{"id":"https://openalex.org/W4389914909","doi":"https://doi.org/10.1007/s10528-023-10592-6","title":"LncRNA MALAT1 Expression Regulates Breast Cancer Progression via PI3K/AKT/mTOR Pathway Modulation","display_name":"LncRNA MALAT1 Expression Regulates Breast Cancer Progression via PI3K/AKT/mTOR Pathway Modulation","publication_year":2023,"publication_date":"2023-12-18","ids":{"openalex":"https://openalex.org/W4389914909","doi":"https://doi.org/10.1007/s10528-023-10592-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/38110774"},"language":"en","primary_location":{"id":"doi:10.1007/s10528-023-10592-6","doi":"https://doi.org/10.1007/s10528-023-10592-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10528-023-10592-6","pdf_url":null,"source":{"id":"https://openalex.org/S8388595","display_name":"Biochemical Genetics","issn_l":"0006-2928","issn":["0006-2928","1573-4927"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093525465","display_name":"Mariam Naveed","orcid":"https://orcid.org/0000-0002-3050-8206","observed_orcids":["https://orcid.org/0000-0002-3050-8206"]},"institutions":[{"id":"https://openalex.org/I172780181","display_name":"University of the Punjab","ror":"https://ror.org/011maz450","country_code":"PK","type":"education","lineage":["https://openalex.org/I172780181"]},{"id":"https://openalex.org/I4210141105","display_name":"Centre of Excellence in Molecular Biology","ror":"https://ror.org/03qfdvc46","country_code":"PK","type":"education","lineage":["https://openalex.org/I4210141105"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Mariam Naveed","raw_affiliation_strings":["Centre of Excellence in Molecular Biology, University of the Punjab, 87-West Canal Road Thokar Niaz Baig , Lahore, 53700, Pakistan"],"raw_orcid":"https://orcid.org/0000-0002-3050-8206","affiliations":[{"raw_affiliation_string":"Centre of Excellence in Molecular Biology, University of the Punjab, 87-West Canal Road Thokar Niaz Baig , Lahore, 53700, Pakistan","institution_ids":["https://openalex.org/I172780181","https://openalex.org/I4210141105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043666589","display_name":"Ayesha M. Malik","orcid":"https://orcid.org/0000-0002-6753-8644","observed_orcids":["https://orcid.org/0000-0002-6753-8644"]},"institutions":[{"id":"https://openalex.org/I172780181","display_name":"University of the Punjab","ror":"https://ror.org/011maz450","country_code":"PK","type":"education","lineage":["https://openalex.org/I172780181"]},{"id":"https://openalex.org/I4210141105","display_name":"Centre of Excellence in Molecular Biology","ror":"https://ror.org/03qfdvc46","country_code":"PK","type":"education","lineage":["https://openalex.org/I4210141105"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Ayesha Malik","raw_affiliation_strings":["Centre of Excellence in Molecular Biology, University of the Punjab, 87-West Canal Road Thokar Niaz Baig , Lahore, 53700, Pakistan"],"raw_orcid":"https://orcid.org/0000-0002-6753-8644","affiliations":[{"raw_affiliation_string":"Centre of Excellence in Molecular Biology, University of the Punjab, 87-West Canal Road Thokar Niaz Baig , Lahore, 53700, Pakistan","institution_ids":["https://openalex.org/I172780181","https://openalex.org/I4210141105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081493771","display_name":"Hamza Anjum","orcid":"https://orcid.org/0009-0005-2486-7308","observed_orcids":["https://orcid.org/0009-0005-2486-7308"]},"institutions":[{"id":"https://openalex.org/I172780181","display_name":"University of the Punjab","ror":"https://ror.org/011maz450","country_code":"PK","type":"education","lineage":["https://openalex.org/I172780181"]},{"id":"https://openalex.org/I4210141105","display_name":"Centre of Excellence in Molecular Biology","ror":"https://ror.org/03qfdvc46","country_code":"PK","type":"education","lineage":["https://openalex.org/I4210141105"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Hamza Anjum","raw_affiliation_strings":["Centre of Excellence in Molecular Biology, University of the Punjab, 87-West Canal Road Thokar Niaz Baig , Lahore, 53700, Pakistan"],"raw_orcid":"https://orcid.org/0009-0005-2486-7308","affiliations":[{"raw_affiliation_string":"Centre of Excellence in Molecular Biology, University of the Punjab, 87-West Canal Road Thokar Niaz Baig , Lahore, 53700, Pakistan","institution_ids":["https://openalex.org/I172780181","https://openalex.org/I4210141105"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014023164","display_name":"Bushra Ijaz","orcid":"https://orcid.org/0000-0002-2979-9501","observed_orcids":["https://orcid.org/0000-0002-2979-9501"]},"institutions":[{"id":"https://openalex.org/I172780181","display_name":"University of the Punjab","ror":"https://ror.org/011maz450","country_code":"PK","type":"education","lineage":["https://openalex.org/I172780181"]},{"id":"https://openalex.org/I4210141105","display_name":"Centre of Excellence in Molecular Biology","ror":"https://ror.org/03qfdvc46","country_code":"PK","type":"education","lineage":["https://openalex.org/I4210141105"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Bushra Ijaz","raw_affiliation_strings":["Laboratory of Applied and Functional Genomics, Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, 87-West Canal Bank Road, Lahore, 53700, Pakistan. bijaz@cemb.edu.pk","Laboratory of Applied and Functional Genomics, Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, 87-West Canal Bank Road, Lahore, 53700, Pakistan"],"raw_orcid":"https://orcid.org/0000-0002-2979-9501","affiliations":[{"raw_affiliation_string":"Laboratory of Applied and Functional Genomics, Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, 87-West Canal Bank Road, Lahore, 