{"id":"https://openalex.org/W4389913475","doi":"https://doi.org/10.3390/fishes8120608","title":"Effects of Recombinant Leptin Proteins on the Expression of Key Genes in the HPG Axis and Liver of Tongue Sole In Vitro","display_name":"Effects of Recombinant Leptin Proteins on the Expression of Key Genes in the HPG Axis and Liver of Tongue Sole In Vitro","publication_year":2023,"publication_date":"2023-12-16","ids":{"openalex":"https://openalex.org/W4389913475","doi":"https://doi.org/10.3390/fishes8120608"},"language":"en","primary_location":{"id":"doi:10.3390/fishes8120608","doi":"https://doi.org/10.3390/fishes8120608","is_oa":true,"landing_page_url":"https://doi.org/10.3390/fishes8120608","pdf_url":"https://www.mdpi.com/2410-3888/8/12/608/pdf?version=1702999586","source":{"id":"https://openalex.org/S4210229736","display_name":"Fishes","issn_l":"2410-3888","issn":["2410-3888"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fishes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2410-3888/8/12/608/pdf?version=1702999586","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101741188","display_name":"Xin Cai","orcid":"https://orcid.org/0000-0001-5238-6193","observed_orcids":["https://orcid.org/0000-0001-5238-6193"]},"institutions":[{"id":"https://openalex.org/I4405261380","display_name":"Yellow Sea Fisheries Research Institute","ror":"https://ror.org/0578w5a44","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4405261380","https://openalex.org/I46529539"]},{"id":"https://openalex.org/I46529539","display_name":"Chinese Academy of Fishery Sciences","ror":"https://ror.org/02bwk9n38","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I46529539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Cai","raw_affiliation_strings":["State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China","institution_ids":["https://openalex.org/I4405261380","https://openalex.org/I46529539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005397488","display_name":"Yaxing Zhang","orcid":"https://orcid.org/0000-0002-1179-8076","observed_orcids":["https://orcid.org/0000-0002-1179-8076"]},"institutions":[{"id":"https://openalex.org/I4405261380","display_name":"Yellow Sea Fisheries Research Institute","ror":"https://ror.org/0578w5a44","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4405261380","https://openalex.org/I46529539"]},{"id":"https://openalex.org/I46529539","display_name":"Chinese Academy of Fishery Sciences","ror":"https://ror.org/02bwk9n38","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I46529539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaxing Zhang","raw_affiliation_strings":["State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China","institution_ids":["https://openalex.org/I4405261380","https://openalex.org/I46529539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100655767","display_name":"Bin Wang","orcid":"https://orcid.org/0000-0001-7419-5080","observed_orcids":["https://orcid.org/0000-0001-7419-5080"]},"institutions":[{"id":"https://openalex.org/I4405261380","display_name":"Yellow Sea Fisheries Research Institute","ror":"https://ror.org/0578w5a44","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4405261380","https://openalex.org/I46529539"]},{"id":"https://openalex.org/I46529539","display_name":"Chinese Academy of Fishery Sciences","ror":"https://ror.org/02bwk9n38","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I46529539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Wang","raw_affiliation_strings":["State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China"],"raw_orcid":"https://orcid.org/0000-0001-7419-5080","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China","institution_ids":["https://openalex.org/I4405261380","https://openalex.org/I46529539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027218700","display_name":"Aijun Cui","orcid":"https://orcid.org/0000-0003-0027-0791","observed_orcids":["https://orcid.org/0000-0003-0027-0791"]},"institutions":[{"id":"https://openalex.org/I4405261380","display_name":"Yellow Sea Fisheries Research Institute","ror":"https://ror.org/0578w5a44","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4405261380","https://openalex.org/I46529539"]},{"id":"https://openalex.org/I46529539","display_name":"Chinese Academy of Fishery Sciences","ror":"https://ror.org/02bwk9n38","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I46529539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aijun Cui","raw_affiliation_strings":["State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China","institution_ids":["https://openalex.org/I4405261380","https://openalex.org/I46529539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061812566","display_name":"Yan