{"id":"https://openalex.org/W4389628403","doi":"https://doi.org/10.1002/psp4.13096","title":"gPKPDviz : A flexible R shiny tool for pharmacokinetic/pharmacodynamic simulations using mrgsolve","display_name":"gPKPDviz : A flexible R shiny tool for pharmacokinetic/pharmacodynamic simulations using mrgsolve","publication_year":2023,"publication_date":"2023-12-12","ids":{"openalex":"https://openalex.org/W4389628403","doi":"https://doi.org/10.1002/psp4.13096","pmid":"https://pubmed.ncbi.nlm.nih.gov/38082557","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10941578"},"language":"en","primary_location":{"id":"doi:10.1002/psp4.13096","doi":"https://doi.org/10.1002/psp4.13096","is_oa":true,"landing_page_url":"https://doi.org/10.1002/psp4.13096","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/psp4.13096","source":{"id":"https://openalex.org/S4210231731","display_name":"CPT Pharmacometrics & Systems Pharmacology","issn_l":"2163-8306","issn":["2163-8306"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CPT: Pharmacometrics & Systems Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/psp4.13096","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101888986","display_name":"Tong Lu","orcid":"https://orcid.org/0000-0001-5899-6857","observed_orcids":["https://orcid.org/0000-0001-5899-6857"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tong Lu","raw_affiliation_strings":["Department of Clinical Pharmacology Genentech, Inc. South San Francisco California USA"],"raw_orcid":"https://orcid.org/0000-0001-5899-6857","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology Genentech, Inc. South San Francisco California USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024761926","display_name":"Victor Poon","orcid":"https://orcid.org/0000-0002-4215-2198","observed_orcids":["https://orcid.org/0000-0002-4215-2198"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor Poon","raw_affiliation_strings":["Department of Clinical Pharmacology Genentech, Inc. South San Francisco California USA"],"raw_orcid":"https://orcid.org/0000-0002-4215-2198","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology Genentech, Inc. South San Francisco California USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102720571","display_name":"Logan Brooks","orcid":"https://orcid.org/0000-0001-9215-408X","observed_orcids":["https://orcid.org/0000-0001-9215-408X"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Logan Brooks","raw_affiliation_strings":["Department of Clinical Pharmacology Genentech, Inc. South San Francisco California USA"],"raw_orcid":"https://orcid.org/0000-0001-9215-408X","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology Genentech, Inc. South San Francisco California USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072515029","display_name":"Erick F. Velasquez","orcid":"https://orcid.org/0000-0002-0874-4317","observed_orcids":["https://orcid.org/0000-0002-0874-4317"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erick Velasquez","raw_affiliation_strings":["Department of Clinical Pharmacology Genentech, Inc. South San Francisco California USA"],"raw_orcid":"https://orcid.org/0000-0002-0874-4317","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology Genentech, Inc. South San Francisco California USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Eric Anderson","orcid":"https://orcid.org/0009-0003-8191-2879","observed_orcids":["https://orcid.org/0009-0003-8191-2879"]},"institutions":[{"id":"https://openalex.org/I4210137375","display_name":"Metrum Research Group (United States)","ror":"https://ror.org/04j2hh758","country_code":"US","type":"company","lineage":["https://openalex.org/I4210137375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Anderson","raw_affiliation_strings":["Metrum Research Group, Tariffville, Connecticut, USA"],"raw_orcid":"https://orcid.org/0009-0003-8191-2879","affiliations":[{"raw_affiliation_string":"Metrum Research Group, Tariffville, Connecticut, USA","institution_ids":["https://openalex.org/I4210137375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075945637","display_name":"Kyle T. Baron","orcid":"https://orcid.org/0000-0001-7252-5656","observed_orcids":["https://orcid.org/0000-0001-7252-5656"]},"institutions":[{"id":"https://openalex.org/I4210137375","display_name":"Metrum Research Group (United States)","ror":"https://ror.org/04j2hh758","country_code":"US","type":"company","lineage":["https://openalex.org/I4210137375"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle Baron","raw_affiliation_strings":["Metrum Research Group, Tariffville, Connecticut, USA"],"raw_orcid":"https://orcid.org/0000-0001-7252-5656","affiliations":[{"raw_affiliation_string":"Metrum