{"id":"https://openalex.org/W4389543763","doi":"https://doi.org/10.1109/ichi57859.2023.00018","title":"Inferring Personalized Treatment Effect of Antihypertensives on Alzheimer\u2019s Disease Using Deep Learning","display_name":"Inferring Personalized Treatment Effect of Antihypertensives on Alzheimer\u2019s Disease Using Deep Learning","publication_year":2023,"publication_date":"2023-06-26","ids":{"openalex":"https://openalex.org/W4389543763","doi":"https://doi.org/10.1109/ichi57859.2023.00018","pmid":"https://pubmed.ncbi.nlm.nih.gov/38516035","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10956734"},"language":"en","primary_location":{"id":"doi:10.1109/ichi57859.2023.00018","doi":"https://doi.org/10.1109/ichi57859.2023.00018","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ichi57859.2023.00018","pdf_url":null,"source":{"id":"https://openalex.org/S4363608310","display_name":"IEEE International Conference on Healthcare Informatics (ICHI)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE 11th International Conference on Healthcare Informatics (ICHI)","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10956734/pdf/nihms-1977754.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020306966","display_name":"Pulakesh Upadhyaya","orcid":"https://orcid.org/0000-0003-1054-1380","observed_orcids":["https://orcid.org/0000-0003-1054-1380"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pulakesh Upadhyaya","raw_affiliation_strings":["Emory University,Department of Biomedical Informatics,Atlanta,USA","Department of Biomedical Informatics, Emory University, Atlanta, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University,Department of Biomedical Informatics,Atlanta,USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Department of Biomedical Informatics, Emory University, Atlanta, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014239985","display_name":"Yaobin Ling","orcid":"https://orcid.org/0000-0002-3183-1670","observed_orcids":["https://orcid.org/0000-0002-3183-1670"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yaobin Ling","raw_affiliation_strings":["UT Health,School of Biomedical Informatics,Houston,USA","School of Biomedical Informatics, UT Health, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT Health,School of Biomedical Informatics,Houston,USA","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"School of Biomedical Informatics, UT Health, Houston, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085539729","display_name":"Luyao Chen","orcid":"https://orcid.org/0000-0003-4698-5784","observed_orcids":["https://orcid.org/0000-0003-4698-5784"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luyao Chen","raw_affiliation_strings":["UT Health,School of Biomedical Informatics,Houston,USA","School of Biomedical Informatics, UT Health, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT Health,School of Biomedical Informatics,Houston,USA","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"School of Biomedical Informatics, UT Health, Houston, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100358135","display_name":"Yejin Kim","orcid":"https://orcid.org/0000-0001-7815-6310","observed_orcids":["https://orcid.org/0000-0001-7815-6310"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yejin Kim","raw_affiliation_strings":["UT Health,School of Biomedical Informatics,Houston,USA","School of Biomedical Informatics, UT Health, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT Health,School of Biomedical Informatics,Houston,USA","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"School of Biomedical Informatics, UT Health, Houston, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055458864","display_name":"Xiaoqian Jiang","orcid":"https://orcid.org/0000-0001-9933-2205","observed_orcids":["https://orcid.org/0000-0001-9933-2205","https://orcid.org/0009-0000-0712-2164","https://orcid.org/0009-0007-8281-4479"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoqian Jiang","raw_affiliation_strings":["UT Health,School of Biomedical Informatics,Houston,USA","School of Biomedical Informatics, UT Health, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT Health,School of Biomedical Informatics,Houston,USA","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"School of Biomedical Informatics, UT Health, Houston, USA","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0081,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.78330475,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"2023","issue":null,"first_page":"49","last_page":"57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.6151999831199646,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.6151999831199646,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10845","display_name":"Advanced Causal Inference Techniques","score":0.16220000386238098,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.11800000071525574,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9919999837875366},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.9980000257492065},{"id":"https://openalex.org/keywords/individual-treatment-effects","display_name":"individual treatment effects","score":0.9020000100135803},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.6179999709129333},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.6890000104904175},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.9919999837875366},{"id":"https://openalex.org/keywords/deep-learning","display_name":"deep learning","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5957121253013611},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5565347075462341},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5158007144927979},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4109008014202118},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3040086030960083},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11376804113388062}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1109/ichi57859.2023.00018","doi":"https://doi.org/10.1109/ichi57859.2023.00018","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ichi57859.2023.00018","pdf_url":null,"source":{"id":"https://openalex.org/S4363608310","display_name":"IEEE International Conference on Healthcare Informatics (ICHI)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE 11th International Conference on Healthcare Informatics (ICHI)","raw_type":"proceedings-article"},{"id":"pmid:38516035","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38516035","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE International Conference on Healthcare Informatics. IEEE International Conference on Healthcare Informatics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10956734","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10956734","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10956734/pdf/nihms-1977754.