Jiang","orcid":"https://orcid.org/0000-0003-1307-7210","observed_orcids":["https://orcid.org/0000-0003-1307-7210"]},"institutions":[{"id":"https://openalex.org/I4405261380","display_name":"Yellow Sea Fisheries Research Institute","ror":"https://ror.org/0578w5a44","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4405261380","https://openalex.org/I46529539"]},{"id":"https://openalex.org/I46529539","display_name":"Chinese Academy of Fishery Sciences","ror":"https://ror.org/02bwk9n38","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I46529539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Jiang","raw_affiliation_strings":["State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China"],"raw_orcid":"https://orcid.org/0000-0003-1307-7210","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China","institution_ids":["https://openalex.org/I4405261380","https://openalex.org/I46529539"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhaojun Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405261380","display_name":"Yellow Sea Fisheries Research Institute","ror":"https://ror.org/0578w5a44","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4405261380","https://openalex.org/I46529539"]},{"id":"https://openalex.org/I46529539","display_name":"Chinese Academy of Fishery Sciences","ror":"https://ror.org/02bwk9n38","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I46529539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaojun Meng","raw_affiliation_strings":["State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China","institution_ids":["https://openalex.org/I4405261380","https://openalex.org/I46529539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100377767","display_name":"Yuting Li","orcid":"https://orcid.org/0000-0002-6716-358X","observed_orcids":["https://orcid.org/0000-0002-6716-358X","https://orcid.org/0000-0003-2541-7024","https://orcid.org/0009-0003-5165-9809"]},"institutions":[{"id":"https://openalex.org/I4405261380","display_name":"Yellow Sea Fisheries Research Institute","ror":"https://ror.org/0578w5a44","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4405261380","https://openalex.org/I46529539"]},{"id":"https://openalex.org/I46529539","display_name":"Chinese Academy of Fishery Sciences","ror":"https://ror.org/02bwk9n38","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I46529539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuting Li","raw_affiliation_strings":["State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China","institution_ids":["https://openalex.org/I4405261380","https://openalex.org/I46529539"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101971199","display_name":"Yongjiang Xu","orcid":"https://orcid.org/0000-0001-6596-3586","observed_orcids":["https://orcid.org/0000-0001-6596-3586"]},"institutions":[{"id":"https://openalex.org/I4405261380","display_name":"Yellow Sea Fisheries Research Institute","ror":"https://ror.org/0578w5a44","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I4405261380","https://openalex.org/I46529539"]},{"id":"https://openalex.org/I46529539","display_name":"Chinese Academy of Fishery Sciences","ror":"https://ror.org/02bwk9n38","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987","https://openalex.org/I46529539"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongjiang Xu","raw_affiliation_strings":["State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China","institution_ids":["https://openalex.org/I4405261380","https://openalex.org/I46529539"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101971199"],"corresponding_institution_ids":["https://openalex.org/I4405261380","https://openalex.org/I46529539"],"apc_list":{"value":1800,"currency":"CHF","value_usd":2002},"apc_paid":{"value":1800,"currency":"CHF","value_usd":2002},"fwci":0.3749,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.51611517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"8","issue":"12","first_page":"608","last_page":"608"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.8310999870300293,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.8310999870300293,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0843999981880188,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0272000003606081,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tongue-sole","display_name":"tongue sole","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cynoglossus-semilaevis","display_name":"Cynoglossus semilaevis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-gonadal-axis","display_name":"hypothalamic-pituitary-gonadal axis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.7940000295639038},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6359999775886536},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8230000138282776},{"id":"https://openalex.org/keywords/sex-hormones","display_name":"sex