{"id":"https://openalex.org/W4389936734","doi":"https://doi.org/10.3233/cbm-230126","title":"Identification of the six-hormone secretion-related gene signature as a prognostic biomarker for colon adenocarcinoma","display_name":"Identification of the six-hormone secretion-related gene signature as a prognostic biomarker for colon adenocarcinoma","publication_year":2023,"publication_date":"2023-12-15","ids":{"openalex":"https://openalex.org/W4389936734","doi":"https://doi.org/10.3233/cbm-230126","pmid":"https://pubmed.ncbi.nlm.nih.gov/38143338"},"language":"en","primary_location":{"id":"doi:10.3233/cbm-230126","doi":"https://doi.org/10.3233/cbm-230126","is_oa":false,"landing_page_url":"https://doi.org/10.3233/cbm-230126","pdf_url":null,"source":{"id":"https://openalex.org/S61994691","display_name":"Cancer Biomarkers","issn_l":"1574-0153","issn":["1574-0153","1875-8592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biomarkers","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12412885/pdf/cbm-38-cbm230126.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033218122","display_name":"Xiongjie Jia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140680","display_name":"Affiliated Hospital of Hebei University","ror":"https://ror.org/049vsq398","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140680"]},{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiongjie Jia","raw_affiliation_strings":["Department of Gastrointestinal Surgery, Affiliated Hospital of Hebei University, Baoding, Heibei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, Affiliated Hospital of Hebei University, Baoding, Heibei, China","institution_ids":["https://openalex.org/I4210140680","https://openalex.org/I43337087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100375710","display_name":"Tao Zhang","orcid":"https://orcid.org/0000-0001-6643-4686","observed_orcids":["https://orcid.org/0000-0001-6643-4686","https://orcid.org/0009-0000-7908-8313"]},"institutions":[{"id":"https://openalex.org/I4210140680","display_name":"Affiliated Hospital of Hebei University","ror":"https://ror.org/049vsq398","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140680"]},{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Zhang","raw_affiliation_strings":["Department of Gastrointestinal Surgery, Affiliated Hospital of Hebei University, Baoding, Heibei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, Affiliated Hospital of Hebei University, Baoding, Heibei, China","institution_ids":["https://openalex.org/I4210140680","https://openalex.org/I43337087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047480726","display_name":"Xinze Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103129","display_name":"Burning Rock Biotech (China)","ror":"https://ror.org/01bdtz792","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210103129"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinze Lv","raw_affiliation_strings":["Burning Rock Biotech, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burning Rock Biotech, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210103129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043832057","display_name":"Haiwei Du","orcid":"https://orcid.org/0000-0002-4329-2088","observed_orcids":["https://orcid.org/0000-0002-4329-2088"]},"institutions":[{"id":"https://openalex.org/I4210103129","display_name":"Burning Rock Biotech (China)","ror":"https://ror.org/01bdtz792","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210103129"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiwei Du","raw_affiliation_strings":["Burning Rock Biotech, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burning Rock Biotech, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210103129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037865142","display_name":"Yongkun Sun","orcid":"https://orcid.org/0000-0003-3302-6023","observed_orcids":["https://orcid.org/0000-0003-3302-6023"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongkun Sun","raw_affiliation_strings":["Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100891785","display_name":"Yin Guan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800232565","display_name":"Beijing Chao-Yang Hospital, Capital Medical University","ror":"https://ror.org/01eff5662","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800232565","https://openalex.org/I4210110145","https://openalex.org/I4210135108"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yin