{"id":"https://openalex.org/W4389542467","doi":"https://doi.org/10.1109/embc40787.2023.10341045","title":"Simultaneous Estimation of Tonic Dopamine and Serotonin with High Temporal Resolution In Vitro Using Deep Learning","display_name":"Simultaneous Estimation of Tonic Dopamine and Serotonin with High Temporal Resolution In Vitro Using Deep Learning","publication_year":2023,"publication_date":"2023-07-24","ids":{"openalex":"https://openalex.org/W4389542467","doi":"https://doi.org/10.1109/embc40787.2023.10341045","pmid":"https://pubmed.ncbi.nlm.nih.gov/38083281"},"language":"en","primary_location":{"id":"doi:10.1109/embc40787.2023.10341045","doi":"https://doi.org/10.1109/embc40787.2023.10341045","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc40787.2023.10341045","pdf_url":null,"source":{"id":"https://openalex.org/S4363608786","display_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","issn_l":"2375-7477","issn":["2375-7477"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["doyens","jufo-1","ki-jl-1","medline","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079236062","display_name":"Seongtak Kang","orcid":"https://orcid.org/0000-0002-6635-4819","observed_orcids":["https://orcid.org/0000-0002-6635-4819"]},"institutions":[{"id":"https://openalex.org/I193352282","display_name":"Daegu Gyeongbuk Institute of Science and Technology","ror":"https://ror.org/03frjya69","country_code":"KR","type":"education","lineage":["https://openalex.org/I193352282"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seongtak Kang","raw_affiliation_strings":["Daegu Gyeongbuk Institute of Science and Technology (DGIST),Department of Electrical Engineering and Computer Science,Daegu,Republic of Korea,42988"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daegu Gyeongbuk Institute of Science and Technology (DGIST),Department of Electrical Engineering and Computer Science,Daegu,Republic of Korea,42988","institution_ids":["https://openalex.org/I193352282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090307645","display_name":"Yunho Jeong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193352282","display_name":"Daegu Gyeongbuk Institute of Science and Technology","ror":"https://ror.org/03frjya69","country_code":"KR","type":"education","lineage":["https://openalex.org/I193352282"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yunho Jeong","raw_affiliation_strings":["DGIST,College of Transdisciplinary Studies,Daegu,Republic of Korea,42988"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DGIST,College of Transdisciplinary Studies,Daegu,Republic of Korea,42988","institution_ids":["https://openalex.org/I193352282"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045263497","display_name":"Ji-Woong Choi","orcid":"https://orcid.org/0000-0001-9109-3860","observed_orcids":["https://orcid.org/0000-0001-9109-3860","https://orcid.org/0000-0001-7996-5507","https://orcid.org/0000-0002-0602-9256"]},"institutions":[{"id":"https://openalex.org/I193352282","display_name":"Daegu Gyeongbuk Institute of Science and Technology","ror":"https://ror.org/03frjya69","country_code":"KR","type":"education","lineage":["https://openalex.org/I193352282"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji-Woong Choi","raw_affiliation_strings":["DGIST,Department of Electrical Engineering and Computer Science,Daegu,Republic of Korea,42988","Brain Engineering Convergence Research Center, DGIST, Daegu, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DGIST,Department of Electrical Engineering and Computer Science,Daegu,Republic of Korea,42988","institution_ids":["https://openalex.org/I193352282"]},{"raw_affiliation_string":"Brain Engineering Convergence Research Center, DGIST, Daegu, Republic of Korea","institution_ids":["https://openalex.org/I193352282"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I193352282"],"apc_list":null,"apc_paid":null,"fwci":2.8307,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.87751678,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"2023","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.6128000020980835,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.6128000020980835,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11434","display_name":"Electrochemical Analysis and Applications","score":0.3734999895095825,"subfield":{"id":"https://openalex.org/subfields/1603","display_name":"Electrochemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tonic-dopamine","display_name":"tonic dopamine","score":0.7749999761581421},{"id":"https://openalex.org/keywords/fast-scan-cyclic-voltammetry","display_name":"fast-scan cyclic voltammetry","score":0.9020000100135803},{"id":"https://openalex.org/keywords/deep-learning","display_name":"deep learning","score":0.7889999747276306},{"id":"https://openalex.org/keywords/background-subtraction","display_name":"background subtraction","score":0.7870000004768372},{"id":"https://openalex.org/keywords/brain-slices","display_name":"brain slices","score":0.6700000166893005},{"id":"https://openalex.org/keywords/high-temporal-resolution","display_name":"high temporal resolution","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C127573956","wikidata":"https://www.wikidata.org/wiki/Q7821376","display_name":"Tonic (physiology)","level":2,"score":0.9559942483901978},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.6502608060836792},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6435668468475342},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5726594924926758},{"id":"https://openalex.org/C68060419","wikidata":"https://www.wikidata.org/wiki/Q40754","display_name":"Subtraction","level":2,"score":0.5287252068519592},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.4728933870792389},{"id":"https://openalex.org/C50156730","wikidata":"https://www.wikidata.org/wiki/Q3856966","display_name":"Microdialysis","level":3,"score":0.4420925974845886},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43359896540641785},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.37679824233055115},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3434382677078247},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3221272826194763},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.26591789722442627},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22111016511917114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1936625838279724},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.19294074177742004},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18563616275787354},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.15376433730125427},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09759587049484253},{"id":"https://openalex.org/C94375191","wikidata":"https://www.wikidata.org/wiki/Q11205","display_name":"Arithmetic","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc40787.2023.10341045","doi":"https://doi.org/10.1109/embc40787.2023.10341045","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc40787.2023.10341045","pdf_url":null,"source":{"id":"https://openalex.org/S4363608786","display_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","issn_l":"2375-7477","issn":["2375-7477"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["doyens","jufo-1","ki-jl-1","medline","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine &amp; Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:38083281","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38083281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W119570941","https://openalex.org/W2027815171","https://openalex.org/W2071501745","https://openalex.org/W2538076117","https://openalex.org/W2799652277","https://openalex.org/W2888602040","https://openalex.org/W2997325579","https://openalex.org/W2997601619","https://openalex.org/W4233296188","https://openalex.org/W4287447283","https://openalex.org/W4291111770"],"related_works":["https://openalex.org/W4395467075","https://openalex.org/W841839581","https://openalex.org/W4287447283","https://openalex.org/W2595472669","https://openalex.org/W1481631390","https://openalex.org/W4291111770","https://openalex.org/W2888602040","https://openalex.org/W3215036817","https://openalex.org/W2538076117","https://openalex.org/W4403592685"],"abstract_inverted_index":{"Quantitative":[0],"measurement":[1,203],"of":[2,18,41,55,91,105,109,119,151,171,204,210],"the":[3,33,52,88,116,130,135,169,176,184,197,205,239],"phasic":[4,37,106,206],"(changes":[5,11],"in":[6,12,144,168,213,238],"several":[7],"seconds)":[8],"and":[9,28,38,77,121,190,207,227],"tonic":[10,39,53,89,117,132,149,208,225,228],"minutes":[13],"to":[14,66,85,146,222],"hours)":[15],"level":[16,90],"changes":[17],"neurotransmitters":[19,43,57,153,212],"is":[20,44],"an":[21],"essential":[22],"technique":[23,199],"for":[24],"understanding":[25],"brain":[26,29],"functions":[27],"diseases":[30],"regulated":[31],"by":[32,124],"neurotransmitters.":[34,93,110],"However,":[35],"monitoring":[36],"levels":[40,54,118,209],"multiple":[42,56,92],"still":[45,102],"a":[46,61,126,220,235],"challenging":[47],"technology.":[48],"Microdialysis":[49],"can":[50],"measure":[51,87,224],"simultaneously":[58,86,123,147,223],"but":[59,80],"has":[60,73],"low":[62],"temporal":[63,75,232],"resolution":[64,76,233],"(minute)":[65],"analyze":[67],"precisely.":[68],"Fast-scan":[69],"cyclic":[70],"voltammetry":[71],"(FSCV)":[72],"high":[74,78,231],"sensitivity,":[79],"it":[81],"was":[82,101,142],"not":[83],"able":[84],"The":[94,137],"recently":[95],"proposed":[96,138,161,177,198],"deep":[97,139],"learning-based":[98],"FSCV":[99],"method":[100,221],"only":[103],"capable":[104],"concentration":[107,173],"estimation":[108,174],"In":[111,166],"this":[112],"study,":[113],"we":[114],"estimate":[115,148],"dopamine":[120,226],"serotonin":[122,172,229],"training":[125],"deep-learning":[127],"network":[128],"with":[129,154,230,234],"extracted":[131],"information":[133],"from":[134],"FSCV.":[136],"learning":[140],"model":[141,178,187],"validated":[143],"vitro":[145],"concentrations":[150],"two":[152],"statistically":[155],"significantly":[156],"higher":[157,180],"accuracy":[158],"than":[159,183],"previously":[160],"background":[162,185],"subtraction-based":[163,186],"models":[164],"(p<0.001).":[165],"particular,":[167],"case":[170],"error,":[175],"showed":[179],"prediction":[181],"performance":[182],"(48":[188],"nM":[189],"73":[191],"nM,":[192],"respectively).":[193],"We":[194],"expect":[195],"that":[196],"will":[200],"help":[201],"simultaneous":[202],"numerous":[211],"vivo":[214],"soon.Clinical":[215],"Relevance-":[216],"This":[217],"study":[218],"proposes":[219],"single":[236],"electrode":[237],"brain.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-12-12T00:00:00"}