{"id":"https://openalex.org/W4389732829","doi":"https://doi.org/10.1038/s41419-023-06358-y","title":"The deubiquitinating enzyme USP44 suppresses hepatocellular carcinoma progression by inhibiting Hedgehog signaling and PDL1 expression","display_name":"The deubiquitinating enzyme USP44 suppresses hepatocellular carcinoma progression by inhibiting Hedgehog signaling and PDL1 expression","publication_year":2023,"publication_date":"2023-12-14","ids":{"openalex":"https://openalex.org/W4389732829","doi":"https://doi.org/10.1038/s41419-023-06358-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/38097536","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10721641"},"language":"en","primary_location":{"id":"doi:10.1038/s41419-023-06358-y","doi":"https://doi.org/10.1038/s41419-023-06358-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-023-06358-y","pdf_url":"https://www.nature.com/articles/s41419-023-06358-y.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4389732829"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41419-023-06358-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100341523","display_name":"Sisi Chen","orcid":"https://orcid.org/0000-0002-1908-5054","observed_orcids":["https://orcid.org/0000-0002-1908-5054"]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sisi Chen","raw_affiliation_strings":["Department of Neurology, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, PR China"],"raw_orcid":"https://orcid.org/0000-0002-1908-5054","affiliations":[{"raw_affiliation_string":"Department of Neurology, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, PR China","institution_ids":["https://openalex.org/I4210108480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102970894","display_name":"Binghai Zhou","orcid":"https://orcid.org/0000-0002-0678-6628","observed_orcids":["https://orcid.org/0000-0002-0678-6628"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]},{"id":"https://openalex.org/I4210121544","display_name":"Second Hospital of Nanchang","ror":"https://ror.org/0261d1g37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121544"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Binghai Zhou","raw_affiliation_strings":["Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, 200032, PR China","Hepato-Biliary-Pancreatic Surgery Division, Department of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, 200032, PR China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Hepato-Biliary-Pancreatic Surgery Division, Department of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, PR China","institution_ids":["https://openalex.org/I4210108480","https://openalex.org/I4210121544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101835504","display_name":"Wei Huang","orcid":"https://orcid.org/0000-0001-8311-8490","observed_orcids":["https://orcid.org/0000-0001-8311-8490"]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Huang","raw_affiliation_strings":["Department of Neurology, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, PR China","institution_ids":["https://openalex.org/I4210108480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404169","display_name":"Qing Li","orcid":"https://orcid.org/0000-0003-2652-6070","observed_orcids":["https://orcid.org/0000-0003-2652-6070","https://orcid.org/0000-0002-0467-8148"]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Li","raw_affiliation_strings":["Department of Pathology, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, PR China","institution_ids":["https://openalex.org/I4210108480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101050396","display_name":"Yu Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ye Yu","raw_affiliation_strings":["Department of Neurology, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, PR China","institution_ids":["https://openalex.org/I4210108480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113071355","display_name":"Xiuqing Kuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiuqing Kuang","raw_affiliation_strings":["Department of Physical Examination, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Examination, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, PR China","institution_ids":["https://openalex.org/I4210108480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003024911","display_name":"Huabin Huang","orcid":"https://orcid.org/0009-0000-7858-5561","observed_orcids":["https://orcid.org/0009-0000-7858-5561","https://orcid.org/0000-0001-8072-3425"]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]},{"id":"https://openalex.org/I4210121544","display_name":"Second Hospital of Nanchang","ror":"https://ror.org/0261d1g37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121544"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huabin Huang","raw_affiliation_strings":["Department of Medical Imaging, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Imaging, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, PR China","institution_ids":["https://openalex.org/I4210108480","https://openalex.org/I4210121544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102888696","display_name":"Wei Wang","orcid":"https://orcid.org/0000-0001-5694-1297","observed_orcids":["https://orcid.org/0000-0001-5694-1297"]},"institutions":[{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Department of Neurology, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, PR