{"id":"https://openalex.org/W4389765746","doi":"https://doi.org/10.14309/01.ajg.0000995904.06419.f0","title":"S41 Case Report: Immunoglobulin G4-Related Disease Mistaken for Crohn\u2019s Disease","display_name":"S41 Case Report: Immunoglobulin G4-Related Disease Mistaken for Crohn\u2019s Disease","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4389765746","doi":"https://doi.org/10.14309/01.ajg.0000995904.06419.f0"},"language":"en","primary_location":{"id":"doi:10.14309/01.ajg.0000995904.06419.f0","doi":"https://doi.org/10.14309/01.ajg.0000995904.06419.f0","is_oa":false,"landing_page_url":"http://dx.doi.org/10.14309/01.ajg.0000995904.06419.f0","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063405650","display_name":"Emma A. Picker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emma A. Picker","raw_affiliation_strings":["University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, Illinois, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, Illinois, United States;","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077001699","display_name":"Reem Jan","orcid":"https://orcid.org/0009-0003-8364-6789","observed_orcids":["https://orcid.org/0009-0003-8364-6789"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reem Jan","raw_affiliation_strings":["Section of Rheumatology, University of Chicago Medicine, Chicago, Illinois, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Rheumatology, University of Chicago Medicine, Chicago, Illinois, United States;","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101708006","display_name":"Christopher R. Weber","orcid":"https://orcid.org/0000-0002-2117-3184","observed_orcids":["https://orcid.org/0000-0002-2117-3184"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Weber","raw_affiliation_strings":["Department of Pathology, University of Chicago Medicine, Chicago, Illinois, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Chicago Medicine, Chicago, Illinois, United States","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058363100","display_name":"Lindsay J. Yassan","orcid":"https://orcid.org/0000-0002-2265-7930","observed_orcids":["https://orcid.org/0000-0002-2265-7930"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsay Yassan","raw_affiliation_strings":["Department of Pathology, University of Chicago Medicine, Chicago, Illinois, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Chicago Medicine, Chicago, Illinois, United States","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101841548","display_name":"John A L Hart","orcid":"https://orcid.org/0000-0002-8929-2462","observed_orcids":["https://orcid.org/0000-0002-8929-2462"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Hart","raw_affiliation_strings":["Department of Pathology, University of Chicago Medicine, Chicago, Illinois, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Chicago Medicine, Chicago, Illinois, United States","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049169459","display_name":"David T. Rubin","orcid":"https://orcid.org/0000-0001-5647-1723","observed_orcids":["https://orcid.org/0000-0001-5647-1723"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Rubin","raw_affiliation_strings":["University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, Illinois, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, Illinois, United States;","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"118","issue":"12S","first_page":"S11","last_page":"S12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11576","display_name":"IgG4-Related and Inflammatory Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11576","display_name":"IgG4-Related and Inflammatory Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12328","display_name":"Autoimmune and Inflammatory Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igg4-related-disease","display_name":"IgG4-related disease","score":0.925000011920929},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.8569999933242798},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.7059999704360962},{"id":"https://openalex.org/keywords/granulomatosis-with-polyangiitis","display_name":"granulomatosis with polyangiitis","score":0.906000018119812},{"id":"https://openalex.org/keywords/intestinal-ultrasound","display_name":"intestinal ultrasound","score":0.37599998712539673},{"id":"https://openalex.org/keywords/serum-igg4","display_name":"serum IgG4","score":0.6499999761581421},{"id":"https://openalex.org/keywords/lymphadenopathy","display_name":"lymphadenopathy","score":0.6460000276565552},{"id":"https://openalex.org/keywords/bone-marrow-biopsy","display_name":"bone marrow biopsy","score":0.45100000500679016},{"id":"https://openalex.org/keywords/refractory-disease","display_name":"refractory disease","score":0.4779999852180481},{"id":"https://openalex.org/keywords/eosinophilic-inflammation","display_name":"eosinophilic