{"id":"https://openalex.org/W4389727282","doi":"https://doi.org/10.1097/cce.0000000000001011","title":"Impact of Various Estimated Glomerular Filtration Rate Equations on the Pharmacokinetics of Meropenem in Critically Ill Adults","display_name":"Impact of Various Estimated Glomerular Filtration Rate Equations on the Pharmacokinetics of Meropenem in Critically Ill Adults","publication_year":2023,"publication_date":"2023-12-01","ids":{"openalex":"https://openalex.org/W4389727282","doi":"https://doi.org/10.1097/cce.0000000000001011","pmid":"https://pubmed.ncbi.nlm.nih.gov/38107538"},"language":"en","primary_location":{"id":"doi:10.1097/cce.0000000000001011","doi":"https://doi.org/10.1097/cce.0000000000001011","is_oa":true,"landing_page_url":"https://doi.org/10.1097/cce.0000000000001011","pdf_url":null,"source":{"id":"https://openalex.org/S4210210302","display_name":"Critical Care Explorations","issn_l":"2639-8028","issn":["2639-8028"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Explorations","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/cce.0000000000001011","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040329994","display_name":"Erin Frazee Barreto","orcid":"https://orcid.org/0000-0002-0996-1487","observed_orcids":["https://orcid.org/0000-0002-0996-1487"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin F. Barreto","raw_affiliation_strings":["Department of Pharmacy, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073981786","display_name":"Jack H. T. Chang","orcid":"https://orcid.org/0000-0002-5645-0014","observed_orcids":["https://orcid.org/0000-0002-5645-0014"]},"institutions":[{"id":"https://openalex.org/I128902783","display_name":"Midwestern University","ror":"https://ror.org/046yatd98","country_code":"US","type":"education","lineage":["https://openalex.org/I128902783"]},{"id":"https://openalex.org/I4210147348","display_name":"Northwestern Medicine","ror":"https://ror.org/04fzwnh64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack Chang","raw_affiliation_strings":["Department of Pharmacy Practice, Chicago College of Pharmacy, Pharmacometrics Center of Excellence, Midwestern University, Downers Grove, IL","Department of Pharmacy, Northwestern Medicine, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, Chicago College of Pharmacy, Pharmacometrics Center of Excellence, Midwestern University, Downers Grove, IL","institution_ids":["https://openalex.org/I128902783"]},{"raw_affiliation_string":"Department of Pharmacy, Northwestern Medicine, Chicago, IL","institution_ids":["https://openalex.org/I4210147348"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031580643","display_name":"Andrew D. Rule","orcid":"https://orcid.org/0000-0003-0338-7784","observed_orcids":["https://orcid.org/0000-0003-0338-7784"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew D. Rule","raw_affiliation_strings":["Division of Epidemiology, Mayo Clinic, Rochester, MN","Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108010599","display_name":"Kristin C. Mara","orcid":"https://orcid.org/0000-0002-8783-0191","observed_orcids":["https://orcid.org/0000-0002-8783-0191"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin C. Mara","raw_affiliation_strings":["Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013212586","display_name":"Laurie A. Meade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurie A. Meade","raw_affiliation_strings":["Anesthesia Clinical Research Unit, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesia Clinical Research Unit, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111092913","display_name":"Johar Paul","orcid":"https://orcid.org/0009-0001-2886-8835","observed_orcids":["https://orcid.org/0009-0001-2886-8835"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Johar Paul","raw_affiliation_strings":["Anesthesia Clinical Research Unit, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesia Clinical Research Unit, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041081700","display_name":"Paul J. Jannetto","orcid":"https://orcid.org/0000-0002-5629-439X","observed_orcids":["https://orcid.org/0000-0002-5629-439X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Paul J. Jannetto","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN","All authors had full access to all of the data in the study and took responsibility for the integrity of the data and the accuracy of the analysis. Drs. Barreto, Chang, Rule, Mara, Athreya, and