{"id":"https://openalex.org/W4389540501","doi":"https://doi.org/10.21203/rs.3.rs-3730564/v1","title":"WITHDRAWN: EIF4A3-regulated circGNAI2 inhibits the progression of triple-negative breast cancer by circGNAI2-miR-454-3p-VGLL4 axis","display_name":"WITHDRAWN: EIF4A3-regulated circGNAI2 inhibits the progression of triple-negative breast cancer by circGNAI2-miR-454-3p-VGLL4 axis","publication_year":2023,"publication_date":"2023-12-11","ids":{"openalex":"https://openalex.org/W4389540501","doi":"https://doi.org/10.21203/rs.3.rs-3730564/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-3730564/v1","doi":"https://doi.org/10.21203/rs.3.rs-3730564/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-3730564/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.21203/rs.3.rs-3730564/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000884730","display_name":"Hongming Song","orcid":"https://orcid.org/0000-0002-1282-6016","observed_orcids":["https://orcid.org/0000-0002-1282-6016"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"hongming song","raw_affiliation_strings":["The Affiliated Hospital of\u00a0Qingdao\u00a0University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of\u00a0Qingdao\u00a0University","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100328793","display_name":"Haibo Wang","orcid":"https://orcid.org/0000-0002-7549-5613","observed_orcids":["https://orcid.org/0000-0002-7549-5613","https://orcid.org/0000-0003-4726-8939"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haibo Wang","raw_affiliation_strings":["The Affiliated Hospital of\u00a0Qingdao\u00a0University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of\u00a0Qingdao\u00a0University","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100684871","display_name":"Jing Peng","orcid":"https://orcid.org/0000-0003-2926-976X","observed_orcids":["https://orcid.org/0000-0003-2926-976X"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Peng","raw_affiliation_strings":["The Affiliated Hospital of\u00a0Qingdao\u00a0University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of\u00a0Qingdao\u00a0University","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008340519","display_name":"Zhaohe Niu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaohe Niu","raw_affiliation_strings":["The Affiliated Hospital of\u00a0Qingdao\u00a0University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of\u00a0Qingdao\u00a0University","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101828365","display_name":"Xiangping Liu","orcid":"https://orcid.org/0000-0001-8764-2038","observed_orcids":["https://orcid.org/0000-0001-8764-2038"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangping Liu","raw_affiliation_strings":["The Affiliated Hospital of\u00a0Qingdao\u00a0University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of\u00a0Qingdao\u00a0University","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112668691","display_name":"Meng Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng lv","raw_affiliation_strings":["The Affiliated Hospital of\u00a0Qingdao\u00a0University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of\u00a0Qingdao\u00a0University","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083498906","display_name":"Yan Mao","orcid":"https://orcid.org/0000-0001-5694-4543","observed_orcids":["https://orcid.org/0000-0001-5694-4543"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Mao","raw_affiliation_strings":["The Affiliated Hospital of\u00a0Qingdao\u00a0University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of\u00a0Qingdao\u00a0University","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100330289","display_name":"Yuan\u2010Yuan Wang","orcid":"https://orcid.org/0000-0001-9589-2977","observed_orcids":["https://orcid.org/0000-0001-9589-2977"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Wang","raw_affiliation_strings":["The Affiliated Hospital of\u00a0Qingdao\u00a0University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of\u00a0Qingdao\u00a0University","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100724873","display_name":"Yongmei Wang","orcid":"https://orcid.org/0000-0002-7418-9489","observed_orcids":["https://orcid.org/0000-0002-7418-9489","https://orcid.org/0000-0002-1328-9574"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongmei Wang","raw_affiliation_strings":["The Affiliated Hospital of\u00a0Qingdao\u00a0University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of\u00a0Qingdao\u00a0University","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037191476","display_name":"Xinggang Wang","orcid":"https://orcid.org/0000-0001-6732-7823","observed_orcids":["https://orcid.org/0000-0001-6732-7823"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinggang Wang","raw_affiliation_strings":["The Affiliated Hospital of\u00a0Qingdao\u00a0University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of\u00a0Qingdao\u00a0University","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100453122","display_name":"Fang Liu","orcid":"https://orcid.org/0000-0003-2922-4414","observed_orcids":["https://orcid.org/0000-0003-2922-4414"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Liu","raw_affiliation_strings":["The Affiliated Hospital