inflammation","score":0.48500001430511475},{"id":"https://openalex.org/keywords/infliximab","display_name":"infliximab","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9522258043289185},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5945183634757996},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4680098295211792},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2894623279571533},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14439350366592407}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/01.ajg.0000995904.06419.f0","doi":"https://doi.org/10.14309/01.ajg.0000995904.06419.f0","is_oa":false,"landing_page_url":"http://dx.doi.org/10.14309/01.ajg.0000995904.06419.f0","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416929218","https://openalex.org/W4390338762","https://openalex.org/W7114775219","https://openalex.org/W4307195450","https://openalex.org/W2923022311","https://openalex.org/W2148528275","https://openalex.org/W4384917904","https://openalex.org/W4312617342","https://openalex.org/W7160240023","https://openalex.org/W2418682304"],"abstract_inverted_index":{"Background:":[0],"Immunoglobulin":[1],"G4-related":[2],"disease":[3,58,70,209],"(IgG4-RD)":[4],"is":[5,21,34],"a":[6,24,40,63,116,255,281,299,313,335,389,423],"rare":[7,440],"fibrous":[8],"and":[9,20,38,46,77,107,115,119,145,179,191,204,210,240,254,265,280,326,334,356,370,413,430,432,447],"chronic":[10],"immune-mediated":[11],"inflammatory":[12,56],"disorder":[13,441],"that":[14],"can":[15],"affect":[16],"most":[17],"organ":[18],"systems":[19],"characterized":[22,194],"by":[23,195,232],"histopathological":[25],"lymphoplasmacytic":[26],"infiltrate":[27],"rich":[28],"in":[29,75,188,396,442],"IgG4+":[30,372],"plasma":[31,373],"cells.":[32,374],"IgG4-RD":[33,426],"difficult":[35],"to":[36,49,164,220,332,342,347,449],"diagnose":[37],"requires":[39],"combined":[41],"analysis":[42],"of":[43,72,86,101,112,124,159,213,270,274,284,392,425,436,438,457],"radiologic,":[44],"histopathological,":[45],"laboratory":[47],"findings":[48,158],"distinguish":[50],"it":[51],"from":[52],"other":[53],"conditions,":[54],"including":[55],"bowel":[57,133,197],"(IBD).":[59],"Methods:":[60],"We":[61,421],"describe":[62],"37-year-old":[64],"man":[65],"previously":[66],"diagnosed":[67],"with":[68,80,83,141,156,215,247,360,400],"Crohn\u2019s":[69],"(CD)":[71],"the":[73,113,122,189,291,322,357,383,393,397,408,434,455],"colon":[74,114,193,385],"2020":[76],"suspected":[78],"granulomatosis":[79,214],"polyangiitis":[81],"(GPA)":[82],"limited":[84],"involvement":[85],"his":[87,98,102,125,136,167,211],"sinuses,":[88],"who":[89],"presented":[90],"3":[91],"years":[92],"later":[93,146],"for":[94,378,404],"an":[95,217],"opinion":[96],"regarding":[97],"management.":[99],"Review":[100],"CD":[103,111,221,429],"history":[104,212],"included":[105],"endoscopic":[106,157],"histologic":[108],"reports":[109],"describing":[110],"CT":[117],"abdomen":[118],"pelvis":[120],"at":[121,237,454],"time":[123,456],"diagnosis":[126,137,219],"which":[127,297,366,387],"did":[128],"not":[129,263],"show":[130],"additional":[131,294],"small":[132],"involvement.":[134],"After":[135],"he":[138,414],"was":[139,170,176,222,267,288,330,340,354,380],"treated":[140],"infliximab,":[142],"adalimumab,":[143],"ustekinumab,":[144],"risankizumab,":[147],"but":[148],"despite":[149],"drug":[150],"escalation,":[151],"had":[152,293],"partial":[153],"clinical":[154],"response":[155,448],"persisting":[160],"pancolitis.":[161],"Upon":[162],"presentation":[163],"our":[165,238],"center,":[166],"dominant":[168],"symptom":[169],"severe":[171],"abdominal":[172],"pain.":[173],"Stool":[174],"calprotectin":[175],">2000":[177],"ug/g,":[178],"point-of-care":[180],"intestinal":[181],"ultrasound":[182],"(in":[183],"clinic)":[184],"revealed":[185,298,367,388],"active":[186,245],"inflammation":[187],"rectum":[190],"sigmoid":[192],"increased":[196,371],"wall":[198],"thickness,":[199],"hyperemia,":[200],"mesenteric":[201],"fat":[202],"stranding":[203],"lymphadenopathy.":[205],"Given":[206],"medically":[207],"resistant":[208],"polyangiitis,":[216],"alternative":[218],"suspected.":[223],"The":[224,328],"patient\u2019s":[225,384,409],"prior":[226,346],"colonoscopic":[227],"biopsies":[228],"were":[229,241,262,278],"subsequently":[230],"reviewed":[231],"two":[233],"expert":[234],"IBD":[235],"pathologists":[236],"center":[239],"interpreted":[242],"as":[243,428],"patchy":[244,282],"colitis":[246],"ulceration,":[248],"erosion,":[249],"mild":[250],"crypt":[251,275],"architectural":[252],"distortion,":[253],"poorly":[256],"formed":[257],"granuloma.":[258],"However,":[259],"CD-type":[260],"granulomas":[261],"identified,":[264],"there":[266],"no":[268],"evidence":[269],"vasculitis.":[271],"Some":[272],"areas":[273],"epithelial":[276],"attenuation":[277],"present,":[279],"prominence":[283],"lamina":[285,398],"propria":[286,399],"eosinophils":[287],"seen.":[289],"Simultaneously,":[290],"patient":[292,329,358],"immunologic":[295],"evaluation":[296],"serum":[300],"IgG4":[301,379,410],"level":[302],"1951.5":[303],"mg/dL,":[304],"elevated":[305],"beta":[306],"2":[307],"globulin,":[308],"low":[309,314],"gamma":[310],"protein":[311],"fraction,":[312],"albumin/globulin":[315],"ratio.":[316],"Pan-CT":[317],"identified":[318],"extensive":[319],"lymphadenopathy":[320],"throughout":[321],"patient\u2018s":[323],"neck,":[324],"chest,":[325],"abdomen.":[327],"referred":[331],"hematology":[333],"subsequent":[336],"bone":[337],"marrow":[338],"biopsy":[339],"performed":[341,381],"rule":[343],"out":[344],"myeloma":[345],"possible":[348],"lymph":[349,363],"node":[350,364],"excision.":[351],"Marrow":[352],"assessment":[353],"normal,":[355],"proceeded":[359],"left":[361],"axillary":[362],"excision":[365],"follicular":[368],"hyperplasia":[369],"Subsequently,":[375],"immunohistochemical":[376],"staining":[377],"on":[382],"biopsies,":[386],"high":[390],"percentage":[391],"IgG":[394],"cells":[395],">":[401],"50%":[402],"positivity":[403],"IgG4.":[405],"This":[406],"confirmed":[407],"mediated":[411],"colitis,":[412],"has":[415],"now":[416],"started":[417],"rituximab":[418,450],"therapy.":[419],"Conclusions:":[420],"demonstrate":[422],"case":[424,459],"misclassified":[427],"GPA":[431],"emphasize":[433],"importance":[435],"consideration":[437],"this":[439,458],"appropriate":[443],"patients.":[444],"Clinical":[445],"follow-up":[446],"will":[451],"be":[452],"described":[453],"presentation.":[460]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-12-15T00:00:00"}