Scheetz: designed the study, performed the statistical analysis, interpreted the data, drafted, and critically revised the article. Dr. Jannetto was responsible for beta-lactam assay validation, sample measurement, and critical revision of the article. Drs. Meade and Paul were responsible for study enrollment, data collection and reporting, and critical revision of the article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"All authors had full access to all of the data in the study and took responsibility for the integrity of the data and the accuracy of the analysis. Drs. Barreto, Chang, Rule, Mara, Athreya, and Scheetz: designed the study, performed the statistical analysis, interpreted the data, drafted, and critically revised the article. Dr. Jannetto was responsible for beta-lactam assay validation, sample measurement, and critical revision of the article. Drs. Meade and Paul were responsible for study enrollment, data collection and reporting, and critical revision of the article","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017994099","display_name":"Arjun P. Athreya","orcid":"https://orcid.org/0000-0001-9764-1768","observed_orcids":["https://orcid.org/0000-0001-9764-1768","https://orcid.org/0000-0002-4172-9055"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arjun P. Athreya","raw_affiliation_strings":["Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022097782","display_name":"Marc H. Scheetz","orcid":"https://orcid.org/0000-0002-1091-6130","observed_orcids":["https://orcid.org/0000-0002-1091-6130"]},"institutions":[{"id":"https://openalex.org/I128902783","display_name":"Midwestern University","ror":"https://ror.org/046yatd98","country_code":"US","type":"education","lineage":["https://openalex.org/I128902783"]},{"id":"https://openalex.org/I4210147348","display_name":"Northwestern Medicine","ror":"https://ror.org/04fzwnh64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc H. Scheetz","raw_affiliation_strings":["Department of Pharmacy Practice, Chicago College of Pharmacy, Pharmacometrics Center of Excellence, Midwestern University, Downers Grove, IL","Department of Pharmacy, Northwestern Medicine, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, Chicago College of Pharmacy, Pharmacometrics Center of Excellence, Midwestern University, Downers Grove, IL","institution_ids":["https://openalex.org/I128902783"]},{"raw_affiliation_string":"Department of Pharmacy, Northwestern Medicine, Chicago, IL","institution_ids":["https://openalex.org/I4210147348"]}]},{"author_position":"last","author":{"id":null,"display_name":"For the BLOOM Study Group","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"For the BLOOM Study Group","raw_affiliation_strings":["An anonymized dataset may be made available upon reasonable request to the corresponding author","For information regarding this article, E-mail: [email\u00a0protected]","Mayo Clinic Institutional Review Board approved the study and waived the need for informed consent (18-004992, 21-003184)","Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal\u2019s website (http://journals.lww.com/ccejournal)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"An anonymized dataset may be made available upon reasonable request to the corresponding author","institution_ids":[]},{"raw_affiliation_string":"For information regarding this article, E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"Mayo Clinic Institutional Review Board approved the study and waived the need for informed consent (18-004992, 21-003184)","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal\u2019s website (http://journals.lww.com/ccejournal)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1600,"currency":"USD","value_usd":1600},"apc_paid":{"value":1600,"currency":"USD","value_usd":1600},"fwci":2.0479,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.87587813,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"5","issue":"12","first_page":"e1011","last_page":"e1011"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meropenem","display_name":"meropenem","score":0.9990000128746033},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cystatin-c","display_name":"cystatin C","score":0.9150000214576721},{"id":"https://openalex.org/keywords/creatinine","display_name":"creatinine","score":0.8880000114440918},{"id":"https://openalex.org/keywords/population-pharmacokinetics","display_name":"population