{"id":"https://openalex.org/W4389728757","doi":"https://doi.org/10.1167/iovs.64.15.15","title":"JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens Fiber Maturation in Murine Lens Development","display_name":"JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens Fiber Maturation in Murine Lens Development","publication_year":2023,"publication_date":"2023-12-14","ids":{"openalex":"https://openalex.org/W4389728757","doi":"https://doi.org/10.1167/iovs.64.15.15","pmid":"https://pubmed.ncbi.nlm.nih.gov/38095908","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10723223"},"language":"en","primary_location":{"id":"doi:10.1167/iovs.64.15.15","doi":"https://doi.org/10.1167/iovs.64.15.15","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.64.15.15","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1167/iovs.64.15.15","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000185754","display_name":"Qihang Sun","orcid":"https://orcid.org/0009-0008-2339-7190","observed_orcids":["https://orcid.org/0009-0008-2339-7190","https://orcid.org/0009-0008-5747-6807"]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qihang Sun","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101801209","display_name":"Jiani Li","orcid":"https://orcid.org/0000-0003-3939-2542","observed_orcids":["https://orcid.org/0000-0003-3939-2542"]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiani Li","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112865478","display_name":"Jingyu Ma","orcid":"https://orcid.org/0000-0002-5524-6353","observed_orcids":["https://orcid.org/0000-0002-5524-6353"]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyu Ma","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066073519","display_name":"Yuxing Zheng","orcid":"https://orcid.org/0000-0002-3635-3110","observed_orcids":["https://orcid.org/0000-0002-3635-3110"]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxing Zheng","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064171059","display_name":"Rong Ju","orcid":"https://orcid.org/0000-0001-9113-9187","observed_orcids":["https://orcid.org/0000-0001-9113-9187"]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Ju","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077886490","display_name":"Xuri Li","orcid":"https://orcid.org/0000-0002-8277-0767","observed_orcids":["https://orcid.org/0000-0002-8277-0767"]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuri Li","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103679252","display_name":"Xiangrong Ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangrong Ren","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101804540","display_name":"Lijuan Huang","orcid":"https://orcid.org/0000-0001-9787-4828","observed_orcids":["https://orcid.org/0000-0001-9787-4828"]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijuan Huang","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052844122","display_name":"Rongyuan Chen","orcid":"https://orcid.org/0000-0003-2790-9161","observed_orcids":["https://orcid.org/0000-0003-2790-9161","https://orcid.org/0000-0001-5048-6174","https://orcid.org/0000-0002-5355-976X"]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongyuan Chen","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045812440","display_name":"Xuhua Tan","orcid":"https://orcid.org/0000-0001-6929-1991","observed_orcids":["https://orcid.org/0000-0001-6929-1991","https://orcid.org/0009-0001-2337-8239"]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuhua Tan","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100619439","display_name":"Lixia Luo","orcid":"https://orcid.org/0000-0002-9806-4074","observed_orcids":["https://orcid.org/0000-0002-9806-4074"]},"institutions":[{"id":"https://openalex.org/I4391768270","display_name":"State Key Laboratory of Ophthalmology","ror":"https://ror.org/003mfbe21","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768270"]},{"id":"https://openalex.org/I4401726874","display_name":"Zhongshan Ophthalmic Center, Sun Yat-sen University","ror":"https://ror.org/02z2yec16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I157773358","https://openalex.org/I4401726874"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lixia