{"id":"https://openalex.org/W4389727017","doi":"https://doi.org/10.1007/s11606-023-08397-9","title":"Effects of Dapagliflozin in Chronic Kidney Disease Across the Spectrum of Age and by Sex","display_name":"Effects of Dapagliflozin in Chronic Kidney Disease Across the Spectrum of Age and by Sex","publication_year":2023,"publication_date":"2023-12-14","ids":{"openalex":"https://openalex.org/W4389727017","doi":"https://doi.org/10.1007/s11606-023-08397-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/38097862","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11074069"},"language":"en","primary_location":{"id":"doi:10.1007/s11606-023-08397-9","doi":"https://doi.org/10.1007/s11606-023-08397-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11606-023-08397-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11606-023-08397-9.pdf","source":{"id":"https://openalex.org/S116608325","display_name":"Journal of General Internal Medicine","issn_l":"0884-8734","issn":["0884-8734","1525-1497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s11606-023-08397-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061759413","display_name":"Mingkai Yu","orcid":"https://orcid.org/0000-0002-3650-2788","observed_orcids":["https://orcid.org/0000-0002-3650-2788","https://orcid.org/0009-0008-4137-0848"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret K. Yu","raw_affiliation_strings":["Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064862183","display_name":"Priya Vart","orcid":"https://orcid.org/0000-0001-5576-820X","observed_orcids":["https://orcid.org/0000-0001-5576-820X"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Priya Vart","raw_affiliation_strings":["Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands","Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018701033","display_name":"Niels Jongs","orcid":"https://orcid.org/0000-0002-0882-3656","observed_orcids":["https://orcid.org/0000-0002-0882-3656"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Niels Jongs","raw_affiliation_strings":["Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060560730","display_name":"Ricardo Correa\u2010Rotter","orcid":"https://orcid.org/0000-0003-0100-8285","observed_orcids":["https://orcid.org/0000-0003-0100-8285"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Ricardo Correa-Rotter","raw_affiliation_strings":["The National Medical Science and Nutrition Institute Salvador Zubiran, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The National Medical Science and Nutrition Institute Salvador Zubiran, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085592050","display_name":"Peter R Rossing","orcid":"https://orcid.org/0000-0002-1531-4294","observed_orcids":["https://orcid.org/0000-0002-1531-4294","https://orcid.org/0009-0004-5073-0009"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I4405255865","display_name":"Steno Diabetes Center Copenhagen","ror":"https://ror.org/03gqzdg87","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I1339947260","https://openalex.org/I2802567020","https://openalex.org/I4210145385","https://openalex.org/I4405255865"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Peter Rossing","raw_affiliation_strings":["Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark","Steno Diabetes Center Copenhagen, Gentofte, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Steno Diabetes Center Copenhagen, Gentofte, Denmark","institution_ids":["https://openalex.org/I4405255865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027213857","display_name":"John J.V. McMurray","orcid":"https://orcid.org/0000-0002-6317-3975","observed_orcids":["https://orcid.org/0000-0002-6317-3975"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John J.V. McMurray","raw_affiliation_strings":["Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025161064","display_name":"Fan Fan Hou","orcid":"https://orcid.org/0000-0003-3117-7418","observed_orcids":["https://orcid.org/0000-0003-3117-7418"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan-Fan Hou","raw_affiliation_strings":["Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020223892","display_name":"Walter Douthat","orcid":"https://orcid.org/0000-0002-4644-6003","observed_orcids":["https://orcid.org/0000-0002-4644-6003"]},"institutions":[{"id":"https://openalex.org/I4210152379","display_name":"Hospital Privado","ror":"https://ror.org/04qtr9c10","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210152379"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Walter Douthat","raw_affiliation_strings":["Department of Nephrology, Hospital Privado Universitario de Cordoba, Cordoba, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Hospital