53700, Pakistan. bijaz@cemb.edu.pk","institution_ids":["https://openalex.org/I172780181","https://openalex.org/I4210141105"]},{"raw_affiliation_string":"Laboratory of Applied and Functional Genomics, Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, 87-West Canal Bank Road, Lahore, 53700, Pakistan","institution_ids":["https://openalex.org/I172780181","https://openalex.org/I4210141105"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014023164"],"corresponding_institution_ids":["https://openalex.org/I172780181","https://openalex.org/I4210141105"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":1.5217,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.83237194,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"62","issue":"5","first_page":"3421","last_page":"3438"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malat1","display_name":"MALAT1","score":0.9179999828338623},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8040000200271606},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.9739999771118164},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.6990000009536743},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5299999713897705},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.8700000047683716},{"id":"https://openalex.org/keywords/pi3k-inhibition","display_name":"PI3K inhibition","score":0.7089999914169312},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8550000190734863},{"id":"https://openalex.org/keywords/pakistani-patients","display_name":"Pakistani patients","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7990689873695374},{"id":"https://openalex.org/C2779134362","wikidata":"https://www.wikidata.org/wiki/Q18056223","display_name":"MALAT1","level":5,"score":0.7844440340995789},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.703267514705658},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6572362184524536},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6470432281494141},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6046460866928101},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4937773644924164},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4823450446128845},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47287508845329285},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4488275349140167},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41116490960121155},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3896692395210266},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28049108386039734},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.2614360749721527},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24566230177879333},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08873316645622253},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.08062240481376648},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.052709728479385376},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10528-023-10592-6","doi":"https://doi.org/10.1007/s10528-023-10592-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10528-023-10592-6","pdf_url":null,"source":{"id":"https://openalex.org/S8388595","display_name":"Biochemical Genetics","issn_l":"0006-2928","issn":["0006-2928","1573-4927"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Genetics","raw_type":"journal-article"},{"id":"pmid:38110774","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38110774","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical genetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1964184380","https://openalex.org/W1968592372","https://openalex.org/W2007942290","https://openalex.org/W2038720191","https://openalex.org/W2053740048","https://openalex.org/W2068728873","https://openalex.org/W2075370291","https://openalex.org/W2107277218","https://openalex.org/W2109078237","https://openalex.org/W2116168949","https://openalex.org/W2124198704","https://openalex.org/W2128619556","https://openalex.org/W2160333540","https://openalex.org/W2166810745","https://openalex.org/W2168133196","https://openalex.org/W2212803193","https://openalex.org/W2276355877","https://openalex.org/W2278129493","https://openalex.org/W2291490667","https://openalex.org/W2306562666","https://openalex.org/W2339566899","https://openalex.org/W2346116488","https://openalex.org/W2364732158","https://openalex.org/W2469215047","https://openalex.org/W2573528692","https://openalex.org/W2588788412","https://openalex.org/W2601258425","https://openalex.org/W2742941889","https://openalex.org/W2789050944","https://openalex.org/W2799337760","https://openalex.org/W2802528458","https://openalex.org/W2808862148","https://openalex.org/W2891543185","https://openalex.org/W2899637278","https://openalex.org/W2902307998","https://openalex.org/W2914866952","https://openalex.org/W2936870695","https://openalex.org/W2968492662","https://openalex.org/W2968733355","https://openalex.org/W2998058610","https://openalex.org/W3009525538","https://openalex.org/W3010696851","https://openalex.org/W3012955228","https://openalex.org/W3020914566","https://openalex.org/W3026056090","https://openalex.org/W3034277644","https://openalex.org/W3134691484","https://openalex.org/W3144288344","https://openalex.org/W3161896632","https://openalex.org/W3189208611","https://openalex.org/W3190171278","https://openalex.org/W4220717799","https://openalex.org/W4291885055"],"related_works":["https://openalex.org/W3207129560","https://openalex.org/W3156545861","https://openalex.org/W4400663585","https://openalex.org/W2562999879","https://openalex.org/W7204785413","https://openalex.org/W2509927942","https://openalex.org/W2917117449","https://openalex.org/W4383186174","https://openalex.org/W4398242458","https://openalex.org/W3180172313"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-12-19T00:00:00"}