pharmacokinetics","score":0.7390000224113464},{"id":"https://openalex.org/keywords/critically-ill-adults","display_name":"critically ill adults","score":0.8799999952316284},{"id":"https://openalex.org/keywords/intensive-care-unit","display_name":"intensive care unit","score":0.6320000290870667},{"id":"https://openalex.org/keywords/renal-clearance","display_name":"renal clearance","score":0.34700000286102295},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.8529999852180481},{"id":"https://openalex.org/keywords/time-dependent-covariates","display_name":"time-varying covariates","score":0.6919999718666077},{"id":"https://openalex.org/keywords/prior-distributions","display_name":"prior distributions","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2779375183","wikidata":"https://www.wikidata.org/wiki/Q421670","display_name":"Meropenem","level":4,"score":0.888873815536499},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.8123823404312134},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7382826805114746},{"id":"https://openalex.org/C139254425","wikidata":"https://www.wikidata.org/wiki/Q1332167","display_name":"Volume of distribution","level":3,"score":0.69454026222229},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.5898236632347107},{"id":"https://openalex.org/C2779548226","wikidata":"https://www.wikidata.org/wiki/Q413243","display_name":"Cystatin C","level":3,"score":0.5620507001876831},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5618541836738586},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5349631905555725},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.46528878808021545},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4492017328739166},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4436842203140259},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.43708446621894836},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39888450503349304},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3241378366947174},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11923953890800476},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.09564030170440674},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1097/cce.0000000000001011","doi":"https://doi.org/10.1097/cce.0000000000001011","is_oa":true,"landing_page_url":"https://doi.org/10.1097/cce.0000000000001011","pdf_url":null,"source":{"id":"https://openalex.org/S4210210302","display_name":"Critical Care Explorations","issn_l":"2639-8028","issn":["2639-8028"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Explorations","raw_type":"journal-article"},{"id":"pmid:38107538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38107538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care explorations","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10723891","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10723891","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10723891/pdf/cc9-5-e1011.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Crit Care Explor","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:fc11b33cdd5447cdb767809ce559a2d9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fc11b33cdd5447cdb767809ce559a2d9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Critical Care Explorations, Vol 5, Iss 12, p e1011 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1097/cce.0000000000001011","doi":"https://doi.org/10.1097/cce.0000000000001011","is_oa":true,"landing_page_url":"https://doi.org/10.1097/cce.0000000000001011","pdf_url":null,"source":{"id":"https://openalex.org/S4210210302","display_name":"Critical Care Explorations","issn_l":"2639-8028","issn":["2639-8028"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Explorations","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6499999761581421}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G5392792593","display_name":null,"funder_award_id":"K23AI143882","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W87474695","https://openalex.org/W1955799584","https://openalex.org/W1978397220","https://openalex.org/W1981902086","https://openalex.org/W1995610280","https://openalex.org/W2035387023","https://openalex.org/W2042616828","https://openalex.org/W2070242840","https://openalex.org/W2099531681","https://openalex.org/W2101416655","https://openalex.org/W2108012895","https://openalex.org/W2118625269","https://openalex.org/W2123677996","https://openalex.org/W2135190942","https://openalex