{"id":"https://openalex.org/W4389627560","doi":"https://doi.org/10.1093/nar/gkad1182","title":"The cysteine-rich domain in CENP-A chaperone Scm3HJURP ensures centromere targeting and kinetochore integrity","display_name":"The cysteine-rich domain in CENP-A chaperone Scm3HJURP ensures centromere targeting and kinetochore integrity","publication_year":2023,"publication_date":"2023-12-12","ids":{"openalex":"https://openalex.org/W4389627560","doi":"https://doi.org/10.1093/nar/gkad1182","pmid":"https://pubmed.ncbi.nlm.nih.gov/38084929","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10899784"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkad1182","doi":"https://doi.org/10.1093/nar/gkad1182","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkad1182","pdf_url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad1182/54334530/gkad1182.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad1182/54334530/gkad1182.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030458091","display_name":"Hernan Diego Folco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H\u00a0Diego Folco","raw_affiliation_strings":["Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health , Bethesda , MD \u00a020892,\u00a0 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health , Bethesda , MD \u00a020892,\u00a0 USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016053889","display_name":"Hua Xiao","orcid":"https://orcid.org/0000-0002-2831-0436","observed_orcids":["https://orcid.org/0000-0002-2831-0436"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Xiao","raw_affiliation_strings":["Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health , Bethesda , MD \u00a020892,\u00a0 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health , Bethesda , MD \u00a020892,\u00a0 USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006526845","display_name":"David Lee Wheeler","orcid":"https://orcid.org/0000-0002-2929-4204","observed_orcids":["https://orcid.org/0000-0002-2929-4204"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Wheeler","raw_affiliation_strings":["Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health , Bethesda , MD \u00a020892,\u00a0 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health , Bethesda , MD \u00a020892,\u00a0 USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072545375","display_name":"Hanqiao Feng","orcid":"https://orcid.org/0000-0003-3488-0600","observed_orcids":["https://orcid.org/0000-0003-3488-0600"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanqiao Feng","raw_affiliation_strings":["Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health , Bethesda , MD \u00a020892,\u00a0 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health , Bethesda , MD \u00a020892,\u00a0 USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069137667","display_name":"Yawen Bai","orcid":"https://orcid.org/0000-0003-3239-1109","observed_orcids":["https://orcid.org/0000-0003-3239-1109"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yawen Bai","raw_affiliation_strings":["Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health , Bethesda , MD \u00a020892,\u00a0 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health , Bethesda , MD \u00a020892,\u00a0 USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020713009","display_name":"Shiv I. S. Grewal","orcid":"https://orcid.org/0000-0002-4552-9261","observed_orcids":["https://orcid.org/0000-0002-4552-9261"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shiv\u00a0I S Grewal","raw_affiliation_strings":["Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health , Bethesda , MD \u00a020892,\u00a0 USA"],"raw_orcid":"https://orcid.org/0000-0002-4552-9261","affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health , Bethesda , MD \u00a020892,\u00a0 USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020713009"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":0.8377,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.66919403,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"52","issue":"4","first_page":"1688","last_page":"1701"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cysteine-rich-domain","display_name":"cysteine-rich domain","score":0.9940000176429749},{"id":"https://openalex.org/keywords/zinc-binding-motif","display_name":"zinc-binding motif","score":0.8180000185966492},{"id":"https://openalex.org/keywords/centromeric-chromatin","display_name":"centromeric chromatin","score":0.8989999890327454},{"id":"https://openalex.org/keywords/chromosome-segregation","display_name":"chromosome segregation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/schizosaccharomyces-pombe","display_name":"Schizosaccharomyces pombe","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C63491729","wikidata":"https://www.wikidata.org/wiki/Q14762596","display_name":"Centromere","level":4,"score":0.898044228553772},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8070038557052612},{"id":"https://openalex.org/C192838845","wikidata":"https://www.wikidata.org/wiki/Q908912","display_name":"Kinetochore","level":4,"score":0.7782788872718811},{"id":"https://openalex.org/C2778354886","wikidata":"https://www.wikidata.org/wiki/Q5113927","display_name":"Chromosome segregation","level":4,"score":0.6847519278526306},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6156593561172485},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5232290625572205},{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.4288256764411926},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.4250227212905884},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4104588031768799},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.24529066681861877},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.11381116509437561},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0872759222984314},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07156580686569214},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000076247","descriptor_name":"Centromere Protein A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000076247","descriptor_name":"Centromere Protein A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002503","descriptor_name":"Centromere","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002503","descriptor_name":"Centromere","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002868","descriptor_name":"Chromosomal Proteins, Non-Histone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002868","descriptor_name":"Chromosomal Proteins, Non-Histone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012568","descriptor_name":"Schizosaccharomyces","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012568","descriptor_name":"Schizosaccharomyces","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018386","descriptor_name":"Kinetochores","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029702","descriptor_name":"Schizosaccharomyces pombe Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029702","descriptor_name":"Schizosaccharomyces pombe Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/nar/gkad1182","doi":"https://doi.org/10.1093/nar/gkad1182","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkad1182","pdf_url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad1182/54334530/gkad1182.