{"id":"https://openalex.org/W4389816366","doi":"https://doi.org/10.1080/21645515.2023.2282803","title":"From bench to bedside via bytes: Multi-omic immunoprofiling and integration using machine learning and network approaches","display_name":"From bench to bedside via bytes: Multi-omic immunoprofiling and integration using machine learning and network approaches","publication_year":2023,"publication_date":"2023-12-15","ids":{"openalex":"https://openalex.org/W4389816366","doi":"https://doi.org/10.1080/21645515.2023.2282803","pmid":"https://pubmed.ncbi.nlm.nih.gov/38100557","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10730168"},"language":"en","primary_location":{"id":"doi:10.1080/21645515.2023.2282803","doi":"https://doi.org/10.1080/21645515.2023.2282803","is_oa":true,"landing_page_url":"https://doi.org/10.1080/21645515.2023.2282803","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/21645515.2023.2282803?download=true","source":{"id":"https://openalex.org/S2483136528","display_name":"Human Vaccines & Immunotherapeutics","issn_l":"2164-5515","issn":["2164-5515","2164-554X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Vaccines &amp; Immunotherapeutics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/21645515.2023.2282803?download=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008871759","display_name":"Hanxi Xiao","orcid":"https://orcid.org/0000-0003-3849-1696","observed_orcids":["https://orcid.org/0000-0003-3849-1696"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanxi Xiao","raw_affiliation_strings":["University of Pittsburgh","Center for Systems Immunology, Departments of Immunology and Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Center for Systems Immunology, Departments of Immunology and Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037394133","display_name":"Aaron B.I. Rosen","orcid":"https://orcid.org/0000-0003-4416-1837","observed_orcids":["https://orcid.org/0000-0003-4416-1837"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Rosen","raw_affiliation_strings":["University of Pittsburgh","Center for Systems Immunology, Departments of Immunology and Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Center for Systems Immunology, Departments of Immunology and Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003971810","display_name":"Prabal Chhibbar","orcid":"https://orcid.org/0000-0003-1666-5050","observed_orcids":["https://orcid.org/0000-0003-1666-5050"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prabal Chhibbar","raw_affiliation_strings":["University of Pittsburgh","Center for Systems Immunology, Departments of Immunology and Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Center for Systems Immunology, Departments of Immunology and Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lenny Moise","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lenny Moise","raw_affiliation_strings":["SeromYx Systems","SeromYx Systems, Woburn, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SeromYx Systems","institution_ids":[]},{"raw_affiliation_string":"SeromYx Systems, Woburn, MA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073031182","display_name":"Jishnu Das","orcid":"https://orcid.org/0000-0002-5747-064X","observed_orcids":["https://orcid.org/0000-0002-5747-064X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jishnu Das","raw_affiliation_strings":["University of Pittsburgh","Center for Systems Immunology, Departments of Immunology and Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-5747-064X","affiliations":[{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Center for Systems Immunology, Departments of Immunology and Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073031182"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":2895,"currency":"EUR","value_usd":3175},"apc_paid":{"value":2895,"currency":"EUR","value_usd":3175},"fwci":0.147,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.12809071,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"19","issue":"3","first_page":"2282803","last_page":"2282803"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multi-omics-integration","display_name":"multi-omics integration","score":0.8640000224113464},{"id":"https://openalex.org/keywords/immune-profiling","display_name":"immune profiling","score":0.8790000081062317},{"id":"https://openalex.org/keywords/machine-learning","display_name":"machine learning","score":0.7639999985694885},{"id":"https://openalex.org/keywords/network-analysis","display_name":"network