.org/W2170293922","https://openalex.org/W2521680245","https://openalex.org/W2569300957","https://openalex.org/W2580180489","https://openalex.org/W2591419591","https://openalex.org/W2735133396","https://openalex.org/W2767005940","https://openalex.org/W2911413417","https://openalex.org/W3009130696","https://openalex.org/W3012161191","https://openalex.org/W3022327571","https://openalex.org/W3042183785","https://openalex.org/W3085901099","https://openalex.org/W3092576010","https://openalex.org/W3093891877","https://openalex.org/W3096336275","https://openalex.org/W3164573227","https://openalex.org/W3201595862","https://openalex.org/W4205193664","https://openalex.org/W4211177544","https://openalex.org/W4224266833","https://openalex.org/W4316928180","https://openalex.org/W4318754883","https://openalex.org/W4320728077","https://openalex.org/W4367599425","https://openalex.org/W4378174329","https://openalex.org/W4378802672","https://openalex.org/W4381662025"],"related_works":["https://openalex.org/W4385567994","https://openalex.org/W2291588333","https://openalex.org/W4385237774","https://openalex.org/W2951469329","https://openalex.org/W3169746786","https://openalex.org/W4381662025","https://openalex.org/W2021712825","https://openalex.org/W2981349837","https://openalex.org/W2037346760","https://openalex.org/W2098798296"],"abstract_inverted_index":{"IMPORTANCE:":[0],"Meropenem":[1],"dosing":[2],"is":[3,15],"typically":[4],"guided":[5],"by":[6],"creatinine-based":[7],"estimated":[8],"glomerular":[9],"filtration":[10],"rate":[11],"(eGFR),":[12],"but":[13],"creatinine":[14,195,250],"a":[16,32,110,157,171,175],"suboptimal":[17],"GFR":[18],"marker":[19],"in":[20,38,70,150,200,209,268],"the":[21,151,188,210,224,228,231],"critically":[22,39,270],"ill.":[23],"OBJECTIVES:":[24],"This":[25,64],"study":[26,66],"aimed":[27],"to":[28,43,79,140,170],"develop":[29],"and":[30,42,118,182,196,217,238,251],"qualify":[31],"population":[33,107,256],"pharmacokinetic":[34,108,257],"model":[35,58,134,149,159,165,212,258],"for":[36,106,177,185],"meropenem":[37,76,142,203,255],"ill":[40,271],"adults":[41,68],"determine":[44],"which":[45],"eGFR":[46,184,189,192,245,266],"equation":[47],"based":[48,193],"on":[49,91,194],"creatinine,":[50],"cystatin":[51,197,252,264],"C,":[52],"or":[53,95,263],"both":[54,249],"biomarkers":[55],"best":[56],"improves":[57],"performance.":[59],"DESIGN,":[60],"SETTING,":[61],"AND":[62,129,242],"PARTICIPANTS:":[63],"single-center":[65],"evaluated":[67],"hospitalized":[69],"an":[71,119],"ICU":[72],"who":[73],"received":[74],"IV":[75],"from":[77],"2018":[78],"2022.":[80],"Patients":[81],"were":[82,90,96,104],"excluded":[83],"if":[84],"they":[85],"had":[86],"acute":[87],"kidney":[88,92],"injury,":[89],"replacement":[93],"therapy,":[94],"treated":[97],"with":[98,160,261],"extracorporeal":[99],"membrane":[100],"oxygenation.":[101],"Two":[102],"cohorts":[103],"used":[105],"modeling:":[109],"richly":[111,152],"sampled":[112,121,153,233],"development":[113,154,225],"cohort":[114,123,155,226,234],"(n":[115,124],"=":[116,125],"19)":[117],"opportunistically":[120,232],"qualification":[122],"32).":[126],"MAIN":[127],"OUTCOMES":[128],"MEASURES:":[130],"A":[131],"nonlinear":[132],"mixed-effects":[133],"was":[135,156,213,219],"developed":[136],"using":[137],"parametric":[138],"methods":[139],"estimate":[141],"serum":[143],"concentrations.":[144],"RESULTS:":[145],"The":[146,163,205],"best-fit":[147],"structural":[148],"two-compartment":[158],"first-order":[161],"elimination.":[162],"final":[164,211],"included":[166],"time-dependent":[167,183],"weight":[168],"normalized":[169],"70-kg":[172],"adult":[173,269],"as":[174,227],"covariate":[176],"volume":[178],"of":[179],"distribution":[180],"(Vd)":[181],"clearance.":[186,204],"Among":[187],"equations":[190,246,267],"evaluated,":[191],"C":[198,253],"expressed":[199],"mL/min":[201],"best-predicted":[202],"mean":[206],"(se)":[207],"Vd":[208],"18.2":[214],"(3.5)":[215],"liters":[216],"clearance":[218],"11.5":[220],"(1.3)":[221],"L/hr.":[222],"Using":[223],"Bayesian":[229],"prior,":[230],"demonstrated":[235],"good":[236],"accuracy":[237],"low":[239],"bias.":[240],"CONCLUSIONS":[241],"RELEVANCE:":[243],"Contemporary":[244],"that":[247],"use":[248],"improved":[254],"performance":[259],"compared":[260],"creatinine-only":[262],"C-only":[265],"patients.":[272]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":4}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