hormones","score":0.7300000190734863},{"id":"https://openalex.org/keywords/fish-reproduction","display_name":"fish reproduction","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.8308544158935547},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7126399278640747},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6009650230407715},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5967888832092285},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5835002660751343},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.575186550617218},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5658824443817139},{"id":"https://openalex.org/C146819174","wikidata":"https://www.wikidata.org/wiki/Q1703595","display_name":"Hypothalamic\u2013pituitary\u2013gonadal axis","level":4,"score":0.5325687527656555},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.47260716557502747},{"id":"https://openalex.org/C2779744641","wikidata":"https://www.wikidata.org/wiki/Q9614","display_name":"Tongue","level":2,"score":0.43314042687416077},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3405207395553589},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19344541430473328},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.1413869559764862},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.10969763994216919},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10304203629493713},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3390/fishes8120608","doi":"https://doi.org/10.3390/fishes8120608","is_oa":true,"landing_page_url":"https://doi.org/10.3390/fishes8120608","pdf_url":"https://www.mdpi.com/2410-3888/8/12/608/pdf?version=1702999586","source":{"id":"https://openalex.org/S4210229736","display_name":"Fishes","issn_l":"2410-3888","issn":["2410-3888"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fishes","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:c77dcb71ce5d4556aaae59e11e02dfef","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c77dcb71ce5d4556aaae59e11e02dfef","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Fishes, Vol 8, Iss 12, p 608 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/fishes8120608","doi":"https://doi.org/10.3390/fishes8120608","is_oa":true,"landing_page_url":"https://doi.org/10.3390/fishes8120608","pdf_url":"https://www.mdpi.com/2410-3888/8/12/608/pdf?version=1702999586","source":{"id":"https://openalex.org/S4210229736","display_name":"Fishes","issn_l":"2410-3888","issn":["2410-3888"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fishes","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1772509952","display_name":null,"funder_award_id":"32072993","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G307452827","display_name":null,"funder_award_id":"CARS-47","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4963169283","display_name":null,"funder_award_id":"CARS-47","funder_id":"https://openalex.org/F4320335447","funder_display_name":"Earmarked Fund for China Agriculture Research System"},{"id":"https://openalex.org/G5642745374","display_name":null,"funder_award_id":"CARS-47","funder_id":"https://openalex.org/F4320338141","funder_display_name":"Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences"},{"id":"https://openalex.org/G6755518608","display_name":null,"funder_award_id":"32072949","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6911357582","display_name":null,"funder_award_id":"2023TD51","funder_id":"https://openalex.org/F4320338141","funder_display_name":"Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335447","display_name":"Earmarked Fund for China Agriculture Research System","ror":null},{"id":"https://openalex.org/F4320338141","display_name":"Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389913475.pdf","grobid_xml":"https://content.openalex.org/works/W4389913475.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W786147314","https://openalex.org/W821609833","https://openalex.org/W1680105951","https://openalex.org/W1776874025","https://openalex.org/W1971023808","https://openalex.org/W1972890667","https://openalex.org/W1973357670","https://openalex.org/W1974305574","https://openalex.org/W1975759742","https://openalex.org/W1981742222","https://openalex.org/W1983999295","https://openalex.org/W1984836542","https://openalex.org/W1990243974","https://openalex.org/W1993048823","https://openalex.org/W1994661888","https://openalex.org/W1996713062","https://openalex.org/W2007867899","https://openalex.org/W2017696771","https://openalex.org/W2019693171","https://openalex.org/W2025089542","https://openalex.org/W2026662846","https://openalex.org/W