{"id":"https://openalex.org/W4389607948","doi":"https://doi.org/10.1021/acschemneuro.3c00684","title":"Design, Synthesis, and Structure\u2013Activity Relationship Studies of Novel GPR88 Agonists (4-Substituted-phenyl)acetamides Based on the Reversed Amide Scaffold","display_name":"Design, Synthesis, and Structure\u2013Activity Relationship Studies of Novel GPR88 Agonists (4-Substituted-phenyl)acetamides Based on the Reversed Amide Scaffold","publication_year":2023,"publication_date":"2023-12-12","ids":{"openalex":"https://openalex.org/W4389607948","doi":"https://doi.org/10.1021/acschemneuro.3c00684","pmid":"https://pubmed.ncbi.nlm.nih.gov/38086012","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10843732"},"language":"en","primary_location":{"id":"doi:10.1021/acschemneuro.3c00684","doi":"https://doi.org/10.1021/acschemneuro.3c00684","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschemneuro.3c00684","pdf_url":null,"source":{"id":"https://openalex.org/S180465690","display_name":"ACS Chemical Neuroscience","issn_l":"1948-7193","issn":["1948-7193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10843732/pdf/nihms-1952370.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068613321","display_name":"Md Toufiqur Rahman","orcid":"https://orcid.org/0000-0003-2752-6822","observed_orcids":["https://orcid.org/0000-0003-2752-6822"]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Md Toufiqur Rahman","raw_affiliation_strings":["Center for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27709, United States"],"raw_orcid":"https://orcid.org/0000-0003-2752-6822","affiliations":[{"raw_affiliation_string":"Center for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27709, United States","institution_ids":["https://openalex.org/I180297670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012022192","display_name":"Dongliang Guan","orcid":"https://orcid.org/0000-0002-7814-1116","observed_orcids":["https://orcid.org/0000-0002-7814-1116","https://orcid.org/0000-0001-8561-210X"]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dongliang Guan","raw_affiliation_strings":["Center for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27709, United States"],"raw_orcid":"https://orcid.org/0000-0002-7814-1116","affiliations":[{"raw_affiliation_string":"Center for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27709, United States","institution_ids":["https://openalex.org/I180297670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018268684","display_name":"Hetti Handi Chaminda Lakmal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hetti Handi Chaminda Lakmal","raw_affiliation_strings":["Center for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27709, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27709, United States","institution_ids":["https://openalex.org/I180297670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006323154","display_name":"Ann M. Decker","orcid":"https://orcid.org/0000-0003-1899-6558","observed_orcids":["https://orcid.org/0000-0003-1899-6558"]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann M. Decker","raw_affiliation_strings":["Center for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27709, United States"],"raw_orcid":"https://orcid.org/0000-0003-1899-6558","affiliations":[{"raw_affiliation_string":"Center for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27709, United States","institution_ids":["https://openalex.org/I180297670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038969095","display_name":"Gregory H. Imler","orcid":"https://orcid.org/0000-0002-9686-9186","observed_orcids":["https://orcid.org/0000-0002-9686-9186"]},"institutions":[{"id":"https://openalex.org/I1288214837","display_name":"United States Naval Research Laboratory","ror":"https://ror.org/04d23a975","country_code":"US","type":"facility","lineage":["https://openalex.org/I1288214837","https://openalex.org/I1330347796","https://openalex.org/I175003984","https://openalex.org/I3130687028"]},{"id":"https://openalex.org/I4388482722","display_name":"Naval Research Laboratory Center for Bio/Molecular Science and Engineering","ror":"https://ror.org/021m46s67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1288214837","https://openalex.org/I1330347796","https://openalex.org/I175003984","https://openalex.org/I3130687028","https://openalex.org/I4388482722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory H. Imler","raw_affiliation_strings":["Center for Biomolecular Science and Engineering, Naval Research Laboratory, Code 6920, Washington, District of Columbia 20375, United States"],"raw_orcid":"https://orcid.org/0000-0002-9686-9186","affiliations":[{"raw_affiliation_string":"Center for Biomolecular Science and Engineering, Naval Research Laboratory, Code 6920, Washington, District of Columbia 20375, United States","institution_ids":["https://openalex.org/I1288214837","https://openalex.org/I4388482722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057821628","display_name":"Andrew