{"id":"https://openalex.org/W4389730232","doi":"https://doi.org/10.1097/01.ccm.0000999832.24501.d0","title":"413: STARTING A MOVEMENT IN THE ICU: NALOXEGOL VERSUS METHYLNALTREXONE FOR OPIOID-INDUCED CONSTIPATION","display_name":"413: STARTING A MOVEMENT IN THE ICU: NALOXEGOL VERSUS METHYLNALTREXONE FOR OPIOID-INDUCED CONSTIPATION","publication_year":2023,"publication_date":"2023-12-14","ids":{"openalex":"https://openalex.org/W4389730232","doi":"https://doi.org/10.1097/01.ccm.0000999832.24501.d0"},"language":"en","primary_location":{"id":"doi:10.1097/01.ccm.0000999832.24501.d0","doi":"https://doi.org/10.1097/01.ccm.0000999832.24501.d0","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.ccm.0000999832.24501.d0","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093126829","display_name":"Daniel Tobben","orcid":"https://orcid.org/0009-0007-0498-7796","observed_orcids":["https://orcid.org/0009-0007-0498-7796"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Tobben","raw_affiliation_strings":["Northwestern"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113031244","display_name":"Sheniece Carpenter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sheniece Carpenter","raw_affiliation_strings":["UNC Health REX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC Health REX","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050101203","display_name":"Rachel Kolar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachel Kolar","raw_affiliation_strings":["UNC Rex Health Care"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC Rex Health Care","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022841353","display_name":"Tia E. Collier","orcid":"https://orcid.org/0000-0001-6252-8060","observed_orcids":["https://orcid.org/0000-0001-6252-8060"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tia Collier","raw_affiliation_strings":["UNC Health REX, Raleigh, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC Health REX, Raleigh, NC","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1811,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.44938847,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"52","issue":"1","first_page":"S180","last_page":"S180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opioid-induced-constipation","display_name":"opioid-induced constipation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/naloxegol","display_name":"naloxegol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/methylnaltrexone","display_name":"methylnaltrexone","score":1.0},{"id":"https://openalex.org/keywords/critically-ill-patients","display_name":"critically ill patients","score":0.8069999814033508},{"id":"https://openalex.org/keywords/intensive-care-unit","display_name":"intensive care unit","score":0.9340000152587891},{"id":"https://openalex.org/keywords/opioid-analgesia","display_name":"opioid analgesia","score":0.6430000066757202},{"id":"https://openalex.org/keywords/time-to-first-bowel-movement","display_name":"time to first bowel movement","score":0.7860000133514404},{"id":"https://openalex.org/keywords/icu-length-of-stay","display_name":"ICU length of stay","score":0.9010000228881836},{"id":"https://openalex.org/keywords/delirium","display_name":"delirium","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.7940000295639038},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.8870000243186951},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.460999995470047},{"id":"https://openalex.org/keywords/stool-frequency","display_name":"stool frequency","score":0.367000013589859}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9448223114013672},{"id":"https://openalex.org/C2781112942","wikidata":"https://www.wikidata.org/wiki/Q178436","display_name":"Constipation","level":2,"score":0.6258495450019836},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5561578273773193},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4953228533267975},{"id":"https://openalex.org/C108797546","wikidata":"https://www.wikidata.org/wiki/Q204015","display_name":"Defecation","level":2,"score":0.4431012272834778},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24964675307273865},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.ccm.0000999832.24501.d0","doi":"https://doi.org/10.1097/01.ccm.0000999832.24501