{"id":"https://openalex.org/W4389625307","doi":"https://doi.org/10.9734/jammr/2023/v35i245318","title":"Effects of \u03b1-Humulene and its Nanoparticles in Experimental Model of Alzheimer's Disease: Behavioral Analysis and Anti-Inflammatory Activity","display_name":"Effects of \u03b1-Humulene and its Nanoparticles in Experimental Model of Alzheimer's Disease: Behavioral Analysis and Anti-Inflammatory Activity","publication_year":2023,"publication_date":"2023-12-12","ids":{"openalex":"https://openalex.org/W4389625307","doi":"https://doi.org/10.9734/jammr/2023/v35i245318"},"language":"en","primary_location":{"id":"doi:10.9734/jammr/2023/v35i245318","doi":"https://doi.org/10.9734/jammr/2023/v35i245318","is_oa":true,"landing_page_url":"https://doi.org/10.9734/jammr/2023/v35i245318","pdf_url":"https://journaljammr.com/index.php/JAMMR/article/download/5318/10595","source":{"id":"https://openalex.org/S4210232404","display_name":"Journal of Advances in Medicine and Medical Research","issn_l":"2231-0614","issn":["2231-0614","2456-8899"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["vabb-shw"],"host_organization":"https://openalex.org/P4310320855","host_organization_name":"Sciencedomain International","host_organization_lineage":["https://openalex.org/P4310320855"],"host_organization_lineage_names":["Sciencedomain International"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Advances in Medicine and Medical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journaljammr.com/index.php/JAMMR/article/download/5318/10595","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090710575","display_name":"Maria Elvira Ribeiro Cordeiro","orcid":"https://orcid.org/0000-0001-8305-3025","observed_orcids":["https://orcid.org/0000-0001-8305-3025"]},"institutions":[{"id":"https://openalex.org/I150729083","display_name":"Universidade de Bras\u00edlia","ror":"https://ror.org/02xfp8v59","country_code":"BR","type":"education","lineage":["https://openalex.org/I150729083"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Maria Elvira Ribeiro Cordeiro","raw_affiliation_strings":["University of Brasilia, DF, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Brasilia, DF, Brazil","institution_ids":["https://openalex.org/I150729083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075331785","display_name":"Luana Rodrigues Vasconcelos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luana Rodrigues Vasconcelos","raw_affiliation_strings":["Mid-West State University, PR, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mid-West State University, PR, Brazil","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059395932","display_name":"Heron Bittencourt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Heron Bittencourt","raw_affiliation_strings":["Mid-West State University, PR, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mid-West State University, PR, Brazil","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051706149","display_name":"Fl\u00e1vio Klinpovous Kerppers","orcid":"https://orcid.org/0000-0002-3675-765X","observed_orcids":["https://orcid.org/0000-0002-3675-765X"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fl\u00e1vio Klinpovous Kerppers","raw_affiliation_strings":["Mid-West State University, PR, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mid-West State University, PR, Brazil","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043072217","display_name":"Andressa Panegalli Hosni","orcid":"https://orcid.org/0000-0002-2980-9773","observed_orcids":["https://orcid.org/0000-0002-2980-9773"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Andressa Panegalli Hosni","raw_affiliation_strings":["Mid-West State University, PR, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mid-West State University, PR, Brazil","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103021139","display_name":"Ivo Ilvan Kerppers","orcid":"https://orcid.org/0000-0002-5901-4007","observed_orcids":["https://orcid.org/0000-0002-5901-4007"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ivo Ilvan Kerppers","raw_affiliation_strings":["Department of Physiotherapy, Mid-West State University, PR, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiotherapy, Mid-West State University, PR, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043015710","display_name":"Rubiana Mara Mainardes","orcid":"https://orcid.org/0000-0002-4442-2075","observed_orcids":["https://orcid.org/0000-0002-4442-2075"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rubiana Mara Mainardes","raw_affiliation_strings":["Pharmacy School, Mid-West State University, Guarapuava, PR, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy School, Mid-West State University, Guarapuava, PR, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012650110","display_name":"Christiane