{"id":"https://openalex.org/W4389917864","doi":"https://doi.org/10.1002/vms3.1339","title":"miR\u20109 promotes canine endothelial\u2010like cell migration by targeting COL15A1","display_name":"miR\u20109 promotes canine endothelial\u2010like cell migration by targeting COL15A1","publication_year":2023,"publication_date":"2023-12-18","ids":{"openalex":"https://openalex.org/W4389917864","doi":"https://doi.org/10.1002/vms3.1339","pmid":"https://pubmed.ncbi.nlm.nih.gov/38109263","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10766037"},"language":"en","primary_location":{"id":"doi:10.1002/vms3.1339","doi":"https://doi.org/10.1002/vms3.1339","is_oa":true,"landing_page_url":"https://doi.org/10.1002/vms3.1339","pdf_url":null,"source":{"id":"https://openalex.org/S4210212351","display_name":"Veterinary Medicine and Science","issn_l":"2053-1095","issn":["2053-1095"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Medicine and Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/vms3.1339","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091352996","display_name":"Heng Jiang","orcid":"https://orcid.org/0000-0001-7991-5956","observed_orcids":["https://orcid.org/0000-0001-7991-5956"]},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Heng Jiang","raw_affiliation_strings":["Institute of Tropical Agriculture and Forestry, Hainan University, Hainan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Tropical Agriculture and Forestry, Hainan University, Hainan, PR China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113964655","display_name":"Mengmeng Liu","orcid":"https://orcid.org/0000-0002-0726-6675","observed_orcids":["https://orcid.org/0000-0002-0726-6675"]},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengmeng Liu","raw_affiliation_strings":["Institute of Tropical Agriculture and Forestry, Hainan University, Hainan, PR China","One Health Institute, Hainan University, Hainan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Tropical Agriculture and Forestry, Hainan University, Hainan, PR China","institution_ids":["https://openalex.org/I20942203"]},{"raw_affiliation_string":"One Health Institute, Hainan University, Hainan, PR China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yao Qin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yao Qin","raw_affiliation_strings":["Institute of Tropical Agriculture and Forestry, Hainan University, Hainan, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Tropical Agriculture and Forestry, Hainan University, Hainan, PR China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100430234","display_name":"Hong Zhang","orcid":"https://orcid.org/0000-0001-6274-6949","observed_orcids":["https://orcid.org/0000-0001-6274-6949"]},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hong Zhang","raw_affiliation_strings":["Institute of Tropical Agriculture and Forestry, Hainan University, Hainan, PR China"],"raw_orcid":"https://orcid.org/0000-0001-6274-6949","affiliations":[{"raw_affiliation_string":"Institute of Tropical Agriculture and Forestry, Hainan University, Hainan, PR China","institution_ids":["https://openalex.org/I20942203"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100430234"],"corresponding_institution_ids":["https://openalex.org/I20942203"],"apc_list":{"value":3520,"currency":"USD","value_usd":3520},"apc_paid":{"value":3520,"currency":"USD","value_usd":3520},"fwci":0.0912,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.30636893,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"10","issue":"1","first_page":"e1339","last_page":"e1339"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.08869999647140503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-9","display_name":"miR-9","score":0.9990000128746033},{"id":"https://openalex.org/keywords/col15a1","display_name":"COL15A1","score":0.9580000042915344},{"id":"https://openalex.org/keywords/collagen-xv","display_name":"collagen XV","score":0.9129999876022339},{"id":"https://openalex.org/keywords/endothelial-like-cells","display_name":"endothelial-like cells","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.8029999732971191},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.7739999890327454},{"id":"https://openalex.org/keywords/canine","display_name":"canine","score":0.3370000123977661},{"id":"https://openalex.org/keywords/myocardium","display_name":"myocardium","score":0.5960000157356262},{"id":"https://openalex.org/keywords/microrna-target-regulation","display_name":"microRNA target regulation","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5141375660896301},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.41281816363334656},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36083781719207764},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3218699097633362},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29902464151382446},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08991363644599915},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/vms3.1339","doi":"https://doi.org/10.1002/vms3.1339","is_oa":true,"landing_page_url":"https://doi.org/10.1002/vms3.1339","pdf_url":null,"source":{"id":"https://openalex.org/S4210212351","display_name":"Veterinary Medicine and Science","issn_l":"2053-1095","issn":["2053-1095"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Medicine and Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10766037","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10766037","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10766037/pdf/VMS3-10-e1339.