Research Group, Tariffville, Connecticut, USA","institution_ids":["https://openalex.org/I4210137375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065578593","display_name":"Jin Y. Jin","orcid":"https://orcid.org/0000-0002-3627-0323","observed_orcids":["https://orcid.org/0000-0002-3627-0323"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin Y. Jin","raw_affiliation_strings":["Department of Clinical Pharmacology Genentech, Inc. South San Francisco California USA"],"raw_orcid":"https://orcid.org/0000-0002-3627-0323","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology Genentech, Inc. South San Francisco California USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048026181","display_name":"Matts K\u00e5gedal","orcid":"https://orcid.org/0000-0002-1261-0354","observed_orcids":["https://orcid.org/0000-0002-1261-0354"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matts K\u00e5gedal","raw_affiliation_strings":["Department of Clinical Pharmacology Genentech, Inc. South San Francisco California USA"],"raw_orcid":"https://orcid.org/0000-0002-1261-0354","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology Genentech, Inc. South San Francisco California USA","institution_ids":["https://openalex.org/I183934855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101888986"],"corresponding_institution_ids":["https://openalex.org/I183934855"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":{"value":3750,"currency":"USD","value_usd":3750},"fwci":1.368,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.77556042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"13","issue":"3","first_page":"341","last_page":"358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.5268999934196472,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.5268999934196472,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.4253000020980835,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacokinetic-pharmacodynamic-modeling","display_name":"pharmacokinetic-pharmacodynamic modeling","score":0.8980000019073486},{"id":"https://openalex.org/keywords/shiny-app","display_name":"Shiny app","score":0.718999981880188},{"id":"https://openalex.org/keywords/dosing-regimen","display_name":"dosing regimen","score":0.8640000224113464},{"id":"https://openalex.org/keywords/model-debugging","display_name":"model debugging","score":0.8569999933242798},{"id":"https://openalex.org/keywords/clinical-pharmacology","display_name":"clinical pharmacology","score":0.746999979019165},{"id":"https://openalex.org/keywords/open-source-software","display_name":"open source software","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.8908945322036743},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6633188724517822},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5504612922668457},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.48581457138061523},{"id":"https://openalex.org/C79581498","wikidata":"https://www.wikidata.org/wiki/Q1367530","display_name":"Suite","level":2,"score":0.418375700712204},{"id":"https://openalex.org/C44154836","wikidata":"https://www.wikidata.org/wiki/Q45045","display_name":"Simulation","level":1,"score":0.33142775297164917},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2818366289138794},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2431754171848297},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.10917818546295166},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/psp4.13096","doi":"https://doi.org/10.1002/psp4.13096","is_oa":true,"landing_page_url":"https://doi.org/10.1002/psp4.13096","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/psp4.13096","source":{"id":"https://openalex.org/S4210231731","display_name":"CPT Pharmacometrics & Systems Pharmacology","issn_l":"2163-8306","issn":["2163-8306"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CPT: Pharmacometrics & Systems Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10941578","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10941578","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10941578/pdf/PSP4-13-341.