Guan","raw_affiliation_strings":["Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I2800232565"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5037865142","https://openalex.org/A5100891785"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2800232565","https://openalex.org/I4210141458"],"apc_list":null,"apc_paid":null,"fwci":0.2062,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.52418713,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"38","issue":"4","first_page":"523","last_page":"535"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.38040000200271606,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.38040000200271606,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.14090000092983246,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.12129999697208405,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colon-adenocarcinoma","display_name":"colon adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/prognostic-gene-signature","display_name":"prognostic gene signature","score":0.949999988079071},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cyp19a1","display_name":"CYP19A1","score":0.8999999761581421},{"id":"https://openalex.org/keywords/foxd1","display_name":"FOXD1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/grp","display_name":"GRP","score":0.972000002861023},{"id":"https://openalex.org/keywords/inhbb","display_name":"INHBB","score":0.9990000128746033},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":1.0},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7900000214576721},{"id":"https://openalex.org/keywords/microsatellite-stability","display_name":"microsatellite stable","score":0.8410000205039978},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.777999997138977},{"id":"https://openalex.org/keywords/tumor-infiltrating-immune-cells","display_name":"tumor-infiltrating immune cells","score":0.781000018119812},{"id":"https://openalex.org/keywords/tide-score","display_name":"TIDE score","score":0.8360000252723694},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitor-response","display_name":"immune checkpoint inhibitor response","score":0.9319999814033508},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9509999752044678},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9240000247955322},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9350000023841858},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6941459774971008},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6393235921859741},{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.5250605940818787},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48572689294815063},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.485419362783432},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4605831503868103},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.45072507858276367},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.43357765674591064},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3897751569747925},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34995654225349426},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3269275426864624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2983092963695526},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27307963371276855},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2436707317829132},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13323000073432922},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3233/cbm-230126","doi":"https://doi.org/10.3233/cbm-230126","is_oa":false,"landing_page_url":"https://doi.org/10.3233/cbm-230126","pdf_url":null,"source":{"id":"https://openalex.org/S61994691","display_name":"Cancer Biomarkers","issn_l":"1574-0153","issn":["1574-0153","1875-8592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biomarkers","raw_type":"journal-article"},{"id":"pmid:38143338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38143338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer biomarkers : section A of Disease markers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12412885","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12412885/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12412885/pdf/cbm-38-cbm230126.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Biomark","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:12412885","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12412885/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12412885/pdf/cbm-38-cbm230126.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Biomark","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5099999904632568,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389936734.pdf","grobid_xml":"https://content.openalex.org/works/W4389936734.