{"id":"https://openalex.org/W4389937753","doi":"https://doi.org/10.1038/s41598-023-49902-8","title":"Inflammatory mediators drive neuroinflammation in autism spectrum disorder and cerebral palsy","display_name":"Inflammatory mediators drive neuroinflammation in autism spectrum disorder and cerebral palsy","publication_year":2023,"publication_date":"2023-12-18","ids":{"openalex":"https://openalex.org/W4389937753","doi":"https://doi.org/10.1038/s41598-023-49902-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/38114596","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10730823"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-023-49902-8","doi":"https://doi.org/10.1038/s41598-023-49902-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-49902-8","pdf_url":"https://www.nature.com/articles/s41598-023-49902-8.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-023-49902-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022788127","display_name":"Uyen Thi Trang Than","orcid":"https://orcid.org/0000-0002-2847-7068","observed_orcids":["https://orcid.org/0000-0002-2847-7068"]},"institutions":[{"id":"https://openalex.org/I4405276989","display_name":"Vinmec Healthcare System","ror":"https://ror.org/012rvtf75","country_code":"VN","type":"healthcare","lineage":["https://openalex.org/I4387154326","https://openalex.org/I4405276989"]},{"id":"https://openalex.org/I4405277745","display_name":"Vinmec Hi-Tech Center","ror":"https://ror.org/03refhz68","country_code":"VN","type":"facility","lineage":["https://openalex.org/I4387154326","https://openalex.org/I4405276989","https://openalex.org/I4405277745"]},{"id":"https://openalex.org/I4405277852","display_name":"Vinmec - VinUni Institute of Immunology","ror":"https://ror.org/043rh7g24","country_code":"VN","type":"facility","lineage":["https://openalex.org/I4210142044","https://openalex.org/I4405277852"]}],"countries":["VN"],"is_corresponding":true,"raw_author_name":"Uyen Thi Trang Than","raw_affiliation_strings":["Vinmec Hi-Tech Center and Vinmec-VinUni Institute of Immunology, Vinmec Healthcare System, Hanoi, 100000, Vietnam. v.uyenttt@vinmec.com","Vinmec Hi-Tech Center and Vinmec-VinUni Institute of Immunology, Vinmec Healthcare System, Hanoi, 100000, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vinmec Hi-Tech Center and Vinmec-VinUni Institute of Immunology, Vinmec Healthcare System, Hanoi, 100000, Vietnam. v.uyenttt@vinmec.com","institution_ids":["https://openalex.org/I4405276989","https://openalex.org/I4405277745","https://openalex.org/I4405277852"]},{"raw_affiliation_string":"Vinmec Hi-Tech Center and Vinmec-VinUni Institute of Immunology, Vinmec Healthcare System, Hanoi, 100000, Vietnam","institution_ids":["https://openalex.org/I4405276989","https://openalex.org/I4405277745","https://openalex.org/I4405277852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107501208","display_name":"Nguy\u1ec5n Thanh Li\u00eam","orcid":"https://orcid.org/0000-0002-4036-0161","observed_orcids":["https://orcid.org/0000-0002-4036-0161"]},"institutions":[{"id":"https://openalex.org/I4210142044","display_name":"VinUniversity","ror":"https://ror.org/052dmdr17","country_code":"VN","type":"education","lineage":["https://openalex.org/I4210142044"]},{"id":"https://openalex.org/I4405276886","display_name":"Vinmec Research Institute of Stem Cell and Gene Technology","ror":"https://ror.org/00nn14q45","country_code":"VN","type":"facility","lineage":["https://openalex.org/I4210142044","https://openalex.org/I4405276886"]},{"id":"https://openalex.org/I4405276989","display_name":"Vinmec Healthcare System","ror":"https://ror.org/012rvtf75","country_code":"VN","type":"healthcare","lineage":["https://openalex.org/I4387154326","https://openalex.org/I4405276989"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Liem Thanh Nguyen","raw_affiliation_strings":["College of Health Sciences, VinUniversity, Hanoi, 100000, Vietnam","Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi, 100000, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Health Sciences, VinUniversity, Hanoi, 