{"id":"https://openalex.org/W4389869805","doi":"https://doi.org/10.55730/1300-0144.5728","title":"[6]-Shogaol and [6]-Gingerol active ingredients may improve neuropathic pain by suppressing cytokine levels in an experimental model","display_name":"[6]-Shogaol and [6]-Gingerol active ingredients may improve neuropathic pain by suppressing cytokine levels in an experimental model","publication_year":2023,"publication_date":"2023-12-12","ids":{"openalex":"https://openalex.org/W4389869805","doi":"https://doi.org/10.55730/1300-0144.5728","pmid":"https://pubmed.ncbi.nlm.nih.gov/38813490","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10760556"},"language":"en","primary_location":{"id":"doi:10.55730/1300-0144.5728","doi":"https://doi.org/10.55730/1300-0144.5728","is_oa":true,"landing_page_url":"https://doi.org/10.55730/1300-0144.5728","pdf_url":"https://journals.tubitak.gov.tr/cgi/viewcontent.cgi?article=5727&context=medical","source":{"id":"https://openalex.org/S68332911","display_name":"TURKISH JOURNAL OF MEDICAL SCIENCES","issn_l":"1300-0144","issn":["1300-0144","1303-6165"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-b","medline","norway-1","poland-40","russia-white-list-1","tr-dizin"],"host_organization":"https://openalex.org/P4310318422","host_organization_name":"Scientific and Technological Research Council of Turkey (TUBITAK)","host_organization_lineage":["https://openalex.org/P4310318422"],"host_organization_lineage_names":["Scientific and Technological Research Council of Turkey (TUBITAK)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.tubitak.gov.tr/cgi/viewcontent.cgi?article=5727&context=medical","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101258215","display_name":"F\u0130KR\u0130 \u00d6ZDEM\u0130R","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799360972","display_name":"Hitit \u00dcniversitesi","ror":"https://ror.org/01x8m3269","country_code":"TR","type":"education","lineage":["https://openalex.org/I2799360972"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"F\u0130KR\u0130 \u00d6ZDEM\u0130R","raw_affiliation_strings":["Department of Anatomy, Faculty of Medicine, Hitit University, \u00c7orum, Turkiye","of , of , Hitit University , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Faculty of Medicine, Hitit University, \u00c7orum, Turkiye","institution_ids":["https://openalex.org/I2799360972"]},{"raw_affiliation_string":"of , of , Hitit University , ,","institution_ids":["https://openalex.org/I2799360972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018247137","display_name":"G\u00fcven Ak\u00e7ay","orcid":"https://orcid.org/0000-0003-3418-8825","observed_orcids":["https://orcid.org/0000-0003-3418-8825"]},"institutions":[{"id":"https://openalex.org/I2799360972","display_name":"Hitit \u00dcniversitesi","ror":"https://ror.org/01x8m3269","country_code":"TR","type":"education","lineage":["https://openalex.org/I2799360972"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"G\u00dcVEN AK\u00c7AY","raw_affiliation_strings":["Department of Biophysics, Faculty of Medicine, Hitit University, \u00c7orum, Turkiye","of , of , University , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics, Faculty of Medicine, Hitit University, \u00c7orum, Turkiye","institution_ids":["https://openalex.org/I2799360972"]},{"raw_affiliation_string":"of , of , University , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012819827","display_name":"Sevil \u00d6zk\u0131nal\u0131","orcid":"https://orcid.org/0000-0001-9166-191X","observed_orcids":["https://orcid.org/0000-0001-9166-191X"]},"institutions":[{"id":"https://openalex.org/I2799360972","display_name":"Hitit \u00dcniversitesi","ror":"https://ror.org/01x8m3269","country_code":"TR","type":"education","lineage":["https://openalex.org/I2799360972"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"SEV\u0130L \u00d6ZKINALI","raw_affiliation_strings":["Department of Chemistry, Faculty of Arts and Sciences, Hitit University, \u00c7orum, Turkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Arts and Sciences, Hitit University, \u00c7orum, Turkiye","institution_ids":["https://openalex.org/I2799360972"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026264388","display_name":"\u00c7a\u011fla \u00c7elik","orcid":"https://orcid.org/0000-0002-5703-2375","observed_orcids":["https://orcid.org/0000-0002-5703-2375"]},"institutions":[{"id":"https://openalex.org/I2799360972","display_name":"Hitit \u00dcniversitesi","ror":"https://ror.org/01x8m3269","country_code":"TR","type":"education","lineage":["https://openalex.org/I2799360972"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u00c7A\u011eLA \u00c7EL\u0130K","raw_affiliation_strings":["Pharmacy Services Program, Vocational School of Health Services, Hitit University, \u00c7orum, Turkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy Services Program, Vocational School of Health Services, Hitit