analysis","score":0.7400000095367432},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.7160000205039978},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.9259999990463257},{"id":"https://openalex.org/keywords/epigenome","display_name":"epigenome","score":0.5709999799728394},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.9789999723434448},{"id":"https://openalex.org/keywords/proteome","display_name":"proteome","score":0.984000027179718},{"id":"https://openalex.org/keywords/metabolome","display_name":"metabolome","score":0.9950000047683716},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/correlates-of-immunity","display_name":"correlates of immunity","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.7987228631973267},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6003888249397278},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.5435627698898315},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4942739009857178},{"id":"https://openalex.org/C2779903281","wikidata":"https://www.wikidata.org/wiki/Q6888026","display_name":"Modalities","level":2,"score":0.49312159419059753},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48777633905410767},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.45048850774765015},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.4153084456920624},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34498825669288635},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.18611064553260803},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.12741529941558838},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/21645515.2023.2282803","doi":"https://doi.org/10.1080/21645515.2023.2282803","is_oa":true,"landing_page_url":"https://doi.org/10.1080/21645515.2023.2282803","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/21645515.2023.2282803?download=true","source":{"id":"https://openalex.org/S2483136528","display_name":"Human Vaccines & Immunotherapeutics","issn_l":"2164-5515","issn":["2164-5515","2164-554X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Vaccines &amp; Immunotherapeutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10730168","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10730168","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10730168/pdf/KHVI_19_2282803.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Vaccin Immunother","raw_type":"Text"},{"id":"pmid:38100557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38100557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human vaccines & immunotherapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8bb18e3410fd4b87834c74af00708fb4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8bb18e3410fd4b87834c74af00708fb4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Vaccines & Immunotherapeutics, Vol 19, Iss 3 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/21645515.2023.2282803","doi":"https://doi.org/10.1080/21645515.2023.2282803","is_oa":true,"landing_page_url":"https://doi.org/10.1080/21645515.2023.2282803","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/21645515.2023.2282803?download=true","source":{"id":"https://openalex.org/S2483136528","display_name":"Human Vaccines & Immunotherapeutics","issn_l":"2164-5515","issn":["2164-5515","2164-554X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Vaccines &amp; Immunotherapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000856425","display_name":"Linking genome variation to transcriptional network dynamics in human B cells","funder_award_id":"U01HG012041","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G9000892550","display_name":"Uncovering latent factors underlying weak and robust responses to influenza vaccine in healthy and obese older adults","funder_award_id":"R01AI170108","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000920869","display_name":"Using three-dimensional protein networks to uncover immuno-modulatory molecular phenotypes in infectious disease","funder_award_id":"DP2AI164325","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389816366.pdf","grobid_xml":"https://content.openalex.org/works/W4389816366.