Privado Universitario de Cordoba, Cordoba, Argentina","institution_ids":["https://openalex.org/I4210152379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035771017","display_name":"Dinesh Khullar","orcid":"https://orcid.org/0000-0003-4276-2575","observed_orcids":["https://orcid.org/0000-0003-4276-2575"]},"institutions":[{"id":"https://openalex.org/I2802464703","display_name":"Max Super Speciality Hospital","ror":"https://ror.org/00e7r7m66","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2802464703","https://openalex.org/I307255591"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dinesh Khullar","raw_affiliation_strings":["Department of Nephrology and Renal Transplant Medicine, Max Super Speciality Hospital, Saket, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Renal Transplant Medicine, Max Super Speciality Hospital, Saket, New Delhi, India","institution_ids":["https://openalex.org/I2802464703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012551917","display_name":"Anna Maria Langkilde","orcid":"https://orcid.org/0000-0002-1696-9356","observed_orcids":["https://orcid.org/0000-0002-1696-9356"]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anna Maria Langkilde","raw_affiliation_strings":["BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069865054","display_name":"David Collins. Wheeler","orcid":"https://orcid.org/0000-0003-0745-3478","observed_orcids":["https://orcid.org/0000-0003-0745-3478"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David C. Wheeler","raw_affiliation_strings":["Department of Renal Medicine, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Renal Medicine, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031624913","display_name":"Hiddo J.L. Heerspink","orcid":"https://orcid.org/0000-0002-3126-3730","observed_orcids":["https://orcid.org/0000-0002-3126-3730"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]}],"countries":["AU","NL"],"is_corresponding":false,"raw_author_name":"Hiddo J. L. Heerspink","raw_affiliation_strings":["Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands","The George Institute for Global Health, Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"The George Institute for Global Health, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I4210110309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034939991","display_name":"Glenn Matthew Chertow","orcid":"https://orcid.org/0000-0002-7599-0534","observed_orcids":["https://orcid.org/0000-0002-7599-0534"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Glenn M. Chertow","raw_affiliation_strings":["Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA. gchertow@stanford.edu","Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. gchertow@stanford.edu","Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-7599-0534","affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA. gchertow@stanford.edu","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. gchertow@stanford.edu","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":10,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5034939991"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":{"value":4690,"currency":"USD","value_usd":4690},"fwci":5.7498,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.9692646,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"39","issue":"6","first_page":"921","last_page":"930"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.07919999957084656,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dapagliflozin","display_name":"dapagliflozin","score":1.0},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9559999704360962},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.8970000147819519},{"id":"https://openalex.org/keywords/age-differences","display_name":"age differences","score":0.6729999780654907},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9980000257492065},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8330000042915344},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.7020000219345093},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate-decline","display_name":"estimated glomerular filtration rate decline","score":0.7170000076293945},{"id":"https://openalex.org/keywords/cardiovascular-events","display_name":"cardiovascular events","score":0.6449999809265137},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.8309999704360962},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.8040000200271606},{"id":"https://openalex.org/keywords/dapa-ckd-trial","display_name":"DAPA-CKD