Schineider Machado Kolc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Christiane Schineider Machado Kolc","raw_affiliation_strings":["Mid-West State University, PR, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mid-West State University, PR, Brazil","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059174496","display_name":"Ana Carolina Dorigoni Bini","orcid":"https://orcid.org/0000-0003-1717-9249","observed_orcids":["https://orcid.org/0000-0003-1717-9249"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Carolina Dorigoni Bini","raw_affiliation_strings":["Mid-West State University, PR, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mid-West State University, PR, Brazil","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048484277","display_name":"Patr\u00edcia Pacheco Tyski Suckow","orcid":"https://orcid.org/0000-0002-5022-7612","observed_orcids":["https://orcid.org/0000-0002-5022-7612"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Patricia Pacheco Tyski Suckow","raw_affiliation_strings":["Mid-West State University, PR, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mid-West State University, PR, Brazil","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001132810","display_name":"Eliane Gon\u00e7alves de Jesus Fonseca","orcid":"https://orcid.org/0000-0002-6540-6111","observed_orcids":["https://orcid.org/0000-0002-6540-6111"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Eliane Gon\u00e7alves de Jesus Fonseca","raw_affiliation_strings":["Mid-West State University, PR, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mid-West State University, PR, Brazil","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001136667","display_name":"Angela Dubiela Julik","orcid":"https://orcid.org/0000-0001-7375-6771","observed_orcids":["https://orcid.org/0000-0001-7375-6771"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Angela Dubiela Julik","raw_affiliation_strings":["Mid-West State University, PR, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mid-West State University, PR, Brazil","institution_ids":["https://openalex.org/I40034438"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090710575"],"corresponding_institution_ids":["https://openalex.org/I150729083"],"apc_list":null,"apc_paid":null,"fwci":0.1866,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.38841913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"35","issue":"24","first_page":"1","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.0430000014603138,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13798","display_name":"Hops Chemistry and Applications","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-humulene","display_name":"\u03b1-humulene","score":0.9929999709129333},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8450000286102295},{"id":"https://openalex.org/keywords/spatial-memory","display_name":"spatial memory","score":0.8790000081062317},{"id":"https://openalex.org/keywords/aversive-memory","display_name":"aversive memory","score":0.9800000190734863},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9359999895095825},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8690000176429749},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9509999752044678},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8040000200271606},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C2777291603","wikidata":"https://www.wikidata.org/wiki/Q1995108","display_name":"Humulene","level":3,"score":0.6405555009841919},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43933573365211487},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4173320233821869},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33246511220932007},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33048492670059204},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25155109167099},{"id":"https://openalex.org/C2777278459","wikidata":"https://www.wikidata.org/wiki/Q170885","display_name":"Essential oil","level":2,"score":0.0},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.9734/jammr/2023/v35i245318","doi":"https://doi.org/10.9734/jammr/2023/v35i245318","is_oa":true,"landing_page_url":"https://doi.org/10.9734/jammr/2023/v35i245318","pdf_url":"https://journaljammr.com/index.php/JAMMR/article/download/5318/10595","source":{"id":"https://openalex.org/S4210232404","display_name":"Journal of Advances in Medicine and Medical Research","issn_l":"2231-0614","issn":["2231-0614","2456-8899"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["vabb-shw"],"host_organization":"https://openalex.org/P4310320855","host_organization_name":"Sciencedomain International","host_organization_lineage":["https://openalex.org/P4310320855"],"host_organization_lineage_names":["Sciencedomain International"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Advances