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CPT Pharmacometrics Syst Pharmacol","raw_type":"Text"},{"id":"pmid:38082557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38082557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CPT: pharmacometrics & systems pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5585c20f28f14cc79f21f329775e6896","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5585c20f28f14cc79f21f329775e6896","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 3, Pp 341-358 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/psp4.13096","doi":"https://doi.org/10.1002/psp4.13096","is_oa":true,"landing_page_url":"https://doi.org/10.1002/psp4.13096","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/psp4.13096","source":{"id":"https://openalex.org/S4210231731","display_name":"CPT Pharmacometrics & Systems Pharmacology","issn_l":"2163-8306","issn":["2163-8306"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CPT: Pharmacometrics & Systems Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389628403.pdf","grobid_xml":"https://content.openalex.org/works/W4389628403.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1611569621","https://openalex.org/W1673551406","https://openalex.org/W1974669325","https://openalex.org/W2000741779","https://openalex.org/W2018147385","https://openalex.org/W2082535104","https://openalex.org/W2089542180","https://openalex.org/W2106743979","https://openalex.org/W2180605142","https://openalex.org/W2571451272","https://openalex.org/W2755747278","https://openalex.org/W2763495507","https://openalex.org/W2781867441","https://openalex.org/W2912430686","https://openalex.org/W2947797594","https://openalex.org/W2981323645","https://openalex.org/W2984927918","https://openalex.org/W2991590450","https://openalex.org/W3108089427","https://openalex.org/W3136536416","https://openalex.org/W3185555613","https://openalex.org/W4200197309","https://openalex.org/W4200303223","https://openalex.org/W4207056105","https://openalex.org/W4286587687"],"related_works":["https://openalex.org/W4407678361","https://openalex.org/W2781867441","https://openalex.org/W3185555613","https://openalex.org/W2566991508","https://openalex.org/W3034501534","https://openalex.org/W2590466594","https://openalex.org/W1611569621","https://openalex.org/W4414253326","https://openalex.org/W2981323645","https://openalex.org/W3049543619"],"abstract_inverted_index":{"GPKPDviz":[0,176,193],"is":[1,22,40,116,132,194],"a":[2,124,159,195],"Shiny":[3,204],"application":[4,232],"(app)":[5],"dedicated":[6],"to":[7,42,104,209,221],"real-time":[8],"simulation,":[9,121],"visualization,":[10],"and":[11,28,31,49,82,102,146,188,202],"assessment":[12],"of":[13,24,47,127,134,197,200,238],"the":[14,19,37,45,67,95,105,112,128,163,167,186,198,211,222,236],"pharmacokinetic/pharmacodynamic":[15],"(PK/PD)":[16],"models.":[17],"Within":[18],"app,":[20],"gPKPDviz":[21,115,131,225],"capable":[23,133],"generating":[25],"virtual":[26],"populations":[27],"complex":[29,84],"dosing":[30,50,75,96,144],"sampling":[32,148],"scenarios,":[33],"which,":[34],"together":[35],"with":[36,123,138],"streamlined":[38],"workflow,":[39],"designed":[41],"efficiently":[43],"assess":[44],"impact":[46],"covariates":[48],"regimens":[51,76,97],"on":[52],"PK/PD":[53],"end":[54],"points.":[55],"The":[56,73],"actual":[57],"population":[58,120],"data":[59],"from":[60],"clinical":[61],"trials":[62],"can":[63,98],"be":[64,99],"loaded":[65,103],"into":[66],"app":[68,106,187],"for":[69,107,119,162],"simulation":[70,113,183],"if":[71],"desired.":[72],"app-generated":[74],"include":[77],"single":[78],"or":[79,90],"multiple":[80],"dosing,":[81],"more":[83],"regimens,":[85],"such":[86],"as":[87,111,171,229],"loading":[88],"doses":[89],"intermittent":[91],"dosing.":[92],"When":[93],"necessary,":[94],"defined":[100],"externally":[101],"simulation.":[108],"Using":[109],"mrgsolve":[110,129,164,190],"engine,":[114],"typically":[117],"used":[118],"however,":[122],"slight":[125],"modification":[126],"model,":[130,165],"performing":[135],"individual":[136,139,143,147],"simulations":[137],"post":[140],"hoc":[141],"parameters,":[142],"logs,":[145],"timepoints":[149],"through":[150],"an":[151,230],"external":[152],"dataset.":[153],"A":[154],"built-in":[155],"text":[156],"editor":[157],"has":[158,177,226],"debugging":[160],"feature":[161],"providing":[166],"same":[168],"error":[169],"messages":[170],"model":[172],"compilation":[173],"in":[174,191,215,233],"R.":[175,192],"had":[178],"stringent":[179],"validation":[180],"by":[181],"comparing":[182],"results":[184],"between":[185],"using":[189],"member":[196],"suite":[199],"Modeling":[201],"Simulation":[203],"apps":[205],"developed":[206],"at":[207],"Genentech":[208],"facilitate":[210],"typical":[212],"modeling":[213],"work":[214],"Clinical":[216],"Pharmacology.":[217],"For":[218],"broader":[219],"access":[220],"Pharmacometric":[223],"community,":[224],"been":[227],"published":[228],"open-source":[231],"GitHub":[234],"under":[235],"terms":[237],"GNU":[239],"General":[240],"Public":[241],"License.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-12-13T00:00:00"}