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vet Med Sci","raw_type":"Text"},{"id":"pmid:38109263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38109263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary medicine and science","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d7c65f6982d54d7988d6809c637be1e2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d7c65f6982d54d7988d6809c637be1e2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Veterinary Medicine and Science, Vol 10, Iss 1, Pp n/a-n/a (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/vms3.1339","doi":"https://doi.org/10.1002/vms3.1339","is_oa":true,"landing_page_url":"https://doi.org/10.1002/vms3.1339","pdf_url":null,"source":{"id":"https://openalex.org/S4210212351","display_name":"Veterinary Medicine and Science","issn_l":"2053-1095","issn":["2053-1095"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Medicine and Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6209390576","display_name":null,"funder_award_id":"31902336","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323370","display_name":"Hainan University","ror":"https://ror.org/03q648j11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389917864.pdf","grobid_xml":"https://content.openalex.org/works/W4389917864.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1577875429","https://openalex.org/W1588127651","https://openalex.org/W1976134498","https://openalex.org/W1989541696","https://openalex.org/W1995343989","https://openalex.org/W2019384864","https://openalex.org/W2047684973","https://openalex.org/W2056302937","https://openalex.org/W2056737526","https://openalex.org/W2085457791","https://openalex.org/W2088726343","https://openalex.org/W2098637032","https://openalex.org/W2107388688","https://openalex.org/W2117037540","https://openalex.org/W2124780785","https://openalex.org/W2127719752","https://openalex.org/W2132754005","https://openalex.org/W2143622343","https://openalex.org/W2147144579","https://openalex.org/W2151515540","https://openalex.org/W2157603347","https://openalex.org/W2220452782","https://openalex.org/W2530392551","https://openalex.org/W2551432813","https://openalex.org/W2592352734","https://openalex.org/W2748965316","https://openalex.org/W2763819018","https://openalex.org/W2789635618","https://openalex.org/W2800647072","https://openalex.org/W2807356395","https://openalex.org/W2811428863","https://openalex.org/W2888277493","https://openalex.org/W2896735777","https://openalex.org/W2900597665","https://openalex.org/W2964528224","https://openalex.org/W2999168693","https://openalex.org/W3036823689","https://openalex.org/W3047645759","https://openalex.org/W3158654926","https://openalex.org/W3168070526","https://openalex.org/W3198749977","https://openalex.org/W3203247547","https://openalex.org/W4282927552"],"related_works":["https://openalex.org/W3092003087","https://openalex.org/W7131251127","https://openalex.org/W2098637032","https://openalex.org/W2608327455","https://openalex.org/W1598008954","https://openalex.org/W2005854045","https://openalex.org/W2575497134","https://openalex.org/W2370038160","https://openalex.org/W2972248612","https://openalex.org/W2080609567"],"abstract_inverted_index":{"BACKGROUND:":[0],"Endothelial":[1],"cell":[2,21,40,170],"migration":[3,22,73,122,171,183,204],"is":[4],"the":[5,32,67,72,96,107,121,130,139,144,182],"initial":[6],"stage":[7],"of":[8,35,69,75,125,132,148,157,184],"angiogenesis.":[9],"In":[10],"previous":[11],"studies,":[12],"miR-9":[13,36,70,158,180],"has":[14],"been":[15],"found":[16],"to":[17,30,52,65,94],"regulate":[18],"angiogenesis":[19,168],"and":[20,50,60,87,123,128,163,169,187,194,205],"in":[23,167,172,201],"human":[24],"medicine.":[25],"OBJECTIVES:":[26],"This":[27],"study":[28],"aimed":[29],"reveal":[31],"regulatory":[33,97],"effect":[34],"on":[37,71],"canine":[38,44,112,126,173,185,198],"endothelial":[39,202],"migration.":[41],"METHODS:":[42],"Embryonic":[43],"ventricle":[45],"myocardium":[46],"tissues":[47,115],"were":[48,63,92],"collected":[49],"induced":[51,106],"differentiate":[53],"into":[54,116],"endothelial-like":[55],"cells":[56,109,203],"(ELCs).":[57],"A":[58],"transwell":[59],"invasion":[61,124],"assay":[62],"used":[64],"evaluate":[66],"impact":[68],"capacity":[74],"ELCs,":[76,127],"after":[77],"which":[78],"a":[79,191],"luciferase":[80],"reporter":[81],"assay,":[82],"western":[83],"blotting,":[84],"RNA":[85,152],"sequencing":[86,153],"reverse":[88],"transcription-polymerase":[89],"chain":[90],"reaction":[91],"conducted":[93],"explore":[95],"mechanism.":[98],"RESULTS:":[99],"Our":[100],"results":[101],"showed":[102,154],"that":[103,155,179],"we":[104],"successfully":[105],"primary":[108],"derived":[110],"from":[111],"cardiac":[113],"embryo":[114],"ELCs.":[117,174],"MiR-9":[118],"also":[119],"promoted":[120],"inhibited":[129],"expression":[131],"collagen":[133],"XV,":[134],"an":[135],"angiogenic":[136],"inhibitor,":[137],"at":[138],"translational":[140],"level":[141],"by":[142],"targeting":[143],"3'":[145],"untranslated":[146],"region":[147],"COL15A1":[149],"gene.":[150],"Furthermore,":[151],"overexpression":[156],"impacted":[159],"several":[160],"signalling":[161],"pathways":[162],"eight":[164],"genes":[165],"involved":[166,200],"CONCLUSIONS:":[175],"These":[176],"findings":[177],"suggest":[178],"enhances":[181],"ELCs":[186],"may":[188],"serve":[189],"as":[190],"potential":[192],"diagnostic":[193],"therapeutic":[195],"target":[196],"for":[197],"diseases":[199],"angiogenesis,":[206],"but":[207],"more":[208],"further":[209],"studies":[210],"are":[211],"needed.":[212]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-19T00:00:00"}