100000, Vietnam","institution_ids":["https://openalex.org/I4210142044"]},{"raw_affiliation_string":"Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi, 100000, Vietnam","institution_ids":["https://openalex.org/I4405276886","https://openalex.org/I4405276989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010679414","display_name":"Hoang-Phuong Nguyen","orcid":"https://orcid.org/0000-0001-9544-5835","observed_orcids":["https://orcid.org/0000-0001-9544-5835"]},"institutions":[{"id":"https://openalex.org/I4210109845","display_name":"Vinmec Times City International Hospital","ror":"https://ror.org/01q2pxs68","country_code":"VN","type":"healthcare","lineage":["https://openalex.org/I4210109845","https://openalex.org/I4387154326","https://openalex.org/I4405276989"]},{"id":"https://openalex.org/I4405276886","display_name":"Vinmec Research Institute of Stem Cell and Gene Technology","ror":"https://ror.org/00nn14q45","country_code":"VN","type":"facility","lineage":["https://openalex.org/I4210142044","https://openalex.org/I4405276886"]},{"id":"https://openalex.org/I4405276989","display_name":"Vinmec Healthcare System","ror":"https://ror.org/012rvtf75","country_code":"VN","type":"healthcare","lineage":["https://openalex.org/I4387154326","https://openalex.org/I4405276989"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Phuong Hoang Nguyen","raw_affiliation_strings":["Vinmec International Hospital Times City, Vinmec Healthcare System, Hanoi, 100000, Vietnam","Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi, 100000, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vinmec International Hospital Times City, Vinmec Healthcare System, Hanoi, 100000, Vietnam","institution_ids":["https://openalex.org/I4210109845","https://openalex.org/I4405276989"]},{"raw_affiliation_string":"Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi, 100000, Vietnam","institution_ids":["https://openalex.org/I4405276886","https://openalex.org/I4405276989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035905672","display_name":"Xuan\u2010Hung Nguyen","orcid":"https://orcid.org/0000-0002-2216-8598","observed_orcids":["https://orcid.org/0000-0002-2216-8598"]},"institutions":[{"id":"https://openalex.org/I4210142044","display_name":"VinUniversity","ror":"https://ror.org/052dmdr17","country_code":"VN","type":"education","lineage":["https://openalex.org/I4210142044"]},{"id":"https://openalex.org/I4405276886","display_name":"Vinmec Research Institute of Stem Cell and Gene Technology","ror":"https://ror.org/00nn14q45","country_code":"VN","type":"facility","lineage":["https://openalex.org/I4210142044","https://openalex.org/I4405276886"]},{"id":"https://openalex.org/I4405276989","display_name":"Vinmec Healthcare System","ror":"https://ror.org/012rvtf75","country_code":"VN","type":"healthcare","lineage":["https://openalex.org/I4387154326","https://openalex.org/I4405276989"]},{"id":"https://openalex.org/I4405277745","display_name":"Vinmec Hi-Tech Center","ror":"https://ror.org/03refhz68","country_code":"VN","type":"facility","lineage":["https://openalex.org/I4387154326","https://openalex.org/I4405276989","https://openalex.org/I4405277745"]},{"id":"https://openalex.org/I4405277852","display_name":"Vinmec - VinUni Institute of Immunology","ror":"https://ror.org/043rh7g24","country_code":"VN","type":"facility","lineage":["https://openalex.org/I4210142044","https://openalex.org/I4405277852"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Xuan-Hung Nguyen","raw_affiliation_strings":["College of Health Sciences, VinUniversity, Hanoi, 100000, Vietnam","Vinmec Hi-Tech Center and Vinmec-VinUni Institute of Immunology, Vinmec Healthcare System, Hanoi, 100000, Vietnam","Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi, 100000, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Health Sciences, VinUniversity, Hanoi, 100000, Vietnam","institution_ids":["https://openalex.org/I4210142044"]},{"raw_affiliation_string":"Vinmec Hi-Tech Center and Vinmec-VinUni Institute of Immunology, Vinmec Healthcare System, Hanoi, 