University, \u00c7orum, Turkiye","institution_ids":["https://openalex.org/I2799360972"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018247137"],"corresponding_institution_ids":["https://openalex.org/I2799360972"],"apc_list":null,"apc_paid":null,"fwci":1.0664,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.69973927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"53","issue":"6","first_page":"1593","last_page":"1604"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8080999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8080999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12347","display_name":"Ginger and Zingiberaceae research","score":0.17399999499320984,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.9449999928474426},{"id":"https://openalex.org/keywords/6-shogaol","display_name":"6-shogaol","score":0.8309999704360962},{"id":"https://openalex.org/keywords/6-gingerol","display_name":"6-gingerol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ginger-extract","display_name":"ginger extract","score":0.8949999809265137},{"id":"https://openalex.org/keywords/ginger","display_name":"ginger","score":0.9470000267028809},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/chronic-constriction-injury","display_name":"chronic constriction injury","score":0.8550000190734863},{"id":"https://openalex.org/keywords/sciatic-nerve-injury","display_name":"sciatic nerve injury","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7900000214576721},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9580000042915344},{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hyperalgesia","display_name":"hyperalgesia","score":0.9259999990463257},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.8450000286102295},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.3330000042915344}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9769201278686523},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.7450101375579834},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4604343771934509},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.43297046422958374},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3376135230064392},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14498645067214966}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002396","descriptor_name":"Catechols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002396","descriptor_name":"Catechols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005233","descriptor_name":"Fatty Alcohols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020939","descriptor_name":"Zingiber officinale","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.55730/1300-0144.5728","doi":"https://doi.org/10.55730/1300-0144.5728","is_oa":true,"landing_page_url":"https://doi.org/10.55730/1300-0144.5728","pdf_url":"https://journals.tubitak.gov.tr/cgi/viewcontent.cgi?article=5727&context=medical","source":{"id":"https://openalex.org/S68332911","display_name":"TURKISH JOURNAL OF MEDICAL SCIENCES","issn_l":"1300-0144","issn":["1300-0144","1303-6165"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-b","medline","norway-1","poland-40","russia-white-list-1","tr-dizin"],"host_organization":"https://openalex.org/P4310318422","host_organization_name":"Scientific and Technological Research Council of Turkey (TUBITAK)","host_organization_lineage":["https://openalex.org/P4310318422"],"host_organization_lineage_names":["Scientific and Technological Research Council of Turkey (TUBITAK)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Medical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10760556","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10760556","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10760556/pdf/turkjmedsci-53-6-1593.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turk J Med Sci","raw_type":"Text"},{"id":"pmid:38813490","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38813490","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish journal of medical sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.55730/1300-0144.5728","doi":"https://doi.org/10.55730/1300-0144.5728","is_oa":true,"landing_page_url":"https://doi.org/10.55730/1300-0144.5728","pdf_url":"https://journals.tubitak.gov.tr/cgi/viewcontent.cgi?article=5727&context=medical","source":{"id":"https://openalex.org/S68332911","display_name":"TURKISH JOURNAL OF MEDICAL SCIENCES","issn_l":"1300-0144","issn":["1300-0144","1303-6165"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-b","medline","norway-1","poland-40","russia-white-list-1","tr-dizin"],"host_organization":"https://openalex.org/P4310318422","host_organization_name":"Scientific and Technological Research Council of Turkey (TUBITAK)","host_organization_lineage":["https://openalex.org/P4310318422"],"host_organization_lineage_names":["Scientific and Technological Research Council of Turkey (TUBITAK)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320331000","display_name":"Hitit \u00dcniversitesi","ror":"https://ror.org/01x8m3269"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389869805.pdf","grobid_xml":"https://content.openalex.org/works/W4389869805.