{"id":"https://openalex.org/W4389616586","doi":"https://doi.org/10.3390/jcdd10120494","title":"Drosophila as a Model to Understand Second Heart Field Development","display_name":"Drosophila as a Model to Understand Second Heart Field Development","publication_year":2023,"publication_date":"2023-12-12","ids":{"openalex":"https://openalex.org/W4389616586","doi":"https://doi.org/10.3390/jcdd10120494","pmid":"https://pubmed.ncbi.nlm.nih.gov/38132661","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10744189"},"language":"en","primary_location":{"id":"doi:10.3390/jcdd10120494","doi":"https://doi.org/10.3390/jcdd10120494","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcdd10120494","pdf_url":"https://www.mdpi.com/2308-3425/10/12/494/pdf?version=1702353078","source":{"id":"https://openalex.org/S2738607712","display_name":"Journal of Cardiovascular Development and Disease","issn_l":"2308-3425","issn":["2308-3425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Development and Disease","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2308-3425/10/12/494/pdf?version=1702353078","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092383963","display_name":"Cayleen Bileckyj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cayleen Bileckyj","raw_affiliation_strings":["Department of Biology, San Diego State University, San Diego, CA 92182, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, San Diego State University, San Diego, CA 92182, USA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092364964","display_name":"Brenna Blotz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brenna Blotz","raw_affiliation_strings":["Department of Biology, San Diego State University, San Diego, CA 92182, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, San Diego State University, San Diego, CA 92182, USA","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086418466","display_name":"Richard M. Cripps","orcid":"https://orcid.org/0000-0001-6565-285X","observed_orcids":["https://orcid.org/0000-0001-6565-285X"]},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard M. Cripps","raw_affiliation_strings":["Department of Biology, San Diego State University, San Diego, CA 92182, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, San Diego State University, San Diego, CA 92182, USA","institution_ids":["https://openalex.org/I26538001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086418466"],"corresponding_institution_ids":["https://openalex.org/I26538001"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2224},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2224},"fwci":0.1054,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.09319967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"10","issue":"12","first_page":"494","last_page":"494"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/second-heart-field","display_name":"second heart field","score":0.8510000109672546},{"id":"https://openalex.org/keywords/drosophila-heart","display_name":"Drosophila heart","score":0.8579999804496765},{"id":"https://openalex.org/keywords/heart-development","display_name":"heart development","score":0.800000011920929},{"id":"https://openalex.org/keywords/metamorphosis","display_name":"metamorphosis","score":0.781000018119812},{"id":"https://openalex.org/keywords/congenital-heart-disease","display_name":"congenital heart disease","score":0.9200000166893005}],"concepts":[{"id":"https://openalex.org/C62425271","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Heart development","level":4,"score":0.7514510154724121},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.7228991389274597},{"id":"https://openalex.org/C136397037","wikidata":"https://www.wikidata.org/wiki/Q33753","display_name":"Metamorphosis","level":3,"score":0.6203008890151978},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6096524000167847},{"id":"https://openalex.org/C100068826","wikidata":"https://www.wikidata.org/wiki/Q485675","display_name":"Hemolymph","level":2,"score":0.5927685499191284},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.492137610912323},{"id":"https://openalex.org/C2988540567","wikidata":"https://www.wikidata.org/wiki/Q12070446","display_name":"Model