100000, Vietnam","institution_ids":["https://openalex.org/I4405276989","https://openalex.org/I4405277745","https://openalex.org/I4405277852"]},{"raw_affiliation_string":"Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi, 100000, Vietnam","institution_ids":["https://openalex.org/I4405276886","https://openalex.org/I4405276989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061563277","display_name":"Dong Phuong Trinh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177233841","display_name":"Vietnam National University, Hanoi","ror":"https://ror.org/02jmfj006","country_code":"VN","type":"education","lineage":["https://openalex.org/I177233841"]},{"id":"https://openalex.org/I67868205","display_name":"VNU University of Science","ror":"https://ror.org/05w54hk79","country_code":"VN","type":"education","lineage":["https://openalex.org/I177233841","https://openalex.org/I67868205"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Dong Phuong Trinh","raw_affiliation_strings":["Faculty of Biology, VNU University of Science, Vietnam National University, Hanoi, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biology, VNU University of Science, Vietnam National University, Hanoi, Vietnam","institution_ids":["https://openalex.org/I177233841","https://openalex.org/I67868205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053458227","display_name":"Diem Huong Hoang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405276989","display_name":"Vinmec Healthcare System","ror":"https://ror.org/012rvtf75","country_code":"VN","type":"healthcare","lineage":["https://openalex.org/I4387154326","https://openalex.org/I4405276989"]},{"id":"https://openalex.org/I4405277745","display_name":"Vinmec Hi-Tech Center","ror":"https://ror.org/03refhz68","country_code":"VN","type":"facility","lineage":["https://openalex.org/I4387154326","https://openalex.org/I4405276989","https://openalex.org/I4405277745"]},{"id":"https://openalex.org/I4405277852","display_name":"Vinmec - VinUni Institute of Immunology","ror":"https://ror.org/043rh7g24","country_code":"VN","type":"facility","lineage":["https://openalex.org/I4210142044","https://openalex.org/I4405277852"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Diem Huong Hoang","raw_affiliation_strings":["Vinmec Hi-Tech Center and Vinmec-VinUni Institute of Immunology, Vinmec Healthcare System, Hanoi, 100000, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vinmec Hi-Tech Center and Vinmec-VinUni Institute of Immunology, Vinmec Healthcare System, Hanoi, 100000, Vietnam","institution_ids":["https://openalex.org/I4405276989","https://openalex.org/I4405277745","https://openalex.org/I4405277852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113979739","display_name":"Phuong Anh Thi Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109845","display_name":"Vinmec Times City International Hospital","ror":"https://ror.org/01q2pxs68","country_code":"VN","type":"healthcare","lineage":["https://openalex.org/I4210109845","https://openalex.org/I4387154326","https://openalex.org/I4405276989"]},{"id":"https://openalex.org/I4405276886","display_name":"Vinmec Research Institute of Stem Cell and Gene Technology","ror":"https://ror.org/00nn14q45","country_code":"VN","type":"facility","lineage":["https://openalex.org/I4210142044","https://openalex.org/I4405276886"]},{"id":"https://openalex.org/I4405276989","display_name":"Vinmec Healthcare System","ror":"https://ror.org/012rvtf75","country_code":"VN","type":"healthcare","lineage":["https://openalex.org/I4387154326","https://openalex.org/I4405276989"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Phuong Anh Thi Nguyen","raw_affiliation_strings":["Vinmec International Hospital Times City, Vinmec Healthcare System, Hanoi, 100000, Vietnam","Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi, 100000, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vinmec International Hospital Times City, Vinmec Healthcare System, Hanoi, 100000, Vietnam","institution_ids":["https://openalex.org/I4210109845","https://openalex.org/I4405276989"]},{"raw_affiliation_string":"Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi, 