{"id":"https://openalex.org/W4389729975","doi":"https://doi.org/10.1097/01.ccm.0001003944.80889.12","title":"1447: HYPO- AND HYPERINFLAMMATORY SUBPHENOTYPES IN SEPSIS WITHIN THE INDIVIDUAL","display_name":"1447: HYPO- AND HYPERINFLAMMATORY SUBPHENOTYPES IN SEPSIS WITHIN THE INDIVIDUAL","publication_year":2023,"publication_date":"2023-12-14","ids":{"openalex":"https://openalex.org/W4389729975","doi":"https://doi.org/10.1097/01.ccm.0001003944.80889.12"},"language":"en","primary_location":{"id":"doi:10.1097/01.ccm.0001003944.80889.12","doi":"https://doi.org/10.1097/01.ccm.0001003944.80889.12","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.ccm.0001003944.80889.12","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035968046","display_name":"Katherine Dittman","orcid":"https://orcid.org/0000-0001-8223-4668","observed_orcids":["https://orcid.org/0000-0001-8223-4668"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Dittman","raw_affiliation_strings":["Washington University of Saint Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University of Saint Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085946949","display_name":"Brandt Lydon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandt Lydon","raw_affiliation_strings":["Washington University in St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008032797","display_name":"Patrick G. Lyons","orcid":"https://orcid.org/0000-0002-1557-2787","observed_orcids":["https://orcid.org/0000-0002-1557-2787"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick Lyons","raw_affiliation_strings":["N/A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N/A","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Andrew Michaelson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Michaelson","raw_affiliation_strings":["Washington University in St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St Louis","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"52","issue":"1","first_page":"S694","last_page":"S694"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/latent-class-analysis","display_name":"latent class analysis","score":0.9179999828338623},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.6620000004768372},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9483358263969421},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6290178298950195},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3923834562301636},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24617409706115723}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.ccm.0001003944.80889.12","doi":"https://doi.org/10.1097/01.ccm.0001003944.80889.12","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.ccm.0001003944.80889.12","pdf_url":null,"source":{"id":"https://openalex.org/S108732581","display_name":"Critical Care Medicine","issn_l":"0090-3493","issn":["0090-3493","1530-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4386102775","https://openalex.org/W4389731338","https://openalex.org/W4225311916","https://openalex.org/W4285094272","https://openalex.org/W4406940819","https://openalex.org/W7223475858","https://openalex.org/W7161579116","https://openalex.org/W7161549690","https://openalex.org/W4224222931","https://openalex.org/W2806376027"],"abstract_inverted_index":{"Introduction:":[0],"Sepsis":[1],"is":[2,284],"a":[3,92,127,143,148,183,285,308,319],"severe":[4],"and":[5,23,50,79,164,182,196,206,218,238],"life-threatening":[6],"condition":[7],"that":[8,91,107,191],"affects":[9],"approximately":[10],"10%":[11],"of":[12,29,37,54,63,74,85,105,151,204,236,260,341],"patients":[13,57,75,98,106,153,172,192,250,257,277,304],"admitted":[14,154],"to":[15,87,97,111,117,123,136,155,160,169,177,189,210,229,245,290,292,326,338],"the":[16,19,112,137,178,293,301,332],"ICU":[17,179],"in":[18,25,35,46,56,215,233,248,273,275,300,331],"United":[20],"States":[21],"yearly":[22],"results":[24],"annual":[26],"healthcare":[27],"costs":[28],"around":[30],"$20":[31],"billion1.":[32],"Additionally,":[33],"mortality":[34],"cases":[36],"septic":[38],"shock":[39],"can":[40,51],"be":[41,323],"as":[42,44],"high":[43,61],"38%":[45],"one":[47],"recent":[48,294],"review":[49,185],"reach":[52],"levels":[53],">50%":[55],"with":[58,307,318],"vasoplegia":[59],"requiring":[60],"doses":[62],"vasopressors.1,2":[64],"Recently,":[65],"latent":[66,212],"class":[67,213],"analysis":[68,214],"methods":[69],"have":[70,82,225,327],"identified":[71],"distinct":[72,195],"subphenotypes":[73,81,132,343],"suffering":[76,99],"from":[77,100,147,158],"ARDS,":[78],"these":[80,234,342],"been":[83,227],"predictive":[84],"responses":[86],"therapies.":[88],"We":[89],"suspect":[90],"similar":[93],"LCA":[94],"model":[95,128],"applied":[96],"sepsis":[101,198,219,253,263,280],"may":[102,108,336],"identify":[103],"subsets":[104],"respond":[109],"differently":[110],"multiple":[113,134,175,252],"therapies":[114],"we":[115],"use":[116],"treat":[118],"sepsis.":[119],"Our":[120],"study":[121,141,146,287],"aims":[122],"determine":[124,230,246],"whether":[125],"such":[126],"would":[129],"consistently":[130],"predict":[131],"over":[133,251,264,278],"admissions":[135,176],"ICU.":[138,302],"Methods:":[139],"This":[140,283,334],"was":[142,186,221,243,269],"retrospective":[144],"cohort":[145],"convenience":[149],"sample":[150],"42":[152],"BJC":[156],"hospitals":[157],"2017":[159],"2022.":[161],"ICD":[162],"9":[163],"10":[165],"codes":[166],"were":[167],"used":[168,209,244],"select":[170],"for":[171,180,262,328],"who":[173],"underwent":[174,193],"sepsis,":[181],"chart":[184],"subsequently":[187],"done":[188],"verify":[190],"two":[194,231],"separate":[197,279],"admissions.":[199,254,281],"A":[200,240],"previously":[201,226],"reported":[202],"set":[203],"clinical":[205],"biological":[207],"values":[208,224,274],"perform":[211],"both":[216],"ARDS":[217],"populations":[220,235],"collected.":[222],"These":[223],"shown":[228],"classes":[232],"hypo-":[237],"hyper-inflammatory4.":[239],"one-way":[241],"ANOVA":[242],"variability":[247],"single":[249,276],"Results:":[255],"34":[256],"met":[258],"criteria":[259],"admission":[261],"30":[265],"days":[266],"apart.":[267],"There":[268],"no":[270],"significant":[271],"difference":[272],"Conclusions:":[282],"small":[286],"which":[288],"hopes":[289],"add":[291],"literature":[295],"on":[296],"inflammatory":[297],"subtypes":[298],"seen":[299],"If":[303],"always":[305],"present":[306],"certain":[309],"subphenotype":[310],"or":[311],"if":[312],"pathogens":[313],"are":[314],"more":[315],"frequently":[316],"associated":[317],"subphenotype,":[320],"this":[321],"could":[322],"useful":[324],"information":[325],"treatment":[329],"while":[330],"hospital.":[333],"also":[335],"lead":[337],"further":[339],"investigation":[340],"at":[344],"an":[345],"individual":[346],"level.":[347]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-12-15T00:00:00"}