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1024036315","https://openalex.org/W1503847694","https://openalex.org/W1519245788","https://openalex.org/W1971466693","https://openalex.org/W1980369017","https://openalex.org/W1985163057","https://openalex.org/W1985282754","https://openalex.org/W1985425684","https://openalex.org/W1999671651","https://openalex.org/W2003572359","https://openalex.org/W2038211748","https://openalex.org/W2040661246","https://openalex.org/W2042707882","https://openalex.org/W2044597171","https://openalex.org/W2046296795","https://openalex.org/W2046299505","https://openalex.org/W2056492757","https://openalex.org/W2058020736","https://openalex.org/W2063153146","https://openalex.org/W2071289799","https://openalex.org/W2077343488","https://openalex.org/W2145938600","https://openalex.org/W2154507501","https://openalex.org/W2170215907","https://openalex.org/W2171230130","https://openalex.org/W2206932305","https://openalex.org/W2316438215","https://openalex.org/W2410498918","https://openalex.org/W2789460654","https://openalex.org/W2883734055","https://openalex.org/W2899206866","https://openalex.org/W2945792041","https://openalex.org/W3030226314","https://openalex.org/W3059814945","https://openalex.org/W3109108604","https://openalex.org/W3185772525","https://openalex.org/W3196871417","https://openalex.org/W3201779057","https://openalex.org/W3207341967","https://openalex.org/W3214509966","https://openalex.org/W4213011844","https://openalex.org/W4214881042","https://openalex.org/W4317708717","https://openalex.org/W4366777120","https://openalex.org/W4380576222","https://openalex.org/W4381852875","https://openalex.org/W4387392017"],"related_works":["https://openalex.org/W3214509966","https://openalex.org/W3059814945","https://openalex.org/W3029207036","https://openalex.org/W3039388971","https://openalex.org/W4282840528","https://openalex.org/W4284883504","https://openalex.org/W4403604985","https://openalex.org/W4294861011","https://openalex.org/W1496398523","https://openalex.org/W2058443165"],"abstract_inverted_index":{"Background/aim:":[0],"Neuropathic":[1],"pain":[2,9],"(NP)":[3],"is":[4],"a":[5,178,193,219,242,264],"type":[6],"of":[7,32,47,56,62,158,230],"chronic":[8,119],"usually":[10],"caused":[11],"by":[12,146],"damage":[13],"to":[14,51,188,203,235,250,262],"the":[15,30,35,53,63,69,75,130,155,159,184,189,199,204,211,223,231,236,246,251],"somatosensory":[16],"system.":[17],"Bioactive":[18],"antioxidant":[19],"compounds,":[20],"such":[21],"as":[22,115],"curcumin":[23],"and":[24,58,72,86,123,140,168,214,226],"ginger,":[25],"are":[26],"widely":[27],"preferred":[28],"in":[29,74,78,94,165,170,183,198,222,245],"treatment":[31,136,259],"NP.":[33],"However,":[34],"ingredient-based":[36],"mechanism":[37],"that":[38],"underlies":[39],"their":[40],"pain-relieving":[41],"activity":[42,162],"remains":[43],"unknown.":[44],"The":[45],"aim":[46],"this":[48,256],"study":[49],"was":[50,127,144,163,181,196,218,241,260],"investigate":[52],"therapeutic":[54,265],"effects":[55],"trans-[6]-Shogaol":[57],"[6]-Gingerol":[59],"active":[60,142],"ingredients":[61,143],"Zingiber":[64],"officinale":[65],"Roscoe":[66],"extract":[67,135],"on":[68,267],"spinal":[70,212],"cord":[71,213],"cortex":[73,215],"neuroinflammatory":[76],"pathway":[77],"rats":[79,109],"with":[80,138],"experimental":[81],"sciatic":[82,270],"nerve":[83,271],"injury.":[84],"Materials":[85],"methods:":[87],"Forty-six":[88],"volatile":[89],"phenolic":[90],"components":[91],"were":[92,110],"identified":[93],"ginger":[95,134,258],"samples":[96],"using":[97,129],"gas":[98],"chromatography-mass":[99],"spectrometry":[100],"analysis.":[101],"Thirty":[102],"3-month-old":[103],"male":[104],"250-300":[105],"g":[106],"Wistar":[107],"Albino":[108],"divided":[111],"into":[112],"three":[113],"groups":[114],"(i)":[116],"sham,":[117],"(ii)":[118],"constriction":[120],"injury":[121],"(CCI),":[122],"(iii)":[124],"CCI+ginger.":[125],"NP":[126],"induced":[128],"CCI":[131,185,205,232,252],"model.":[132],"A":[133],"enriched":[137],"trans-[6]-shogaol":[139],"[6]-gingerol":[141],"administered":[145],"gavage":[147],"at":[148],"200":[149],"mg/kg/day":[150],"for":[151],"7":[152],"days.":[153],"On":[154],"14th":[156],"day":[157],"experiment,":[160],"locomotor":[161],"evaluated":[164],"open":[166],"field":[167],"hyperalgesia":[169],"tail":[171],"flick":[172],"tests.":[173],"Results:":[174],"In":[175,210,255],"behavioural":[176],"experiments,":[177],"significant":[179,194,220,243],"decrease":[180,244],"observed":[182,197],"group":[186,201,206,233,248],"compared":[187,202,234,249],"sham":[190,237],"group,":[191,238],"while":[192,239],"increase":[195,221],"CCI+ginger":[200,247],"(p":[207],"<":[208],"0.05).":[209],"tissues,":[216],"there":[217,240],"TNF-\u03b1,":[224],"IL-1\u00df,":[225],"IL-18":[227],"neuroinflammation":[228,268],"results":[229],"group.":[253],"Conclusion:":[254],"study,":[257],"shown":[261],"have":[263],"effect":[266],"against":[269],"damage.":[272]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-12-18T00:00:00"}