system","level":2,"score":0.420987993478775},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.41343531012535095},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38298237323760986},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3417043685913086},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27134352922439575},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2452118992805481},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21020859479904175},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.20087575912475586},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19602042436599731},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.15202513337135315},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.13901197910308838},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.09717583656311035}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/jcdd10120494","doi":"https://doi.org/10.3390/jcdd10120494","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcdd10120494","pdf_url":"https://www.mdpi.com/2308-3425/10/12/494/pdf?version=1702353078","source":{"id":"https://openalex.org/S2738607712","display_name":"Journal of Cardiovascular Development and Disease","issn_l":"2308-3425","issn":["2308-3425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Development and Disease","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10744189","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10744189","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10744189/pdf/jcdd-10-00494.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cardiovasc Dev Dis","raw_type":"Text"},{"id":"pmid:38132661","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38132661","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular development and disease","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a4389bffad5348399a7d993d08da8a6b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a4389bffad5348399a7d993d08da8a6b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Cardiovascular Development and Disease, Vol 10, Iss 12, p 494 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/jcdd10120494","doi":"https://doi.org/10.3390/jcdd10120494","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcdd10120494","pdf_url":"https://www.mdpi.com/2308-3425/10/12/494/pdf?version=1702353078","source":{"id":"https://openalex.org/S2738607712","display_name":"Journal of Cardiovascular Development and Disease","issn_l":"2308-3425","issn":["2308-3425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Development and Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1053467587","display_name":"Genetic Regulation of Muscle Fiber Diversity","funder_award_id":"R01GM061738","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1185237958","display_name":"Establishing the role of the conserved TN Domain in Tinman","funder_award_id":"915296","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G1189078667","display_name":null,"funder_award_id":"GM124498","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G4191757077","display_name":null,"funder_award_id":"GM061738","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6104785443","display_name":null,"funder_award_id":"GM061738","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G8372213740","display_name":null,"funder_award_id":"915296","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8538815408","display_name":null,"funder_award_id":"GM124498","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000875160","display_name":"Molecular genetic analysis of MEF2 function in Drosophila","funder_award_id":"R01GM124498","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389616586.pdf","grobid_xml":"https://content.openalex.org/works/W4389616586.grobid-xml"},"referenced_works_count":123,"referenced_works":["https://openalex.org/W109270128","https://openalex.org/W1482498530","https://openalex.org/W1501608538","https://openalex.org/W1506409704","https://openalex.org/W1535517524","https://openalex.org/W1554463652","https://openalex.org/W1560792299","https://openalex.org/W1681270309","https://openalex.org/W1926307205","https://openalex.org/W1964506754","https://openalex.org/W1965271063","https://openalex.org/W1966563415","https://openalex.org/W1971123996","https://openalex.org/W1971977081","https://openalex.org/W1972744693","https://openalex.org/W1973431915","https://openalex.org/W1977746306","https://openalex.org/W1980692621","https://openalex.org/W1980898099","https://openalex.org/W1983022886","https://openalex.org/W1986960652","https://openalex.org/W1989022363","https://openalex.org/W1990158689","https://openalex.org/W1994142299","https://openalex.org/W1994193635","https://openalex.org/W1994465080","https://openalex.org/W1994648165","https://openalex.org/W1995854414","https://openalex.org/W1997362403","https://openalex.org/W2001243412","https://openalex.org/W2002248474","https://openalex.org/W2002732720","https://openalex.org/W2003653681","https://openalex.org/W2004087850","https://openalex.org/W2005435367","https://openalex.org/W2011884985","https://openalex.org/W2015082418","https://openalex.org/W2026266777","https://openalex.org/W2038185740","https://openalex.org/W2040740850","https://openalex.org/W2041668737","https://openalex.org/W2042773729","https://openalex.org/W2049073959","https://openalex.org/W2051026229","https://openalex.org/W2