100000, Vietnam","institution_ids":["https://openalex.org/I4405276886","https://openalex.org/I4405276989"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002693442","display_name":"Van Duc Dang","orcid":"https://orcid.org/0000-0002-0403-6479","observed_orcids":["https://orcid.org/0000-0002-0403-6479"]},"institutions":[{"id":"https://openalex.org/I177233841","display_name":"Vietnam National University, Hanoi","ror":"https://ror.org/02jmfj006","country_code":"VN","type":"education","lineage":["https://openalex.org/I177233841"]},{"id":"https://openalex.org/I4210095248","display_name":"German Rheumatism Research Centre","ror":"https://ror.org/00shv0x82","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210095248"]},{"id":"https://openalex.org/I4405276886","display_name":"Vinmec Research Institute of Stem Cell and Gene Technology","ror":"https://ror.org/00nn14q45","country_code":"VN","type":"facility","lineage":["https://openalex.org/I4210142044","https://openalex.org/I4405276886"]},{"id":"https://openalex.org/I4405276989","display_name":"Vinmec Healthcare System","ror":"https://ror.org/012rvtf75","country_code":"VN","type":"healthcare","lineage":["https://openalex.org/I4387154326","https://openalex.org/I4405276989"]},{"id":"https://openalex.org/I67868205","display_name":"VNU University of Science","ror":"https://ror.org/05w54hk79","country_code":"VN","type":"education","lineage":["https://openalex.org/I177233841","https://openalex.org/I67868205"]}],"countries":["DE","VN"],"is_corresponding":true,"raw_author_name":"Van Duc Dang","raw_affiliation_strings":["Deutsches Rheuma-Forschungszentrum Berlin, Leibniz Institute, Charit\u00e9platz 1, 10117, Berlin, Germany. van_duc.dang@drfz.de","Faculty of Biology, VNU University of Science, Vietnam National University, Hanoi, Vietnam. van_duc.dang@drfz.de","Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi, 100000, Vietnam. van_duc.dang@drfz.de","Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi, 100000, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deutsches Rheuma-Forschungszentrum Berlin, Leibniz Institute, Charit\u00e9platz 1, 10117, Berlin, Germany. van_duc.dang@drfz.de","institution_ids":["https://openalex.org/I4210095248"]},{"raw_affiliation_string":"Faculty of Biology, VNU University of Science, Vietnam National University, Hanoi, Vietnam. van_duc.dang@drfz.de","institution_ids":["https://openalex.org/I177233841","https://openalex.org/I67868205"]},{"raw_affiliation_string":"Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi, 100000, Vietnam. van_duc.dang@drfz.de","institution_ids":["https://openalex.org/I4405276886","https://openalex.org/I4405276989"]},{"raw_affiliation_string":"Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi, 100000, Vietnam","institution_ids":["https://openalex.org/I4405276886","https://openalex.org/I4405276989"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5002693442","https://openalex.org/A5022788127"],"corresponding_institution_ids":["https://openalex.org/I177233841","https://openalex.org/I4210095248","https://openalex.org/I4405276886","https://openalex.org/I4405276989","https://openalex.org/I4405277745","https://openalex.org/I4405277852","https://openalex.org/I67868205"],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":{"value":2390,"currency":"USD","value_usd":2390},"fwci":8.949,"has_fulltext":true,"cited_by_count":86,"citation_normalized_percentile":{"value":0.9874029,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"13","issue":"1","first_page":"22587","last_page":"22587"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.46630001068115234,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.46630001068115234,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.3928000032901764,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.05559999868273735,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cerebral-palsy","display_name":"cerebral palsy","score":1.0},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuroimmune-dysregulation","display_name":"neuroimmune