trial","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.962064266204834},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.6584361791610718},{"id":"https://openalex.org/C2777422806","wikidata":"https://www.wikidata.org/wiki/Q409898","display_name":"Dapagliflozin","level":4,"score":0.5859760046005249},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38207459449768066},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18301385641098022},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.1389653980731964},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077203","descriptor_name":"Sodium-Glucose Transporter 2 Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001559","descriptor_name":"Benzhydryl Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001559","descriptor_name":"Benzhydryl Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005960","descriptor_name":"Glucosides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005960","descriptor_name":"Glucosides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1007/s11606-023-08397-9","doi":"https://doi.org/10.1007/s11606-023-08397-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11606-023-08397-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11606-023-08397-9.pdf","source":{"id":"https://openalex.org/S116608325","display_name":"Journal of General Internal Medicine","issn_l":"0884-8734","issn":["0884-8734","1525-1497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Internal Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11074069","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11074069","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11074069/pdf/11606_2023_Article_8397.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gen Intern Med","raw_type":"Text"},{"id":"pmid:38097862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38097862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of general internal medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/40a093a8-d777-4661-815b-864853f10980","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/40a093a8-d777-4661-815b-864853f10980","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yu, M K, Vart, P, Jongs, N, Correa-Rotter, R, Rossing, P, McMurray, J J V, Hou, F-F, Douthat, W, Khullar, D, Langkilde, A M, Wheeler, D C, Heerspink, H J L & Chertow, G M 2024, 'Effects of Dapagliflozin in Chronic Kidney Disease Across the Spectrum of Age and by Sex', Journal of General Internal Medicine, vol. 39, no. 6, pp. 921-930. https://doi.org/10.1007/s11606-023-08397-9","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10184362","doi":null,"is_oa":true,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10184362/","pdf_url":"https://discovery.ucl.ac.uk/10184362/1/s11606-023-08397-9.pdf","source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of General Internal Medicine (2023) (In press).","raw_type":"Article"},{"id":"pmh:oai:pure.rug.nl:openaire/4762f9df-b3d6-4d4d-b49a-0a840a1e8015","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/4762f9df-b3d6-4d4d-b49a-0a840a1e8015","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Yu, M K, Vart, P, Jongs, N, Correa-Rotter, R, Rossing, P, McMurray, J J V, Hou, F F, Douthat, W, Khullar, D, Langkilde, A M, Wheeler, D C, Heerspink, H J L & Chertow, G M 2024, 'Effects of Dapagliflozin in Chronic Kidney Disease Across the Spectrum of Age and by Sex', Journal of General Internal Medicine, vol. 39, no. 6, pp. 921-930. https://doi.org/10.1007/s11606-023-08397-9","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.60692/f08m0-ef550","doi":"https://doi.org/10.60692/f08m0-ef550","is_oa":true,"landing_page_url":"https://doi.org/10.60692/f08m0-ef550","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/tnnpp-ffc60","doi":"https://doi.org/10.60692/tnnpp-ffc60","is_oa":true,"landing_page_url":"https://doi.org/10.60692/tnnpp-ffc60","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1007/s11606-023-08397-9","doi":"https://doi.org/10.1007/s11606-023-08397-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11606-023-08397-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11606-023-08397-9.pdf","source":{"id":"https://openalex.org/S116608325","display_name":"Journal of General Internal Medicine","issn_l":"0884-8734","issn":["0884-8734","1525-1497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Internal Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389727017.pdf","grobid_xml":"https://content.openalex.org/works/W4389727017.