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10899784","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10899784","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10899784/pdf/gkad1182.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:38084929","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38084929","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/nar/gkad1182","doi":"https://doi.org/10.1093/nar/gkad1182","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkad1182","pdf_url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad1182/54334530/gkad1182.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389627560.pdf","grobid_xml":"https://content.openalex.org/works/W4389627560.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1539010571","https://openalex.org/W1764647617","https://openalex.org/W1963814491","https://openalex.org/W1970569685","https://openalex.org/W1970597357","https://openalex.org/W1973946233","https://openalex.org/W1978631580","https://openalex.org/W1979589349","https://openalex.org/W1981354816","https://openalex.org/W1994092873","https://openalex.org/W1994181100","https://openalex.org/W1994634104","https://openalex.org/W1995275121","https://openalex.org/W1995808589","https://openalex.org/W1995967793","https://openalex.org/W2003345607","https://openalex.org/W2005654623","https://openalex.org/W2014270114","https://openalex.org/W2017165841","https://openalex.org/W2024177760","https://openalex.org/W2026304022","https://openalex.org/W2035458388","https://openalex.org/W2048061807","https://openalex.org/W2052770408","https://openalex.org/W2058582467","https://openalex.org/W2060605945","https://openalex.org/W2074286944","https://openalex.org/W2075819285","https://openalex.org/W2080457024","https://openalex.org/W2084872847","https://openalex.org/W2088164618","https://openalex.org/W2092354451","https://openalex.org/W2096525273","https://openalex.org/W2097908786","https://openalex.org/W2102859326","https://openalex.org/W2103089522","https://openalex.org/W2105516199","https://openalex.org/W2116402707","https://openalex.org/W2116467086","https://openalex.org/W2139194779","https://openalex.org/W2150304956","https://openalex.org/W2152573465","https://openalex.org/W2153744866","https://openalex.org/W2158789637","https://openalex.org/W2159079025","https://openalex.org/W2169456326","https://openalex.org/W2169821755","https://openalex.org/W2178153806","https://openalex.org/W2287127061","https://openalex.org/W2288886458","https://openalex.org/W2514207328","https://openalex.org/W2588691895","https://openalex.org/W2766323111","https://openalex.org/W2804902596","https://openalex.org/W2922301063","https://openalex.org/W2951912016","https://openalex.org/W2954240568","https://openalex.org/W2965121944","https://openalex.org/W2979774348","https://openalex.org/W2990922505","https://openalex.org/W3198209447","https://openalex.org/W4205440119","https://openalex.org/W4230009270","https://openalex.org/W4289274885","https://openalex.org/W4328114933","https://openalex.org/W4377020432","https://openalex.org/W7100806209"],"related_works":["https://openalex.org/W2017165841","https://openalex.org/W2026304022","https://openalex.org/W1995275121","https://openalex.org/W1979589349","https://openalex.org/W7162099153","https://openalex.org/W2005877793","https://openalex.org/W2088929283","https://openalex.org/W2080457024","https://openalex.org/W1764647617","https://openalex.org/W2092354451"],"abstract_inverted_index":{"Centromeric":[0],"chromatin":[1],"plays":[2],"a":[3,49,136],"crucial":[4],"role":[5,179],"in":[6,57,80,184],"kinetochore":[7,113,160],"assembly":[8],"and":[9,82,88,111,142,152,159,188],"chromosome":[10,157],"segregation.":[11],"Centromeres":[12],"are":[13],"specified":[14],"through":[15],"the":[16,19,25,37,45,53,86,121,146,169,177,181,193],"loading":[17],"of":[18,31,70,90,100,180,195],"histone":[20],"H3":[21],"variant":[22],"CENP-A":[23,147],"by":[24,42,96,155,167],"conserved":[26,66],"chaperone":[27],"Scm3/HJURP.":[28],"The":[29],"N-terminus":[30],"Scm3/HJURP":[32],"interacts":[33],"with":[34,44,133],"CENP-A,":[35],"while":[36],"C-terminus":[38],"facilitates":[39],"centromere":[40,109,197],"localization":[41,87,110],"interacting":[43],"Mis18":[46],"holocomplex":[47],"via":[48],"small":[50],"domain,":[51,149],"called":[52],"Mis16-binding":[54],"domain":[55,68,183],"(Mis16-BD)":[56],"fission":[58,91],"yeast.":[59],"Fungal":[60],"Scm3":[61,108,186,196],"proteins":[62,187],"contain":[63],"an":[64],"additional":[65],"cysteine-rich":[67,182],"(CYS)":[69],"unknown":[71],"function.":[72],"Here,":[73],"we":[74],"find":[75],"that":[76],"CYS":[77,95,116,170],"binds":[78],"zinc":[79],"vitro":[81],"is":[83,128,153],"essential":[84,178],"for":[85],"function":[89],"yeast":[92],"Scm3.":[93],"Disrupting":[94],"deletion":[97],"or":[98],"introduction":[99],"point":[101],"mutations":[102],"within":[103],"its":[104,126],"zinc-binding":[105,171],"motif":[106],"prevents":[107],"compromises":[112],"integrity.":[114],"Interestingly,":[115],"alone":[117],"can":[118,164],"localize":[119],"to":[120],"centromere,":[122],"albeit":[123],"weakly,":[124],"but":[125,144],"targeting":[127],"greatly":[129],"enhanced":[130],"when":[131],"combined":[132],"Mis16-BD.":[134],"Expressing":[135],"truncated":[137],"protein":[138],"containing":[139],"both":[140],"Mis16-BD":[141],"CYS,":[143],"lacking":[145],"binding":[148],"causes":[150],"toxicity":[151],"accompanied":[154],"considerable":[156],"missegregation":[158],"loss.":[161],"These":[162],"effects":[163],"be":[165],"mitigated":[166],"mutating":[168],"motif.":[172],"Collectively,":[173],"our":[174],"findings":[175],"establish":[176],"fungal":[185],"provide":[189],"valuable":[190],"insights":[191],"into":[192],"mechanism":[194],"targeting.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-12-13T00:00:00"}
