{"id":"https://openalex.org/W4389547192","doi":"https://doi.org/10.1371/journal.ppat.1011867","title":"Functional and biochemical characterization of the Toxoplasma gondii succinate dehydrogenase complex","display_name":"Functional and biochemical characterization of the Toxoplasma gondii succinate dehydrogenase complex","publication_year":2023,"publication_date":"2023-12-11","ids":{"openalex":"https://openalex.org/W4389547192","doi":"https://doi.org/10.1371/journal.ppat.1011867","pmid":"https://pubmed.ncbi.nlm.nih.gov/38079448","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10735183"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1011867","doi":"https://doi.org/10.1371/journal.ppat.1011867","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1011867","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011867&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011867&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064894969","display_name":"Mariana Ferreira Silva","orcid":"https://orcid.org/0000-0002-9034-3650","observed_orcids":["https://orcid.org/0000-0002-9034-3650"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mariana F. Silva","raw_affiliation_strings":["Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113067990","display_name":"Kiera Douglas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kiera Douglas","raw_affiliation_strings":["Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015854329","display_name":"Sofia Sandalli","orcid":"https://orcid.org/0000-0001-7226-8848","observed_orcids":["https://orcid.org/0000-0001-7226-8848"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sofia Sandalli","raw_affiliation_strings":["Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059039151","display_name":"Andrew E. Maclean","orcid":"https://orcid.org/0000-0002-9274-9486","observed_orcids":["https://orcid.org/0000-0002-9274-9486"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Andrew E. Maclean","raw_affiliation_strings":["Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-9274-9486","affiliations":[{"raw_affiliation_string":"Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009013134","display_name":"Lilach Sheiner","orcid":"https://orcid.org/0000-0001-5909-2307","observed_orcids":["https://orcid.org/0000-0001-5909-2307"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Lilach Sheiner","raw_affiliation_strings":["Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-5909-2307","affiliations":[{"raw_affiliation_string":"Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009013134","https://openalex.org/A5059039151"],"corresponding_institution_ids":["https://openalex.org/I7882870"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.6278,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.96735724,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"19","issue":"12","first_page":"e1011867","last_page":"e1011867"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toxoplasma-gondii","display_name":"Toxoplasma gondii","score":1.0},{"id":"https://openalex.org/keywords/succinate-dehydrogenase","display_name":"succinate dehydrogenase","score":0.9559999704360962},{"id":"https://openalex.org/keywords/complex-ii","display_name":"complex II","score":0.7860000133514404},{"id":"https://openalex.org/keywords/mitochondrial-electron-transport-chain","display_name":"mitochondrial electron transport chain","score":0.9919999837875366},{"id":"https://openalex.org/keywords/apicomplexa","display_name":"Apicomplexa","score":0.7839999794960022},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.7279999852180481},{"id":"https://openalex.org/keywords/bradyzoite-differentiation","display_name":"bradyzoite differentiation","score":0.9459999799728394},{"id":"https://openalex.org/keywords/membrane-anchoring","display_name":"membrane anchoring","score":0.6740000247955322},{"id":"https://openalex.org/keywords/parasite-growth","display_name":"parasite growth","score":0.5580000281333923},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C2779620337","wikidata":"https://www.wikidata.org/wiki/Q14907256","display_name":"SDHA","level":4,"score":0.7745990753173828},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.759182333946228},{"id":"https://openalex.org/C2778128430","wikidata":"https://www.wikidata.org/wiki/Q131003","display_name":"Toxoplasma gondii","level":3,"score":0.6621095538139343},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5919526815414429},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5514885783195496},{"id":"https://openalex.org/C2776319529","wikidata":"https://www.wikidata.org/wiki/Q3869349","display_name":"NADH dehydrogenase","level":4,"score":0.538695752620697},{"id":"https://openalex.org/C2781330172","wikidata":"https://www.wikidata.org/wiki/Q412837","display_name":"Succinate