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W2041725636","https://openalex.org/W2086258146","https://openalex.org/W2107694629","https://openalex.org/W2131333712","https://openalex.org/W2138874874","https://openalex.org/W2155965977","https://openalex.org/W2160134719","https://openalex.org/W2306356166","https://openalex.org/W2424539745","https://openalex.org/W2592398938","https://openalex.org/W2607031541","https://openalex.org/W2900413769","https://openalex.org/W2902720064","https://openalex.org/W2939222610","https://openalex.org/W2948407021","https://openalex.org/W2986132895","https://openalex.org/W2995152480","https://openalex.org/W3005350465","https://openalex.org/W3022144945","https://openalex.org/W3026184045","https://openalex.org/W3088173406","https://openalex.org/W3100542962","https://openalex.org/W3129813952","https://openalex.org/W3143309498","https://openalex.org/W3153561131","https://openalex.org/W3154396324","https://openalex.org/W3161141693","https://openalex.org/W3179094902","https://openalex.org/W3201867211","https://openalex.org/W4288708863","https://openalex.org/W4293332281","https://openalex.org/W4308183941","https://openalex.org/W4308372801","https://openalex.org/W4308683070","https://openalex.org/W4311572573","https://openalex.org/W4312221549","https://openalex.org/W4317801936","https://openalex.org/W4323309098"],"related_works":["https://openalex.org/W4380626438","https://openalex.org/W3196177583","https://openalex.org/W3088173406","https://openalex.org/W2995152480","https://openalex.org/W3111429257","https://openalex.org/W3112405194","https://openalex.org/W3102435759","https://openalex.org/W3100692031","https://openalex.org/W4224235109","https://openalex.org/W4396996323"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"sodium-glucose":[2],"cotransporter":[3],"type":[4,27,83],"2":[5,28,84],"inhibitor":[6],"dapagliflozin":[7,61,186,206,219,239,281],"reduces":[8],"the":[9,36,183,203,216,221,236,249,278],"risk":[10,164],"of":[11,38,60,101,151,165,213,215,218,238,251,269,280],"progressive":[12],"kidney":[13,22,108,111,118,166],"disease":[14],"and":[15,25,40,43,58,66,81,110,139,155,177,185,189,197,205,255,264,285],"cardiovascular":[16,113,128,130,137,152,253],"events":[17],"in":[18,53,160,171,182,191,202,258,262,282],"patients":[19,172,192],"with":[20,24,80],"chronic":[21,243],"disease,":[23,109],"without":[26,82,127],"diabetes.":[29,85],"Whether":[30],"its":[31],"effects":[32,217,237],"are":[33,288],"uniform":[34],"across":[35],"spectrum":[37],"age":[39,65,228,232],"among":[41],"men":[42,286],"women":[44,284],"is":[45],"unknown.":[46],"OBJECTIVE:":[47],"We":[48],"performed":[49],"a":[50,99],"pre-specified":[51],"analysis":[52],"DAPA-CKD":[54],"to":[55,63,290],"evaluate":[56],"efficacy":[57],"safety":[59],"according":[62],"baseline":[64],"sex.":[67,230],"DESIGN:":[68],"Prospective":[69],"randomized":[70],"placebo-controlled":[71],"trial.":[72],"PARTICIPANTS:":[73],";":[74],"urinary":[75],"albumin-to-creatinine":[76],"ratio":[77],"200-5000":[78],"mg/g)":[79],"INTERVENTION:":[86],"Dapagliflozin":[87,247],"10":[88],"mg":[89],"versus":[90],"placebo":[91,184,204],"once":[92],"daily.":[93],"MAIN":[94],"MEASURES:":[95],"Primary":[96],"endpoint":[97,120,125,132,154,168],"was":[98,146,169,210],"composite":[100,119,124,131,153,167],"\u2265":[102,193],"50%":[103],"sustained":[104],"eGFR":[105,244],"decline,":[106],"end-stage":[107],"or":[112,136,223,229,242],"death.":[114],"Secondary":[115],"endpoints":[116,225],"included":[117],"(same":[121],"as":[122],"primary":[123,222],"but":[126],"death),":[129,138],"(hospitalized":[133],"heart":[134],"failure":[135],"all-cause":[140,156],"mortality.":[141],"KEY":[142],"RESULTS:":[143],"Median":[144],"follow-up":[145],"2.4":[147],"years.":[148],"Absolute":[149,163],"risks":[150,250],"mortality":[157],"were":[158],"higher":[159],"older":[161,259,283],"patients.":[162],"highest":[170],"<":[173],"50":[174],"years":[175,195],"(10.7":[176],"6.2":[178],"per":[179,199],"100":[180,200],"patient-years":[181,201],"groups,":[187,207],"respectively)":[188],"lowest":[190],"80":[194],"(3.0":[196],"1.2":[198],"respectively).":[208],"There":[209],"no":[211],"evidence":[212],"heterogeneity":[214],"on":[220,227,240],"secondary":[224],"based":[226],"Neither":[231],"nor":[233],"sex":[234],"modified":[235],"total":[241],"slope.":[245],"CONCLUSIONS:":[246],"reduced":[248],"mortality,":[252],"events,":[254],"CKD":[256],"progression":[257],"patients,":[260],"including":[261],"septuagenarians":[263],"octogenarians":[265],"who":[266,287],"comprised":[267],"25%":[268],"participants.":[270],"Ageism":[271],"and/or":[272],"therapeutic":[273],"nihilism":[274],"should":[275],"not":[276],"discourage":[277],"use":[279],"likely":[289],"experience":[291],"considerable":[292],"benefit.":[293],"TRIAL":[294,298],"REGISTRY:":[295],"clinicaltrials.gov":[296],"NIH":[297],"REGISTRY":[299],"NUMBER:":[300],"NCT03036150.":[301]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-12-15T00:00:00"}