dysregulation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.9319999814033508},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9950000047683716},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.8799999952316284},{"id":"https://openalex.org/keywords/autologous-bone-marrow-mononuclear-cells","display_name":"autologous bone marrow mononuclear cells","score":0.8259999752044678},{"id":"https://openalex.org/keywords/intrathecal-infusion","display_name":"intrathecal infusion","score":0.9399999976158142},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8190000057220459},{"id":"https://openalex.org/keywords/gdf15","display_name":"GDF15","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8050000071525574},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.9024864435195923},{"id":"https://openalex.org/C2779421357","wikidata":"https://www.wikidata.org/wiki/Q210427","display_name":"Cerebral palsy","level":2,"score":0.7513155937194824},{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.7440719604492188},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.6154286861419678},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5954521298408508},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5293237566947937},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.3846721649169922},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.34091126918792725},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33916234970092773},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2806302309036255},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.24265316128730774},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18915808200836182},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18721872568130493}],"mesh":[{"descriptor_ui":"D000067877","descriptor_name":"Autism Spectrum Disorder","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002547","descriptor_name":"Cerebral Palsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055436","descriptor_name":"Growth Differentiation Factor 15","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41598-023-49902-8","doi":"https://doi.org/10.1038/s41598-023-49902-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-49902-8","pdf_url":"https://www.nature.com/articles/s41598-023-49902-8.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10730823","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10730823","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10730823/pdf/41598_2023_Article_49902.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:38114596","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38114596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:53066eda1c1f45c693b0f64b2c7515ac","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/53066eda1c1f45c693b0f64b2c7515ac","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)","raw_type":"article"},{"id":"doi:10.60692/kap2v-q2669","doi":"https://doi.org/10.60692/kap2v-q2669","is_oa":true,"landing_page_url":"https://doi.org/10.60692/kap2v-q2669","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/t6rj7-92g26","doi":"https://doi.org/10.60692/t6rj7-92g26","is_oa":true,"landing_page_url":"https://doi.org/10.60692/t6rj7-92g26","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1038/s41598-023-49902-8","doi":"https://doi.org/10.1038/s41598-023-49902-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-49902-8","pdf_url":"https://www.nature.com/articles/s41598-023-49902-8.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389937753.pdf","grobid_xml":"https://content.openalex.org/works/W4389937753.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1084497830","https://openalex.org/W1409858176","https://openalex.org/W1994668373","https://openalex.org/W1994723621","https://openalex.org/W1995441076","https://openalex.org/W2000528744","https://openalex.org/W2016156103","https://openalex.org/W2017918524","https://openalex.org/W2020860790","https://openalex.org/W2021678927","https://openalex.org/W2022167001","https://openalex.org/W2022900996","https://openalex.org/W2023766860","https://openalex.org/W2028764793","https://openalex.org/W2053889945","https://openalex.org/W2086080135","https://openalex.org/W2095298460","https://openalex.org/W2107948768","https://openalex.org/W2137386978","https://openalex.org/W2144120552","https://openalex.org/W2522978005","https://openalex.org/W2559475643","https://openalex.org/W2574487650","https://openalex.org/W2604343829","https://openalex.org/W2607246646","https://openalex.org/W2770120393","https://openalex.org/W2771472591","https://openalex.org/W2810938035","https://openalex.org/W2883326166","https://openalex.org/W2885484006","https://openalex.org/W2888510495","https://openalex.org/W2954091661","https://openalex.org/W2969446747","https://openalex.org/W2972957576","https://openalex.org/W2980875245","https://openalex.org/W2984989497","https://openalex.org/W2989190040","https://openalex.org/W3022103698","https://openalex.org/W3024189495","https://openalex.org/W3032605986","https://openalex.org/W3084146010","https://openalex.org/W3094533074","https://openalex.org/W3124267950","https://openalex.org/W3126920123","https://openalex.org/W3177468671","https://openalex.org/W3186610103","https://openalex.org/W4285008675","https://openalex.org/W4288826042","https://openalex.org/W4383533832"],"related_works":["https://openalex.org/W4313340435","https://openalex.org/W3208965256","https://openalex.org/W7213628661","https://openalex.org/W2004265420","https://openalex.org/W7164176293","https://openalex.org/W2579983640","https://openalex.org/W2046989317","https://openalex.org/W3035058965","https://openalex.org/W7095980194","https://openalex.org/W2120701088"],"abstract_inverted_index":{"Inflammation":[0],"conditions":[1],"are":[2,186],"associated":[3],"with":[4,163],"autism":[5],"spectrum":[6],"disorder":[7],"(ASD)":[8],"and":[9,25,53,72,94,100,109,115,135,143,160,172,196],"cerebral":[10],"palsy":[11],"(CP),":[12],"primarily":[13],"observed":[14],"in":[15,51,133,138,158,183],"the":[16,21,36,44,48,139,153,164],"peripheral":[17],"immune":[18],"system.":[19],"However,":[20],"extent":[22],"of":[23,38,65,83,121,141,156],"neuro-inflammation":[24],"neuro-immune":[26,49],"dysregulation":[27],"remains":[28],"poorly":[29],"studied.":[30],"In":[31],"this":[32,184],"study,":[33],"we":[34],"analyzed":[35],"composition":[37,155],"cerebrospinal":[39],"fluid":[40],"(CSF)":[41],"to":[42,75,112,129,166],"uncover":[43],"inflammatory":[45,67,85],"mediators":[46],"driving":[47],"system":[50],"ASD":[52,60,116,142,159],"CP":[54,78,144,161],"patients.":[55,117],"Our":[56,147],"findings":[57],"revealed":[58],"that":[59],"patients":[61,79],"had":[62],"elevated":[63],"levels":[64,82,137],"four":[66],"cytokines":[68,86],"(TNF-\u03b1,":[69],"IL-4,":[70,91],"IL-21,":[71],"BAFF)":[73],"compared":[74,111],"controls,":[76],"while":[77],"exhibited":[80],"increased":[81],"eight":[84],"(IFN-\u03b3,":[87],"GM-CSF,":[88],"TNF-\u03b1,":[89],"IL-2,":[90],"IL-6,":[92],"IL-17A":[93],"IL-12),":[95],"one":[96],"anti-inflammatory":[97],"cytokine":[98],"(IL-10),":[99],"five":[101],"growth":[102],"factors":[103],"(GFs)":[104],"(NGF-\u03b2,":[105],"EGF,":[106],"GDF-15,":[107],"G-CSF":[108],"BMP-9)":[110],"both":[113],"controls":[114],"Additionally,":[118],"intrathecal":[119],"infusion":[120],"autologous":[122],"bone":[123],"marrow":[124],"mononuclear":[125],"cells":[126],"(BMMNCs)":[127],"led":[128],"a":[130],"slight":[131],"decrease":[132],"TGF-\u03b2":[134],"GDF-15":[136],"CSF":[140,157,180],"patients,":[145,162],"respectively.":[146],"study":[148,185],"provides":[149],"new":[150],"insights":[151],"into":[152],"molecular":[154],"potential":[165],"develop":[167],"more":[168],"effective":[169],"diagnosis":[170],"methods":[171],"improved":[173],"treatment":[174],"for":[175],"these":[176],"diseases.Clinical":[177],"trial":[178],"registration":[179],"samples":[181],"used":[182],"from":[187],"clinical":[188],"trials":[189],"NCT03225651,":[190],"NCT05307536,":[191],"NCT02569775,":[192],"NCT03123562,":[193],"NCT02574923,":[194],"NCT05472428":[195],"previous":[197],"reports":[198],"[7,":[199],"9,":[200],"17-19].":[201]},"counts_by_year":[{"year":2026,"cited_by_count":30},{"year":2025,"cited_by_count":36},{"year":2024,"cited_by_count":20}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-12-20T00:00:00"}