China. wuhansy@126.com","Department of Neurology, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, PR China"],"raw_orcid":"https://orcid.org/0000-0001-5694-1297","affiliations":[{"raw_affiliation_string":"Department of Neurology, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, PR China. wuhansy@126.com","institution_ids":["https://openalex.org/I4210108480"]},{"raw_affiliation_string":"Department of Neurology, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, PR China","institution_ids":["https://openalex.org/I4210108480"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050191965","display_name":"Peiyi Xie","orcid":"https://orcid.org/0000-0001-5130-1506","observed_orcids":["https://orcid.org/0000-0001-5130-1506"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Peiyi Xie","raw_affiliation_strings":["Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, 200032, PR China. peiyi0505@163.com","Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, 200032, PR China"],"raw_orcid":"https://orcid.org/0000-0001-5130-1506","affiliations":[{"raw_affiliation_string":"Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, 200032, PR China. peiyi0505@163.com","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, 200032, PR China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5050191965","https://openalex.org/A5102888696"],"corresponding_institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210108480","https://openalex.org/I4210127074"],"apc_list":{"value":4490,"currency":"USD","value_usd":4490},"apc_paid":{"value":4490,"currency":"USD","value_usd":4490},"fwci":1.4105,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.80348165,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"14","issue":"12","first_page":"830","last_page":"830"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.044599998742341995,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/usp44","display_name":"USP44","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8730000257492065},{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.9380000233650208},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.8960000276565552},{"id":"https://openalex.org/keywords/itch-e3-ubiquitin-ligase","display_name":"Itch E3 ubiquitin ligase","score":0.9229999780654907},{"id":"https://openalex.org/keywords/gli1","display_name":"Gli1","score":0.9390000104904175},{"id":"https://openalex.org/keywords/deubiquitination","display_name":"deubiquitination","score":0.9079999923706055},{"id":"https://openalex.org/keywords/protein-stabilization","display_name":"protein stabilization","score":0.8069999814033508},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8349999785423279},{"id":"https://openalex.org/keywords/gant61","display_name":"GANT61","score":0.8740000128746033},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9300000071525574}],"concepts":[{"id":"https://openalex.org/C2779933373","wikidata":"https://www.wikidata.org/wiki/Q14886430","display_name":"GLI1","level":4,"score":0.8837364912033081},{"id":"https://openalex.org/C102658986","wikidata":"https://www.wikidata.org/wiki/Q5266092","display_name":"Deubiquitinating enzyme","level":4,"score":0.8643560409545898},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.7117223143577576},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6786292195320129},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.6714251041412354},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.5939662456512451},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5557427406311035},{"id":"https://openalex.org/C193270364","wikidata":"https://www.wikidata.org/wiki/Q17141925","display_name":"Tissue microarray","level":3,"score":0.544100284576416},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5278149843215942},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5235295295715332},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.48886364698410034},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4561365246772766},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4396301209926605},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2238614857196808},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1648920774459839},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14417871832847595},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05877736210823059}],"mesh":[{"descriptor_ui":"D000071676","descriptor_name":"Zinc Finger Protein GLI1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071676","descriptor_name":"Zinc Finger Protein GLI1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000072017","descriptor_name":"Deubiquitinating Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043222","descriptor_name":"Ubiquitin Thiolesterase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043222","descriptor_name":"Ubiquitin Thiolesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41419-023-06358-y","doi":"https://doi.org/10.1038/s41419-023-06358-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-023-06358-y","pdf_url":"https://www.nature.com/articles/s41419-023-06358-y.