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1964680364","https://openalex.org/W2009494176","https://openalex.org/W2056241741","https://openalex.org/W2132177725","https://openalex.org/W2166973467","https://openalex.org/W2272984102","https://openalex.org/W2277514049","https://openalex.org/W2342496683","https://openalex.org/W2589692120","https://openalex.org/W2615399205","https://openalex.org/W2734910575","https://openalex.org/W2769165694","https://openalex.org/W2785180944","https://openalex.org/W2805421814","https://openalex.org/W2890846394","https://openalex.org/W2895926103","https://openalex.org/W2901068426","https://openalex.org/W2905048422","https://openalex.org/W2918104070","https://openalex.org/W2946089174","https://openalex.org/W2970045605","https://openalex.org/W2980682287","https://openalex.org/W3012240350","https://openalex.org/W3037381138","https://openalex.org/W3127164223","https://openalex.org/W3174022783","https://openalex.org/W3204208409","https://openalex.org/W3207746722","https://openalex.org/W3211375066","https://openalex.org/W4200200266","https://openalex.org/W4210292526","https://openalex.org/W4210531600","https://openalex.org/W4221123198","https://openalex.org/W4224078346","https://openalex.org/W4224880107","https://openalex.org/W4231887599","https://openalex.org/W4280534092","https://openalex.org/W4280592682","https://openalex.org/W4281982624","https://openalex.org/W4282015487","https://openalex.org/W4317480133","https://openalex.org/W4323543969","https://openalex.org/W4382774960","https://openalex.org/W4383101784","https://openalex.org/W4383679888"],"related_works":["https://openalex.org/W1671124163","https://openalex.org/W2533581028","https://openalex.org/W2168674042","https://openalex.org/W2090817358","https://openalex.org/W3030774134","https://openalex.org/W2111160383","https://openalex.org/W2056890439","https://openalex.org/W2104499293","https://openalex.org/W2092424613","https://openalex.org/W2535275505"],"abstract_inverted_index":{"BACKGROUND:":[0],"Colon":[1],"adenocarcinoma":[2],"(COAD)":[3],"is":[4,22],"a":[5,13,39,89,141,155,177,236,266,287],"globally":[6],"prevalent":[7],"cancer,":[8],"with":[9,112,193,205,228,243],"hormone":[10,29,44,71,272],"secretion":[11,30,91],"playing":[12],"crucial":[14],"role":[15],"in":[16,57,164,182,221,275,294],"its":[17],"progression.":[18],"Despite":[19],"this,":[20],"there":[21],"limited":[23],"understanding":[24],"of":[25,28,54,265],"the":[26,50,99,126,160,173,194,222,232,262],"impact":[27],"on":[31,43,270],"COAD":[32,67,295],"prognosis.":[33],"This":[34,259],"study":[35,139,260],"aimed":[36],"to":[37,48,87,133,250],"establish":[38],"prognostic":[40,142,263],"signature":[41,268,283],"based":[42,269],"secretion-related":[45,72,273],"genes":[46,56,73,84,274],"and":[47,81,102,118,125,128,148,163,170,199,203,207],"elucidate":[49],"potential":[51],"functional":[52,189],"mechanisms":[53],"these":[55],"COAD.":[58,276],"METHODS:":[59],"Using":[60],"data":[61],"from":[62,252],"The":[63,106,138,151,188,211,277],"Cancer":[64],"Genome":[65],"Atlas":[66],"cohort":[68],"(TCGA-COAD),":[69],"six":[70,271],"were":[74,85,123,131],"identified":[75],"(CYP19A1,":[76],"FOXD1,":[77],"GRP,":[78],"INHBB,":[79],"SPP1,":[80],"UCN).":[82],"These":[83],"used":[86,132],"develop":[88],"Hormone":[90],"score":[92,220],"(HSS),":[93],"which":[94],"was":[95,109],"then":[96],"evaluated":[97],"using":[98],"Kaplan-Meier":[100],"curve":[101],"multivariable":[103],"Cox":[104],"analysis.":[105],"HSS":[107,245,267],"model":[108],"further":[110],"validated":[111],"external":[113],"GEO":[114],"cohorts":[115],"(GSE41258,":[116],"GSE39582,":[117,169],"GSE87211).":[119],"Functional":[120],"enrichment":[121],"analyses":[122],"performed,":[124],"CIBERSORT":[127,219],"TIDE":[129,238],"algorithms":[130],"assess":[134],"tumor":[135,212,229],"infiltration.":[136],"RESULTS:":[137],"developed":[140],"signature,":[143],"dividing":[144],"patients":[145,183,242],"into":[146],"HSS-high":[147,152,174,192,223,233],"HSS-low":[149],"groups.":[150],"group":[153,175,234],"showed":[154,235],"notably":[156],"worse":[157],"prognosis":[158],"within":[159],"TCGA-COAD":[161],"dataset":[162],"three":[165],"independent":[166],"datasets:":[167],"GSE41258,":[168],"GSE87211.":[171],"Moreover,":[172],"predicted":[176],"shorter":[178],"overall":[179],"survival":[180,292],"rate":[181],"maintaining":[184],"microsatellite":[185],"stability":[186],"(MSS).":[187],"analysis":[190,215],"associated":[191],"hypoxic,":[195],"epithelial-mesenchymal":[196],"transition":[197],"(EMT),":[198],"TGF-\u03b2":[200],"signaling":[201],"pathways":[202],"correlated":[204],"distant":[206],"lymph":[208],"node":[209],"metastases.":[210],"immune":[213],"microenvironment":[214],"revealed":[216],"an":[217,226],"elevated":[218],"group,":[224],"suggesting":[225],"association":[227],"metastasis.":[230],"Further,":[231],"higher":[237],"score,":[239],"indicating":[240],"that":[241,280],"high":[244],"scores":[246],"are":[247],"less":[248],"likely":[249],"benefit":[251],"Immune":[253],"Checkpoint":[254],"Inhibitor":[255],"(ICI)":[256],"therapy.":[257],"CONCLUSIONS:":[258],"demonstrated":[261],"significance":[264],"findings":[278],"suggest":[279],"this":[281],"gene":[282],"may":[284],"serve":[285],"as":[286],"reliable":[288],"biomarker":[289],"for":[290],"predicting":[291],"outcomes":[293],"patients.":[296]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}