Luo","raw_affiliation_strings":["State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China","institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100619439"],"corresponding_institution_ids":["https://openalex.org/I4391768270","https://openalex.org/I4401726874"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.7095,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.64740501,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"64","issue":"15","first_page":"15","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.6474999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.6474999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":0.32839998602867126,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jam-c","display_name":"JAM-C","score":0.9760000109672546},{"id":"https://openalex.org/keywords/lens-development","display_name":"lens development","score":0.9210000038146973},{"id":"https://openalex.org/keywords/lens-epithelial-cell-proliferation","display_name":"lens epithelial cell proliferation","score":0.925000011920929},{"id":"https://openalex.org/keywords/congenital-cataract","display_name":"congenital cataract","score":0.9629999995231628},{"id":"https://openalex.org/keywords/foxe3","display_name":"FOXE3","score":0.9139999747276306},{"id":"https://openalex.org/keywords/connexin-46","display_name":"connexin 46","score":0.9169999957084656},{"id":"https://openalex.org/keywords/connexin-50","display_name":"connexin 50","score":1.0},{"id":"https://openalex.org/keywords/gamma-crystallin","display_name":"gamma-crystallin","score":0.8679999709129333},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cell-cycle-exit","display_name":"cell cycle exit","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C2909221355","wikidata":"https://www.wikidata.org/wiki/Q146701","display_name":"Lens Fiber","level":3,"score":0.8010727763175964},{"id":"https://openalex.org/C15336307","wikidata":"https://www.wikidata.org/wiki/Q1766051","display_name":"Lens (geology)","level":2,"score":0.728700578212738},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5801722407341003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5734379291534424},{"id":"https://openalex.org/C2780225610","wikidata":"https://www.wikidata.org/wiki/Q127724","display_name":"Cataracts","level":2,"score":0.5206807851791382},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.43378281593322754},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4201072156429291},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4075991213321686},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3973138928413391},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.33378055691719055},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0987091064453125},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09715154767036438},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07760018110275269},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062786","descriptor_name":"Junctional Adhesion Molecule C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1167/iovs.64.15.15","doi":"https://doi.org/10.1167/iovs.64.15.15","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.64.15.15","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10723223","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10723223","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Invest Ophthalmol Vis Sci","raw_type":"Text"},{"id":"pmid:38095908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38095908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1167/iovs.64.15.15","doi":"https://doi.org/10.1167/iovs.64.15.15","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.64.15.15","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W1523693806","https://openalex.org/W1576809538","https://openalex.org/W1582808786","https://openalex.org/W1964525081","https://openalex.org/W1967949725","https://openalex.org/W1968411842","https://openalex.org/W1971070905","https://openalex.org/W1976327882","https://openalex.org/W1976985900","https://openalex.org/W1978204191","https://openalex.org/W1983104893","https://openalex.org/W1985549353","https://openalex.org/W1995604667","https://openalex.org/W1997963479","https://openalex.org/W2013898010","https://openalex.org/W2017688904","https://openalex.org/W2023772886","https://openalex.org/W2037023131","https://openalex.org/W2041419610","https://openalex.org/W2043597725","https://openalex.org/W2043838659","https://openalex.org/W2044185043","https://openalex.org/W2059904798","https://openalex.org/W2063034492","https://openalex.org/W2071421762","https://openalex.org/W2075643803","https://openalex.org/W2078705996","https://openalex.org/W2080425802","https://openalex.org/W2087499480","https://openalex.org/W2094697218","https://openalex.org/W2100067283","https://openalex.org/W2106376936","https://openalex.org/W2106616739","https://openalex.org/W2109127883","https://openalex.org/W2111630397","https://openalex