of\u00a0Qingdao\u00a0University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of\u00a0Qingdao\u00a0University","institution_ids":["https://openalex.org/I4210116869"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210116869"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9670000076293945},{"id":"https://openalex.org/keywords/eif4a3","display_name":"EIF4A3","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mir-454-3p","display_name":"miR-454-3p","score":0.9890000224113464},{"id":"https://openalex.org/keywords/vgll4","display_name":"VGLL4","score":1.0},{"id":"https://openalex.org/keywords/stat3-signaling","display_name":"STAT3 signaling","score":0.8199999928474426},{"id":"https://openalex.org/keywords/circular-rna","display_name":"circular RNA","score":0.7419999837875366},{"id":"https://openalex.org/keywords/microrna-sponging","display_name":"microRNA sponging","score":0.8709999918937683},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7409999966621399},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.8637232780456543},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7073817849159241},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.647591233253479},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6284013986587524},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5383405089378357},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.4824545979499817},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.412663072347641},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3899954557418823},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3495316505432129},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3442270755767822},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34235143661499023},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3107663094997406},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2662322521209717},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.12259671092033386},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10973548889160156},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06903067231178284}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-3730564/v1","doi":"https://doi.org/10.21203/rs.3.rs-3730564/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-3730564/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-3730564/v1","doi":"https://doi.org/10.21203/rs.3.rs-3730564/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-3730564/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1997754945","https://openalex.org/W2003234142","https://openalex.org/W2024694407","https://openalex.org/W2061754318","https://openalex.org/W2570066480","https://openalex.org/W2889139276","https://openalex.org/W2912017471","https://openalex.org/W2964331590","https://openalex.org/W2990526911","https://openalex.org/W3006786463","https://openalex.org/W3008831128","https://openalex.org/W3010944657","https://openalex.org/W3020855961","https://openalex.org/W3086574231","https://openalex.org/W3092533209","https://openalex.org/W3094159415","https://openalex.org/W3121721028","https://openalex.org/W3128646645","https://openalex.org/W3135601062","https://openalex.org/W3162005642","https://openalex.org/W3184592431","https://openalex.org/W3207086014","https://openalex.org/W3213834237","https://openalex.org/W4200074879","https://openalex.org/W4206841660","https://openalex.org/W4207033714","https://openalex.org/W4211069901","https://openalex.org/W4214710575","https://openalex.org/W4214859818","https://openalex.org/W4282922986","https://openalex.org/W4293435090","https://openalex.org/W4296120550","https://openalex.org/W4327573938","https://openalex.org/W4362506549","https://openalex.org/W4387439217"],"related_works":["https://openalex.org/W4413100615","https://openalex.org/W2919182022","https://openalex.org/W4214859818","https://openalex.org/W4392354528","https://openalex.org/W2990526911","https://openalex.org/W4323653650","https://openalex.org/W7036681313","https://openalex.org/W7203948127","https://openalex.org/W4389101027","https://openalex.org/W4286685079"],"abstract_inverted_index":{"Abstract":[0],"Triple-negative":[1],"breast":[2,11],"cancer":[3,12],"(TNBC)":[4],"is":[5],"a":[6],"particularly":[7],"aggressive":[8],"subtype":[9],"of":[10,19,49,67,102],"(BC)":[13],"with":[14],"high":[15,17],"invasiveness,":[16],"rate":[18],"recurrence":[20],"and":[21,23,39,46,54,63,90],"metastasis,":[22],"poor":[24],"prognosis.":[25],"In":[26],"this":[27],"study,":[28],"we":[29],"demonstrated":[30],"that":[31],"circGNAI2":[32,59,73,81],"was":[33,74],"lower":[34],"expressed":[35],"in":[36,52,55],"TNBC":[37,50,84],"tissues":[38],"cell":[40],"lines.":[41],"CircGNAI2":[42],"suppressed":[43],"the":[44,65,100],"proliferation":[45],"migration":[47],"abilities":[48],"cells":[51],"vivo":[53],"vitro.":[56],"Of":[57],"note,":[58],"can":[60],"upregulate":[61],"VGLL4":[62],"inhibit":[64,83],"phosphorylation":[66],"STAT3":[68,91],"via":[69],"sponging":[70],"miR-454-3p.":[71],"Moreover,":[72],"downregulated":[75],"by":[76,86],"EIF4A3.":[77],"Taken":[78],"together,":[79],"EIF4A3-regulated":[80],"could":[82],"progression":[85],"regulating":[87],"circGNAI2-miR-454-3p-VGLL4":[88],"axis":[89],"signaling":[92],"pathway,":[93],"providing":[94],"pivotal":[95],"potential":[96],"therapeutic":[97],"targets":[98],"for":[99],"treatment":[101],"TNBC.":[103]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-12-12T00:00:00"}