in Medicine and Medical Research","raw_type":"journal-article"},{"id":"pmh:oai:journaljammr.com:article/5318","doi":null,"is_oa":true,"landing_page_url":"https://www.journaljammr.com/index.php/JAMMR/article/view/5318","pdf_url":null,"source":{"id":"https://openalex.org/S4210232404","display_name":"Journal of Advances in Medicine and Medical Research","issn_l":"2231-0614","issn":["2231-0614","2456-8899"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["vabb-shw"],"host_organization":"https://openalex.org/P4310320855","host_organization_name":"Sciencedomain International","host_organization_lineage":["https://openalex.org/P4310320855"],"host_organization_lineage_names":["Sciencedomain International"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2456-8899","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-05138916v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05138916","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Advances in Medicine and Medical Research, 2023, 35 (24), pp.1-13","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.9734/jammr/2023/v35i245318","doi":"https://doi.org/10.9734/jammr/2023/v35i245318","is_oa":true,"landing_page_url":"https://doi.org/10.9734/jammr/2023/v35i245318","pdf_url":"https://journaljammr.com/index.php/JAMMR/article/download/5318/10595","source":{"id":"https://openalex.org/S4210232404","display_name":"Journal of Advances in Medicine and Medical Research","issn_l":"2231-0614","issn":["2231-0614","2456-8899"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["vabb-shw"],"host_organization":"https://openalex.org/P4310320855","host_organization_name":"Sciencedomain International","host_organization_lineage":["https://openalex.org/P4310320855"],"host_organization_lineage_names":["Sciencedomain International"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Advances in Medicine and Medical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389625307.pdf","grobid_xml":"https://content.openalex.org/works/W4389625307.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1967363201","https://openalex.org/W1992702571","https://openalex.org/W2017169966","https://openalex.org/W2020592333","https://openalex.org/W2031551869","https://openalex.org/W2033283555","https://openalex.org/W2066936530","https://openalex.org/W2115017507","https://openalex.org/W2119337283","https://openalex.org/W2140201388","https://openalex.org/W2466814158","https://openalex.org/W2557174471","https://openalex.org/W2759589557","https://openalex.org/W2789535394","https://openalex.org/W2900402836","https://openalex.org/W2917469075","https://openalex.org/W2996726990","https://openalex.org/W3034184782","https://openalex.org/W3041707034","https://openalex.org/W3048101422","https://openalex.org/W3133291488","https://openalex.org/W3157779922","https://openalex.org/W3158055698","https://openalex.org/W3159661950","https://openalex.org/W6780736395"],"related_works":["https://openalex.org/W4390533846","https://openalex.org/W4411484105","https://openalex.org/W2555922125","https://openalex.org/W4411687510","https://openalex.org/W7221771202","https://openalex.org/W4407768358","https://openalex.org/W4399113841","https://openalex.org/W2979558737","https://openalex.org/W2919546012","https://openalex.org/W2943105857"],"abstract_inverted_index":{"The":[0,90,115],"aim":[1],"was":[2,77],"to":[3,40,54,67,94],"analyze":[4],"the":[5,24,103,133,139],"effects":[6],"of":[7,12,19,31,42,46,56,69,87,97,126],"\u03b1-humulene":[8,74],"in":[9,132,138],"experimental":[10],"models":[11],"Alzheimer\u2019s":[13],"disease":[14],"(AD).":[15],"A":[16],"sample":[17],"composed":[18],"33":[20],"rats,":[21],"divided":[22],"into":[23],"NC":[25],"group:":[26],"3":[27],"animals,":[28],"for":[29,81],"analysis":[30],"normal":[32],"tissue":[33],"and":[34,58,62,71,100,108,122],"behavior,":[35],"PC:":[36],"10":[37,51,64],"animals":[38,52,65,91,117],"submitted":[39,53,66,93],"induction":[41,55,68],"AD":[43,57,70],"by":[44,112],"application":[45],"\u03b2-amyloid,":[47],"without":[48],"treatment,":[49],"HUM:":[50],"treated":[59,72,116],"with":[60,73,129,135],"\u03b1-humulene,":[61],"NHUM:":[63],"nanoparticles.":[75],"Treatment":[76],"performed":[78],"once":[79],"daily":[80],"14":[82],"days":[83],"at":[84],"a":[85],"dose":[86],"6.5\u00b5g,":[88],"orally.":[89],"were":[92,110],"behavioral":[95],"tests":[96],"spatial":[98],"memory":[99],"aversive":[101],"memory,":[102],"cytokines":[104],"TNF,":[105],"IL-10,":[106],"IL-2":[107],"IL-4":[109],"analyzed":[111],"flow":[113],"cytometry.":[114],"obtained":[118],"superior":[119],"cognitive":[120],"performance":[121],"expressed":[123],"lower":[124],"levels":[125],"inflammatory":[127],"markers,":[128],"better":[130,136],"results":[131,137],"group":[134],"NHUM.":[140]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2023-12-13T00:00:00"}