T. Kerr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288214837","display_name":"United States Naval Research Laboratory","ror":"https://ror.org/04d23a975","country_code":"US","type":"facility","lineage":["https://openalex.org/I1288214837","https://openalex.org/I1330347796","https://openalex.org/I175003984","https://openalex.org/I3130687028"]},{"id":"https://openalex.org/I4388482722","display_name":"Naval Research Laboratory Center for Bio/Molecular Science and Engineering","ror":"https://ror.org/021m46s67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1288214837","https://openalex.org/I1330347796","https://openalex.org/I175003984","https://openalex.org/I3130687028","https://openalex.org/I4388482722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew T. Kerr","raw_affiliation_strings":["Center for Biomolecular Science and Engineering, Naval Research Laboratory, Code 6920, Washington, District of Columbia 20375, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biomolecular Science and Engineering, Naval Research Laboratory, Code 6920, Washington, District of Columbia 20375, United States","institution_ids":["https://openalex.org/I1288214837","https://openalex.org/I4388482722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062312719","display_name":"Danni L. Harris","orcid":"https://orcid.org/0000-0003-4231-1926","observed_orcids":["https://orcid.org/0000-0003-4231-1926"]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Danni L. Harris","raw_affiliation_strings":["Center for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27709, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27709, United States","institution_ids":["https://openalex.org/I180297670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049083915","display_name":"Chunyang Jin","orcid":"https://orcid.org/0000-0001-6733-3094","observed_orcids":["https://orcid.org/0000-0001-6733-3094"]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chunyang Jin","raw_affiliation_strings":["Center for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27709, United States"],"raw_orcid":"https://orcid.org/0000-0001-6733-3094","affiliations":[{"raw_affiliation_string":"Center for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27709, United States","institution_ids":["https://openalex.org/I180297670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5049083915","https://openalex.org/A5062312719"],"corresponding_institution_ids":["https://openalex.org/I180297670"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.5321,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.58002534,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"15","issue":"1","first_page":"169","last_page":"192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gpr88","display_name":"GPR88","score":0.9990000128746033},{"id":"https://openalex.org/keywords/orphan-gpcrs","display_name":"orphan G protein-coupled receptor","score":0.8420000076293945},{"id":"https://openalex.org/keywords/allosteric-agonists","display_name":"allosteric agonists","score":0.9020000100135803},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8389999866485596},{"id":"https://openalex.org/keywords/camp-accumulation","display_name":"cAMP accumulation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/allosteric-site","display_name":"allosteric site","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.8550240397453308},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.615727961063385},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.545881986618042},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5331833362579346},{"id":"https://openalex.org/C2776038425","wikidata":"https://www.wikidata.org/wiki/Q2649417","display_name":"Allosteric modulator","level":4,"score":0.5128024220466614},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.4915090501308441},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.4881961941719055},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.42003333568573},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3510820269584656},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28864234685897827},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24922823905944824},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17188915610313416},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.05484780669212341},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000081","descriptor_name":"Acetamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002839","descriptor_name":"Chromans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010133","descriptor_name":"p-Chloroamphetamine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acschemneuro.3c00684","doi":"https://doi.org/10.1021/acschemneuro.3c00684","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschemneuro.3c00684","pdf_url":null,"source":{"id":"https://openalex.org/S180465690","display_name":"ACS Chemical Neuroscience","issn_l":"1948-7193","issn":["1948-7193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Neuroscience","raw_type":"journal-article"},{"id":"pmid:38086012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38086012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS chemical neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10843732","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10843732","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10843732/pdf/nihms-1952370.