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Proc (IEEE Int Conf Healthc Inform)","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.library.tmc.edu:uthshis_docs-1378","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/uthshis_docs/379","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty, Staff and Student Publications","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10956734","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10956734","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10956734/pdf/nihms-1977754.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Proc (IEEE Int Conf Healthc Inform)","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4219384955","display_name":"Recruitment of Rising Stars","funder_award_id":"RR180012","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G4789247823","display_name":"Open Health Natural Language Processing Collaboratory","funder_award_id":"U01TR002062","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4948104884","display_name":"Finding combinatorial drug repositioning therapy for Alzheimer's disease and related dementias","funder_award_id":"R01AG066749","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5388406022","display_name":null,"funder_award_id":"RR180012","funder_id":"https://openalex.org/F4320313675","funder_display_name":"University of Texas Health Science Center at Houston"},{"id":"https://openalex.org/G6391021328","display_name":"Collaborative Research: SaTC: CORE: Medium: PREMED: Privacy-Preserving and Robust Computational Phenotyping using Multisite EHR Data","funder_award_id":"2124789","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G863230492","display_name":"Harmonizing multiple clinical trials for Alzheimer's disease to investigate differential responses to treatment via federated counterfactual learning","funder_award_id":"R01AG082721","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000869378","display_name":"Decentralized differentially-private methods for dynamic data release and analysis","funder_award_id":"R01LM013712","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320313675","display_name":"University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320338440","display_name":"HORIZON EUROPE Health","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4389543763.pdf","grobid_xml":"https://content.openalex.org/works/W4389543763.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W174622552","https://openalex.org/W1516659296","https://openalex.org/W1552526595","https://openalex.org/W1555463606","https://openalex.org/W1967645451","https://openalex.org/W1969208427","https://openalex.org/W1996649563","https://openalex.org/W2003292054","https://openalex.org/W2013395798","https://openalex.org/W2050618398","https://openalex.org/W2054826663","https://openalex.org/W2076393535","https://openalex.org/W2100135916","https://openalex.org/W2101090291","https://openalex.org/W2104999604","https://openalex.org/W2105816186","https://openalex.org/W2128984831","https://openalex.org/W2140899775","https://openalex.org/W2150291618","https://openalex.org/W2160643135","https://openalex.org/W2165146299","https://openalex.org/W2296578831","https://openalex.org/W2297715268","https://openalex.org/W2389937032","https://openalex.org/W2618851150","https://openalex.org/W2624816748","https://openalex.org/W2742407816","https://openalex.org/W2761479329","https://openalex.org/W2891635110","https://openalex.org/W2904462606","https://openalex.org/W2948807347","https://openalex.org/W2962681511","https://openalex.org/W3010652504","https://openalex.org/W3027747864","https://openalex.org/W3031243109","https://openalex.org/W3048374209","https://openalex.org/W3118897201","https://openalex.org/W3123436326","https://openalex.org/W3129177568","https://openalex.org/W3160795331","https://openalex.org/W3168410956","https://openalex.org/W3186606013","https://openalex.org/W4221094744","https://openalex.org/W4242615744","https://openalex.org/W4310170174"],"related_works":["https://openalex.org/W3111142929","https://openalex.org/W7171533082","https://openalex.org/W2841964432","https://openalex.org/W2074708674","https://openalex.org/W2316371288","https://openalex.org/W4414479029","https://openalex.org/W4405749531","https://openalex.org/W4391646627","https://openalex.org/W2322343581","https://openalex.org/W4292057388"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1],"(AD)":[2],"is":[3,25,77],"one":[4,140],"of":[5,9,55,70,89,100,105,125,135,141,186,201,217],"the":[6,12,17,53,74,85,98,103,121,136,142,145,148,169,184,197,215],"leading":[7],"causes":[8],"death":[10],"in":[11,30,34,58,163,189],"United":[13],"States,":[14],"especially":[15],"among":[16],"elderly.":[18],"Recent":[19],"studies":[20,48,72,153],"have":[21,45,50,65,159],"shown":[22],"how":[23],"hypertension":[24],"related":[26],"to":[27,37,119,174],"cognitive":[28,60],"decline":[29],"elderly":[31],"patients,":[32,81],"which":[33],"turn":[35],"leads":[36],"increased":[38],"mortality":[39],"as":[40,42,144,150],"well":[41],"morbidity.":[43],"There":[44],"been":[46],"various":[47,179,187,218],"that":[49,97,155,196,214],"looked":[51],"at":[52],"effect":[54,76,99],"antihypertensive":[56,90,131],"drugs":[57,143],"reducing":[59],"decline,":[61],"and":[62,133,147,213],"their":[63,178],"results":[64,194],"proved":[66],"inconclusive.":[67],"However,":[68],"most":[69],"these":[71],"assume":[73,96],"treatment":[75,87,123,146,199],"similar":[78],"for":[79],"all":[80],"thus":[82],"considering":[83],"only":[84],"average":[86],"effects":[88,124,200],"drugs.":[91],"In":[92],"this":[93],"paper,":[94],"we":[95],"antihypertensives":[101,158],"on":[102,108,167,177],"onset":[104,166],"AD":[106,165],"depends":[107],"patient":[109,203],"characteristics.":[110,180],"We":[111,128,181],"develop":[112],"a":[113,160,209],"deep":[114,210],"learning":[115,211],"method":[116],"called":[117],"LASSO-Dragonnet":[118],"estimate":[120],"individualized":[122,198],"each":[126,134,202],"patient.":[127],"considered":[129,139],"six":[130,137],"drugs,":[132],"models":[138],"remaining":[149],"control.":[151],"Our":[152,193],"showed":[154,195],"although":[156],"many":[157],"positive":[161],"impact":[162,170],"delaying":[164],"average,":[168],"varies":[171],"from":[172],"individual":[173],"individual,":[175],"depending":[176],"also":[182],"analyzed":[183],"importance":[185,216],"covariates":[188,219],"such":[190],"an":[191],"estimation.":[192],"could":[204,220],"be":[205,221],"estimated":[206],"accurately":[207],"using":[208],"method,":[212],"determined.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-12-12T00:00:00"}
