{"id":"https://openalex.org/W4389804497","doi":"https://doi.org/10.1016/j.arabjc.2023.105567","title":"Inhibitory effects of platinum nanoparticles coated with polyethylene glycol and conjugated with Rutin on the MCF-7 breast cancer cell line","display_name":"Inhibitory effects of platinum nanoparticles coated with polyethylene glycol and conjugated with Rutin on the MCF-7 breast cancer cell line","publication_year":2023,"publication_date":"2023-12-16","ids":{"openalex":"https://openalex.org/W4389804497","doi":"https://doi.org/10.1016/j.arabjc.2023.105567"},"language":"en","primary_location":{"id":"doi:10.1016/j.arabjc.2023.105567","doi":"https://doi.org/10.1016/j.arabjc.2023.105567","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.arabjc.2023.105567","pdf_url":null,"source":{"id":"https://openalex.org/S2357026","display_name":"Arabian Journal of Chemistry","issn_l":"1878-5352","issn":["1878-5352","1878-5379"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arabian Journal of Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.arabjc.2023.105567","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101485253","display_name":"Yue Li","orcid":"https://orcid.org/0000-0003-4678-3568","observed_orcids":["https://orcid.org/0000-0003-4678-3568"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210103956","display_name":"Third Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/01f77gp95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Li","raw_affiliation_strings":["Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin 150086, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210103956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076184087","display_name":"Jianming Guo","orcid":"https://orcid.org/0000-0002-9300-8401","observed_orcids":["https://orcid.org/0000-0002-9300-8401"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210103956","display_name":"Third Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/01f77gp95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianming Guo","raw_affiliation_strings":["Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210103956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101199322","display_name":"Xue Gong","orcid":"https://orcid.org/0009-0004-6846-8192","observed_orcids":["https://orcid.org/0009-0004-6846-8192"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210103956","display_name":"Third Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/01f77gp95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Gong","raw_affiliation_strings":["Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210103956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101468621","display_name":"Huanyu Zhang","orcid":"https://orcid.org/0000-0001-6480-2510","observed_orcids":["https://orcid.org/0000-0001-6480-2510"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210103956","display_name":"Third Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/01f77gp95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huanyu Zhang","raw_affiliation_strings":["Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210103956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085823894","display_name":"Keru Ma","orcid":"https://orcid.org/0000-0003-3397-5667","observed_orcids":["https://orcid.org/0000-0003-3397-5667"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210103956","display_name":"Third Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/01f77gp95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Keru Ma","raw_affiliation_strings":["Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210103956"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuan Sui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210103956","display_name":"Third Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/01f77gp95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Sui","raw_affiliation_strings":["Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210103956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057786669","display_name":"Baihui Chen","orcid":"https://orcid.org/0009-0007-4334-7337","observed_orcids":["https://orcid.org/0009-0007-4334-7337","https://orcid.org/0009-0003-5925-2050","https://orcid.org/0009-0003-3182-108X"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210103956","display_name":"Third Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/01f77gp95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baihui Chen","raw_affiliation_strings":["Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210103956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080831482","display_name":"Yubo Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210103956","display_name":"Third Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/01f77gp95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yubo Du","raw_affiliation_strings":["Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210103956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100371630","display_name":"Tianyu Chen","orcid":"https://orcid.org/0000-0003-3314-365X","observed_orcids":["https://orcid.org/0000-0003-3314-365X"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210103956","display_name":"Third Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/01f77gp95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianyu Chen","raw_affiliation_strings":["Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210103956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067065755","display_name":"Dongxu Yang","orcid":"https://orcid.org/0000-0002-4753-1154","observed_orcids":["https://orcid.org/0000-0002-4753-1154"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210103956","display_name":"Third Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/01f77gp95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongxu Yang","raw_affiliation_strings":["Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210103956"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101419399","display_name":"Dalin Li","orcid":"https://orcid.org/0000-0003-4738-0074","observed_orcids":["https://orcid.org/0000-0003-4738-0074"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210103956","display_name":"Third Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/01f77gp95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103956"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dalin Li","raw_affiliation_strings":["Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210103956"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101419399"],"corresponding_institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210103956"],"apc_list":{"value":1350,"currency":"USD","value_usd":1350},"apc_paid":{"value":1350,"currency":"USD","value_usd":1350},"fwci":0.4862,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.51517238,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"17","issue":"3","first_page":"105567","last_page":"105567"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.6054999828338623,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.6054999828338623,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.25369998812675476,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.08919999748468399,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platinum-nanoparticles","display_name":"platinum nanoparticles","score":0.9980000257492065},{"id":"https://openalex.org/keywords/polyethylene-glycol-coating","display_name":"polyethylene glycol coating","score":0.9290000200271606},{"id":"https://openalex.org/keywords/rutin","display_name":"rutin","score":0.7990000247955322},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7210000157356262},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8220000267028809},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8650000095367432},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.7360000014305115},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9860000014305115},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.9309999942779541},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8450000286102295},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9300000071525574},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9700000286102295},{"id":"https://openalex.org/keywords/anticancer-mechanism","display_name":"anticancer mechanism","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C2775963812","wikidata":"https://www.wikidata.org/wiki/Q407857","display_name":"Rutin","level":3,"score":0.9062715172767639},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8098334074020386},{"id":"https://openalex.org/C109541995","wikidata":"https://www.wikidata.org/wiki/Q1881253","display_name":"MCF-7","level":5,"score":0.8005886077880859},{"id":"https://openalex.org/C2776964284","wikidata":"https://www.wikidata.org/wiki/Q410083","display_name":"Polyethylene glycol","level":2,"score":0.6309456825256348},{"id":"https://openalex.org/C54400483","wikidata":"https://www.wikidata.org/wiki/Q1793202","display_name":"PEG ratio","level":2,"score":0.6023448705673218},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4856458902359009},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4054489731788635},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3545738458633423},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.30588623881340027},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2911689877510071},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2697014808654785},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1618238091468811},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08176693320274353},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08092817664146423},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.06552311778068542},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.05315941572189331},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.arabjc.2023.105567","doi":"https://doi.org/10.1016/j.arabjc.2023.105567","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.arabjc.2023.105567","pdf_url":null,"source":{"id":"https://openalex.org/S2357026","display_name":"Arabian Journal of Chemistry","issn_l":"1878-5352","issn":["1878-5352","1878-5379"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arabian Journal of