[68],"(TREK-1)":[69],"mechanically":[71,199],"evoked":[72,200],"PLD2":[74,101,113,142,177,189],"spatial":[76],"patterning":[77],"involving":[78],"ordered":[79,91],"GM1":[80,104,169],"4,5-":[82],"bisphosphate":[83],"(PIP2)":[84],"clusters.":[85,118],"First,":[86],"deforms":[89],"lipids,":[92,105],"which":[93,126],"lowers":[94],"cholesterol,":[96],"disrupts":[97],"interaction":[99],"with":[102,116,121,192],"allows":[107],"complex":[109],"TREK-1":[111,144,156,167,193],"associate":[115],"PIP2":[117,122],"association":[120],"activates":[123],"enzyme,":[125],"produces":[127],"second":[129],"messenger":[130],"phosphatidic":[131],"acid":[132],"(PA)":[133],"gates":[135],"channel.":[137],"Co-expression":[138],"catalytically":[140],"inactive":[141],"inhibits":[143,155],"currents":[146,157],"membrane.":[150],"Cellular":[151],"uptake":[152],"culture":[159],"depletion":[161],"from":[164,168],"astrocytes":[165],"releases":[166],"lipids":[170],"mouse":[172],"brain.":[173],"Depletion":[174],"ortholog":[178],"flies":[180],"results":[181],"hypersensitivity":[183],"force.":[186],"We":[187],"conclude":[188],"mechanosensitivity":[190],"combines":[191],"ion":[194],"permeability":[195],"elicit":[197],"response.":[201]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-12-20T00:00:00"}