.d0","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.ccm.0000999832.24501.d0","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387948493","https://openalex.org/W2556644374","https://openalex.org/W4307774722","https://openalex.org/W4389730279","https://openalex.org/W3005040067","https://openalex.org/W7219921138","https://openalex.org/W4310153937","https://openalex.org/W3004235380","https://openalex.org/W2138520181","https://openalex.org/W4221131468"],"abstract_inverted_index":{"Introduction:":[0],"Constipation":[1],"impacts":[2],"critically":[3],"ill":[4],"patients":[5,62,308],"and":[6,12,23,68,88,158,170,214,243,274,287,304,327,357],"increases":[7],"delirium":[8,173],"risk,":[9],"ventilator":[10],"time,":[11],"intensive":[13],"care":[14],"unit":[15],"(ICU)":[16],"length":[17,154],"of":[18,35,43,60,98,121,148,155,172,194,202,263,302,306],"stay":[19,156],"(LOS).":[20],"Naloxegol":[21],"(NGL)":[22],"methylnaltrexone":[24],"(MNTX),":[25],"are":[26],"used":[27],"to":[28,39,83,136,232,238,254,319,336,339,343,370],"treat":[29],"opioid-induced":[30],"constipation":[31],"(OIC).":[32],"The":[33],"purpose":[34],"this":[36,365],"study":[37,59,99,130,333],"was":[38,54,134,183,241,252,270,282,323,368],"evaluate":[40],"the":[41,212,217],"efficacy":[42],"NGL":[44,86,142,213,233,251,277,291,307,335,367],"versus":[45,248],"MNTX":[46,84,140,218,247,255,273,286,303,326,340],"for":[47,79,246,272,276,325,329],"OIC":[48,125],"in":[49,211,216,300,341,347,354],"ICU":[50,61,153,280,348],"patients.":[51,349],"Methods:":[52],"This":[53,332],"a":[55,195,199,321,345],"retrospective,":[56],"multi-center,":[57],"cohort":[58,206],"admitted":[63],"between":[64],"January":[65],"1,":[66,70],"2014":[67],"September":[69],"2022.":[71],"Patients":[72,101],"were":[73,102,146,222,229,315,352,362],"included":[74,162,207],"if":[75,104],"received":[76,123,128],"opioid":[77,227],"infusions":[78],"\u22654":[80],"hours":[81,245,266],"prior":[82,231],"or":[85,112,127,141,312],"use":[87,193],"had":[89,109,116],"no":[90,358],"bowel":[91,114],"movement":[92],"(BM)":[93],"within":[94],"48-hours":[95],"before":[96],"start":[97],"drug.":[100],"excluded":[103],"receiving":[105],"nothing":[106],"by":[107,174,192],"mouth,":[108],"an":[110],"ileus":[111],"small":[113],"obstruction,":[115],"gastric":[117],"residuals":[118],">500mL,":[119],"history":[120],"OIC,":[122],"another":[124],"drug,":[126],"both":[129],"drugs.":[131],"Primary":[132,181],"outcome":[133,182],"time":[135,237,342],"first":[137,239],"BM":[138,240,322,346],"from":[139],"initiation.":[143],"Secondary":[144],"outcomes":[145,161],"number":[147,262],"BMs":[149,264],"at":[150],"72":[151,265],"hours,":[152],"(LOS),":[157],"cost-effectiveness.":[159],"Safety":[160],"aspiration":[163,311],"with":[164,168,198,285,290],"NGL,":[165,249],"injection":[166,313],"reactions":[167,314],"MNTX,":[169],"development":[171],"positive":[175,296],"CAM-ICU":[176,297],"score":[177,298],"after":[178,267],"drug":[179,268],"start.":[180],"assessed":[184],"via":[185],"weighted":[186],"Cox":[187],"proportional":[188],"hazards":[189],"model":[190],"followed":[191],"non-inferiority":[196],"test":[197],"preset":[200],"margin":[201],"10%.":[203],"Results:":[204],"Final":[205],"161":[208],"patients:":[209],"110":[210],"51":[215],"group.":[219],"Baseline":[220],"characteristics":[221],"similar":[223],"among":[224],"groups.":[225],"Higher":[226],"dosages":[228],"administered":[230],"initiation":[234,269],"(p=0.0058).":[235],"Median":[236,261,279],"18.3":[242],"23.7":[244],"respectively.":[250],"non-inferior":[253,338],"(Wald":[256],"Statistic":[257],"=":[258],"1.67;":[259],"p=0.047).":[260],"4":[271],"3":[275],"(p=0.70).":[278],"LOS":[281],"12":[283],"days":[284,289],"14":[288],"(p=0.57).":[292],"At":[293],"least":[294],"1":[295],"occurred":[299],"58.8%":[301],"54.5%":[305],"(p=0.61).":[309],"No":[310,350],"noted.":[316],"Average":[317],"cost":[318],"produce":[320,344],"$159.71":[324],"$20.50":[328],"NGL.":[330],"Conclusions:":[331],"found":[334,369],"be":[337,371],"differences":[351],"seen":[353],"secondary":[355],"outcomes,":[356],"major":[359],"safety":[360],"events":[361],"observed.":[363],"For":[364],"trial,":[366],"more":[372],"cost-effective":[373],"than":[374],"MNTX.":[375]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2023-12-15T00:00:00"}