2036682908","https://openalex.org/W2040140630","https://openalex.org/W2045578578","https://openalex.org/W2053580024","https://openalex.org/W2075113499","https://openalex.org/W2075685933","https://openalex.org/W2079772076","https://openalex.org/W2080891415","https://openalex.org/W2081941747","https://openalex.org/W2083729360","https://openalex.org/W2085031019","https://openalex.org/W2086616081","https://openalex.org/W2086719259","https://openalex.org/W2090993069","https://openalex.org/W2093442321","https://openalex.org/W2105945542","https://openalex.org/W2111500030","https://openalex.org/W2111676948","https://openalex.org/W2116182538","https://openalex.org/W2119101110","https://openalex.org/W2122729366","https://openalex.org/W2124704622","https://openalex.org/W2129142602","https://openalex.org/W2142475688","https://openalex.org/W2152586454","https://openalex.org/W2158353831","https://openalex.org/W2165108111","https://openalex.org/W2172894491","https://openalex.org/W2255490958","https://openalex.org/W2287604137","https://openalex.org/W2395458008","https://openalex.org/W2488893308","https://openalex.org/W2745499544","https://openalex.org/W2747729170","https://openalex.org/W2755211939","https://openalex.org/W2806501403","https://openalex.org/W2885839597","https://openalex.org/W2904014941","https://openalex.org/W2914487169","https://openalex.org/W2951297618","https://openalex.org/W3033977233","https://openalex.org/W3112098306","https://openalex.org/W3131105746","https://openalex.org/W3134988375","https://openalex.org/W3169071660","https://openalex.org/W3217630009","https://openalex.org/W4200234162","https://openalex.org/W4205943196","https://openalex.org/W4210742425","https://openalex.org/W4213080991","https://openalex.org/W4225595725","https://openalex.org/W4242033877","https://openalex.org/W4378084028","https://openalex.org/W7073687958"],"related_works":["https://openalex.org/W2806501403","https://openalex.org/W4401793574","https://openalex.org/W2989803319","https://openalex.org/W2944488551","https://openalex.org/W2747426647","https://openalex.org/W2172894491","https://openalex.org/W1983999295","https://openalex.org/W4407164245","https://openalex.org/W2255490958","https://openalex.org/W4401393687"],"abstract_inverted_index":{"Leptin":[0],"(Lep)":[1],"plays":[2],"a":[3,126,135,218],"crucial":[4],"role":[5,128],"in":[6,14,27,45,63,85,115,132,145,159,213],"controlling":[7],"food":[8],"intake":[9],"and":[10,55,67,69,83,97,113,119,187,205,211,221],"maintaining":[11],"energy":[12],"balance":[13],"mammals.":[15],"While":[16],"several":[17],"studies":[18],"have":[19,124],"shown":[20],"the":[21,40,71,76,106,116,141,148,194,199,208],"presence":[22],"of":[23,42,78,100,108,138,143,163,201],"multiple":[24],"leptin":[25,57,154,183],"genes":[26,44,79,109],"teleosts,":[28],"limited":[29],"information":[30],"is":[31,193],"currently":[32],"available":[33],"on":[34,129],"how":[35],"sex":[36],"steroid":[37,130],"hormones":[38],"regulate":[39],"expression":[41,77,107,142],"these":[43],"fish.":[46],"In":[47],"this":[48,192],"study,":[49],"we":[50,151],"used":[51,70],"two":[52],"previously":[53],"expressed":[54],"purified":[56],"proteins":[58,99],"to":[59,74,81,111,155,168,197],"incubate":[60,156],"four":[61,157],"tissues":[62,158],"vitro":[64],"(hypothalamic-pituitary-gonadal":[65],"axis":[66,118,210],"liver)":[68],"RT-qPCR":[72],"method":[73],"detect":[75],"related":[80,110],"growth":[82,112],"reproduction":[84,114],"tongue":[86,101,172,202],"sole":[87,102,173,203],"(Cynoglossus":[88],"semilaevis).":[89],"The":[90],"results":[91,216],"showed":[92],"that":[93],"both":[94],"recombinant":[95],"LepA":[96,139,204],"LepB":[98,122,206],"almost":[103],"entirely":[104],"suppressed":[105],"hypothalamic-pituitary-gonadal":[117,209],"liver,":[120],"while":[121],"may":[123],"had":[125,165],"positive":[127],"synthesis":[131],"gonads.":[133],"Further,":[134],"high":[136],"concentration":[137],"facilitated":[140],"IGF-\u0399":[144],"liver.":[146],"At":[147],"same":[149],"time,":[150],"utilized":[152],"human":[153],"vitro;":[160],"although":[161],"most":[162],"them":[164],"trends":[166],"similar":[167],"those":[169],"stimulated":[170],"with":[171],"leptins,":[174],"there":[175],"were":[176],"still":[177],"some":[178],"differences,":[179],"indicating":[180],"differences":[181],"among":[182],"homologs":[184],"between":[185],"humans":[186],"fishes.":[188],"To":[189],"our":[190],"knowledge,":[191],"first":[195],"study":[196],"explore":[198],"function":[200],"within":[207],"liver":[212],"vitro.":[214],"Our":[215],"provide":[217],"valuable":[219],"resource":[220],"foundation":[222],"for":[223],"future":[224],"studies.":[225]},"counts_by_year":[{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-12-19T00:00:00"}