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W1994803330","https://openalex.org/W2021340905","https://openalex.org/W2024103356","https://openalex.org/W2042789810","https://openalex.org/W2047693963","https://openalex.org/W2062706447","https://openalex.org/W2088891952","https://openalex.org/W2112811019","https://openalex.org/W2119097398","https://openalex.org/W2130790725","https://openalex.org/W2135782683","https://openalex.org/W2161738112","https://openalex.org/W2172112723","https://openalex.org/W2223009545","https://openalex.org/W2305116528","https://openalex.org/W2521361619","https://openalex.org/W2613240323","https://openalex.org/W2616922646","https://openalex.org/W2772039551","https://openalex.org/W2782153240","https://openalex.org/W2806375253","https://openalex.org/W2885744227","https://openalex.org/W2888437865","https://openalex.org/W2889236955","https://openalex.org/W2904824676","https://openalex.org/W2915848182","https://openalex.org/W2923240451","https://openalex.org/W2939422961","https://openalex.org/W2948469692","https://openalex.org/W2949177718","https://openalex.org/W2950802088","https://openalex.org/W2963869377","https://openalex.org/W2972343718","https://openalex.org/W3005561908","https://openalex.org/W3007282081","https://openalex.org/W3022285953","https://openalex.org/W3023033208","https://openalex.org/W3027051073","https://openalex.org/W3027087100","https://openalex.org/W3044993434","https://openalex.org/W3047880178","https://openalex.org/W3092220003","https://openalex.org/W3093858607","https://openalex.org/W3095016916","https://openalex.org/W3099530525","https://openalex.org/W3126460810","https://openalex.org/W3129476455","https://openalex.org/W3144696998","https://openalex.org/W3157384750","https://openalex.org/W3164692211","https://openalex.org/W3164812509","https://openalex.org/W3176444924","https://openalex.org/W3182898074","https://openalex.org/W3198511950","https://openalex.org/W3211795874","https://openalex.org/W3216894362","https://openalex.org/W4200581587","https://openalex.org/W4205817967","https://openalex.org/W4206896921","https://openalex.org/W4207077800","https://openalex.org/W4213211303","https://openalex.org/W4220737595","https://openalex.org/W4220978613","https://openalex.org/W4221049186","https://openalex.org/W4221097055","https://openalex.org/W4224300882","https://openalex.org/W4280578986","https://openalex.org/W4281689850","https://openalex.org/W4292117722","https://openalex.org/W4293764391","https://openalex.org/W4300861664","https://openalex.org/W4304196242","https://openalex.org/W4307184360","https://openalex.org/W4307715796","https://openalex.org/W4307716642","https://openalex.org/W4309648210","https://openalex.org/W4312067520","https://openalex.org/W4318775173","https://openalex.org/W4321369676","https://openalex.org/W4321611238","https://openalex.org/W4378212544","https://openalex.org/W4378716051","https://openalex.org/W4380871243","https://openalex.org/W4389564148"],"related_works":["https://openalex.org/W4385186489","https://openalex.org/W3043026144","https://openalex.org/W4296691020","https://openalex.org/W4392558563","https://openalex.org/W3033962666","https://openalex.org/W4320150005","https://openalex.org/W1972067160","https://openalex.org/W4392845062","https://openalex.org/W4378348446","https://openalex.org/W2007219269"],"abstract_inverted_index":{"A":[0],"significant":[1],"surge":[2],"in":[3],"research":[4],"endeavors":[5],"leverages":[6],"the":[7,56,74],"vast":[8],"potential":[9],"of":[10,18,36,45,115],"high-throughput":[11],"omic":[12],"technology":[13],"platforms":[14],"for":[15,72],"broad":[16],"profiling":[17],"biological":[19],"responses":[20],"to":[21,51,85,102,108],"vaccines":[22],"and":[23,26,39,49,58,64,80,95,104,113,117],"cutting-edge":[24],"immunotherapies":[25],"stem-cell":[27],"therapies":[28],"under":[29],"development.":[30],"These":[31],"profiles":[32],"capture":[33,55],"different":[34,43],"aspects":[35],"core":[37],"regulatory":[38],"functional":[40],"processes":[41],"at":[42],"scales":[44],"resolution":[46],"from":[47],"molecular":[48],"cellular":[50],"organismal.":[52],"Systems":[53],"approaches":[54,97],"complex":[57],"intricate":[59],"interplay":[60],"between":[61],"these":[62,106],"layers":[63],"scales.":[65],"Here,":[66],"we":[67],"summarize":[68],"experimental":[69],"data":[70],"modalities,":[71,107],"characterizing":[73],"genome,":[75],"epigenome,":[76],"transcriptome,":[77],"proteome,":[78],"metabolome,":[79],"antibody-ome,":[81],"that":[82,98],"enable":[83],"us":[84],"generate":[86],"large-scale":[87],"immune":[88],"profiles.":[89],"We":[90],"also":[91],"discuss":[92],"machine":[93],"learning":[94],"network":[96],"are":[99],"commonly":[100],"used":[101],"analyze":[103],"integrate":[105],"gain":[109],"insights":[110],"into":[111],"correlates":[112],"mechanisms":[114],"natural":[116],"vaccine-mediated":[118],"immunity":[119],"as":[120,122],"well":[121],"therapy-induced":[123],"immunomodulation.":[124]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-16T00:00:00"}