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Chem Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10843732","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10843732","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10843732/pdf/nihms-1952370.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Chem Neurosci","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1993337783","display_name":"GPR88 Agonist for Alcoholism Treatment","funder_award_id":"R01AA026820","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389607948.pdf","grobid_xml":"https://content.openalex.org/works/W4389607948.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W647659435","https://openalex.org/W1560061125","https://openalex.org/W1966456689","https://openalex.org/W1973091091","https://openalex.org/W1975616682","https://openalex.org/W1975947882","https://openalex.org/W1986552985","https://openalex.org/W1995850373","https://openalex.org/W2004151531","https://openalex.org/W2009979602","https://openalex.org/W2011150852","https://openalex.org/W2013818660","https://openalex.org/W2023346294","https://openalex.org/W2027423337","https://openalex.org/W2038231047","https://openalex.org/W2049535760","https://openalex.org/W2065283382","https://openalex.org/W2085313140","https://openalex.org/W2102377211","https://openalex.org/W2117024164","https://openalex.org/W2124042056","https://openalex.org/W2155014655","https://openalex.org/W2158700816","https://openalex.org/W2170426869","https://openalex.org/W2323694572","https://openalex.org/W2424643883","https://openalex.org/W2481416678","https://openalex.org/W2558811538","https://openalex.org/W2793301337","https://openalex.org/W2799662852","https://openalex.org/W2809303314","https://openalex.org/W2810929045","https://openalex.org/W2884874610","https://openalex.org/W2905480784","https://openalex.org/W2957750487","https://openalex.org/W2981377770","https://openalex.org/W2982218704","https://openalex.org/W3004104740","https://openalex.org/W3043420392","https://openalex.org/W3044388665","https://openalex.org/W3105946202","https://openalex.org/W3163542566","https://openalex.org/W3192786658","https://openalex.org/W4225278923","https://openalex.org/W4293223886","https://openalex.org/W4295086707","https://openalex.org/W4319338553"],"related_works":["https://openalex.org/W3105946202","https://openalex.org/W2558811538","https://openalex.org/W1975616682","https://openalex.org/W2481416678","https://openalex.org/W3192786658","https://openalex.org/W4225278923","https://openalex.org/W2049535760","https://openalex.org/W7221804734","https://openalex.org/W2013818660","https://openalex.org/W7140091210"],"abstract_inverted_index":{"The":[0],"development":[1,141],"of":[2,18,31,34,50,57,67,71,90,115,133,142],"synthetic":[3],"agonists":[4,108],"for":[5,25,139],"the":[6,16,45,55,63,88,111,130],"orphan":[7],"receptor":[8],"GPR88":[9,19,83,107,116,134,143],"has":[10],"recently":[11,46],"attracted":[12],"significant":[13],"interest,":[14],"given":[15],"promise":[17],"as":[20,42,44,82],"a":[21,58,136],"novel":[22,72,106],"drug":[23],"target":[24],"psychiatric":[26],"and":[27,40,76,126,135],"neurodegenerative":[28],"disorders.":[29],"Examination":[30],"structure-activity":[32],"relationships":[33],"two":[35],"known":[36],"agonist":[37],"scaffolds":[38],"2-PCCA":[39,118],"2-AMPP,":[41],"well":[43],"resolved":[47],"cryo-EM":[48],"structure":[49],"2-PCCA-bound":[51],"GPR88,":[52],"led":[53,86],"to":[54,87,98,110],"design":[56],"new":[59,137],"scaffold":[60,138],"based":[61],"on":[62],"\"reversed":[64],"amide\"":[65],"strategy":[66],"2-AMPP.":[68,99],"A":[69],"series":[70],"(4-substituted-phenyl)acetamides":[73],"were":[74],"synthesized":[75],"assessed":[77],"in":[78],"cAMP":[79],"accumulation":[80],"assays":[81],"agonists,":[84],"which":[85],"discovery":[89],"several":[91],"compounds":[92],"with":[93],"better":[94],"or":[95],"comparable":[96],"potencies":[97],"Computational":[100],"docking":[101],"studies":[102],"suggest":[103],"that":[104,117],"these":[105],"bind":[109],"same":[112],"allosteric":[113,131,144],"site":[114,132],"occupies.":[119],"Collectively,":[120],"our":[121],"findings":[122],"provide":[123],"structural":[124],"insight":[125],"SAR":[127],"requirement":[128],"at":[129],"further":[140],"agonists.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-12-13T00:00:00"}