Chemistry","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.4621885","doi":"https://doi.org/10.2139/ssrn.4621885","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4621885","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:doaj.org/article:03a4e52c56ed40a9aa388e0146dedf69","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/03a4e52c56ed40a9aa388e0146dedf69","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arabian Journal of Chemistry, Vol 17, Iss 3, Pp 105567- (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.arabjc.2023.105567","doi":"https://doi.org/10.1016/j.arabjc.2023.105567","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.arabjc.2023.105567","pdf_url":null,"source":{"id":"https://openalex.org/S2357026","display_name":"Arabian Journal of Chemistry","issn_l":"1878-5352","issn":["1878-5352","1878-5379"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arabian Journal of Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1543358981","https://openalex.org/W1980301519","https://openalex.org/W1986170309","https://openalex.org/W1987074318","https://openalex.org/W1996690996","https://openalex.org/W2002321863","https://openalex.org/W2005370671","https://openalex.org/W2005427648","https://openalex.org/W2048552732","https://openalex.org/W2051871150","https://openalex.org/W2063705045","https://openalex.org/W2076598575","https://openalex.org/W2107277218","https://openalex.org/W2108966286","https://openalex.org/W2117986744","https://openalex.org/W2157999078","https://openalex.org/W2278097313","https://openalex.org/W2303311035","https://openalex.org/W2344113150","https://openalex.org/W2400821311","https://openalex.org/W2610328326","https://openalex.org/W2610950101","https://openalex.org/W2728130392","https://openalex.org/W2734984037","https://openalex.org/W2768768130","https://openalex.org/W2773170910","https://openalex.org/W2906587283","https://openalex.org/W2910387680","https://openalex.org/W2945363791","https://openalex.org/W2964823449","https://openalex.org/W2966022540","https://openalex.org/W2981456530","https://openalex.org/W2986565960","https://openalex.org/W2989039999","https://openalex.org/W3015142340","https://openalex.org/W3016462724","https://openalex.org/W3111621473","https://openalex.org/W3128646645","https://openalex.org/W3165234606","https://openalex.org/W3166586081","https://openalex.org/W3199402884","https://openalex.org/W4210853074","https://openalex.org/W4224218910","https://openalex.org/W4296893337","https://openalex.org/W6790598159"],"related_works":["https://openalex.org/W4388505178","https://openalex.org/W4402432688","https://openalex.org/W2778752945","https://openalex.org/W3029440098","https://openalex.org/W2034925509","https://openalex.org/W3111920553","https://openalex.org/W4405336989","https://openalex.org/W7204087762","https://openalex.org/W1994452439","https://openalex.org/W4283712635"],"abstract_inverted_index":{"The":[0,51,95,143,163,192],"objective":[1],"of":[2,11,53,97,138,165,184,194],"this":[3],"work":[4],"is":[5],"to":[6,140],"characterize":[7],"the":[8,45,54,73,89,98,111,117,131,166,182,185,195,201,210,215,221],"anticancer":[9],"mechanism":[10],"platinum":[12],"nanoparticles":[13],"coated":[14,36],"with":[15,20,37,40,66,212,225],"polyethylene":[16],"glycol":[17],"and":[18,42,49,59,68,79,85,91,102,105,113,125,170,178,197,204,217,231],"conjugated":[19,39],"Rutin":[21],"(Rutin-PEG-PtNPs)":[22],"in":[23,88,116,134,189,220],"a":[24,135],"breast":[25,55,61,150,158],"cancer":[26,56,151],"cell":[27,222],"line.":[28],"PtNPs":[29],"were":[30,93,121,133,227],"synthesized":[31],"using":[32],"Dendrobium":[33],"officinale":[34],"extract,":[35],"PEG,":[38],"Rutin,":[41],"characterized":[43],"by":[44,72,123,174,229],"FT-IR,":[46],"XRD,":[47],"DLS,":[48],"TEM.":[50],"viability":[52],"cells":[57,62,152,159,211],"(MCF-7)":[58],"normal":[60,157],"(MCF-10A)":[63],"after":[64,208],"treatment":[65],"PEG-PtNPs":[67,90],"Rutin-PEG-PtNPs":[69,92,118,144,226],"was":[70,172,187],"studied":[71],"MTT":[74],"assay.":[75],"Superoxide":[76],"dismutase":[77],"(SOD)":[78],"catalase":[80],"(CAT)":[81],"activity,":[82],"MDA":[83,205],"level,":[84],"LDH":[86,202],"leakage":[87,203],"measured.":[94],"expression":[96,164,183],"p53,":[99,167],"Bax,":[100,168],"Bcl-2,":[101],"caspase":[103],"\u22128,":[104],"\u22129":[106,171],"genes,":[107],"as":[108,110],"well":[109],"NF-\u03baB":[112,216],"IL-6":[114,218],"levels":[115,206,219],"treated":[119,224],"cells,":[120],"investigated":[122],"qPCR":[124],"ELISA":[126],"assays.":[127],"Results":[128],"demonstrated":[129],"that":[130],"NPs":[132],"size":[136],"range":[137],"30":[139],"60":[141],"nm.":[142],"showed":[145],"greater":[146],"cytotoxic":[147],"effects":[148],"on":[149],"(IC50:":[153,160],"45.5":[154],"\u00b5g/mL)":[155],"than":[156],"69.4":[161],"\u00b5g/mL).":[162],"caspase-8,":[169],"upregulated":[173],"1.96,":[175],"1.84,":[176],"1.31,":[177],"2.79":[179],"folds,":[180],"while":[181,200],"Bcl-2":[186],"reduced":[188,228],"Rutin-PEG-PtNP-treated":[190],"cells.":[191,242],"activity":[193],"SOD":[196],"CAT":[198],"decreased,":[199],"increased":[207],"treating":[209],"Rutin-PEG-PtNPs.":[213],"Also,":[214],"cultures":[223],"22.6":[230],"17.0":[232],"%,":[233],"respectively.":[234],"Rutin-PEG-Pt":[235],"indicated":[236],"promising":[237],"inhibitory":[238],"potential":[239],"against":[240],"MCF-7":[241]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-16T00:00:00"}