.org/W2118450542","https://openalex.org/W2129265219","https://openalex.org/W2131142658","https://openalex.org/W2132049966","https://openalex.org/W2143624016","https://openalex.org/W2148877366","https://openalex.org/W2154587358","https://openalex.org/W2157172376","https://openalex.org/W2161194374","https://openalex.org/W2171804915","https://openalex.org/W2187301037","https://openalex.org/W2188445889","https://openalex.org/W2278262965","https://openalex.org/W2434683450","https://openalex.org/W2520852005","https://openalex.org/W2543788539","https://openalex.org/W2752838959","https://openalex.org/W2753920982","https://openalex.org/W2755101839","https://openalex.org/W2783987800","https://openalex.org/W2790182155","https://openalex.org/W2794371764","https://openalex.org/W2794421837","https://openalex.org/W2808891837","https://openalex.org/W2951277451","https://openalex.org/W2972667829","https://openalex.org/W2989755450","https://openalex.org/W2991094870","https://openalex.org/W3080560884","https://openalex.org/W3177083530","https://openalex.org/W3186828687","https://openalex.org/W3197606812","https://openalex.org/W4211020944","https://openalex.org/W4235339519","https://openalex.org/W4238108166","https://openalex.org/W4238545728","https://openalex.org/W4245403415","https://openalex.org/W4294012858","https://openalex.org/W4362620050"],"related_works":["https://openalex.org/W4294012858","https://openalex.org/W4415681440","https://openalex.org/W2794421837","https://openalex.org/W2009578263","https://openalex.org/W3012009382","https://openalex.org/W2060836614","https://openalex.org/W2026677619","https://openalex.org/W2080444077","https://openalex.org/W3173532410","https://openalex.org/W2410638036"],"abstract_inverted_index":{"Purpose:":[0],"The":[1,88,157,175,195],"underlying":[2],"mechanism":[3],"of":[4,12,118,135,139,159,170,191,197,211,216,220,237,244],"congenital":[5],"cataracts":[6],"caused":[7],"by":[8],"deficiency":[9],"or":[10],"mutation":[11],"junctional":[13],"adhesion":[14],"molecule":[15],"C":[16],"(JAM-C)":[17],"gene":[18],"remains":[19],"unclear.":[20],"Our":[21],"study":[22],"aims":[23],"to":[24,38,68,98,114,234],"elucidate":[25],"the":[26,35,76,116,133,205,235],"abnormal":[27,241],"developmental":[28,61],"process":[29,134],"in":[30,56,142,177,204],"Jamc-/-":[31,160,178,212],"lenses":[32,161,179],"and":[33,51,80,93,105,109,124,146,154,165,193,208,223,240,246],"reveal":[34],"genes":[36],"related":[37,233],"lens":[39,100,119,125,136,144,148,184,228],"development":[40],"that":[41],"JAM-C":[42,129,217],"may":[43,231],"regulate.":[44],"Methods:":[45],"Jamc":[46,140],"knockout":[47],"(Jamc-/-)":[48],"mouse":[49],"embryos":[50],"pups":[52],"were":[53,73,96,112,180],"generated":[54],"for":[55,75,85],"vivo":[57],"studies.":[58],"Four":[59],"key":[60,171],"stages":[62],"from":[63,152],"embryonic":[64],"day":[65,70],"(E)":[66],"12.5":[67],"postnatal":[69],"(P)":[71],"0.5":[72],"selected":[74],"following":[77],"experiments.":[78],"Hematoxylin":[79],"eosin":[81],"staining":[82,95],"was":[83,130,201],"used":[84,113],"histological":[86],"analysis.":[87],"5-bromo-2'-deoxyuridine":[89],"(BrdU)":[90],"incorporation":[91],"assay":[92],"TUNEL":[94],"performed":[97],"label":[99],"epithelial":[101],"cell":[102,121],"(LEC)":[103],"proliferation":[104,222],"apoptosis,":[106],"respectively.":[107],"Immunofluorescence":[108],"Western":[110],"blot":[111],"analyze":[115],"markers":[117],"epithelium,":[120],"cycle":[122],"exit,":[123],"fiber":[126,198,224],"differentiation.":[127],"Results:":[128],"expressed":[131],"throughout":[132],"development.":[137],"Deletion":[138,215],"resulted":[141],"decreased":[143,163,203],"size":[145],"disorganized":[147],"fibers,":[149],"which":[150,230],"arose":[151],"E16.5":[153],"aggravated":[155],"gradually.":[156],"LECs":[158],"showed":[162,186],"quantity":[164],"proliferation,":[166],"accompanied":[167],"with":[168],"reduction":[169],"transcription":[172],"factor,":[173],"FOXE3.":[174],"fibers":[176,185,210],"disorganized.":[181],"Moreover,":[182],"Jamc-deficient":[183],"significantly":[187],"altered":[188],"distribution":[189],"patterns":[190,243],"Cx46":[192,245],"Cx50.":[194,247],"marker":[196],"homeostasis,":[199],"\u03b3-crystallin,":[200],"also":[202],"inner":[206],"cortex":[207],"core":[209],"lenses.":[213],"Conclusions:":[214],"exhibits":[218],"malfunction":[219],"LEC":[221],"maturation":[225],"during":[226],"murine":[227],"development,":[229],"be":[232],"downregulation":[236],"FOXE3":[238],"expression":[239],"localization":[242]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-12-15T00:00:00"}