051116695","https://openalex.org/W2053480435","https://openalex.org/W2054191145","https://openalex.org/W2057427802","https://openalex.org/W2058004965","https://openalex.org/W2058120450","https://openalex.org/W2062748827","https://openalex.org/W2063724508","https://openalex.org/W2064586774","https://openalex.org/W2067370329","https://openalex.org/W2071699551","https://openalex.org/W2073500834","https://openalex.org/W2075469935","https://openalex.org/W2076600697","https://openalex.org/W2078422108","https://openalex.org/W2078587203","https://openalex.org/W2081757480","https://openalex.org/W2088513836","https://openalex.org/W2089749943","https://openalex.org/W2091441330","https://openalex.org/W2093477438","https://openalex.org/W2093523770","https://openalex.org/W2096851897","https://openalex.org/W2097836010","https://openalex.org/W2098324477","https://openalex.org/W2103674953","https://openalex.org/W2105039688","https://openalex.org/W2109628745","https://openalex.org/W2110643873","https://openalex.org/W2111473168","https://openalex.org/W2111525541","https://openalex.org/W2115681985","https://openalex.org/W2115798328","https://openalex.org/W2120609231","https://openalex.org/W2122192059","https://openalex.org/W2123338247","https://openalex.org/W2126774045","https://openalex.org/W2133460513","https://openalex.org/W2135801344","https://openalex.org/W2136815686","https://openalex.org/W2139639100","https://openalex.org/W2147848503","https://openalex.org/W2148559371","https://openalex.org/W2150972545","https://openalex.org/W2154070829","https://openalex.org/W2154847292","https://openalex.org/W2155287484","https://openalex.org/W2159443353","https://openalex.org/W2254174322","https://openalex.org/W2297830784","https://openalex.org/W2298369384","https://openalex.org/W2318364303","https://openalex.org/W2397281151","https://openalex.org/W2416254565","https://openalex.org/W2623322330","https://openalex.org/W2738739664","https://openalex.org/W2784600881","https://openalex.org/W2788780716","https://openalex.org/W2802169073","https://openalex.org/W2895544043","https://openalex.org/W2919287201","https://openalex.org/W2932627705","https://openalex.org/W2951911538","https://openalex.org/W2952402797","https://openalex.org/W2952849195","https://openalex.org/W2998481872","https://openalex.org/W3002652237","https://openalex.org/W3045758613","https://openalex.org/W3125626725","https://openalex.org/W3153012503","https://openalex.org/W3162580982","https://openalex.org/W3213208965","https://openalex.org/W4294012183","https://openalex.org/W4317037303","https://openalex.org/W4328048326","https://openalex.org/W4365148239","https://openalex.org/W4386593203","https://openalex.org/W6604489375","https://openalex.org/W7073714702"],"related_works":["https://openalex.org/W1891076175","https://openalex.org/W3213208965","https://openalex.org/W1973540851","https://openalex.org/W1982100452","https://openalex.org/W4234323389","https://openalex.org/W1964276310","https://openalex.org/W2338757051","https://openalex.org/W2548626240","https://openalex.org/W4365148239","https://openalex.org/W4415401887"],"abstract_inverted_index":{"The":[0,20,91],"genetic":[1],"model":[2,156],"system":[3,58,120],"Drosophila":[4,23,63,119],"has":[5],"contributed":[6],"fundamentally":[7],"to":[8,51,85,101,121,135],"our":[9],"understanding":[10,123,158],"of":[11,43,59,74,82,93,117,124,132],"mammalian":[12,105,136],"heart":[13,18,24,84,107,125,137],"specification,":[14],"development,":[15],"and":[16,33,38,70,127,139,141,161],"congenital":[17],"disease.":[19,162],"relatively":[21],"simple":[22],"is":[25,31,68],"a":[26,71,154],"linear":[27],"muscular":[28],"tube":[29,67],"that":[30],"specified":[32],"develops":[34],"in":[35],"the":[36,41,44,55,60,65,79,83,87,114,118,122,130,133,145],"embryo":[37],"persists":[39],"throughout":[40],"life":[42],"animal.":[45],"It":[46],"functions":[47],"at":[48],"all":[49],"stages":[50],"circulate":[52],"hemolymph":[53],"within":[54],"open":[56],"circulatory":[57],"body.":[61],"During":[62],"metamorphosis,":[64],"cardiac":[66,149],"remodeled,":[69],"new":[72],"layer":[73],"muscle":[75],"fibers":[76,95],"spreads":[77],"over":[78],"ventral":[80,88,146],"surface":[81],"form":[86],"longitudinal":[89,147],"muscles.":[90],"formation":[92],"these":[94],"depends":[96],"critically":[97],"upon":[98],"genes":[99],"known":[100],"be":[102],"necessary":[103],"for":[104,157],"second":[106],"field":[108],"(SHF)":[109],"formation.":[110],"Here,":[111],"we":[112],"review":[113],"prior":[115],"contributions":[116],"development":[126,138,160],"disease,":[128,140],"discuss":[129,143],"importance":[131],"SHF":[134,159],"then":[142],"how":[144],"adult":[148],"muscles":[150],"can":[151],"serve":[152],"as":[153],"novel":[155]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-12-13T00:00:00"}