dehydrogenase","level":3,"score":0.5099393129348755},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47861212491989136},{"id":"https://openalex.org/C11701378","wikidata":"https://www.wikidata.org/wiki/Q3493378","display_name":"Mitochondrial matrix","level":4,"score":0.46113479137420654},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.45819908380508423},{"id":"https://openalex.org/C165135838","wikidata":"https://www.wikidata.org/wiki/Q133895","display_name":"Citric acid cycle","level":3,"score":0.452169269323349},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44763100147247314},{"id":"https://openalex.org/C145488412","wikidata":"https://www.wikidata.org/wiki/Q425007","display_name":"Mitochondrial carrier","level":5,"score":0.4324818551540375},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.356819748878479},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.32465699315071106},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25917837023735046},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.13039705157279968},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.08094733953475952},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002952","descriptor_name":"Citric Acid Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013385","descriptor_name":"Succinate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014122","descriptor_name":"Toxoplasma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014122","descriptor_name":"Toxoplasma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051336","descriptor_name":"Mitochondrial Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.ppat.1011867","doi":"https://doi.org/10.1371/journal.ppat.1011867","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1011867","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011867&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10735183","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10735183","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10735183/pdf/ppat.1011867.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmid:38079448","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38079448","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.gla.ac.uk:315334","doi":null,"is_oa":true,"landing_page_url":"https://eprints.gla.ac.uk/315334/1/315334.pdf","pdf_url":"https://eprints.gla.ac.uk/315334/1/315334.pdf","source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Articles"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1011867","doi":"https://doi.org/10.1371/journal.ppat.1011867","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1011867","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011867&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1296595485","display_name":null,"funder_award_id":"UNS85804","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G1983426421","display_name":"Elucidating the structure and function of the divergent and essential cytochrome bc1 complex in apicomplexan parasites","funder_award_id":"221681","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G7875091695","display_name":"Wellcome Trust Technology Platform","funder_award_id":"097945","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G7883952905","display_name":"Characterization of critical differences between human and parasite respiratory complex II","funder_award_id":"MR/W002221/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8883219429","display_name":"Elucidating the structure and function of the divergent and essential cytochrome bc1 complex in apicomplexan parasites","funder_award_id":"221681/Z/20/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G9000309238","display_name":null,"funder_award_id":"097945/B/11/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320310838","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389547192.pdf","grobid_xml":"https://content.openalex.org/works/W4389547192.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1487362570","https://openalex.org/W1798402781","https://openalex.org/W1911888926","https://openalex.org/W1964025113","https://openalex.org/W1974807435","https://openalex.org/W1976977157","https://openalex.org/W1983430686","https://openalex.org/W1985943082","https://openalex.org/W1986431188","https://openalex.org/W2004392895","https://openalex.org/W2007561244","https://openalex.org/W2009082036","https://openalex.org/W2029191170","https://openalex.org/W2033365688","https://openalex.org/W2035737415","https://openalex.org/W2044414180","https://openalex.org/W2051476652","https://openalex.org/W2054531333","https://openalex.org/W2079394317","https://openalex.org/W2080903262","https://openalex.org/W2084603737","https://openalex.org/W2091339923","https://openalex.org/W2095745314","https://openalex.org/W2114296160","https://openalex.org/W2126405180","https://openalex.org/W2135414906","https://openalex.org/W2137062868","https://openalex.org/W2137424160","https://openalex.org/W2138488546","https://openalex.org/W2150853746","https://openalex.org/W2150909904","https://openalex.org/W2164082202","https://openalex.org/W2315458227","https://openalex.org/W2501987374","https://openalex.org/W2511428910","https://openalex.org/W2561556653","https://openalex.org/W2586320694","https://openalex.org/W2587791215","https://openalex.org/W2809193439","https://openalex.org/W2889885114","https://openalex.org/W2908914412","https://openalex.org/W2952197919","https://openalex.org/W2964165737","https://openalex.org/W3016117371","https://openalex.org/W3083406432","https://openalex.org/W3093371308","https://openalex.org/W3123012763","https://openalex.org/W3125247928","https://openalex.org/W3126294759","https://openalex.org/W3129182913","https://openalex.org/W3135549026","https://openalex.org/W3173765706","https://openalex.org/W3177828909","https://openalex.org/W3200535531","https://openalex.org/W3211795435","https://openalex.org/W3212265749","https://openalex.org/W3212441067","https://openalex.org/W4206709479","https://openalex.org/W4220999962","https://openalex.org/W4221045112","https://openalex.org/W4290546426","https://openalex.org/W4304163398","https://openalex.org/W4307499980","https://openalex.org/W4353056837","https://openalex.org/W4366981282","https://openalex.org/W4378651437"],"related_works":["https://openalex.org/W4399357177","https://openalex.org/W3135549026","https://openalex.org/W4410479875","https://openalex.org/W6964678845","https://openalex.org/W4221045112","https://openalex.org/W2889885114","https://openalex.org/W2036945901","https://openalex.org/W4379058178","https://openalex.org/W7097062030","https://openalex.org/W7134278479"],"abstract_inverted_index":{"The":[0,70],"mitochondrial":[1,19,204],"electron":[2],"transport":[3],"chain":[4],"(mETC)":[5],"is":[6,37,246],"a":[7,102,238],"series":[8],"of":[9,121,126,140,167,201,211,243,259,270],"membrane":[10,152,224,232],"embedded":[11],"enzymatic":[12],"complexes":[13],"critical":[14],"for":[15,91,110,181,195,248,280],"energy":[16],"conversion":[17],"and":[18,27,67,130,145,153,177,184,198,206,234,251,265],"metabolism.":[20],"In":[21],"commonly":[22],"studied":[23],"eukaryotes,":[24],"including":[25,85],"humans":[26],"animals,":[28],"complex":[29,249],"II,":[30],"also":[31],"known":[32],"as":[33,44,172],"succinate":[34],"dehydrogenase":[35],"(SDH),":[36],"an":[38,45],"essential":[39,247],"four-subunit":[40],"enzyme":[41],"that":[42,147,189,199,219,237],"acts":[43],"entry":[46],"point":[47],"to":[48,101,115,150,263],"the":[49,55,111,122,127,132,151,168,220,256,268,271,278],"mETC,":[50],"by":[51],"harvesting":[52],"electrons":[53],"from":[54],"TCA":[56],"cycle.":[57],"Apicomplexa":[58],"are":[59,124,193,223],"pathogenic":[60],"parasites":[61],"with":[62,106,227],"significant":[63],"impact":[64],"on":[65,88],"human":[66],"animal":[68],"health.":[69],"phylum":[71],"includes":[72],"Toxoplasma":[73,112,260],"gondii":[74],"which":[75],"can":[76],"cause":[77],"fatal":[78],"infections":[79],"in":[80,117,138,155,161,208,231,241,274],"immunocompromised":[81],"people.":[82],"Most":[83],"apicomplexans,":[84],"Toxoplasma,":[86],"rely":[87],"their":[89,179,228],"mETC":[90],"survival,":[92],"yet":[93],"SDH":[94,105,149,175,182,202,261,275],"remains":[95],"largely":[96],"understudied.":[97],"Previous":[98],"studies":[99],"pointed":[100],"divergent":[103,257],"apicomplexan":[104],"nine":[107,123],"subunits":[108,171,192,222,273],"proposed":[109,170],"complex,":[113],"compared":[114,262],"four":[116],"humans.":[118],"While":[119],"two":[120],"homologs":[125,137,160],"well-studied":[128],"SDHA":[129],"B,":[131],"other":[133,141],"seven":[134,169],"have":[135,158],"no":[136,159],"SDHs":[139],"systems.":[142],"Moreover,":[143],"SDHC":[144],"D,":[146],"anchor":[148],"participate":[154],"substrate":[156],"bindings,":[157],"Apicomplexa.":[162],"Here,":[163],"we":[164,216,235],"validated":[165],"five":[166,191,221],"bona":[173],"fide":[174],"components":[176],"demonstrated":[178],"importance":[180],"assembly":[183],"activity.":[185],"We":[186],"further":[187],"find":[188],"all":[190],"important":[194],"parasite":[196],"growth,":[197],"disruption":[200],"impairs":[203],"respiration":[205],"results":[207],"spontaneous":[209],"initiation":[210],"differentiation":[212],"into":[213],"bradyzoites.":[214],"Finally,":[215],"provide":[217],"evidence":[218],"bound,":[225],"consistent":[226],"potential":[229],"role":[230,269],"anchoring,":[233],"demonstrate":[236],"DY":[239],"motif":[240],"one":[242],"them,":[244],"SDH10,":[245],"formation":[250],"function.":[252],"Our":[253],"study":[254],"confirms":[255],"composition":[258],"human,":[264],"starts":[266],"exploring":[267],"lineage-specific":[272],"function,":[276],"paving":[277],"way":[279],"future":[281],"mechanistic":[282],"studies.":[283]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-12-12T00:00:00"}