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-3209355/v1","doi":"https://doi.org/10.21203/rs.3.rs-3209355/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-3209355/v1","pdf_url":"https://www.researchsquare.com/article/rs-3209355/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10721641","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10721641","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Dis","raw_type":"Text"},{"id":"pmid:38097536","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38097536","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death & disease","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c4a9aa23c5c448f48f1c06d279f5f92e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c4a9aa23c5c448f48f1c06d279f5f92e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Death and Disease, Vol 14, Iss 12, Pp 1-13 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41419-023-06358-y","doi":"https://doi.org/10.1038/s41419-023-06358-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-023-06358-y","pdf_url":"https://www.nature.com/articles/s41419-023-06358-y.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4941957506","display_name":null,"funder_award_id":"82160576","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322665","display_name":"Natural Science Foundation of Jiangxi Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389732829.pdf","grobid_xml":"https://content.openalex.org/works/W4389732829.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1911660058","https://openalex.org/W1935464246","https://openalex.org/W1971837077","https://openalex.org/W1981286174","https://openalex.org/W1990542926","https://openalex.org/W2004134367","https://openalex.org/W2013248580","https://openalex.org/W2077623588","https://openalex.org/W2088342479","https://openalex.org/W2097299991","https://openalex.org/W2108707301","https://openalex.org/W2123561446","https://openalex.org/W2139364069","https://openalex.org/W2143460288","https://openalex.org/W2163007274","https://openalex.org/W2164490846","https://openalex.org/W2495215685","https://openalex.org/W2507824656","https://openalex.org/W2546627178","https://openalex.org/W2624919543","https://openalex.org/W2799736753","https://openalex.org/W2885434620","https://openalex.org/W2939437655","https://openalex.org/W2963970758","https://openalex.org/W2979719147","https://openalex.org/W2990602950","https://openalex.org/W3004008945","https://openalex.org/W3007708807","https://openalex.org/W3011463191","https://openalex.org/W3015216613","https://openalex.org/W3027847652","https://openalex.org/W3040977984","https://openalex.org/W3068579391","https://openalex.org/W3084734383","https://openalex.org/W3087091547","https://openalex.org/W3087629715","https://openalex.org/W3119841990","https://openalex.org/W3128646645","https://openalex.org/W3153590649","https://openalex.org/W3166489160","https://openalex.org/W4324262440","https://openalex.org/W4377019240","https://openalex.org/W6783246885"],"related_works":["https://openalex.org/W4377019240","https://openalex.org/W4391473771","https://openalex.org/W3164361698","https://openalex.org/W4411136629","https://openalex.org/W3087291586","https://openalex.org/W7150900564","https://openalex.org/W2793760515","https://openalex.org/W4401474284","https://openalex.org/W4365135369","https://openalex.org/W2895880370"],"abstract_inverted_index":{"Hepatocellular":[0],"carcinoma":[1],"(HCC)":[2],"is":[3,25],"one":[4],"of":[5,22,30,41,49,56,63,111,120,125,136,152,186],"the":[6,10,14,19,28,42,84,107,117,134,139,149,153,157],"deadliest":[7],"malignancies":[8],"in":[9,60,64,67,102,116,165,178],"world.":[11],"Research":[12],"into":[13],"key":[15],"genes":[16],"that":[17,76,92],"maintain":[18],"malignant":[20],"behavior":[21],"cancer":[23],"cells":[24],"crucial":[26],"for":[27,197],"treatment":[29],"HCC.":[31,137],"Here,":[32],"we":[33,74,90],"identified":[34],"ubiquitin-specific":[35],"peptidase":[36],"44":[37],"(USP44),":[38],"a":[39,46,61,175],"member":[40],"deubiquitinase":[43],"family,":[44],"as":[45,174],"novel":[47,194],"regulator":[48],"HCC":[50,79,140,179,199],"progression.":[51],"The":[52],"tumor":[53],"suppressive":[54,176],"function":[55],"USP44":[57,77,93,171],"was":[58,143,161],"evaluated":[59],"series":[62],"vitro":[65],"and":[66,105,109,122,133,184,188],"vivo":[68],"experiments.":[69],"Through":[70],"quantitative":[71],"proteomics":[72],"examination,":[73],"demonstrated":[75],"inhibits":[78],"PDL1":[80,131,189],"expression":[81,132],"by":[82,145,180],"downregulating":[83],"Hedgehog":[85],"(Hh)":[86],"signaling":[87],"pathway.":[88],"Mechanistically,":[89],"found":[91,162],"directly":[94],"interacts":[95],"with":[96,167],"Itch,":[97],"an":[98,192],"E3":[99],"ligase":[100],"involved":[101],"Hh":[103,126,182],"signaling,":[104,127,183],"promotes":[106],"deubiquitination":[108],"stabilization":[110],"Itch.":[112],"These":[113],"events":[114],"result":[115],"proteasomal":[118],"degradation":[119],"Gli1":[121,158,187],"subsequent":[123],"inactivation":[124],"which":[128],"ultimately":[129],"suppresses":[130],"progression":[135],"Furthermore,":[138],"tissue":[141],"microarray":[142],"analyzed":[144],"immunohistochemistry":[146],"to":[147,163],"evaluate":[148],"pathological":[150],"relevance":[151],"USP44/Itch/Gli1/PDL1":[154],"axis.":[155],"Finally,":[156],"inhibitor":[159],"GANT61":[160],"act":[164,173],"synergy":[166],"anti-PDL1":[168],"therapy.":[169],"Overall,":[170],"can":[172],"gene":[177],"modulating":[181],"co-inhibition":[185],"might":[190],"be":[191],"effective":[193],"combination":[195],"strategy":[196],"treating":[198],"patients.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-12-15T00:00:00"}